DE602004014525D1 - 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs - Google Patents

6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs

Info

Publication number
DE602004014525D1
DE602004014525D1 DE602004014525T DE602004014525T DE602004014525D1 DE 602004014525 D1 DE602004014525 D1 DE 602004014525D1 DE 602004014525 T DE602004014525 T DE 602004014525T DE 602004014525 T DE602004014525 T DE 602004014525T DE 602004014525 D1 DE602004014525 D1 DE 602004014525D1
Authority
DE
Germany
Prior art keywords
halo
aryl
imidazoä1
aüpyrimidine
against cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004014525T
Other languages
English (en)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Wyeth LLC
Original Assignee
Wyeth Holdings LLC
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC, Wyeth LLC filed Critical Wyeth Holdings LLC
Publication of DE602004014525D1 publication Critical patent/DE602004014525D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602004014525T 2003-09-24 2004-09-17 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs Active DE602004014525D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
DE602004014525D1 true DE602004014525D1 (de) 2008-07-31

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014525T Active DE602004014525D1 (de) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs

Country Status (14)

Country Link
US (2) US7285555B2 (de)
EP (1) EP1684763B1 (de)
JP (1) JP4695595B2 (de)
CN (1) CN100486580C (de)
AT (1) ATE398452T1 (de)
AU (1) AU2004275728A1 (de)
BR (1) BRPI0414778A (de)
CA (1) CA2537520A1 (de)
DE (1) DE602004014525D1 (de)
DK (1) DK1684763T3 (de)
ES (1) ES2308256T3 (de)
MX (1) MXPA06002939A (de)
PL (1) PL1684763T3 (de)
WO (1) WO2005030218A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU769569B2 (en) * 1998-12-18 2004-01-29 Alza Corporation Method of administering a compound to multi-drug resistant cells
PL1973545T3 (pl) 2005-12-23 2013-05-31 Ariad Pharma Inc Bicykliczne Związki Heteroarylowe
BRPI0807458A2 (pt) * 2007-01-08 2014-06-03 Basf Se Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (de) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
TW258648B (de) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
EP0984919B1 (de) 1997-03-18 2003-01-22 Basf Aktiengesellschaft Verfahren zur herstellung von arylmalonaten
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
JP3423290B2 (ja) 1998-02-11 2003-07-07 アメリカン・サイアナミド・カンパニー 殺菌剤７−アルキル−トリアゾロピリミジン
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
CA2324154C (en) 1998-03-23 2008-03-18 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
ES2214890T3 (es) 1998-09-25 2004-09-16 Basf Aktiengesellschaft Concentrado no acuoso para suspensiones.
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
SK18412002A3 (sk) * 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
JP2004506662A (ja) 2000-08-25 2004-03-04 ビーエーエスエフ　アクチェンゲゼルシャフト 殺菌剤
JP2004515502A (ja) 2000-12-06 2004-05-27 ビーエーエスエフ アクチェンゲゼルシャフト 殺真菌性を有する６−（トリフルオロメチル−フェニル）−トリアゾロピリミジン類
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
EE200300499A (et) 2001-04-11 2003-12-15 Basf Aktiengesellschaft 5-halogeen-6-fenüül-7-fluoroalküülaminotriasolopürimidiinid
US7211545B2 (en) * 2001-09-04 2007-05-01 Sumitomo Chemical Company, Limited Imidazo[1,2-a]pyrimidine and fungicidal compositions containing thereof
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
US7915266B2 (en) 2011-03-29
US20080255157A1 (en) 2008-10-16
EP1684763B1 (de) 2008-06-18
WO2005030218A1 (en) 2005-04-07
US7285555B2 (en) 2007-10-23
EP1684763A1 (de) 2006-08-02
CN100486580C (zh) 2009-05-13
JP2007506745A (ja) 2007-03-22
AU2004275728A1 (en) 2005-04-07
ES2308256T3 (es) 2008-12-01
DK1684763T3 (da) 2008-09-01
ATE398452T1 (de) 2008-07-15
US20050065167A1 (en) 2005-03-24
MXPA06002939A (es) 2006-05-31
CA2537520A1 (en) 2005-04-07
PL1684763T3 (pl) 2008-11-28
JP4695595B2 (ja) 2011-06-08
BRPI0414778A (pt) 2006-11-21
CN1856311A (zh) 2006-11-01

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