EP0746609A4 - Transgenic non-human animals capable of producing heterologous antibodies - Google Patents

Transgenic non-human animals capable of producing heterologous antibodies

Info

Publication number
EP0746609A4
EP0746609A4 EP93901143A EP93901143A EP0746609A4 EP 0746609 A4 EP0746609 A4 EP 0746609A4 EP 93901143 A EP93901143 A EP 93901143A EP 93901143 A EP93901143 A EP 93901143A EP 0746609 A4 EP0746609 A4 EP 0746609A4
Authority
EP
European Patent Office
Prior art keywords
human
transgenic
antibodies
non
immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93901143A
Other languages
German (de)
French (fr)
Other versions
EP0746609A1 (en
Inventor
Nils Lonberg
Robert M Kay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GenPharm International Inc
Original Assignee
GenPharm International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/810,279 priority Critical patent/US5569825A/en
Priority to US810279 priority
Priority to US07/853,408 priority patent/US5789650A/en
Priority to US853408 priority
Priority to US904068 priority
Priority to US90406892A priority
Application filed by GenPharm International Inc filed Critical GenPharm International Inc
Priority to PCT/US1992/010983 priority patent/WO1993012227A1/en
Priority claimed from EP02079536A external-priority patent/EP1288229A3/en
Publication of EP0746609A1 publication Critical patent/EP0746609A1/en
Publication of EP0746609A4 publication Critical patent/EP0746609A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knockout animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Humanized animals, e.g. knockin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007Carcino-embryonic Antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0381Animal model for diseases of the hematopoietic system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppresed by antisense polynucleotides and/or by antiserum directed against endogenous immunoglobulins. Heterologous antibodies are encoded by immunoglobulin genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, one or more transgenes containing sequences of unrearranged heterogolous human immunoglobulin heavy chains are introduced into a non-human animal thereby forming a transgenic animal capable of functionally rearranging transgenic immunoglobulin sequences and producing a repertoire of antibodies of various isotypes encoded by human immunoglobulin genes. Such heterologous human antibodies are produced in B-cells which are thereafter immortalized, e.g., by fusing with an immortalizing cell line such as a myeloma or by manipulating such B-cells by other techniques to perpetuate a cell line capable of producing a monoclonal heterologous antibody. The invention also relates to heavy and light chain immunoglobulin transgenes for making such transgenic non-human animals as well as methods and vectors for disrupting endogenous immunoglobulin loci in the transgenic animal.
EP93901143A 1990-08-29 1992-12-17 Transgenic non-human animals capable of producing heterologous antibodies Withdrawn EP0746609A4 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US07/810,279 US5569825A (en) 1990-08-29 1991-12-17 Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US810279 1991-12-17
US07/853,408 US5789650A (en) 1990-08-29 1992-03-18 Transgenic non-human animals for producing heterologous antibodies
US853408 1992-03-18
US90406892A true 1992-06-23 1992-06-23
US904068 1992-06-23
PCT/US1992/010983 WO1993012227A1 (en) 1991-12-17 1992-12-17 Transgenic non-human animals capable of producing heterologous antibodies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02079536A EP1288229A3 (en) 1991-12-17 1992-12-17 Transgenic non human animals capable of producing heterologous antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP02079536A Division EP1288229A3 (en) 1990-08-29 1992-12-17 Transgenic non human animals capable of producing heterologous antibodies

Publications (2)

Publication Number Publication Date
EP0746609A1 EP0746609A1 (en) 1996-12-11
EP0746609A4 true EP0746609A4 (en) 1997-12-17

Family

ID=27420056

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901143A Withdrawn EP0746609A4 (en) 1990-08-29 1992-12-17 Transgenic non-human animals capable of producing heterologous antibodies

Country Status (5)

Country Link
EP (1) EP0746609A4 (en)
JP (2) JPH07503132A (en)
AU (1) AU3328493A (en)
CA (1) CA2124967C (en)
WO (1) WO1993012227A1 (en)

Families Citing this family (616)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU6819494A (en) * 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5827690A (en) * 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5885574A (en) * 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US6130364A (en) * 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
AU4376400A (en) * 1995-04-27 2000-11-30 Abgenix, Inc. Human antibodies derived from immunized xenomice
AU2008202860B9 (en) * 1995-04-27 2012-03-29 Amgen Fremont Inc. Human Antibodies Derived From Immunized Xenomice
EP0822830B1 (en) * 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
US6046310A (en) * 1996-03-13 2000-04-04 Protein Design Labs., Inc. FAS ligand fusion proteins and their uses
EP0966971A4 (en) 1996-04-23 1999-12-29
US5961976A (en) * 1996-06-03 1999-10-05 United Biomedical, Inc. Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV
US7084260B1 (en) 1996-10-10 2006-08-01 Genpharm International, Inc. High affinity human antibodies and human antibodies against human antigens
AT549918T (en) 1996-12-03 2012-04-15 Amgen Fremont Inc Human antibodies expressly binding human tnf alpha
AU713473B2 (en) 1996-12-23 1999-12-02 Immunex Corporation Receptor activator of NF-kappa B, receptor is member of TNF receptor superfamily
AT547119T (en) 1997-03-21 2012-03-15 Chugai Pharmaceutical Co Ltd Preventive or therapeutic agent with an il-6 antagonist as an active substance for sensitized t cells
EP1657255B1 (en) 1997-04-15 2014-07-30 Sankyo Company, Limited Novel protein and method for producing the protein
US5843678A (en) * 1997-04-16 1998-12-01 Amgen Inc. Osteoprotegerin binding proteins
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
GB9711167D0 (en) * 1997-05-31 1997-07-23 Babraham The Inst Telomere-associated chromosome fragmentation
KR20090068385A (en) 1997-08-15 2009-06-26 츄가이 세이야꾸 가부시키가이샤 Preventives and/or remedies for systemic lupus erythematosus containing anti-il-6 receptor antibody as the active ingredient
EP1015633A1 (en) * 1997-09-19 2000-07-05 Laboratories Inc. Medelys Method and kit for early diagnosis of autoimmunity and lymphoma in central nervous system
CA2251263A1 (en) * 1997-11-14 1999-05-14 Hajime Karasuyama Transgenic animal allergy models and methods for their use
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
BRPI9916853B1 (en) 1998-12-23 2018-04-24 Pfizer Inc. Monoclonal antibody or antigen-binding fragment of the same which specifically links to cytotoxic t-lymphocyte 4 (ctla-4) and nucleic acid antigen
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
EE05627B1 (en) 1998-12-23 2013-02-15 Pfizer Inc. Anti-CTLA-4 human monoclonal antibodies
EP1604997A1 (en) * 1999-02-05 2005-12-14 Therapeutic Human Polyclonals, Inc. Human polyclonal antibodies from transgenic nonhuman animals
ES2250105T3 (en) * 1999-02-05 2006-04-16 Therapeutic Human Polyclonals, Inc. Human polyclonal antibodies of non human transgenic animals
DK1167537T3 (en) 1999-03-30 2008-11-10 Japan Tobacco Inc Process for producing a monoclonal antibody
JP4488579B2 (en) * 1999-03-30 2010-06-23 アムジェン フレモント インク. Method for producing monoclonal antibody
US6911429B2 (en) 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
CA2375104C (en) 1999-06-01 2013-12-24 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6833268B1 (en) * 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
EP1213028B1 (en) 1999-08-23 2008-08-13 Chugai Seiyaku Kabushiki Kaisha Hm1.24 antigen expression potentiators
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
EP2829609A1 (en) 1999-08-24 2015-01-28 E. R. Squibb & Sons, L.L.C. Human CTLA-4 antibodies and their uses
AU6871900A (en) 1999-09-06 2001-04-10 Chugai Seiyaku Kabushiki Kaisha Tsg-like gene
EP2316848A1 (en) 1999-09-21 2011-05-04 Chugai Seiyaku Kabushiki Kaisha Transporter genes OATP-B, C, D and E
HU0203486A2 (en) 1999-10-01 2003-02-28 Chugai Seiyaku Kabushiki Kaisha Prevention and treatment of blood coagulation-related diseases
EP1987842A1 (en) 2000-04-28 2008-11-05 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitor
EP1287364B1 (en) 2000-04-29 2008-10-22 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
DK1354034T3 (en) 2000-11-30 2008-03-25 Medarex Inc Transgenic transchromosomal rodents for the production of human antibodies
PE20020574A1 (en) 2000-12-06 2002-07-02 Wyeth Corp Humanized antibodies that recognize beta amyloid peptide
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US7931897B2 (en) 2001-02-07 2011-04-26 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for hematopoietic tumors
JP3702274B2 (en) 2001-04-02 2005-10-05 中外製薬株式会社 Childhood chronic arthritis-related disease treatment agent
DE122010000047I1 (en) 2001-06-26 2011-05-05 Amgen Fremont Inc Antibodies against opgl
WO2003048301A2 (en) 2001-10-11 2003-06-12 Protein Design Labs Inc. Anti-hla-dr antibodies and the methods of using thereof
DK1461442T3 (en) 2001-11-30 2017-12-04 Amgen Fremont Inc Transgenic animals with human Ig lambda light chain genes
ES2536709T3 (en) 2002-02-14 2015-05-27 Chugai Seiyaku Kabushiki Kaisha Use of acetic acid to eliminate problems induced by the Fe ion in anti-HM1.24 or anti-IL6R antibody formulations
EP2110434A1 (en) 2002-02-25 2009-10-21 Genentech, Inc. Type-1 cytokine receptor GLM-R
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
MXPA04009681A (en) 2002-04-05 2005-01-11 Amgen Inc Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors.
PT1503794E (en) 2002-04-12 2012-06-21 Medarex Inc Methods of treatement using ctla-4 antibodies
AU2003231802A1 (en) 2002-05-17 2003-12-02 Protein Design Labs Treatment of crohn's disease or psoriasis using anti-inteferon gamma antibodies
CA2484000A1 (en) 2002-05-24 2003-12-04 Schering Corporation Neutralizing human anti-igfr antibody
AU2002368055B2 (en) 2002-06-28 2008-09-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist
JP4489591B2 (en) 2002-08-27 2010-06-23 中外製薬株式会社 Method for stabilizing protein solution formulations
WO2004022597A1 (en) 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha Antibody against blood-solubilized n-terminal peptide in gpc3
WO2004022718A2 (en) 2002-09-06 2004-03-18 Amgen, Inc. Therapeutic human anti-il-1r1 monoclonal antibody
ES2558303T3 (en) 2002-09-11 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Protein Purification Method
TW200413725A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
WO2004034988A2 (en) 2002-10-16 2004-04-29 Amgen Inc. Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors
JP4754219B2 (en) 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド Antibodies directed against tumor necrosis factor and their use
US9259459B2 (en) 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
US9243064B2 (en) 2003-01-31 2016-01-26 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
JP2007525434A (en) 2003-03-19 2007-09-06 アブジェニックス インコーポレイテッド Antibodies to T cells, immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof.
US20040208876A1 (en) 2003-04-18 2004-10-21 Kim Kyung Jin Monoclonal antibodies to hepatocyte growth factor
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
EP2395016A3 (en) 2003-05-30 2012-12-19 Merus B.V. Design and use of paired variable regions of specific binding molecules
US7405274B2 (en) 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
CA2542232A1 (en) 2003-06-09 2005-01-20 Alnylam Pharmaceuticals, Inc. Method for treating neurodegenerative disease by inhibiting alpha-synuclein
EP2228445A1 (en) 2003-06-18 2010-09-15 Chugai Seiyaku Kabushiki Kaisha Fucose Transporter
US7736644B2 (en) 2003-06-27 2010-06-15 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
DK2287195T3 (en) 2004-07-01 2019-08-19 Innate Pharma Pan-kir2dl nk-receptor antibodies and use in diagnostics and therapy
US20060162014A1 (en) 2003-07-07 2006-07-20 Jaffe Eileen K Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
US8153410B2 (en) 2003-07-07 2012-04-10 Fox Chase Cancer Center Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
ME00226B (en) 2004-07-15 2011-02-10 Medarex Llc Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
TWI395756B (en) 2003-07-18 2013-05-11 Amgen Inc Specific binding agents to hepatocyte growth factor
EP1652923B1 (en) 2003-08-08 2011-10-12 Perseus Proteomics Inc. Gene overexpressed in cancer
CN1838968A (en) 2003-08-08 2006-09-27 艾伯吉尼斯公司 Antibodies aimed to parathyroid hormone (PTH) and uses thereof
AU2003271174A1 (en) 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
EP1693448A4 (en) 2003-10-14 2008-03-05 Chugai Pharmaceutical Co Ltd Double specific antibodies substituting for functional protein
US8298816B2 (en) 2003-12-03 2012-10-30 Chugai Seiyaku Kabushiki Kaisha Expression systems using mammalian beta-actin promoter
DK2418220T3 (en) 2003-12-10 2017-11-06 Squibb & Sons Llc Interferon-alpha antibodies and applications thereof
US20050191293A1 (en) 2003-12-10 2005-09-01 Shrikant Deshpande IP-10 antibodies and their uses
WO2005056605A1 (en) 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha Modified antibodies recognizing trimer receptor or higher
US7973134B2 (en) 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US7935790B2 (en) 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7625549B2 (en) 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
CA2564989C (en) 2004-03-19 2014-05-27 Amgen, Inc. Reducing the risk of human and anti-human antibodies through v gene manipulation
AT496142T (en) 2004-03-23 2011-02-15 Oncotherapy Science Inc Method for the diagnosis of non-small cellulose cancer
US20050227289A1 (en) 2004-04-09 2005-10-13 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
SI2662390T1 (en) 2004-06-21 2017-10-30 E. R. Squibb & Sons, L.L.C. Interferon alpha receptor 1 antibodies and their uses
CN105820249A (en) 2004-07-09 2016-08-03 中外制药株式会社 Anti-glypican 3 antibody
CN101389214A (en) 2004-10-22 2009-03-18 雷维维科公司 Ungulates with genetically modified immune systems
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
JP5173426B2 (en) 2004-10-25 2013-04-03 メルク・シャープ・エンド・ドーム・コーポレイション Anti-ADDL antibodies and uses thereof
CA2587903A1 (en) 2004-11-17 2006-05-26 Amgen Fremont Inc. Fully human monoclonal antibodies to il-13
EP1838348B1 (en) 2004-12-15 2013-06-26 Janssen Alzheimer Immunotherapy Humanized amyloid beta antibodies for use in improving cognition
CA2592249C (en) 2004-12-20 2014-07-29 Amgen Fremont Inc. Binding proteins specific for human matriptase
RS52036B (en) 2004-12-21 2012-04-30 Medimmune Limited Antibodies directed to angiopoietin-2 and uses thereof
US7807789B2 (en) 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
JPWO2006067847A1 (en) 2004-12-22 2008-06-12 中外製薬株式会社 Antibody production method using cells in which fucose transporter function is inhibited
WO2006081139A2 (en) 2005-01-26 2006-08-03 Abgenix, Inc. Antibodies against interleukin-1 beta
WO2006104677A2 (en) 2005-03-24 2006-10-05 Millennium Pharmaceuticals, Inc. Antibodies that bind ov064 and methods of use therefor
WO2006106905A1 (en) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
CA2957144A1 (en) 2005-04-08 2006-10-19 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
CA2970873A1 (en) 2005-05-09 2006-11-16 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
WO2006132363A1 (en) 2005-06-10 2006-12-14 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
EA019344B1 (en) 2005-07-01 2014-03-31 МЕДАРЕКС, Эл.Эл.Си. Human monoclonal antibodies to programmed death ligand 1 (pd-l1) and uses thereof
EP2388276A3 (en) 2005-07-18 2013-11-27 Amgen, Inc Human anti-B7RP1 neutralizing antibodies
DE602006019977D1 (en) 2005-08-18 2011-03-17 Genmab As Therapy with anti-cd4 antibodies and irradiation
WO2007027906A2 (en) 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
US8193328B2 (en) 2005-09-08 2012-06-05 Philadelphia Health & Education Corporation Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents
US8945573B2 (en) 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
AU2006294663B2 (en) 2005-09-26 2012-03-22 Medarex, Inc. Human monoclonal antibodies to CD70
AU2006300234B2 (en) 2005-10-14 2013-01-10 Chugai Seiyaku Kabushiki Kaisha Agents for suppressing damage to transplanted islets after islet transplantation
GB0521139D0 (en) 2005-10-18 2005-11-23 Univ Sheffield Therapeutic agent
AU2006303452B2 (en) 2005-10-21 2011-06-09 Novartis Ag Human antibodies against IL13 and therapeutic uses
CN101330930B (en) 2005-10-21 2011-11-23 中外制药株式会社 Therapeutic agent for heart disease
WO2007059082A1 (en) 2005-11-10 2007-05-24 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
WO2007055378A1 (en) 2005-11-14 2007-05-18 Cell Signals Inc. Method for treatment or prevention of disease associated with functional disorder of regulatory t cell
AR056806A1 (en) 2005-11-14 2007-10-24 Amgen Inc Chimeric antibody molecules rankl- PTH / PTHrP
AR057582A1 (en) 2005-11-15 2007-12-05 Nat Hospital Organization Agents to suppress the induction of cytotoxic T lymphocytes
AR057941A1 (en) 2005-11-25 2007-12-26 Univ Keio therapeutic agents for prostate cancer
US9829494B2 (en) 2005-12-01 2017-11-28 Adrenomed Ag Methods of treatment using ADM antibodies
CN101325971A (en) 2005-12-07 2008-12-17 米德列斯公司 CTLA-4 antibody dosage escalation regimens
SI1960434T1 (en) 2005-12-08 2012-11-30 Medarex Inc Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1
DOP2006000277A (en) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp Mn antibodies and methods for their use
AT552853T (en) 2005-12-13 2012-04-15 Medimmune Ltd Proteins that specifically bind insulin-similar growth factors and their applications
GB2433740A (en) 2005-12-23 2007-07-04 Rapid Biosensor Systems Ltd Detection of tuberculosis infection
EP1977763A4 (en) 2005-12-28 2010-06-02 Chugai Pharmaceutical Co Ltd Antibody-containing stabilizing preparation
AR056857A1 (en) 2005-12-30 2007-10-24 U3 Pharma Ag Antibodies directed to HER-3 receptor (the human epidermal growth factor-3) and their uses
ES2586825T3 (en) 2006-01-12 2016-10-19 Alexion Pharmaceuticals, Inc. Antibodies for OX-2 / CD200 and their uses
WO2007084672A2 (en) 2006-01-17 2007-07-26 Medarex, Inc. Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
AR059213A1 (en) 2006-01-27 2008-03-19 Univ Keio therapeutic agents for diseases involving choroidal neovascularization
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
WO2007117410A2 (en) 2006-03-31 2007-10-18 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
CN104761637A (en) 2006-03-31 2015-07-08 中外制药株式会社 Methods for controlling blood pharmacokinetics of antibodies
AR059922A1 (en) 2006-04-01 2008-05-07 Galaxy Biotech Llc Humanized monoclonal antibodies to hepatocyte growth factor
PL2371865T3 (en) 2006-04-07 2018-02-28 Aerpio Therapeutics, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTP-ß) and uses thereof
BRPI0709481A2 (en) 2006-04-07 2011-07-19 Government Of The Us Secretary Dept Of Health And Human Services isolated monoclonal antibody, isolated human monoclonal antibody, pharmaceutical composition, isolated recombinant anti-igf-i and anti-igf-ii antibody or antigen-binding fragment thereof, method for detecting human insulin growth factor ieo factor II in a sample , method for detecting human insulin growth factor i in a sample, isolated nucleic acid, recombinant cell, host cell, method for preparing an antibody, method for preparing an antibody, method for treating a neoplastic disease in a mammal individual, method for to diagnose neoplastic disease in a mammalian individual and method for classifying a drug candidate compound
JP5754875B2 (en) 2006-04-07 2015-07-29 国立大学法人大阪大学 Muscle regeneration promoter
TW200813091A (en) 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
JP5242382B2 (en) 2006-04-14 2013-07-24 株式会社医学生物学研究所 Polypeptide variant having effector function
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2007129457A1 (en) 2006-04-25 2007-11-15 The University Of Tokyo Therapeutic agents for alzheimer's disease and cancer
EP2035448A4 (en) 2006-06-01 2010-11-03 Elan Pharm Inc Neuroactive fragments of app
KR101557603B1 (en) 2006-06-08 2015-10-06 추가이 세이야쿠 가부시키가이샤 Preventive or remedy for inflammatory disease
US20100040600A1 (en) 2006-06-14 2010-02-18 Chugai Seiyaku Kabushiki Kaisha Agents for Promoting the Growth of Hematopoietic Stem Cells
EP1983002A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
CL2007002057A1 (en) 2006-07-13 2008-01-11 Chugai Pharmaceutical Co Ltd Diabody anti-human leukocyte antigen (HLA), uses the diabody to prepare a medicament useful as an inducer of cell death suppressor cell crecimeinto or antitumor agent.
WO2008010556A1 (en) 2006-07-21 2008-01-24 Chugai Seiyaku Kabushiki Kaisha Remedy for renal disease
CL2007002225A1 (en) 2006-08-03 2008-04-18 Astrazeneca Ab Specific binding agent for the receptor platelet-derived growth factor (PDGFR-alpha); nucleic acid molecule encoding it; vector and host cell comprising it; conjugate comprising the agent; and use of the agent of a
JP5362563B2 (en) 2006-08-03 2013-12-11 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag Antibodies against αVβ6 and uses thereof
US7939636B2 (en) 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
JP5317697B2 (en) 2006-08-14 2013-10-16 中外製薬株式会社 Diagnosis and treatment of cancer using anti-Desmoglein3 antibody
JP2010502220A (en) 2006-09-05 2010-01-28 ツィンマーマン デボラ エル. Antibodies against bone morphogenetic proteins and their receptors and methods of use thereof
EP2083017A4 (en) 2006-09-14 2011-01-12 Med & Biological Lab Co Ltd Antibody having enhanced adcc activity and method for production thereof
CA2665239A1 (en) 2006-10-02 2008-05-22 Medarex, Inc. Human antibodies that bind cxcr4 and uses thereof
US9017684B2 (en) 2006-10-12 2015-04-28 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-EREG antibody
CA2666682C (en) 2006-10-19 2014-07-08 Merck & Co., Inc. Anti-il-13r.alpha.1 antibodies and their uses thereof
CN101589059A (en) 2006-10-20 2009-11-25 株式会社未来创药研究所 Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient
JP5378795B2 (en) 2006-10-20 2013-12-25 中外製薬株式会社 Pharmaceutical composition comprising anti-HB-EGF antibody as an active ingredient
AR063840A1 (en) 2006-11-15 2009-02-25 Medarex Inc Human monoclonal antibodies to BTLA, and methods of use
CN103172743B (en) 2006-12-01 2015-04-08 梅达雷克斯有限责任公司 Human Antibodies That Bind Cd22 And Uses Thereof
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human monoclonal antibody anti-CD19; composition comprising; and method of inhibiting the growth of tumor cells.
JP2010513306A (en) 2006-12-14 2010-04-30 メダレックス インコーポレーティッド Human antibodies that bind to CD70 and uses thereof
JP5632582B2 (en) 2006-12-14 2014-11-26 中外製薬株式会社 Anti-Claudin3 monoclonal antibody and cancer treatment and diagnosis using same
WO2008081942A1 (en) 2007-01-05 2008-07-10 The University Of Tokyo Diagnosis and treatment of cancer by using anti-prg-3 antibody
KR101508019B1 (en) 2007-01-23 2015-04-06 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 chronic rejection inhibitor
JP5241518B2 (en) 2007-02-15 2013-07-17 国立大学法人九州大学 Interstitial lung disease therapeutic agent comprising anti-HMGB-1 antibody
NZ579644A (en) 2007-02-16 2012-05-25 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
JP5374360B2 (en) 2007-02-27 2013-12-25 中外製薬株式会社 Pharmaceutical composition comprising anti-GRP78 antibody as an active ingredient
US20090081659A1 (en) 2007-03-07 2009-03-26 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
CL2008000719A1 (en) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Therapeutic agent for cancer resistant to chemotherapeutic agents comprising an antibody that recognizes HLA class I as an active ingredient; pharmaceutical composition comprising said antibody; and method of treating cancer resistant
CA2681530C (en) 2007-03-22 2017-03-28 Biogen Idec Ma Inc. Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154
EP1975184A3 (en) 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serine or threonine phosphorylation sites
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983003A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
FI20075278A0 (en) 2007-04-20 2007-04-20 Biotie Therapies Corp Novel completely human anti-VAP-1 monoclonal antibodies
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
JP5117765B2 (en) 2007-05-28 2013-01-16 国立大学法人 東京大学 Tumor diagnostic agent for PET containing anti-ROBO1 antibody
US7709215B2 (en) 2007-06-01 2010-05-04 Cytonics Corporation Method for diagnosing and treating acute joint injury
EA200901646A1 (en) 2007-06-05 2010-08-30 Йел Юниверсити Receptor thyrozinkinase inhibitors and their application
US20080317768A1 (en) 2007-06-21 2008-12-25 Boeing Company Bioconjugated nanoparticles
US8722858B2 (en) 2007-06-25 2014-05-13 Chugai Seiyaku Kabushiki Kaisha Anti-Prominin-1 antibody having ADCC activity or CDC activity
US20100129355A1 (en) 2007-07-26 2010-05-27 Osaka University Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient
US8613920B2 (en) 2007-07-27 2013-12-24 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
AU2008317495B2 (en) 2007-08-02 2013-08-01 Novimmune S.A. Anti-RANTES antibodies and methods of use thereof
US9693539B2 (en) 2007-08-10 2017-07-04 E. R. Squibb & Sons, L.L.C. HCO32 and HCO27 and related examples
EP2185188B1 (en) 2007-08-22 2014-08-06 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
BR122018012430B1 (en) 2007-08-23 2019-10-08 Amgen Inc. Monoclonal antibody connecting to pcsk9 humana, and pharmaceutical composition
WO2009032845A2 (en) 2007-09-04 2009-03-12 Compugen, Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
US9096651B2 (en) 2007-09-26 2015-08-04 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
KR101652125B1 (en) 2007-09-26 2016-08-29 우드라이 파마 게엠베하 Heparin-binding epidermal growth factor-like growth factor antigen binding proteins
CL2009000647A1 (en) 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd pharmaceutical composition for treating or preventing liver cancer comprising a combination of a chemotherapeutic agent and an anti-glypican 3 antibody; agent to attenuate a side effect comprising said antibody; method for treating or preventing liver cancer in a subject.
CN101809162B (en) 2007-09-28 2013-06-05 中外制药株式会社 Anti-glypican-3 antibody having improved kinetics in plasma
WO2009044774A1 (en) 2007-10-02 2009-04-09 Chugai Seiyaku Kabushiki Kaisha Remedy for graft-versus-host disease comprising interleukin-6 receptor inhibitor as the active ingredient
TWI489993B (en) 2007-10-12 2015-07-01 Novartis Ag Compositions and methods of use for antibodies against sclerostin
PL2202307T3 (en) 2007-10-15 2015-02-27 Chugai Pharmaceutical Co Ltd Method for production of antibody
JO3076B1 (en) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
AU2008314567B2 (en) 2007-10-18 2014-11-20 Cell Signaling Technology, Inc. Translocation and mutant ROS kinase in human non-small cell lung carcinoma
JP5620106B2 (en) 2007-10-24 2014-11-05 株式会社糖鎖工学研究所 Polypeptide having enhanced effector function
CN101951954A (en) 2007-11-02 2011-01-19 诺瓦提斯公司 Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (LRP6)
SG10201605208QA (en) 2007-11-07 2016-08-30 Celldex Therapeutics Inc Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
KR20100097684A (en) 2007-11-12 2010-09-03 우드라이 파마 게엠베하 Axl antibodies
JP5676107B2 (en) 2007-11-14 2015-02-25 中外製薬株式会社 Diagnosis and treatment of cancer using anti-GPR49 antibody
MX2010005397A (en) 2007-11-15 2010-10-04 Chugai Pharmaceutical Co Ltd Monoclonal antibody capable of binding to anexelekto, and use thereof.
EP2062920A3 (en) 2007-11-21 2009-06-17 Peter Hornbeck Protein phosphorylation by basophilic serine/threonine kinases in insulin signalling pathways
RU2596397C2 (en) 2007-12-05 2016-09-10 Чугаи Сейяку Кабусики Кайся Therapeutic agent for itching
JP5682995B2 (en) 2007-12-05 2015-03-11 中外製薬株式会社 Anti-NR10 antibody and use thereof
US20110262425A1 (en) 2007-12-12 2011-10-27 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
EP2222706B2 (en) 2007-12-14 2016-08-10 Novo Nordisk A/S Antibodies against human nkg2d and uses thereof
US8779088B2 (en) 2007-12-17 2014-07-15 Marfl Ab Vaccine for the treatment of Mycobacterium related disorders
PE20091174A1 (en) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Liquid formulation containing a high concentration of antibody
KR101603076B1 (en) 2007-12-28 2016-03-14 프로테나 바이오사이언시즈 리미티드 Treatment and prophylaxis of amyloidosis
JP5848863B2 (en) 2008-01-11 2016-01-27 国立大学法人 東京大学 Anti-CLDN6 antibody
FR2926438B1 (en) * 2008-01-22 2013-01-11 Univ Limoges Non-human transgenic mammal for the constant region of the heavy chain of human class g immunoglobulins and its applications
CN101970006B (en) 2008-02-05 2014-08-06 百时美施贵宝公司 Alpha 5 - beta 1 antibodies and their uses
CA2718975A1 (en) 2008-04-10 2009-10-15 Cell Signaling Technology, Inc. Compositions and methods for detecting egfr mutations in cancer
DK2708558T3 (en) 2008-04-11 2018-06-14 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of repeatedly binding two or more antigen molecules
KR101590495B1 (en) 2008-05-29 2016-02-01 갤럭시 바이오테크, 엘엘씨 Monoclonal antibodies to basic fibroblast growth factor
EP2283862B1 (en) 2008-06-02 2018-08-08 The University of Tokyo Combination treatment of cancer comprising anti-mfg-e8 antibody
CN104906581A (en) 2008-06-05 2015-09-16 国立研究开发法人国立癌症研究中心 Neuroinvasion inhibitor
CA2728473A1 (en) 2008-06-20 2009-12-23 National University Corporation Okayama University Antibody against oxidized ldl/.beta.2gpi complex and use of the same
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CN105191863A (en) * 2008-06-27 2015-12-30 莫鲁斯有限公司 Antibody producing non-human mammals
WO2010011999A2 (en) 2008-07-25 2010-01-28 The Regents Of The University Of California Methods and compositions for eliciting an amyloid-selective immune response
MY159396A (en) 2008-08-05 2016-12-30 Novartis Ag Compositions and methods for antibodies targeting complement protein c5
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc human antibodies that bind to the gene 3 of lymphocyte activation (LAG-3) and uses these
RU2581962C2 (en) 2008-09-19 2016-04-20 Медиммун Ллк Targeted binding agents against dll4 and application thereof
NZ592308A (en) 2008-09-30 2012-11-30 Ablexis Llc Non-human mammals for the production of chimeric antibodies
ES2548377T3 (en) 2008-10-27 2015-10-16 Revivicor, Inc. immunosuppressed ungulates
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
PT2842573T (en) 2008-11-07 2017-12-04 Galaxy Biotech Llc Monoclonal antibodies to fibroblast growth factor receptor 2
JP6223659B2 (en) 2008-11-10 2017-11-01 アレクシオン ファーマシューティカルズ, インコーポレイテッド Methods and compositions for treating complement related disorders
JP2010210772A (en) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd Method of manufacturing liquid crystal display device
EP2373690B1 (en) 2008-12-08 2015-02-11 Compugen Ltd. Antibodies specific for tmem154
EP2376537B1 (en) 2008-12-09 2016-09-28 Genmab A/S Human antibodies against human tissue factor.
RU2011129459A (en) * 2008-12-18 2013-01-27 Эрасмус Юниверсити Медикал Сентр Роттердам Transgenic animals (not human), expressing humanized antibodies, and their application
US8846870B2 (en) 2008-12-22 2014-09-30 Chugai Seiyaku Kabushiki Kaisha Anti-HS6ST2 antibodies and uses thereof
CA2748158A1 (en) 2008-12-23 2010-07-01 Astrazeneca Ab Targeted binding agents directed to .alpha.5.beta.1 and uses thereof
WO2010073694A1 (en) 2008-12-25 2010-07-01 国立大学法人東京大学 Diagnosis of treatment of cancer using anti-tm4sf20 antibody
KR20110099762A (en) 2008-12-26 2011-09-08 가부시키가이샤 미라이 소오야쿠 켄큐죠 Diagnosis and treatment of cancer using anti-lgr7 antibody
WO2010085590A1 (en) 2009-01-23 2010-07-29 Biosynexus Incorporated Opsonic and protective antibodies specific for lipoteichoic acid gram positive bacteria
ES2637174T3 (en) 2009-02-12 2017-10-11 Cell Signaling Technology, Inc. Expression of mutant ROS in human liver cancer
UA102891C2 (en) 2009-03-05 2013-08-27 Медарекс, Інк. Fully human antibodies specific to cadm1
EP2424894A1 (en) 2009-04-27 2012-03-07 Novartis AG Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit
US8597650B2 (en) 2009-04-08 2013-12-03 Olle Hernell Methods for treating rheumatoid arthritis with anti-bile salt-stimulated lipase (BSSL) antibodies
EP2420515A4 (en) 2009-04-16 2013-08-28 Univ Tokyo Diagnosis and treatment of cancer using anti-tmprss11e antibody
US20120052064A1 (en) 2009-04-17 2012-03-01 Yuuki Ito Anti-hgf antibody combinational cancer therapies
US9062116B2 (en) 2009-04-23 2015-06-23 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
CA2993053A1 (en) 2009-04-27 2010-11-04 Novartis Ag Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
EP2426149A4 (en) 2009-05-01 2013-01-23 Univ Tokyo Anti-cadherin antibody
PT2448970E (en) 2009-05-04 2014-10-20 Abbvie Res B V Antibodies against nerve growth factor (ngf) with enhanced in vivo stability
AU2010244142B2 (en) 2009-05-05 2016-07-21 Novimmune Sa Anti-IL-17F antibodies and methods of use thereof
JP5808052B2 (en) 2009-05-29 2015-11-10 中外製薬株式会社 Pharmaceutical composition comprising antagonist of EGF family ligand as ingredient
US20120101262A1 (en) 2009-06-25 2012-04-26 Bristol-Myers Squibb Company Protein purification by caprylic acid (octanoic acid) precipitation
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
KR20180010347A (en) 2009-07-17 2018-01-30 바이오아트라, 엘엘씨 Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
EP2459594A1 (en) 2009-07-31 2012-06-06 N.V. Organon Fully human antibodies to btla
JP5752038B2 (en) 2009-07-31 2015-07-22 愼 前田 cancer metastasis inhibitor
WO2011017294A1 (en) 2009-08-07 2011-02-10 Schering Corporation Human anti-rankl antibodies
AU2010285974A1 (en) 2009-08-17 2012-03-22 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient
WO2011021146A1 (en) 2009-08-20 2011-02-24 Pfizer Inc. Osteopontin antibodies
EP2480561B1 (en) 2009-09-23 2016-07-13 E. R. Squibb & Sons, L.L.C. Cation exchange chromatography
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
MX351635B (en) 2009-10-16 2017-10-23 Servier Lab MONOCLONAL ANTIBODIES to PROGASTRIN and THEIR USES.
GEP20166504B (en) 2009-10-23 2016-06-27 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
EP2496604B1 (en) 2009-11-06 2017-08-23 IDEXX Laboratories, Inc. Canine anti-cd20 antibodies
EP2499494B1 (en) 2009-11-09 2017-03-08 Alexion Pharmaceuticals, Inc. Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders
CN102812045B (en) 2009-11-13 2018-04-13 第一三共欧洲有限公司 For treating or preventing the material and method of human epidermal growth factor acceptor 3 (HER 3) relevant disease
EP3255153A1 (en) 2009-11-17 2017-12-13 E. R. Squibb & Sons, L.L.C. Methods for enhanced protein production
MX359551B (en) 2009-11-24 2018-10-02 Medimmune Ltd Targeted binding agents against b7-h1.
EP2507265B1 (en) 2009-12-01 2016-05-11 Compugen Ltd. Antibody specific for heparanase splice variant T5 and its use.
RU2012134369A (en) 2010-01-11 2014-02-20 Алексион Фармасьютикалз, Инк Biomarkers of immunomodulating effects in people exposed to antimetal treatment against cd200
AR080428A1 (en) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulations Stabilized liquid contentivas antibody
CN102712769B (en) 2010-01-29 2014-12-03 东丽株式会社 Polylactic acid-based resin sheet
SI2530091T1 (en) 2010-01-29 2018-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-dll3 antibody
US9228171B2 (en) 2010-02-05 2016-01-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Regulatory B cells (tBREGS) and their use
WO2011099524A1 (en) 2010-02-10 2011-08-18 富士フイルムRiファーマ株式会社 Radioactive metal-labeled anti-cadherin antibody
WO2011103490A2 (en) 2010-02-18 2011-08-25 The Regents Of The University Of California INTEGRIN αVβ8 NEUTRALIZING ANTIBODY
EP2540827A4 (en) 2010-02-26 2013-09-04 Chugai Pharmaceutical Co Ltd Anti-icam3 antibody and use thereof
US20130058915A1 (en) 2010-03-02 2013-03-07 Children's Medica Center Corporation Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
WO2011108714A1 (en) 2010-03-04 2011-09-09 中外製薬株式会社 Antibody constant region variant
JP2013522313A (en) 2010-03-17 2013-06-13 アボツト・リサーチ・ベー・フエー Anti-nerve growth factor (NGF) antibody composition
WO2012133782A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
TWI667346B (en) 2010-03-30 2019-08-01 中外製藥股份有限公司 Antibodies with modified affinity to fcrn that promote antigen clearance
KR20180030941A (en) 2010-03-31 2018-03-26 아블렉시스, 엘엘씨 Genetic engineering of non-human animals for the production of chimeric antibodies
WO2011130434A2 (en) 2010-04-13 2011-10-20 Celldex Therapeutics Inc. Antibodies that bind human cd27 and uses thereof
NZ603226A (en) 2010-04-30 2015-02-27 Alexion Pharma Inc Anti-c5a antibodies and methods for using the antibodies
CA2798273A1 (en) 2010-05-04 2011-11-10 Merrimack Pharmaceuticals, Inc. Antibodies against epidermal growth factor receptor (egfr) and uses thereof
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
US9290573B2 (en) 2010-05-06 2016-03-22 Novartis Ag Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
JP2013527762A (en) 2010-05-06 2013-07-04 ノバルティス アーゲー Therapeutic low density lipoprotein related protein 6 (LRP6) antibody compositions and methods of use
EP2578233B1 (en) 2010-05-28 2017-04-26 National Cancer Center Therapeutic agent for pancreatic cancer
JP6051049B2 (en) 2010-05-28 2016-12-21 中外製薬株式会社 Anti-tumor T cell response enhancer
LT2582728T (en) 2010-06-15 2017-12-11 Genmab A/S Human antibody drug conjugates against tissue factor
AU2011270959A1 (en) 2010-06-22 2013-01-10 Musc Foundation For Research Development Antibodies to the C3d fragment of complement component 3
WO2012040617A2 (en) 2010-09-23 2012-03-29 Neogenix Oncology, Inc. Colon and pancreas cancer peptidomimetics
EP2585476A4 (en) 2010-06-22 2014-01-22 Neogenix Oncology Inc Colon and pancreas cancer specific antigens and antibodies
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
AU2011279221B2 (en) 2010-07-14 2015-06-11 Merck Sharp & Dohme Corp. Anti-ADDL monoclonal antibody and uses thereof
DK2593797T3 (en) 2010-07-16 2019-08-05 Bioatla Llc Unknown procedures for protein evolution
US20120156130A1 (en) 2010-08-06 2012-06-21 Thore Hettmann Use of her3 binding agents in prostate treatment
WO2012019132A2 (en) 2010-08-06 2012-02-09 Cell Signaling Technology, Inc. Anaplastic lymphoma kinase in kidney cancer
EP2606130B1 (en) 2010-08-16 2019-03-13 Duke University Camkk-beta as a marker in prostate cancer
AU2011290672B2 (en) 2010-08-20 2015-07-09 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3)
EP2616100B1 (en) 2010-09-17 2016-08-31 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
CN103282042B (en) 2010-09-17 2014-12-10 巴克斯特国际公司 Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH
EP2434285A1 (en) 2010-09-22 2012-03-28 IMBA-Institut für Molekulare Biotechnologie GmbH Breast cancer diagnostics
EP2433644A1 (en) 2010-09-22 2012-03-28 IMBA-Institut für Molekulare Biotechnologie GmbH Breast cancer therapeutics
WO2012045703A1 (en) 2010-10-05 2012-04-12 Novartis Ag Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders
ES2686550T3 (en) * 2010-10-11 2018-10-18 Biogen International Neuroscience Gmbh Human anti-tau antibodies
CN103491978A (en) 2010-10-25 2014-01-01 明尼苏达大学评议会 Therapeutic composition for treatment of glioblastoma
LT2634194T (en) 2010-10-29 2018-10-25 Perseus Proteomics Inc. Anti-cdh3 antibody having high internalization capacity
KR101398290B1 (en) 2010-11-17 2014-05-22 추가이 세이야쿠 가부시키가이샤 Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor VIII
GB201019467D0 (en) 2010-11-17 2010-12-29 Biotecnol Sa Therapeutic agent
WO2012069466A1 (en) 2010-11-24 2012-05-31 Novartis Ag Multispecific molecules
CA2857159A1 (en) 2011-11-30 2013-06-06 Chugai Seiyaku Kabushiki Kaisha Drug containing carrier into cell for forming immune complex
MX365235B (en) 2010-11-30 2019-05-28 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly.
RU2663123C2 (en) 2010-11-30 2018-08-01 Чугаи Сейяку Кабусики Кайся Cytotoxicity-inducing therapeutic agent
PT2648752T (en) 2010-12-06 2017-03-28 Seattle Genetics Inc Humanized antibodies to liv-1 and use of same to treat cancer
US9315566B2 (en) 2011-01-24 2016-04-19 National University Of Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
AR085141A1 (en) 2011-02-03 2013-09-11 Alexion Pharma Inc A method for prolonging survival of a kidney allograft, the use of an anti-CD200 to prolong allograft survival
SG10201610870XA (en) 2011-09-30 2017-02-27 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for promoting loss of antigens
CN104244980B (en) 2012-02-24 2017-11-10 中外制药株式会社 Promote the antigen binding molecules of antigen elimination via Fc γ IIB
CN103492565A (en) 2011-02-25 2014-01-01 中外制药株式会社 FcgRIIb-specific Fc antibody
DK2683736T3 (en) 2011-03-09 2018-04-23 Cell Signaling Technology Inc Methods and reagents for creating monoclonal antibodies
EP2500073A1 (en) 2011-03-17 2012-09-19 ChromaCon AG Method for identification and purification of multi-specific polypeptides
TW201817745A (en) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance
WO2012138774A2 (en) 2011-04-04 2012-10-11 University Of Iowa Research Foundation Methods of improving vaccine immunogenicity
CN103619881B (en) 2011-04-07 2017-07-28 安姆根有限公司 New EGFR associated proteins
WO2012142164A1 (en) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Human monoclonal antibodies that bind insulin-like growth factor (igf) i and ii
WO2012142238A2 (en) 2011-04-12 2012-10-18 Duke University Compositions and methods for the treatment of tissue fibrosis
RU2016147206A (en) 2011-04-15 2018-10-19 Компуджен Лтд. Polypeptides and polynucleotides and their use for the treatment of immunological disorders and cancer
WO2012144208A1 (en) 2011-04-18 2012-10-26 国立大学法人東京大学 Diagnosis and treatment of cancer using anti-itm2a antibody
AP201307303A0 (en) 2011-05-10 2013-12-31 Amgen Inc Methods of treating or preventing cholesterol related disorders
TWI560200B (en) 2011-05-25 2016-12-01 Innate Pharma Sa Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
AU2012271413B2 (en) 2011-06-17 2017-07-13 President And Fellows Of Harvard College Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer
CA2836855A1 (en) 2011-06-30 2013-01-03 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
BR112013032630A2 (en) 2011-06-30 2017-01-24 Chugai Pharmaceutical Co Ltd heterodimerized polypeptide
JP6472999B2 (en) 2011-07-01 2019-02-20 ノバルティス アーゲー Methods for treating metabolic disorders
EP2731970B1 (en) 2011-07-15 2018-11-28 MorphoSys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt)
WO2013012855A1 (en) 2011-07-18 2013-01-24 Amgen Inc. Apelin antigen-binding proteins and uses thereof
US9574005B2 (en) 2011-07-19 2017-02-21 Chugai Seiyaku Kabushiki Kaisha Stable Protein-containing preparation containing argininamide or analogous compound thereof
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
WO2013017691A1 (en) 2011-08-04 2013-02-07 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
JP6101205B2 (en) 2011-08-23 2017-03-22 中外製薬株式会社 Novel anti-DDR1 antibody having antitumor activity
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
ES2612935T3 (en) * 2011-09-19 2017-05-19 Kymab Limited Antibodies, variable domains and chains adapted for use in humans
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
AU2012317395B2 (en) 2011-09-30 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule inducing immune response to target antigen
JP6322411B2 (en) 2011-09-30 2018-05-09 中外製薬株式会社 Antigen-binding molecules that promote the disappearance of antigens with multiple physiological activities
CN103975060A (en) 2011-09-30 2014-08-06 中外制药株式会社 Ion concentration-dependent binding molecule library
EP2765192A4 (en) 2011-10-05 2015-04-15 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for promoting clearance from plasma of antigen comprising saccharide chain receptor-binding domain
JP2014532072A (en) 2011-10-13 2014-12-04 エアピオ セラピューティックス, インコーポレイテッド Treatment of eye diseases
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
CN104080471B (en) 2011-10-14 2018-08-10 诺华股份有限公司 Antibody and method for Wnt approach relevant diseases
JP6291254B2 (en) 2011-10-28 2018-03-14 中外製薬株式会社 Cancer stem cell specific molecule
CN104080926B (en) 2011-10-28 2019-04-23 米伦纽姆医药公司 To the biomarker of the reaction of NEDD8 activating enzymes (NAE) inhibitor
WO2013065708A1 (en) 2011-10-31 2013-05-10 中外製薬株式会社 Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
AU2012332593B2 (en) 2011-11-01 2016-11-17 Bionomics, Inc. Anti-GPR49 antibodies
WO2013067054A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Antibodies and methods of treating cancer
AU2012332590B2 (en) 2011-11-01 2016-10-20 Bionomics, Inc. Anti-GPR49 antibodies
AU2012332588B2 (en) 2011-11-01 2017-09-07 Bionomics, Inc. Methods of blocking cancer stem cell growth
WO2013071142A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
EP2776586B1 (en) 2011-11-11 2018-03-07 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
HUE032648T2 (en) 2011-11-16 2017-10-30 Sphingotec Gmbh Adrenomedullin assays and methods for determining mature adrenomedullin
LT2780371T (en) 2011-11-16 2019-05-27 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease
CN110054690A (en) 2011-11-16 2019-07-26 艾德里诺医药公司 Anti- ADM antibody or anti-ADM antibody fragment for treatment
AU2012338733B2 (en) 2011-11-16 2017-08-24 Adrenomed Ag Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for use in therapy of an acute disease or acute condition of a patient for stabilizing the circulation
EP2594587B1 (en) 2011-11-16 2014-05-21 AdrenoMed AG Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig protein scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition
SG10201801919QA (en) 2011-11-16 2018-04-27 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition
EP2780040A1 (en) 2011-11-16 2014-09-24 Amgen Inc. Methods of treating epidermal growth factor deletion mutant viii related disorders
MX2014006733A (en) 2011-12-05 2015-05-12 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3.
UY34487A (en) 2011-12-05 2013-07-31 Novartis Ag Receptor antibodies to epidermal growth factor 3 (HER3)
RS58761B1 (en) * 2011-12-20 2019-06-28 Regeneron Pharma Humanized light chain mice
JP6231493B2 (en) 2011-12-21 2017-11-15 ノバルティス アーゲー Compositions and methods for antibodies targeting factor P
TWI593705B (en) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
CN104185681A (en) 2012-02-01 2014-12-03 卡姆普根有限公司 C10RF32 antibodies, and uses thereof for treatment of cancer
EA201400875A1 (en) 2012-02-06 2015-01-30 Инхибркс Ллк Antibodies to cd47 and methods of their application
EP2813568A4 (en) 2012-02-09 2016-04-06 Chugai Pharmaceutical Co Ltd Modified fc region of antibody
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
JP6280031B2 (en) 2012-03-29 2018-02-14 中外製薬株式会社 Anti-LAMP5 antibody and use thereof
KR20150003251A (en) 2012-04-04 2015-01-08 가부시키가이샤 페르세우스 프로테오믹스 Conjugate Of Anti-CDH3(P-Cadherin) Antibody And Drug
EP2838998B1 (en) 2012-04-18 2017-10-11 Cell Signaling Technology, Inc. Egfr and ros1 in cancer
US20150139996A1 (en) 2012-04-20 2015-05-21 Merus B.V. Methods and means for the production of ig-like molecules
US20140030270A1 (en) 2012-05-03 2014-01-30 Amgen Inc. Methods of treating or preventing cholesterol related disorders
EP2847231B1 (en) 2012-05-10 2019-07-10 Bioatla LLC Multi-specific monoclonal antibodies
US20130309223A1 (en) 2012-05-18 2013-11-21 Seattle Genetics, Inc. CD33 Antibodies And Use Of Same To Treat Cancer
WO2013180201A1 (en) 2012-05-30 2013-12-05 中外製薬株式会社 Antigen-binding molecule for eliminating aggregated antigens
AU2013268418B2 (en) 2012-05-30 2017-12-07 Chugai Seiyaku Kabushiki Kaisha Target-tissue-specific antigen-binding molecule
US9453080B2 (en) 2012-06-11 2016-09-27 Amgen Inc. Dual receptor antagonistic antigen-binding proteins and uses thereof
JPWO2013187495A1 (en) 2012-06-14 2016-02-08 中外製薬株式会社 Antigen binding molecules comprising modified Fc regions
WO2013192504A1 (en) 2012-06-22 2013-12-27 The Trustees Of Dartmouth College Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders
CN109793893A (en) 2012-09-07 2019-05-24 达特茅斯大学理事会 VISTA regulator for diagnosing and treating cancer
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimization of antibodies that bind to the gene of T cell activation 3 (LAG-3) and their uses
US9616101B2 (en) 2012-07-06 2017-04-11 Kyoto Prefectural Public University Corporation Differentiation marker and differentiation control of eye cell
EP2869897A4 (en) 2012-07-06 2016-09-28 Univ Duke Activation of trpv4 ion channel by physical stimuli and critical role for trpv4 in organ-specific inflammation and itch
MX2015000438A (en) 2012-07-13 2016-04-25 Univ Pennsylvania Toxicity management for anti-tumor activity of cars.
JPWO2014030750A1 (en) 2012-08-24 2016-08-08 中外製薬株式会社 Mouse FcγRII specific Fc antibody
RU2015110250A (en) 2012-08-24 2016-10-20 Чугаи Сейяку Кабусики Кайся OPTIONS FcγRIIB-SPECIFIC Fc-AREA
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
US20150307945A1 (en) 2012-09-27 2015-10-29 Chugai Seiyaku Kabushiki Kaisha Fgfr3 fusion gene and pharmaceutical drug targeting same
RU2683933C2 (en) 2012-09-28 2019-04-03 Чугаи Сейяку Кабусики Кайся Method for evaluating reaction of blood coagulation
CN104822844B (en) 2012-10-01 2019-05-07 米伦纽姆医药公司 Predict to the biomarker of the reaction of inhibitor and method with and application thereof
AU2013329381B2 (en) 2012-10-08 2018-09-06 Prothena Biosciences Limited Antibodies recognizing alpha-synuclein
CN104797600A (en) 2012-11-08 2015-07-22 国立大学法人宫崎大学 Antibody capable of specifically recognizing transferrin receptor
SG10201608703SA (en) 2012-11-08 2016-12-29 Eleven Biotherapeutics Inc Il-6 antagonists and uses thereof
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
US9365646B2 (en) 2012-12-05 2016-06-14 Novartis Ag Compositions and methods for antibodies targeting EPO
CN104995303A (en) 2012-12-18 2015-10-21 诺华股份有限公司 Compositions and methods that utilize a peptide tag that binds to hyaluronan
CN105102618B (en) 2012-12-27 2018-04-17 中外制药株式会社 heterodimerization polypeptide
EP2938633B1 (en) 2012-12-28 2018-02-07 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
US9920121B2 (en) 2013-01-25 2018-03-20 Amgen Inc. Antibodies targeting CDH19 for melanoma
UY35286A (en) 2013-01-25 2014-07-31 Amgen Res Munich Gmbh Antibody constructs to CD3 and CDH19
EP3161001A2 (en) 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
SG11201505330QA (en) 2013-02-08 2015-08-28 Novartis Ag Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders
WO2014140927A2 (en) 2013-02-13 2014-09-18 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
AU2014217561B2 (en) 2013-02-13 2018-11-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-TNF-alpha antibodies and uses thereof
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
HUE040169T2 (en) 2013-03-13 2019-02-28 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
EA201591285A1 (en) 2013-03-13 2016-02-29 Протена Биосайенсес Лимитед Immunotherapy tau
EP2970479B1 (en) 2013-03-14 2019-04-24 Novartis AG Antibodies against notch 3
US9980470B2 (en) 2013-03-14 2018-05-29 Erasmus University Medical Center Antibody production
US9816088B2 (en) 2013-03-15 2017-11-14 Abvitro Llc Single cell bar-coding for antibody discovery
WO2014140368A1 (en) 2013-03-15 2014-09-18 Amgen Research (Munich) Gmbh Antibody constructs for influenza m2 and cd3
TW201525001A (en) 2013-03-15 2015-07-01 Amgen Res Munich Gmbh Single chain binding molecules comprising N-terminal ABP
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
CN105102985B (en) 2013-03-20 2018-05-18 斯弗因高泰克有限公司 For blood pressure to be instructed to decline the adrenomedulin of therapy
TWI636062B (en) 2013-04-02 2018-09-21 中外製藥股份有限公司 Fc region variant
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
WO2014185550A1 (en) 2013-05-16 2014-11-20 Kyoto University Method for determining prognosis of cancer
WO2014186877A1 (en) 2013-05-24 2014-11-27 Uger Marni Diane FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
JP6442404B2 (en) 2013-06-11 2018-12-19 国立研究開発法人国立精神・神経医療研究センター Method for predicting treatment prognosis in patients with relapsing-remitting multiple sclerosis (RRMS), and method for determining new treatment indication
AR096601A1 (en) 2013-06-21 2016-01-20 Novartis Ag Antibodies receptor 1 ldl similar oxidized lectin and methods of use
MX2015017852A (en) 2013-06-24 2016-08-11 Chugai Pharmaceutical Co Ltd Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma.
CA2916259A1 (en) 2013-06-28 2014-12-31 Amgen Inc. Methods for treating homozygous familial hypercholesterolemia
CN105517572B (en) 2013-07-05 2019-05-31 华盛顿大学商业中心 The monoclonal antibody of neutralization soluble M IC for treating cancer
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
EP3033356A1 (en) 2013-08-14 2016-06-22 The Governing Council of the University of Toronto Antibodies against frizzled proteins and methods of use thereof
EP3033358A2 (en) 2013-08-14 2016-06-22 Novartis AG Methods of treating sporadic inclusion body myositis
WO2015041310A1 (en) 2013-09-20 2015-03-26 中外製薬株式会社 Treatment for hemorrhagic diseases by anti-protein-c antibody
JP6534615B2 (en) 2013-09-27 2019-06-26 中外製薬株式会社 Method for producing polypeptide heteromultimer
NL2013554B1 (en) 2013-10-01 2016-01-08 Kymab Ltd Animal models and therapeutic molecules.
EP3070168A4 (en) 2013-11-11 2017-06-28 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified antibody variable region
WO2015083764A1 (en) 2013-12-04 2015-06-11 中外製薬株式会社 Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
US8883157B1 (en) 2013-12-17 2014-11-11 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
EP3087986B1 (en) 2013-12-27 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Fgfr gatekeeper mutant gene and drug targeting same
SG11201605256YA (en) 2013-12-27 2016-08-30 Chugai Pharmaceutical Co Ltd Method for purifying antibody having low isoelectric point
CN105849564A (en) 2014-01-07 2016-08-10 生物蛋白有限公司 Proteins targeting orthologs
EP3105252B1 (en) 2014-02-12 2019-07-24 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
JP2017514458A (en) 2014-03-12 2017-06-08 プロセナ バイオサイエンシーズ リミテッド Anti-laminin 4 antibody specific for LG4-5
US10407506B2 (en) 2014-03-12 2019-09-10 Prothena Biosciences Limited Anti-MCAM antibodies and associated methods of use
TW201623331A (en) 2014-03-12 2016-07-01 普羅帝納生物科學公司 Anti-MCAM antibodies and associated methods of use
JP2017512772A (en) 2014-03-12 2017-05-25 プロセナ バイオサイエンシーズ リミテッド Anti-laminin 4 antibody specific for LG1-3
NZ724815A (en) 2014-04-04 2017-11-24 Bionomics Inc Humanized antibodies that bind lgr5
TW201622746A (en) 2014-04-24 2016-07-01 諾華公司 Methods of improving or accelerating physical recovery after surgery for hip fracture
KR101923326B1 (en) 2014-06-06 2018-11-29 브리스톨-마이어스 스큅 컴퍼니 Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
TW201625685A (en) 2014-06-18 2016-07-16 梅爾莎納醫療公司 Monoclonal antibodies against HER2 epitope and methods of use thereof
EP3160991A2 (en) 2014-06-25 2017-05-03 Novartis AG Compositions and methods for long acting proteins
EP3160990A2 (en) 2014-06-25 2017-05-03 Novartis AG Compositions and methods for long acting proteins
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
WO2016007414A1 (en) 2014-07-08 2016-01-14 New York University Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US9051378B1 (en) 2014-07-15 2015-06-09 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9034332B1 (en) 2014-07-15 2015-05-19 Kymab Limited Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US8945560B1 (en) 2014-07-15 2015-02-03 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9023359B1 (en) 2014-07-15 2015-05-05 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US9139648B1 (en) 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US9045548B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
US9150660B1 (en) 2014-07-15 2015-10-06 Kymab Limited Precision Medicine by targeting human NAV1.8 variants for treatment of pain
US20170349668A1 (en) 2014-07-31 2017-12-07 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody contructs
JP2017522891A (en) 2014-07-31 2017-08-17 アムゲン リサーチ (ミュンヘン) ゲーエムベーハーAMGEN Research(Munich)GmbH Bispecific single chain antibody construct with improved tissue distribution
AR101669A1 (en) 2014-07-31 2017-01-04 Amgen Res (Munich) Gmbh Antibody constructs to CD3 and cdh19
ES2726645T3 (en) 2014-08-01 2019-10-08 Inst Nat Sante Rech Med An anti-CD45RC antibody to use as a medicine
WO2016020880A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
US9988443B2 (en) 2014-08-07 2018-06-05 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
WO2016028325A1 (en) 2014-08-22 2016-02-25 Duke University Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch
US20160075772A1 (en) 2014-09-12 2016-03-17 Regeneron Pharmaceuticals, Inc. Treatment of Fibrodysplasia Ossificans Progressiva
AU2015318011A1 (en) 2014-09-15 2017-04-06 Abvitro Llc High-throughput nucleotide library sequencing
WO2016047722A1 (en) 2014-09-26 2016-03-31 中外製薬株式会社 Cytotoxicity-inducing therapeutic agent
WO2016059220A1 (en) 2014-10-16 2016-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Tcr-activating agents for use in the treatment of t-all
EP3207128A4 (en) 2014-10-17 2018-02-28 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US20170313742A1 (en) 2014-11-03 2017-11-02 Bristol-Myers Squibb Company Use of caprylic acid precipitation for protein purification
WO2016073894A1 (en) 2014-11-07 2016-05-12 Eleven Biotherapeutics, Inc. Therapeutic agents with increased ocular retention
EA201790986A1 (en) 2014-11-21 2017-10-31 Бристол-Майерс Сквибб Компани Antibodies to cd73 and their applications
EP3226900A4 (en) 2014-12-05 2018-09-19 Immunext, Inc. Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
UY36449A (en) 2014-12-19 2016-07-29 Novartis Ag Compositions and methods for antibodies directed to BMP6
JP2019532617A (en) 2016-07-02 2019-11-14 プロセナ バイオサイエンシーズ リミテッド Anti-transthyretin antibody
TW201636371A (en) 2015-01-28 2016-10-16 普羅佘納生物科技有限公司 Anti-transthyretin antibodies
TW201636372A (en) 2015-01-28 2016-10-16 普羅佘納生物科技有限公司 Anti-transthyretin antibodies
TW201632554A (en) 2015-01-28 2016-09-16 普羅佘納生物科技有限公司 Anti-transthyretin antibodies
EP3478716A2 (en) 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
JP2019530427A (en) 2016-07-02 2019-10-24 プロセナ バイオサイエンシーズ リミテッド Anti-transthyretin antibody
BR112017014328A2 (en) 2015-02-05 2018-01-02 Chugai Pharmaceutical Co Ltd antibodies comprising an ion concentration-dependent antigen binding domain, fc region variants, il-8 binding antibodies, methods of producing them and for prolonging or reducing the half-life of an antibody in plasma, pharmaceutical composition, nucleic acid, vector, host cell
SG10201908027QA (en) 2015-03-13 2019-10-30 Squibb Bristol Myers Co Use of alkaline washes during chromatography to remove impurities
WO2016153978A1 (en) 2015-03-20 2016-09-29 Bristol-Myers Squibb Company Use of dextran to enhance protein purification by affinity chromatography
US20180105555A1 (en) 2015-03-20 2018-04-19 Bristol-Myers Squibb Company Use of dextran for protein purification
AR104309A1 (en) 2015-04-17 2017-07-12 Bayer Pharma AG Construction of bispecific antibodies to CDH3 and cd3
KR20170125977A (en) 2015-04-17 2017-11-15 에프. 호프만-라 로슈 아게 Combination therapy of coagulation factors and multispecific antibodies
CA2984249A1 (en) 2015-04-29 2016-11-03 Regeneron Pharmaceuticals, Inc. Treatment of fibrodysplasia ossificans progressiva
US20180237534A1 (en) 2015-05-29 2018-08-23 Bristol-Myers Squibb Company Antibodies against ox40 and uses thereof
EA201792561A1 (en) 2015-06-05 2018-04-30 Новартис Аг Antibodies aimed on morphogenetic bone 9 protection (bmp9) and methods of their application
AU2016285920A1 (en) 2015-06-29 2018-02-01 Bristol-Myers Squibb Company Antibodies to CD40 with enhanced agonist activity
TW201716436A (en) 2015-07-13 2017-05-16 H 朗德貝克公司 Antibodies specific for hyperphosphorylated tau and methods of use thereof
TW201708256A (en) 2015-07-31 2017-03-01 安美基研究(慕尼黑)公司 Antibody constructs for MSLN and CD3
TW201716441A (en) 2015-07-31 2017-05-16 安美基研究(慕尼黑)公司 Antibody constructs for EGFRVIII and CD3
TW201708257A (en) 2015-07-31 2017-03-01 安美基研究(慕尼黑)公司 Antibody constructs for FLT3 and CD3
TW201706307A (en) 2015-07-31 2017-02-16 安美基研究(慕尼黑)公司 Antibody constructs for CD70 and CD3
TW201708261A (en) 2015-07-31 2017-03-01 Amgen Res (Munich) Gmbh Antibody constructs for DLL3 and CD3
CN108350072A (en) 2015-08-03 2018-07-31 诺华股份有限公司 The method for treating FGF21 associated diseases
UY36889A (en) 2015-09-09 2017-04-28 Novartis Ag Binding molecules thymic stromal lymphopoietin (TSLP) and methods of using the molecules
WO2017046776A2 (en) 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
WO2017046774A2 (en) 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
MX2018003005A (en) 2015-09-18 2018-04-11 Chugai Pharmaceutical Co Ltd Il-8-binding antibodies and uses thereof.
CA2999888A1 (en) 2015-09-24 2017-03-30 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
AU2017332495A1 (en) 2016-09-24 2019-04-11 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
US20190025299A1 (en) 2015-09-25 2019-01-24 Francois Vigneault High throughput process for t cell receptor target identification of natively-paired t cell receptor sequences
US20190077872A1 (en) 2015-11-18 2019-03-14 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
EA201891121A1 (en) 2015-11-19 2018-12-28 Бристол-Майерс Сквибб Компани Antibodies to the glukortikoid-induced receptor of the tumor necrosis factor (gitr) and their applications
WO2017095875A1 (en) 2015-11-30 2017-06-08 Bristol-Myers Squibb Company Anti human ip-10 antibodies and their uses
US20170198040A1 (en) 2015-12-18 2017-07-13 Novartis Ag ANTIBODIES TARGETING CD32b AND METHODS OF USE THEREOF
EP3395835A4 (en) 2015-12-25 2019-09-11 Chugai Pharmaceutical Co Ltd Antibody having enhanced activity, and method for modifying same
WO2017125897A1 (en) 2016-01-21 2017-07-27 Novartis Ag Multispecific molecules targeting cll-1
AU2017216230A1 (en) 2016-02-03 2018-07-19 Amgen Inc. BCMA and CD3 bispecific T cell engaging antibody constructs
WO2017149513A1 (en) 2016-03-03 2017-09-08 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
AU2017228470A1 (en) 2016-03-04 2018-08-30 Bristol-Myers Squibb Company Combination therapy with anti-CD73 antibodies
AU2016394956A1 (en) 2016-03-04 2018-10-11 The Rockefeller University Antibodies to CD40 with enhanced agonist activity
WO2017153955A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
WO2017153953A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
KR20180116215A (en) 2016-03-14 2018-10-24 추가이 세이야쿠 가부시키가이샤 Cytotoxicity-inducing therapeutic agent for treating cancer
MX2018011204A (en) 2016-03-15 2019-03-07 Mersana Therapeutics Inc Napi2b-targeted antibody-drug conjugates and methods of use thereof.
MX2018012717A (en) 2016-04-19 2019-05-15 Amgen Res Munich Gmbh Administration of a bispecific construct binding to cd33 and cd3 for use in a method for the treatment of myeloid leukemia.
US20190145981A1 (en) 2016-04-21 2019-05-16 Sphingotec Therapeutics Gmbh Methods for determining dpp3 and therapeutic methods
MX2018013384A (en) 2016-05-02 2019-02-28 Prothena Biosciences Ltd Antibodies recognizing tau.
CU20180135A7 (en) 2016-05-02 2019-06-04 Prothena Biosciences Ltd isolated monoclonal antibodies that compete for binding with the antibody tau 3d6
US20190135928A1 (en) 2016-05-09 2019-05-09 Bristol-Myers Squibb Company Tl1a antibodies and uses thereof
WO2017208210A1 (en) 2016-06-03 2017-12-07 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
CN109311991A (en) 2016-06-06 2019-02-05 希望之城 BAFF-R targets the T cell and application thereof of Chimeric antigen receptor modification
CN109641957A (en) 2016-06-06 2019-04-16 希望之城 BAFF-R antibody and application thereof
KR20190018690A (en) 2016-06-15 2019-02-25 노파르티스 아게 Methods for the treatment of diseases using inhibitors of bone morphogenetic protein 6 (BMP6)
EP3474887A1 (en) 2016-06-27 2019-05-01 AiCuris Anti-infective Cures GmbH Hcmv entry inhibitors
CA3030214A1 (en) 2016-07-08 2018-01-11 Sphingotec Gmbh Adrenomedullin for assessing congestion in a subject with acute heart failure
KR20190028436A (en) 2016-07-12 2019-03-18 하. 룬드벡 아크티에셀스카브 Antibodies Specific to Hyperphosphorylated Tau and Their Use
BR112019000431A2 (en) 2016-07-14 2019-07-09 Squibb Bristol Myers Co antibodies against tim3 and their uses
CN109562153A (en) 2016-08-07 2019-04-02 诺华股份有限公司 The immunization method that mRNA is mediated
US20190218248A1 (en) 2016-08-12 2019-07-18 Bristol-Myers Squibb Company Methods of purifying proteins
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
WO2018049261A1 (en) 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus expressing immune checkpoint modulators
US20190263899A1 (en) 2016-11-14 2019-08-29 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion
CA3039316A1 (en) 2016-11-28 2018-05-31 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand binding activity
KR20190120174A (en) 2016-12-16 2019-10-23 아드레노메드 아게 Anti-Adrenomedulin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for use in the mediation and treatment of congestion in patients in need of intervention and treatment of congestion
EP3339324A1 (en) 2016-12-22 2018-06-27 sphingotec GmbH Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof
WO2018129451A2 (en) 2017-01-09 2018-07-12 Merrimack Pharmaceuticals, Inc. Anti-fgfr antibodies and methods of use
CA3052098A1 (en) 2017-02-02 2018-08-09 Amgen Research (Munich) Gmbh Low ph pharmaceutical composition comprising t cell engaging antibody constructs
AU2018218557A1 (en) 2017-02-08 2019-08-22 Novartis Ag FGF21 mimetic antibodies and uses thereof
CA3051839A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
AU2018240938A1 (en) 2017-03-24 2019-10-10 Zenyaku Kogyo Co., Ltd. Anti-IgM/B cell surface antigen bispecific antibody
AU2018240117A1 (en) 2017-03-24 2019-09-19 Beth Israel Deaconess Medical Center, Inc. Methods for preventing and treating heart disease
WO2018181870A1 (en) 2017-03-31 2018-10-04 公立大学法人奈良県立医科大学 Medicinal composition usable for preventing and/or treating blood coagulation factor ix abnormality, comprising multispecific antigen binding molecule replacing function of blood coagulation factor viii
TW201843173A (en) 2017-04-07 2018-12-16 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
AU2018261951A1 (en) 2017-05-05 2019-10-31 Amgen Inc. Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
WO2018218222A1 (en) 2017-05-26 2018-11-29 Goldfless Stephen Jacob High-throughput polynucleotide library sequencing and transcriptome analysis
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
WO2018229251A1 (en) 2017-06-16 2018-12-20 Imba - Institut Für Molekulare Biotechnologie Gmbh Blood vessel organoid, methods of producing and using said organoids
TW201906865A (en) 2017-06-28 2019-02-16 瑞士商諾華公司 Prevention and treatment of urinary incontinence
US20190023788A1 (en) 2017-07-20 2019-01-24 H. Lundbeck A/S Agents, uses and methods for treatment
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. Methods of identifying cellular attributes related to outcomes associated with cell therapy
WO2019057992A2 (en) 2017-09-25 2019-03-28 Adrenomed Ag Anti-adrenomedullin (adm) binder for use in therapy or prevention of symptoms of illness
WO2019077082A1 (en) 2017-10-18 2019-04-25 Adrenomed Ag Therapy monitoring under treatment with an anti-adrenomedullin (adm) binder
WO2019081595A2 (en) 2017-10-25 2019-05-02 Sphingotec Therapeutics Gmbh Dpp3 binder directed to and binding to specific dpp3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag Antibodies targeting cd32b and methods of use thereof
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
WO2019118426A1 (en) 2017-12-11 2019-06-20 Amgen Inc. Continuous manufacturing process for bispecific antibody products
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
UY38041A (en) 2017-12-29 2019-06-28 Amgen Inc Construction of bispecific antibody directed to CD3 and MUC17
UY38050A (en) 2018-01-12 2019-07-31 Amgen Inc PAC1 antibodies and their uses cross-reference to related applications
WO2019140229A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Antibodies against tim3 and uses thereof
WO2019150309A1 (en) 2018-02-02 2019-08-08 Hammack Scott Modulators of gpr68 and uses thereof for treating and preventing diseases
WO2019154900A1 (en) 2018-02-08 2019-08-15 Sphingotec Gmbh Adrenomedullin (adm) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia
WO2019191416A1 (en) 2018-03-29 2019-10-03 Bristol-Myers Squibb Company Methods of purifying monomeric monoclonal antibodies
EP3569614A1 (en) 2018-05-18 2019-11-20 Julius-Maximilians-Universität Würzburg Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991000906A1 (en) * 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
WO1991010741A1 (en) * 1990-01-12 1991-07-25 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1992003918A1 (en) * 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991000906A1 (en) * 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
WO1991010741A1 (en) * 1990-01-12 1991-07-25 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1992003918A1 (en) * 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J.E. BERMAN ET AL.: "CONTENT AND ORGANIZATION OF THE HUMAN Ig Vh LOCUS: DEFINITION OF THREE NEW Vh FAMILIES AND LINKAGE TO THE Ig Ch LOCUS", EMBO JOURNAL., vol. 7, no. 3, 1988, EYNSHAM, OXFORD GB, pages 727 - 737, XP002041127 *
L.D. TAYLOR ET AL.: "A TRANSGENIC MOUSE THAT EXPRESSES A DIVERSITY OF HUMAN SEQUENCE HEAVY AND LIGHT CHAIN IMMUNOGLOBULINS.", NUCLEIC ACIDS RESEARCH., vol. 20, no. 23, 11 December 1992 (1992-12-11), OXFORD GB, pages 6287 - 6295, XP002041128 *
M. BRÜGGEMANN ET AL.: "A REPERTOIRE OF MONOCLONAL ANTIBODIES WITH HUMAN HEAVY CHAINS FROM TRANSGENIC MICE.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 86, 1989, WASHINGTON US, pages 6709 - 6713, XP000068417 *
See also references of WO9312227A1 *

Also Published As

Publication number Publication date
JPH07503132A (en) 1995-04-06
AU3328493A (en) 1993-07-19
EP0746609A1 (en) 1996-12-11
CA2124967C (en) 2008-04-08
JP2004008218A (en) 2004-01-15
WO1993012227A1 (en) 1993-06-24
CA2124967A1 (en) 1993-06-24

Similar Documents

Publication Publication Date Title
Lonberg et al. Antigen-specific human antibodies from mice comprising four distinct genetic modifications
JP6073441B2 (en) Hybrid light chain mouse
Chen et al. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone.
US6255458B1 (en) High affinity human antibodies and human antibodies against digoxin
ES2579231T3 (en) Enhanced mammalian expression vectors and uses thereof
AU2009263082B2 (en) Antibody producing non-human mammals
Lee et al. Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
Mendez et al. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
KR102008655B1 (en) Mice that make binding proteins comprising vl domains
US5874299A (en) Transgenic non-human animals capable of producing heterologous antibodies
EP1813672A2 (en) Transgenic non-human animals capable of producing heterologous antibodies
EP2989893B1 (en) Non-human animals expressing antibodies having a common light chain
EP1001019A1 (en) Transgenic animals harboring APP Allele having Swedish mutation
JP2009045066A (en) Transgenic non-human animal producing heterologous antibody
US8231877B2 (en) Heterologous antibodies which bind human CD4
US20180142002A1 (en) Antibody producing non-human animals
KR101826224B1 (en) Non-human mammals for the production of chimeric antibodies
EP2505654B1 (en) Common light chain mouse
JP6271450B2 (en) Mice producing heavy chain antibodies
US5569825A (en) Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
Maki et al. The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
US7501552B2 (en) Transgenic non-human animals for producing chimeric antibodies
DK2798950T3 (en) Animal models and therapeutic molecules
Brüggemann et al. A repertoire of monoclonal antibodies with human heavy chains from transgenic mice
US5633425A (en) Transgenic non-human animals capable of producing heterologous antibodies

Legal Events

Date Code Title Description
AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17P Request for examination filed

Effective date: 19940719

A4 Supplementary search report drawn up and despatched

Effective date: 19971030

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20001213

18W Application withdrawn

Withdrawal date: 20021111

RAP1 Rights of an application transferred

Owner name: GENPHARM INTERNATIONAL, INC.

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LONBERG, NILS

Inventor name: KAY, ROBERT M.