BRPI0414778A - 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer - Google Patents
6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncerInfo
- Publication number
- BRPI0414778A BRPI0414778A BRPI0414778-2A BRPI0414778A BRPI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A
- Authority
- BR
- Brazil
- Prior art keywords
- imidazo
- halo
- aryl
- pyrimidines
- anticancer agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"6-ARIL-7-HALO-IMIDAZO¢1,2-a!PIRIMIDINAS COMO AGENTES ANTICáNCER". A presente invenção refere-se a certas 6-arila-7-halo-imidazo ¢1,2-a!pirimidinas ou sais farmaceuticamente aceitáveis das mesmas, e composições contendo os referidos compostos ou sais farmaceuticamente aceitáveis dos mesmos, em que os referidos compostos são agentes anticâncer úteis para o tratamento de câncer em mamíferos por promoção de polimerização de microtúbulo. Esta invenção também refere-se a um método de tratar ou inibir o desenvolvimento de células de tumores cancerosos e doenças associadas em um mamífero e também fornece um método para o tratamento ou prevenção de tumores cancerosos que expressam resistência à múltiplas drogas (MDR) ou são resistentes por causa da MDR, em um mamífero com necessidade do mesmo cujo método compreende administrar ao referido mamífero uma quantidade eficaz dos referidos compostos ou sais farmaceuticamente aceitáveis dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50548603P | 2003-09-24 | 2003-09-24 | |
PCT/US2004/030595 WO2005030218A1 (en) | 2003-09-24 | 2004-09-17 | 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414778A true BRPI0414778A (pt) | 2006-11-21 |
Family
ID=34393021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414778-2A BRPI0414778A (pt) | 2003-09-24 | 2004-09-17 | 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer |
Country Status (14)
Country | Link |
---|---|
US (2) | US7285555B2 (pt) |
EP (1) | EP1684763B1 (pt) |
JP (1) | JP4695595B2 (pt) |
CN (1) | CN100486580C (pt) |
AT (1) | ATE398452T1 (pt) |
AU (1) | AU2004275728A1 (pt) |
BR (1) | BRPI0414778A (pt) |
CA (1) | CA2537520A1 (pt) |
DE (1) | DE602004014525D1 (pt) |
DK (1) | DK1684763T3 (pt) |
ES (1) | ES2308256T3 (pt) |
MX (1) | MXPA06002939A (pt) |
PL (1) | PL1684763T3 (pt) |
WO (1) | WO2005030218A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035422A2 (en) * | 1998-12-18 | 2000-06-22 | Hadasit Medical Research Services & Development Ltd. | Method of administering a compound to multi-drug resistant cells |
CN103044432B (zh) | 2005-12-23 | 2016-08-03 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
US20100056371A1 (en) * | 2007-01-08 | 2010-03-04 | Basf Se | Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi |
CN107935870A (zh) * | 2017-11-09 | 2018-04-20 | 华中药业股份有限公司 | 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593996A (en) * | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
TW224044B (pt) | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
JP2794510B2 (ja) | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
IL108747A (en) | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
IL108731A (en) | 1993-03-04 | 1997-03-18 | Shell Int Research | 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES |
RU2147584C1 (ru) | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
US5817663A (en) | 1996-10-07 | 1998-10-06 | American Cyanamid Company | Pentafluorophenylazolopyrimidines |
US5750766A (en) | 1997-03-18 | 1998-05-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
AU6558498A (en) | 1997-03-18 | 1998-10-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
US5948783A (en) | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6117876A (en) | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
US6255309B1 (en) | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
TWI252231B (en) | 1997-04-14 | 2006-04-01 | American Cyanamid Co | Fungicidal trifluorophenyl-triazolopyrimidines |
US5994360A (en) | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
HUP0100885A3 (en) | 1998-02-11 | 2002-12-28 | American Cyanamid Company Madi | Fungicidal 7-alkyl-triazolopyrimidines |
US6020338A (en) | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
JPH11322517A (ja) | 1998-03-17 | 1999-11-24 | American Cyanamid Co | トリアゾロピリミジン類の効力の増進 |
US6124301A (en) | 1998-03-17 | 2000-09-26 | American Cyanamid Company | Enhancement of the efficacy of triazolopyrimidines |
WO1999048893A1 (en) | 1998-03-23 | 1999-09-30 | American Cyanamid Company | Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines |
US6284762B1 (en) | 1998-03-23 | 2001-09-04 | American Cyanamid Company | Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines |
US5981534A (en) | 1998-09-25 | 1999-11-09 | American Cyanamid Company | Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines |
US6268371B1 (en) | 1998-09-10 | 2001-07-31 | American Cyanamid Co. | Fungicidal mixtures |
US6117865A (en) | 1998-09-10 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
JP2000103790A (ja) | 1998-09-25 | 2000-04-11 | American Cyanamid Co | 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類 |
US6156925A (en) | 1998-09-25 | 2000-12-05 | American Cyanamid Company | Process for the preparation of halogenated phenylmaloates |
ATE240648T1 (de) | 1998-09-25 | 2003-06-15 | Basf Ag | Fungizide mischungen |
NZ510741A (en) | 1998-09-25 | 2003-08-29 | Basf Ag | Non-aqueous suspension concentrate containing a triazolopyrimidine crop protection active compound, and its use as a pesticide |
US5985883A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trichlorophenyl-triazolopyrimidines |
US5986135A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6277856B1 (en) | 1998-09-25 | 2001-08-21 | American Cynamid Co. | Fungicidal mixtures |
US6242451B1 (en) | 1998-09-25 | 2001-06-05 | Klaus-Juergen Pees | Fungicidal trihalophenyl-triazolopyrimidines |
JP4025468B2 (ja) | 1999-07-29 | 2007-12-19 | 三井化学株式会社 | 有機電界発光素子 |
AU3154601A (en) | 1999-11-18 | 2001-05-30 | Basf Aktiengesellschaft | Non-aqueous concentrated spreading oil composition |
US6559151B2 (en) | 2000-05-08 | 2003-05-06 | Basf Aktiengesellschaft | 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines |
NZ523807A (en) * | 2000-06-30 | 2004-09-24 | Wyeth Corp | Substituted-triazolopyrimidines as anticancer agents |
AU2002214958B2 (en) | 2000-08-25 | 2007-03-29 | Basf Aktiengesellschaft | Fungicidal formulation |
AU2001223629A1 (en) | 2000-12-06 | 2002-06-18 | Basf Aktiengesellschaft | Fungicidal 6-(trifluoromethyl-phenyl)-triazolopyrimidines |
WO2002067679A1 (en) | 2001-02-19 | 2002-09-06 | Basf Aktiengesellschaft | Fungicidal mixtures |
HUP0401092A3 (en) | 2001-04-11 | 2005-10-28 | Basf Ag | 5-halogen-6-phenyl-7-fluoralkylamino-triazolopyrimidines as fungicides, preparation and use thereof |
US7211545B2 (en) * | 2001-09-04 | 2007-05-01 | Sumitomo Chemical Company, Limited | Imidazo[1,2-a]pyrimidine and fungicidal compositions containing thereof |
AU2003211651A1 (en) * | 2002-04-19 | 2003-11-03 | Sumitomo Chemical Company, Limited | 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME |
-
2004
- 2004-09-17 WO PCT/US2004/030595 patent/WO2005030218A1/en active Application Filing
- 2004-09-17 BR BRPI0414778-2A patent/BRPI0414778A/pt not_active IP Right Cessation
- 2004-09-17 JP JP2006528080A patent/JP4695595B2/ja not_active Expired - Fee Related
- 2004-09-17 ES ES04784454T patent/ES2308256T3/es active Active
- 2004-09-17 AU AU2004275728A patent/AU2004275728A1/en not_active Withdrawn
- 2004-09-17 DK DK04784454T patent/DK1684763T3/da active
- 2004-09-17 DE DE602004014525T patent/DE602004014525D1/de active Active
- 2004-09-17 MX MXPA06002939A patent/MXPA06002939A/es active IP Right Grant
- 2004-09-17 CA CA002537520A patent/CA2537520A1/en not_active Abandoned
- 2004-09-17 PL PL04784454T patent/PL1684763T3/pl unknown
- 2004-09-17 CN CNB2004800273126A patent/CN100486580C/zh not_active Expired - Fee Related
- 2004-09-17 AT AT04784454T patent/ATE398452T1/de not_active IP Right Cessation
- 2004-09-17 EP EP04784454A patent/EP1684763B1/en active Active
- 2004-09-24 US US10/950,542 patent/US7285555B2/en not_active Expired - Fee Related
-
2007
- 2007-09-19 US US11/903,100 patent/US7915266B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2308256T3 (es) | 2008-12-01 |
MXPA06002939A (es) | 2006-05-31 |
DK1684763T3 (da) | 2008-09-01 |
ATE398452T1 (de) | 2008-07-15 |
PL1684763T3 (pl) | 2008-11-28 |
CN1856311A (zh) | 2006-11-01 |
EP1684763B1 (en) | 2008-06-18 |
JP4695595B2 (ja) | 2011-06-08 |
CA2537520A1 (en) | 2005-04-07 |
WO2005030218A1 (en) | 2005-04-07 |
US7285555B2 (en) | 2007-10-23 |
JP2007506745A (ja) | 2007-03-22 |
US20080255157A1 (en) | 2008-10-16 |
DE602004014525D1 (de) | 2008-07-31 |
US20050065167A1 (en) | 2005-03-24 |
US7915266B2 (en) | 2011-03-29 |
AU2004275728A1 (en) | 2005-04-07 |
CN100486580C (zh) | 2009-05-13 |
EP1684763A1 (en) | 2006-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |