AR046756A1 - Derivados de hidronopol como agonistas de receptores orl-1 humanos. - Google Patents
Derivados de hidronopol como agonistas de receptores orl-1 humanos.Info
- Publication number
- AR046756A1 AR046756A1 ARP040104561A ARP040104561A AR046756A1 AR 046756 A1 AR046756 A1 AR 046756A1 AR P040104561 A ARP040104561 A AR P040104561A AR P040104561 A ARP040104561 A AR P040104561A AR 046756 A1 AR046756 A1 AR 046756A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- hidronopol
- orl
- refers
- agonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Se refiere a un grupo de derivados de hidronopol que son agonistas de receptores ORL1 humanos (nociceptina). También se refiere a la preparación de estos compuestos, a composiciones farmacéuticas que contienen como ingrediente activo una cantidad farmacológicamente activa de al menos uno de estos nuevos derivados de hidronopol, como así también al uso de estas composiciones farmacéuticas para el tratamiento de trastornos en los cuales están implicados receptores ORL1. Se refiere a compuestos de fórmula general 1 donde los símbolos tienen los significados dados en la memoria descriptiva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104662 | 2003-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR046756A1 true AR046756A1 (es) | 2005-12-21 |
Family
ID=34924140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040104561A AR046756A1 (es) | 2003-12-12 | 2004-12-07 | Derivados de hidronopol como agonistas de receptores orl-1 humanos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US7241770B2 (es) |
EP (1) | EP1694675A2 (es) |
JP (1) | JP2007513922A (es) |
CN (1) | CN1890238A (es) |
AR (1) | AR046756A1 (es) |
AU (1) | AU2004298436A1 (es) |
BR (1) | BRPI0417161A (es) |
CA (1) | CA2547633A1 (es) |
MX (1) | MXPA06005675A (es) |
RU (1) | RU2351600C2 (es) |
TW (1) | TW200522949A (es) |
UA (1) | UA84896C2 (es) |
WO (1) | WO2005058890A2 (es) |
ZA (1) | ZA200604791B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR045843A1 (es) * | 2003-10-03 | 2005-11-16 | Solvay Pharm Bv | Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos |
TW200804382A (en) | 2005-12-05 | 2008-01-16 | Incyte Corp | Lactam compounds and methods of using the same |
CL2007001795A1 (es) * | 2006-06-20 | 2008-01-18 | Wyeth Corp | Compuestos derivados de 4-oxo-1,2,8-triaza-espiro[4.5] decano, que actuan como inhibidores del canal de potasio kv1.5; composicion farmaceutica que los comprende; y uso de los compuestos en la prepararcion de medicamentos para tratar o prevenir arritmias cardiacas |
RU2458902C1 (ru) * | 2011-07-08 | 2012-08-20 | Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН | Способ получения миртанола |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
US9040533B2 (en) | 2012-12-27 | 2015-05-26 | Purdue Pharma L.P. | Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators |
US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
WO2014102590A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
US9963458B2 (en) | 2012-12-27 | 2018-05-08 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
US9708241B2 (en) | 2013-09-12 | 2017-07-18 | Shin-Etsu Chemical Co., Ltd. | Methods for producing β-cyclolavandulal and derivative of same |
JP2015078179A (ja) * | 2013-09-12 | 2015-04-23 | 信越化学工業株式会社 | シクロラバンジュロール及びその誘導体の製造方法 |
CN104557653A (zh) * | 2014-12-31 | 2015-04-29 | 大连联化化学有限公司 | 7-甲基-氮杂-二环[4,1,0]庚烷的制备方法 |
JP6832914B2 (ja) | 2015-07-31 | 2021-02-24 | ファイザー・インク | Magl阻害薬としての1,1,1−トリフルオロ−3−ヒドロキシプロパン−2−イルカルバマート誘導体および1,1,1−トリフルオロ−4−ヒドロキシブタン−2−イルカルバマート誘導体 |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
WO2018013999A1 (en) * | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
CA3050625C (en) | 2017-01-20 | 2021-07-20 | Pfizer Inc. | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors |
MX2019008690A (es) | 2017-01-23 | 2019-09-18 | Pfizer | Compuestos espiro heterociclicos como inhibidores de magl. |
IT201800007580A1 (it) * | 2018-07-27 | 2020-01-27 | Maria Cecilia Hospital Spa | Composti 1,3,8-triazaspiro e loro uso come medicamenti |
CN115124441B (zh) * | 2022-06-30 | 2024-04-02 | 南京林业大学 | 一类诺卜酸酰肼类化合物的制备方法和产品及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
EP0997464B1 (en) * | 1998-10-23 | 2005-02-16 | Pfizer Inc. | 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists |
JP2000169476A (ja) * | 1998-12-09 | 2000-06-20 | Banyu Pharmaceut Co Ltd | 4−オキソイミダゾリジン−5−スピロ−含窒素複素環式化合物 |
US6686370B2 (en) * | 1999-12-06 | 2004-02-03 | Euro-Celtique S.A. | Triazospiro compounds having nociceptin receptor affinity |
JP4601254B2 (ja) * | 2001-04-10 | 2010-12-22 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Orl−1受容体介在障害の治療に有用な1,3,8−トリアザスピロ[4.5]デカン−4−オン誘導体 |
BR0306309A (pt) | 2002-09-09 | 2004-10-19 | Janssen Pharmaceutica Nv | Derivados de 1,3,8-triazaespiro[4.5]decan-4-ona substituìda com hidroxialquila úteis para o tratamento de distúrbios mediados pelo receptor orl-1 |
-
2004
- 2004-12-07 AR ARP040104561A patent/AR046756A1/es not_active Application Discontinuation
- 2004-12-09 CA CA002547633A patent/CA2547633A1/en not_active Abandoned
- 2004-12-09 UA UAA200607374A patent/UA84896C2/ru unknown
- 2004-12-09 AU AU2004298436A patent/AU2004298436A1/en not_active Abandoned
- 2004-12-09 EP EP04804747A patent/EP1694675A2/en not_active Withdrawn
- 2004-12-09 BR BRPI0417161-6A patent/BRPI0417161A/pt not_active IP Right Cessation
- 2004-12-09 US US11/007,255 patent/US7241770B2/en not_active Expired - Fee Related
- 2004-12-09 MX MXPA06005675A patent/MXPA06005675A/es active IP Right Grant
- 2004-12-09 TW TW093138116A patent/TW200522949A/zh unknown
- 2004-12-09 WO PCT/EP2004/053373 patent/WO2005058890A2/en active Application Filing
- 2004-12-09 CN CNA2004800365151A patent/CN1890238A/zh active Pending
- 2004-12-09 RU RU2006124856/04A patent/RU2351600C2/ru active
- 2004-12-09 JP JP2006543547A patent/JP2007513922A/ja not_active Withdrawn
-
2006
- 2006-06-09 ZA ZA200604791A patent/ZA200604791B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0417161A (pt) | 2007-03-06 |
US20050131004A1 (en) | 2005-06-16 |
RU2006124856A (ru) | 2008-01-20 |
WO2005058890A3 (en) | 2005-08-18 |
TW200522949A (en) | 2005-07-16 |
JP2007513922A (ja) | 2007-05-31 |
EP1694675A2 (en) | 2006-08-30 |
AU2004298436A1 (en) | 2005-06-30 |
CN1890238A (zh) | 2007-01-03 |
MXPA06005675A (es) | 2006-08-17 |
US7241770B2 (en) | 2007-07-10 |
UA84896C2 (ru) | 2008-12-10 |
ZA200604791B (en) | 2008-07-30 |
CA2547633A1 (en) | 2005-06-30 |
RU2351600C2 (ru) | 2009-04-10 |
WO2005058890A2 (en) | 2005-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |