NO20061318L - 6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler - Google Patents
6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midlerInfo
- Publication number
- NO20061318L NO20061318L NO20061318A NO20061318A NO20061318L NO 20061318 L NO20061318 L NO 20061318L NO 20061318 A NO20061318 A NO 20061318A NO 20061318 A NO20061318 A NO 20061318A NO 20061318 L NO20061318 L NO 20061318L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- pharmaceutically acceptable
- acceptable salts
- mammal
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår visse 6-[(substituert)fenyl]-triazolpyrimidin-forbindelser eller farmasøytisk akseptable salter derav, og preparater som inneholder de nevnte forbindelser eller farmasøytisk akseptable salter derav, hvor de nevnte forbindelser er antikreftmidler som er anvendelige for behandling av kreft hos pattedyr. Foreliggende oppfinnelse angår videre en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr, og tilveiebringer videre en metode for behandling eller forebygging av cancerøse tumorer som oppviser multiresistens (MDR) eller er resistente på grunn av MDR, hos et pattedyr med behov for dette, hvor metoden omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser eller farmasøytisk akseptable salter derav. Foreliggende oppfinnelse angår en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr med behov for dette, ved å fremme mikrotubuli-polymerisering, som omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser og farmasøytisk akseptable salter derav. Foreliggende oppfinnelse angår visse 6-[(substituert)fenyl]-triazolpyrimidin-forbindelser eller farmasøytisk akseptable salter derav, og preparater som inneholder de nevnte forbindelser eller farmasøytisk akseptable salter derav, hvor de nevnte forbindelser er antikreftmidler som er anvendelige for behandling av kreft hos pattedyr. Foreliggende oppfinnelse angår videre en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr, og tilveiebringer videre en metode for behandling eller forebygging av cancerøse tumorer som oppviser multiresistens (MDR) eller er resistente på grunn av MDR, hos et pattedyr med behov for dette, hvor metoden omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser eller farmasøytisk akseptable salter derav. Foreliggende oppfinnelse angår en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr med behov for dette, ved å fremme mikrotubuli-polymerisering, som omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser og farmasøytisk akseptable salter derav.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50554403P | 2003-09-24 | 2003-09-24 | |
PCT/US2004/030515 WO2005030775A1 (en) | 2003-09-24 | 2004-09-17 | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20061318L true NO20061318L (no) | 2006-04-21 |
Family
ID=34393032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20061318A NO20061318L (no) | 2003-09-24 | 2006-03-23 | 6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler |
Country Status (31)
Country | Link |
---|---|
US (1) | US7507739B2 (no) |
EP (1) | EP1680425B1 (no) |
JP (1) | JP2007506744A (no) |
KR (1) | KR20060098368A (no) |
CN (1) | CN100519559C (no) |
AR (1) | AR045810A1 (no) |
AU (1) | AU2004276240A1 (no) |
BR (1) | BRPI0414700A (no) |
CA (1) | CA2539252A1 (no) |
CO (1) | CO5690598A2 (no) |
CR (1) | CR8288A (no) |
CY (1) | CY1106392T1 (no) |
DE (1) | DE602004004295T8 (no) |
DK (1) | DK1680425T3 (no) |
EC (1) | ECSP066458A (no) |
ES (1) | ES2279452T3 (no) |
GT (1) | GT200400190A (no) |
HK (1) | HK1090374A1 (no) |
IL (1) | IL174281A0 (no) |
MX (1) | MXPA06003206A (no) |
NO (1) | NO20061318L (no) |
PA (1) | PA8613301A1 (no) |
PE (1) | PE20050433A1 (no) |
PL (1) | PL1680425T3 (no) |
PT (1) | PT1680425E (no) |
RU (1) | RU2006107579A (no) |
SA (1) | SA04250302A (no) |
SI (1) | SI1680425T1 (no) |
TW (1) | TW200512211A (no) |
WO (1) | WO2005030775A1 (no) |
ZA (1) | ZA200602387B (no) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
EA006483B1 (ru) * | 2000-06-30 | 2005-12-29 | Уайт | Замещенные триазолопиримидины в качестве противораковых средств |
CA2539252A1 (en) | 2003-09-24 | 2005-04-07 | Wyeth Holdings Corporation | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents |
US7419982B2 (en) * | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
MY179926A (en) * | 2003-12-08 | 2020-11-19 | Wyeth Corp | Process for the preparation of tubulin inhibitors |
EP1891052A1 (en) * | 2005-06-13 | 2008-02-27 | Wyeth | Tubulin inhibitor and process for its preparation |
CN101193884A (zh) | 2005-06-13 | 2008-06-04 | 惠氏公司 | 微管蛋白抑制剂和其制备方法 |
BRPI0612676A2 (pt) * | 2005-06-27 | 2016-11-29 | Basf Ag | processo para preparar compostos, compostos, e, uso de compostos |
BRPI0619962A2 (pt) * | 2005-12-16 | 2011-10-25 | Wyeth Corp | composições liofilizadas de um composto triazolopirimidina |
EP1963330A1 (en) * | 2005-12-16 | 2008-09-03 | Wyeth a Corporation of the State of Delaware | Dimers and adducts of 6-[substituted) phenyl] triazolopyrimidines useful as anticancer agents |
US20100056371A1 (en) * | 2007-01-08 | 2010-03-04 | Basf Se | Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi |
EP2903436B1 (en) * | 2012-09-19 | 2019-07-17 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
EP3758696A4 (en) * | 2018-03-02 | 2021-12-08 | The Trustees of the University of Pennsylvania | [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AND USE OF THESE IN THE STABILIZATION OF MICROTUBULES |
CN114369098B (zh) * | 2022-01-06 | 2023-03-10 | 苏州大学 | 一种三唑并嘧啶醇类化合物及其制备方法和应用 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593996A (en) * | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
TW224044B (no) | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
JP2794510B2 (ja) | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
IL108747A (en) * | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
IL108731A (en) * | 1993-03-04 | 1997-03-18 | Shell Int Research | 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES |
RU2147584C1 (ru) * | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
US5817663A (en) * | 1996-10-07 | 1998-10-06 | American Cyanamid Company | Pentafluorophenylazolopyrimidines |
ATE231485T1 (de) | 1997-03-18 | 2003-02-15 | Basf Ag | Verfahren zur herstellung von arylmalonaten |
US5750766A (en) * | 1997-03-18 | 1998-05-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
TWI252231B (en) | 1997-04-14 | 2006-04-01 | American Cyanamid Co | Fungicidal trifluorophenyl-triazolopyrimidines |
US6117876A (en) * | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
US5948783A (en) * | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US5994360A (en) * | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
US6020338A (en) * | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
BR9907863A (pt) | 1998-02-11 | 2000-10-24 | American Cyanamid Co | Composto, processo para a preparação do mesmo, composição fungicida, processo para combater fungo em um local, e, uso do composto ou da composição |
JPH11322517A (ja) | 1998-03-17 | 1999-11-24 | American Cyanamid Co | トリアゾロピリミジン類の効力の増進 |
US6124301A (en) * | 1998-03-17 | 2000-09-26 | American Cyanamid Company | Enhancement of the efficacy of triazolopyrimidines |
US6284762B1 (en) * | 1998-03-23 | 2001-09-04 | American Cyanamid Company | Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines |
US5981534A (en) * | 1998-09-25 | 1999-11-09 | American Cyanamid Company | Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines |
DK1066291T3 (da) | 1998-03-23 | 2005-09-19 | Basf Ag | Svampedræbende 6-(2-halogen-4-alkoxyphenyl)-triazolopyrimidiner |
US6117865A (en) * | 1998-09-10 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
US6268371B1 (en) * | 1998-09-10 | 2001-07-31 | American Cyanamid Co. | Fungicidal mixtures |
JP2000103790A (ja) | 1998-09-25 | 2000-04-11 | American Cyanamid Co | 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類 |
US5985883A (en) * | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trichlorophenyl-triazolopyrimidines |
US5986135A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
CN1215764C (zh) | 1998-09-25 | 2005-08-24 | 美国氰胺公司 | 浓缩非水悬浮液 |
US6242451B1 (en) * | 1998-09-25 | 2001-06-05 | Klaus-Juergen Pees | Fungicidal trihalophenyl-triazolopyrimidines |
DK0988790T3 (da) | 1998-09-25 | 2003-09-22 | Basf Ag | Fungicide blandinger |
US6277856B1 (en) * | 1998-09-25 | 2001-08-21 | American Cynamid Co. | Fungicidal mixtures |
US6521628B1 (en) * | 1999-01-29 | 2003-02-18 | Basf Aktiengesellschaft | Fungicidal mixtures |
US6699874B2 (en) * | 1999-09-24 | 2004-03-02 | Basf Aktiengesellschaft | Fungicidal mixtures |
AU3154601A (en) * | 1999-11-18 | 2001-05-30 | Basf Aktiengesellschaft | Non-aqueous concentrated spreading oil composition |
US6559151B2 (en) * | 2000-05-08 | 2003-05-06 | Basf Aktiengesellschaft | 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines |
EA006483B1 (ru) * | 2000-06-30 | 2005-12-29 | Уайт | Замещенные триазолопиримидины в качестве противораковых средств |
DE60104126T2 (de) * | 2000-08-25 | 2004-10-28 | Basf Ag | Fungizide formulierung |
US6459602B1 (en) * | 2000-10-26 | 2002-10-01 | O2 Micro International Limited | DC-to-DC converter with improved transient response |
WO2002038565A2 (de) | 2000-11-13 | 2002-05-16 | Basf Aktiengesellschaft | 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen |
ES2226968T3 (es) | 2000-12-06 | 2005-04-01 | Wyeth | 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas. |
DE10063115A1 (de) | 2000-12-18 | 2002-06-27 | Bayer Ag | Triazolopyrimidine |
WO2002067679A1 (en) | 2001-02-19 | 2002-09-06 | Basf Aktiengesellschaft | Fungicidal mixtures |
ATE287405T1 (de) | 2001-04-11 | 2005-02-15 | Wyeth Corp | 5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide |
DE10124208A1 (de) * | 2001-05-18 | 2002-11-21 | Bayer Ag | Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide |
JP2005504743A (ja) | 2001-07-18 | 2005-02-17 | ビーエーエスエフ アクチェンゲゼルシャフト | 殺菌薬としての置換された6−(2−メトキシ−フェニル)−トリアゾロピリミジン |
CA2539252A1 (en) | 2003-09-24 | 2005-04-07 | Wyeth Holdings Corporation | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents |
-
2004
- 2004-09-17 CA CA002539252A patent/CA2539252A1/en not_active Abandoned
- 2004-09-17 BR BRPI0414700-6A patent/BRPI0414700A/pt not_active IP Right Cessation
- 2004-09-17 DE DE602004004295T patent/DE602004004295T8/de active Active
- 2004-09-17 EP EP04788820A patent/EP1680425B1/en active Active
- 2004-09-17 CN CNB2004800302006A patent/CN100519559C/zh not_active Expired - Fee Related
- 2004-09-17 KR KR1020067005785A patent/KR20060098368A/ko not_active Application Discontinuation
- 2004-09-17 DK DK04788820T patent/DK1680425T3/da active
- 2004-09-17 RU RU2006107579/04A patent/RU2006107579A/ru not_active Application Discontinuation
- 2004-09-17 AU AU2004276240A patent/AU2004276240A1/en not_active Withdrawn
- 2004-09-17 PL PL04788820T patent/PL1680425T3/pl unknown
- 2004-09-17 JP JP2006528075A patent/JP2007506744A/ja not_active Withdrawn
- 2004-09-17 PT PT04788820T patent/PT1680425E/pt unknown
- 2004-09-17 WO PCT/US2004/030515 patent/WO2005030775A1/en active IP Right Grant
- 2004-09-17 SI SI200430195T patent/SI1680425T1/sl unknown
- 2004-09-17 ES ES04788820T patent/ES2279452T3/es active Active
- 2004-09-17 MX MXPA06003206A patent/MXPA06003206A/es active IP Right Grant
- 2004-09-21 TW TW093128500A patent/TW200512211A/zh unknown
- 2004-09-22 SA SA04250302A patent/SA04250302A/ar unknown
- 2004-09-23 AR ARP040103440A patent/AR045810A1/es not_active Application Discontinuation
- 2004-09-23 PE PE2004000925A patent/PE20050433A1/es not_active Application Discontinuation
- 2004-09-24 US US10/950,543 patent/US7507739B2/en not_active Expired - Fee Related
- 2004-09-24 GT GT200400190A patent/GT200400190A/es unknown
- 2004-09-24 PA PA20048613301A patent/PA8613301A1/es unknown
-
2006
- 2006-03-13 IL IL174281A patent/IL174281A0/en unknown
- 2006-03-14 CR CR8288A patent/CR8288A/es not_active Application Discontinuation
- 2006-03-23 NO NO20061318A patent/NO20061318L/no not_active Application Discontinuation
- 2006-03-23 ZA ZA200602387A patent/ZA200602387B/xx unknown
- 2006-03-24 EC EC2006006458A patent/ECSP066458A/es unknown
- 2006-04-21 CO CO06038133A patent/CO5690598A2/es not_active Application Discontinuation
- 2006-11-01 HK HK06112040A patent/HK1090374A1/xx not_active IP Right Cessation
-
2007
- 2007-03-16 CY CY20071100373T patent/CY1106392T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20061318L (no) | 6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler | |
NO20061319L (no) | 5-arylpyrimidiner som anticancer legemidler | |
MX2010003927A (es) | Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b. | |
EA200700902A1 (ru) | 3-ариламинопиридиновые производные | |
NO20082730L (no) | Morfolinopyrimidinderivater og deres anvendelse i terapi | |
TW200510380A (en) | Mitotic kinesin inhibitors | |
NO20070681L (no) | 2, 4, 6-Trisubstituterte pyrimidiner som fosfotidylinositol-(PI)-3-kinaseinhibitorer og disses anvendelse i behandling av kreft | |
EA200701780A1 (ru) | Противоопухолевое средство | |
TNSN05188A1 (en) | 4-aminopyrimidine-5-one | |
AU2006273692A8 (en) | 1,4-Dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | |
BR9814059A (pt) | Composto, composição farmacéutica, e, processos para tratamento de um indivìduo com câncer de mama ou de próstata, para inibir o crescimento de células tumorais da mama ou da próstata, e, para induzir a apoptose de células tumorais da mama ou da próstata | |
PL1732926T3 (pl) | Inhibitory kinezyn motorycznych | |
ATE238981T1 (de) | Antitumorwirkstoffe | |
WO2005103034A8 (en) | Novel piperidine substituted diaminothiazoles | |
TW200612929A (en) | Novel 2,6-diaminopyridine-3-one derivatives | |
MXPA06002939A (es) | 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer. | |
WO2003080624A3 (en) | Dithiolopyrrolone derivatives useful in the treatment of proliferative diseases | |
WO2007075465A8 (en) | Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents | |
DE602004009097D1 (de) | 1.3.4-triaza-phenalen- und 1,3,4,6-tetraazaphenalen-derivative | |
WO2004062586A3 (en) | Antineoplastic ether lipid compounds | |
WO2002067855A3 (en) | Enantiomers of unsaturated alkyllysophosphonocholines and use as anti-neoplastics | |
WO2006048761A3 (en) | Methods for preparing indazole compounds | |
UA100390C2 (en) | Pyrrolo[2,3-d]pyrimidin derivatives as protein kinase b inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |