WO2006125555A3 - Chinazolinone - Google Patents

Chinazolinone Download PDF

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Publication number
WO2006125555A3
WO2006125555A3 PCT/EP2006/004655 EP2006004655W WO2006125555A3 WO 2006125555 A3 WO2006125555 A3 WO 2006125555A3 EP 2006004655 W EP2006004655 W EP 2006004655W WO 2006125555 A3 WO2006125555 A3 WO 2006125555A3
Authority
WO
WIPO (PCT)
Prior art keywords
quinazolinones
compounds
tumors
things
formula
Prior art date
Application number
PCT/EP2006/004655
Other languages
English (en)
French (fr)
Other versions
WO2006125555A2 (de
Inventor
Hans-Peter Buchstaller
Dirk Finsinger
Kai Schiemann
Ulrich Emde
Frank Zenke
Christiane Amendt
Original Assignee
Merck Patent Gmbh
Hans-Peter Buchstaller
Dirk Finsinger
Kai Schiemann
Ulrich Emde
Frank Zenke
Christiane Amendt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US11/913,149 priority Critical patent/US20080234299A1/en
Application filed by Merck Patent Gmbh, Hans-Peter Buchstaller, Dirk Finsinger, Kai Schiemann, Ulrich Emde, Frank Zenke, Christiane Amendt filed Critical Merck Patent Gmbh
Priority to CA002609391A priority patent/CA2609391A1/en
Priority to JP2008512734A priority patent/JP2008542215A/ja
Priority to AU2006251355A priority patent/AU2006251355A1/en
Priority to EP06753676A priority patent/EP1885702A2/de
Publication of WO2006125555A2 publication Critical patent/WO2006125555A2/de
Publication of WO2006125555A3 publication Critical patent/WO2006125555A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Verbindungen der Formel (I), worin R, R1 , R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3, k und Y1 die in Anspruch 1 angegebenen Bedeutungen haben, können u.a. zur Behandlung von Tumoren eingesetzt werden.
PCT/EP2006/004655 2005-05-25 2006-05-17 Chinazolinone WO2006125555A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US11/913,149 US20080234299A1 (en) 2005-05-25 2006-03-17 Quinazolinones
CA002609391A CA2609391A1 (en) 2005-05-25 2006-05-17 Quinazolinones
JP2008512734A JP2008542215A (ja) 2005-05-25 2006-05-17 キナゾリノン
AU2006251355A AU2006251355A1 (en) 2005-05-25 2006-05-17 Quinazolinones
EP06753676A EP1885702A2 (de) 2005-05-25 2006-05-17 Chinazolinone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005024017.8 2005-05-25
DE102005024017A DE102005024017A1 (de) 2005-05-25 2005-05-25 Chinazolinone

Publications (2)

Publication Number Publication Date
WO2006125555A2 WO2006125555A2 (de) 2006-11-30
WO2006125555A3 true WO2006125555A3 (de) 2007-05-18

Family

ID=36954835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/004655 WO2006125555A2 (de) 2005-05-25 2006-05-17 Chinazolinone

Country Status (8)

Country Link
US (1) US20080234299A1 (de)
EP (1) EP1885702A2 (de)
JP (1) JP2008542215A (de)
AR (1) AR057322A1 (de)
AU (1) AU2006251355A1 (de)
CA (1) CA2609391A1 (de)
DE (1) DE102005024017A1 (de)
WO (1) WO2006125555A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6143362B2 (ja) 2010-10-01 2017-06-07 アプライド メディカル リソーシーズ コーポレイション ジョー及び／又は電極、及び電気手術用増幅器を持つ電気手術器具
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6207100B2 (ja) 2012-12-21 2017-10-04 ギリアード カリストガ エルエルシー イソキノリノンまたはキナゾリノンホスファチジルイノシトール３−キナーゼ阻害剤
CA2895782C (en) 2012-12-21 2017-08-22 Gilead Calistoga Llc Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors
JP6030783B2 (ja) 2013-06-14 2016-11-24 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
PL3052485T3 (pl) 2013-10-04 2022-02-28 Infinity Pharmaceuticals, Inc. Związki heterocykliczne i ich zastosowania
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG11201607705XA (en) 2014-03-19 2016-10-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
EP3370518B1 (de) 2015-10-14 2023-08-23 X-Therma, Inc. Zusammensetzungen und verfahren zur verringerung der eiskristallbildung
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322756A (en) * 1963-05-18 1967-05-30 Hoechst Ag 2-aminoalkyl-3-hydrocarbon quinazolones-(4)
WO2001098278A1 (en) * 2000-06-21 2001-12-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
WO2002058684A2 (en) * 2000-11-06 2002-08-01 Combinatorx, Incorporated Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders
WO2003035075A1 (en) * 2001-10-19 2003-05-01 Icos Corporation Inhibitors of human phosphatidyl-inositol 3-kinase delta
WO2003043961A2 (en) * 2001-11-19 2003-05-30 Iconix Pharmaceuticals, Inc. Modulators of rho c activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322756A (en) * 1963-05-18 1967-05-30 Hoechst Ag 2-aminoalkyl-3-hydrocarbon quinazolones-(4)
WO2001098278A1 (en) * 2000-06-21 2001-12-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
WO2002058684A2 (en) * 2000-11-06 2002-08-01 Combinatorx, Incorporated Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders
WO2003035075A1 (en) * 2001-10-19 2003-05-01 Icos Corporation Inhibitors of human phosphatidyl-inositol 3-kinase delta
WO2003043961A2 (en) * 2001-11-19 2003-05-30 Iconix Pharmaceuticals, Inc. Modulators of rho c activity

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
AGER I R ET AL: "Synthesis and central nervous system activity of quinazolones related to 2-methyl-3-(o-tolyl)-4(3H)- quinazolone (methaqualone)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 20, no. 3, March 1977 (1977-03-01), pages 379 - 386, XP002156696, ISSN: 0022-2623 *
BERGMAN J ET AL: "SYNTHESIS OF CHRYSOGINE, A METABOLITE OF PENICILLIUM CHRYSOGENUM AND SOME RELATED 2-SUBSTITUTED 4-(3H)-QUINAZOLINONES", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 46, no. 4, January 1990 (1990-01-01), pages 1295 - 1310, XP002009812, ISSN: 0040-4020 *
BOLTZE K-H ET AL: "SUBSTITUIERTE CHINAZOLINONE-(4) ALS HYPNOTICA UND ANTIKONVULSIVA", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 13, no. 8, August 1963 (1963-08-01), pages 688 - 701, XP002064150, ISSN: 0004-4172 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1938, XP002400459 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1962, XP002400460 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1969, XP002400462 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1973, XP002400461 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1977, XP002400464 *
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DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1981, XP002400451 *
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DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1984, XP002400455 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1985, XP002400452 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1990, XP002400454 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1996, XP002400458 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1999, XP002400463 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 2001, XP002400453 *
HATTORI KOUJI ET AL: "Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.", JOURNAL OF MEDICINAL CHEMISTRY. 12 AUG 2004, vol. 47, no. 17, 12 August 2004 (2004-08-12), pages 4151 - 4154, XP002399543, ISSN: 0022-2623 *
HUGHES L R ET AL: "QUINAZOLINE ANTIFOLATE THYMIDILATE SYNTHASE INHIBITORS: ALKYL, SUBSTITUTED ALKYL, AND ARYL SUBSTITUENTS IN THE C2 POSITION", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 11, 1990, pages 3060 - 3067, XP002370288, ISSN: 0022-2623 *
IWASHITA AKINORI ET AL: "Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. JUN 2004, vol. 309, no. 3, June 2004 (2004-06-01), pages 1067 - 1078, XP002399542, ISSN: 0022-3565 *
JIANG J B ET AL: "Synthesis and Biological Evaluation of 2-Styrylquinazolin-4(3H)-ones, a new Class of Antimitotic Anticancer Agents Which Inhibit Tubulin Polymerisation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, 1990, pages 1721 - 1728, XP002010826, ISSN: 0022-2623 *
O'MAHONY D J R ET AL: "Traceless synthesis of 3H-quinazolin-4-ones via a combination of solid-phase and solution methodologies", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 43, no. 6, 4 February 2002 (2002-02-04), pages 939 - 942, XP004333931, ISSN: 0040-4039 *
PARASHARYA P M ET AL: "4(3H)-quinazolones. Part I: 2-Alkyl/arylaminomethyl-3-p-hydroxy/metho xyphenyl-4(3H)-quinazolones", 1994, CHEMICAL ABSTRACTS + INDEXES, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, PAGE(S) 1065, ISSN: 0009-2258, XP002229326 *
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Also Published As

Publication number Publication date
WO2006125555A2 (de) 2006-11-30
EP1885702A2 (de) 2008-02-13
DE102005024017A1 (de) 2006-11-30
AU2006251355A1 (en) 2006-11-30
JP2008542215A (ja) 2008-11-27
CA2609391A1 (en) 2006-11-30
AR057322A1 (es) 2007-11-28
US20080234299A1 (en) 2008-09-25

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