WO2006048761A3 - Methods for preparing indazole compounds - Google Patents

Methods for preparing indazole compounds Download PDF

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Publication number
WO2006048761A3
WO2006048761A3 PCT/IB2005/003348 IB2005003348W WO2006048761A3 WO 2006048761 A3 WO2006048761 A3 WO 2006048761A3 IB 2005003348 W IB2005003348 W IB 2005003348W WO 2006048761 A3 WO2006048761 A3 WO 2006048761A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
indazole compounds
compounds
formula
protein kinases
Prior art date
Application number
PCT/IB2005/003348
Other languages
French (fr)
Other versions
WO2006048761A2 (en
Inventor
Srinivasan Babu
Raymond Dagnino Jr
Aubrey Haddach
Mark Bryan Mitchell
Michael Allen Ouellette
James Edward Saenz
Jayaram Katsuri Srirangam
Shu Yu
Scott Edward Zook
Original Assignee
Pfizer
Srinivasan Babu
Raymond Dagnino Jr
Aubrey Haddach
Mark Bryan Mitchell
Michael Allen Ouellette
James Edward Saenz
Jayaram Katsuri Srirangam
Shu Yu
Scott Edward Zook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Srinivasan Babu, Raymond Dagnino Jr, Aubrey Haddach, Mark Bryan Mitchell, Michael Allen Ouellette, James Edward Saenz, Jayaram Katsuri Srirangam, Shu Yu, Scott Edward Zook filed Critical Pfizer
Priority to EP05797459A priority Critical patent/EP1814859A2/en
Priority to AU2005300241A priority patent/AU2005300241A1/en
Priority to MX2007006554A priority patent/MX2007006554A/en
Priority to CA002591313A priority patent/CA2591313A1/en
Priority to RU2007120635/04A priority patent/RU2007120635A/en
Publication of WO2006048761A2 publication Critical patent/WO2006048761A2/en
Publication of WO2006048761A3 publication Critical patent/WO2006048761A3/en
Priority to IL183605A priority patent/IL183605A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention relates to methods for preparing compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof. Compounds of the formula (I) are useful as anti-angiogenesis agents and as agents for modulating and/or inhibiting the activity of protein kinases, thus providing treatments for cancer or other diseases associated with cellular proliferation mediated by protein kinases.
PCT/IB2005/003348 2004-11-02 2005-10-21 Methods for preparing indazole compounds WO2006048761A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP05797459A EP1814859A2 (en) 2004-11-02 2005-10-21 Methods for preparing indazole compounds
AU2005300241A AU2005300241A1 (en) 2004-11-02 2005-10-21 Methods for preparing indazole compounds
MX2007006554A MX2007006554A (en) 2004-11-02 2005-10-21 Methods for preparing indazole compounds.
CA002591313A CA2591313A1 (en) 2004-11-02 2005-10-21 Methods for preparing indazole compounds
RU2007120635/04A RU2007120635A (en) 2004-11-02 2005-10-21 METHODS FOR OBTAINING INDOSOLIC COMPOUNDS
IL183605A IL183605A0 (en) 2004-11-02 2007-05-31 Methods for preparing indazole compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62471904P 2004-11-02 2004-11-02
US60/624,719 2004-11-02
US62480104P 2004-12-14 2004-12-14
US60/624,801 2004-12-14

Publications (2)

Publication Number Publication Date
WO2006048761A2 WO2006048761A2 (en) 2006-05-11
WO2006048761A3 true WO2006048761A3 (en) 2006-06-22

Family

ID=35456957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003348 WO2006048761A2 (en) 2004-11-02 2005-10-21 Methods for preparing indazole compounds

Country Status (9)

Country Link
EP (1) EP1814859A2 (en)
KR (1) KR20070085727A (en)
AU (1) AU2005300241A1 (en)
CA (1) CA2591313A1 (en)
IL (1) IL183605A0 (en)
MX (1) MX2007006554A (en)
RU (1) RU2007120635A (en)
TW (1) TW200630345A (en)
WO (1) WO2006048761A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2136284A1 (en) * 1971-02-08 1972-08-31 Diamond Shamrock Corp., Cleveland, Ohio (V.StA.) Herbicidal pyrrolidinyl-carboxanilides - from arylisocyanates and pyrrolidines in organic solvents
WO2001002369A2 (en) * 1999-07-02 2001-01-11 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2136284A1 (en) * 1971-02-08 1972-08-31 Diamond Shamrock Corp., Cleveland, Ohio (V.StA.) Herbicidal pyrrolidinyl-carboxanilides - from arylisocyanates and pyrrolidines in organic solvents
WO2001002369A2 (en) * 1999-07-02 2001-01-11 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHANG KIU LEE, JI SOOK YU, YOUNG RAN LI: "Determination of Aromaticity Indices of Thiophene and Furan by Nuclear Magnetic Resonance Spectroscopic Analysis of Their Anilides", J. HETEROCYCLIC CHEM., vol. 39, 2002, pages 1219 - 1227, XP002375492 *
CHATTAWAY F D ET AL: "DERIVATIVES OF 3:5-DIHALOGEN-SUBSTITUTED ANILINES", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1935, pages 1005 - 1008, XP008058035, ISSN: 0368-1769 *
D. E. PEARSON, H. W. POPE, W. W. HARGROVE, W. E. STAMPER: "The Swamping Catalyst Effect. II. Nuclear Halogenation of Aromatic Aldehydes and Ketones", J. ORG. CHEM., vol. 23, 1958, pages 1412 - 1416, XP002375494 *
HINKEL L E ET AL: "DICHLORO-O-XYLENES", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1934, pages 1946 - 1948, XP008058037, ISSN: 0368-1769 *
HUTCHINSON ET AL: "Antitumor Benzothiazoles. 14. Synthesis and in Vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, 2001, pages 1446 - 1455, XP002215317, ISSN: 0022-2623 *
KOHICHIRO YOSHINO, NORIYUKI HORI, MANABU HORI: "Organic Phosphorus Compounds. Part 3 [1]. Synthesis of 5-Fluorosubstituted Benzothiazolylbenzylphosphonates", J. HETEROCYCLIC CHEM., vol. 26, 1989, pages 1039 - 1043, XP002375493 *
LAEV S S ET AL: "A new approach to polyfluoroaromatic amines with an unsubstituted position ortho to the amino group", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 110, no. 1, 25 July 2001 (2001-07-25), pages 43 - 46, XP004255410, ISSN: 0022-1139 *
PERRY R J ET AL: "2-Arylbenzoxazole Formation Through ortho-Fluoro Displacement Reactions", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 57, no. 23, 6 November 1992 (1992-11-06), pages 6351 - 6354, XP001005503, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
AU2005300241A2 (en) 2006-05-11
MX2007006554A (en) 2007-06-19
WO2006048761A2 (en) 2006-05-11
EP1814859A2 (en) 2007-08-08
AU2005300241A1 (en) 2006-05-11
KR20070085727A (en) 2007-08-27
CA2591313A1 (en) 2006-05-11
TW200630345A (en) 2006-09-01
RU2007120635A (en) 2008-12-10
IL183605A0 (en) 2007-09-20

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