MXPA06002939A - 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer. - Google Patents

6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer.

Info

Publication number
MXPA06002939A
MXPA06002939A MXPA06002939A MXPA06002939A MXPA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A
Authority
MX
Mexico
Prior art keywords
mammal
compounds
pharmaceutically acceptable
acceptable salts
pyrimidines
Prior art date
Application number
MXPA06002939A
Other languages
English (en)
Inventor
Nan Zhang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA06002939A publication Critical patent/MXPA06002939A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invencion se relaciona con ciertas 6-aril-7-haloimidazo[1,2-a]pirimidinas o sales farmaceuticamente aceptables de las mismas y composiciones que contienen a dichos compuestos o sales farmaceuticamente aceptables de los mismos, en donde los compuestos son agentes contra el cancer utiles para el tratamiento de cancer en mamiferos al promover la polimerizacion de los microtubulos. Esta invencion se relaciona adicionalmente con un metodo para tratar o inhibir el crecimiento de celulas tumorales cancerosas y enfermedades relacionadas en un mamifero y proporciona ademas un metodo para el tratamiento o prevencion de tumores cancerosos que expresan resistencia a medicamentos multiples (MDR) o que son resistentes debido a MDR, en un mamifero en necesidad del mismo, metodo el cual comprende administrar al mamifero una cantidad eficaz de los compuestos o sales farmaceuticamente aceptables de los mismos.
MXPA06002939A 2003-09-24 2004-09-17 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer. MXPA06002939A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
MXPA06002939A true MXPA06002939A (es) 2006-05-31

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06002939A MXPA06002939A (es) 2003-09-24 2004-09-17 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer.

Country Status (14)

Country Link
US (2) US7285555B2 (es)
EP (1) EP1684763B1 (es)
JP (1) JP4695595B2 (es)
CN (1) CN100486580C (es)
AT (1) ATE398452T1 (es)
AU (1) AU2004275728A1 (es)
BR (1) BRPI0414778A (es)
CA (1) CA2537520A1 (es)
DE (1) DE602004014525D1 (es)
DK (1) DK1684763T3 (es)
ES (1) ES2308256T3 (es)
MX (1) MXPA06002939A (es)
PL (1) PL1684763T3 (es)
WO (1) WO2005030218A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU769569B2 (en) * 1998-12-18 2004-01-29 Alza Corporation Method of administering a compound to multi-drug resistant cells
DK2495016T3 (da) 2005-12-23 2019-12-16 Ariad Pharma Inc Bicykliske heteroarylforbindelser
US20100056371A1 (en) * 2007-01-08 2010-03-04 Basf Se Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
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TW224044B (es) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
ATE231485T1 (de) 1997-03-18 2003-02-15 Basf Ag Verfahren zur herstellung von arylmalonaten
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
BR9907863A (pt) 1998-02-11 2000-10-24 American Cyanamid Co Composto, processo para a preparação do mesmo, composição fungicida, processo para combater fungo em um local, e, uso do composto ou da composição
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6124301A (en) * 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
DK1066291T3 (da) 1998-03-23 2005-09-19 Basf Ag Svampedræbende 6-(2-halogen-4-alkoxyphenyl)-triazolopyrimidiner
US6284762B1 (en) * 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US6268371B1 (en) * 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) * 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
DK0988790T3 (da) 1998-09-25 2003-09-22 Basf Ag Fungicide blandinger
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
CN1215764C (zh) 1998-09-25 2005-08-24 美国氰胺公司 浓缩非水悬浮液
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
AU3154601A (en) * 1999-11-18 2001-05-30 Basf Aktiengesellschaft Non-aqueous concentrated spreading oil composition
US6559151B2 (en) * 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
EA006483B1 (ru) * 2000-06-30 2005-12-29 Уайт Замещенные триазолопиримидины в качестве противораковых средств
DE60104126T2 (de) * 2000-08-25 2004-10-28 Basf Ag Fungizide formulierung
ES2226968T3 (es) 2000-12-06 2005-04-01 Wyeth 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas.
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
ATE287405T1 (de) 2001-04-11 2005-02-15 Wyeth Corp 5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide
ES2287312T3 (es) * 2001-09-04 2007-12-16 Sumitomo Chemical Company, Limited Imidazo(1,2-a)pirimidinas y composiciones fungicidas que las contienen.
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
BRPI0414778A (pt) 2006-11-21
DE602004014525D1 (de) 2008-07-31
ATE398452T1 (de) 2008-07-15
EP1684763B1 (en) 2008-06-18
US7285555B2 (en) 2007-10-23
CN1856311A (zh) 2006-11-01
CA2537520A1 (en) 2005-04-07
WO2005030218A1 (en) 2005-04-07
AU2004275728A1 (en) 2005-04-07
DK1684763T3 (da) 2008-09-01
US7915266B2 (en) 2011-03-29
JP2007506745A (ja) 2007-03-22
US20080255157A1 (en) 2008-10-16
US20050065167A1 (en) 2005-03-24
PL1684763T3 (pl) 2008-11-28
ES2308256T3 (es) 2008-12-01
JP4695595B2 (ja) 2011-06-08
CN100486580C (zh) 2009-05-13
EP1684763A1 (en) 2006-08-02

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