EP0478627A4 - Co-expression of heteromeric receptors - Google Patents

Co-expression of heteromeric receptors

Info

Publication number
EP0478627A4
EP0478627A4 EP19900909432 EP90909432A EP0478627A4 EP 0478627 A4 EP0478627 A4 EP 0478627A4 EP 19900909432 EP19900909432 EP 19900909432 EP 90909432 A EP90909432 A EP 90909432A EP 0478627 A4 EP0478627 A4 EP 0478627A4
Authority
EP
European Patent Office
Prior art keywords
expression
heteromeric receptors
heteromeric
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900909432
Other versions
EP0478627A1 (en
Inventor
William D. Huse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0478627A1 publication Critical patent/EP0478627A1/en
Publication of EP0478627A4 publication Critical patent/EP0478627A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP19900909432 1989-05-16 1990-05-15 Co-expression of heteromeric receptors Withdrawn EP0478627A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US35323589A 1989-05-16 1989-05-16
US353235 1989-05-16
US41073589A 1989-09-20 1989-09-20
US410735 1989-09-20
US44633389A 1989-12-04 1989-12-04
US446333 1989-12-04

Publications (2)

Publication Number Publication Date
EP0478627A1 EP0478627A1 (en) 1992-04-08
EP0478627A4 true EP0478627A4 (en) 1992-08-19

Family

ID=27408104

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900909432 Withdrawn EP0478627A4 (en) 1989-05-16 1990-05-15 Co-expression of heteromeric receptors

Country Status (5)

Country Link
EP (1) EP0478627A4 (en)
AU (1) AU652539B2 (en)
CA (1) CA2057923A1 (en)
FI (1) FI915411A0 (en)
WO (1) WO1990014443A1 (en)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0184860B1 (en) 1988-11-11 1999-04-01 메디칼 리써어치 카운실 Single domain ligands receptors comprising said ligands methods for their production and use of said ligands
US6291158B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6291160B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6291161B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
CA2016842A1 (en) * 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
US6291159B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US7063943B1 (en) 1990-07-10 2006-06-20 Cambridge Antibody Technology Methods for producing members of specific binding pairs
GB9206318D0 (en) * 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
DK0585287T3 (en) * 1990-07-10 2000-04-17 Cambridge Antibody Tech Process for producing specific binding pair elements
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
IL99552A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
DE69131017T2 (en) * 1990-12-20 1999-07-15 Ixsys Inc OPTIMIZATION OF BINDING PROTEINS
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
DE69230142T2 (en) 1991-05-15 2000-03-09 Cambridge Antibody Tech METHOD FOR PRODUCING SPECIFIC BINDING PAIRS
US6492160B1 (en) 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5858657A (en) * 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US5962255A (en) * 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
ES2136092T3 (en) * 1991-09-23 1999-11-16 Medical Res Council PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES.
DK0605522T3 (en) * 1991-09-23 2000-01-17 Medical Res Council Process for producing humanized antibodies
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733731A (en) * 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5872215A (en) * 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
DK1024191T3 (en) * 1991-12-02 2008-12-08 Medical Res Council Preparation of autoantibodies displayed on phage surfaces from antibody segment libraries
DE69233408T2 (en) * 1991-12-02 2005-09-22 Cambridge Antibody Technology Ltd., Melbourn Production of Antibodies on Phage Surfaces Starting from Antibody Segment Libraries.
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9225453D0 (en) 1992-12-04 1993-01-27 Medical Res Council Binding proteins
JP3720353B2 (en) * 1992-12-04 2005-11-24 メディカル リサーチ カウンシル Multivalent and multispecific binding proteins, their production and use
US7368111B2 (en) 1995-10-06 2008-05-06 Cambridge Antibody Technology Limited Human antibodies specific for TGFβ2
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
AU1449499A (en) 1997-10-31 1999-05-24 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
US6365377B1 (en) 1999-03-05 2002-04-02 Maxygen, Inc. Recombination of insertion modified nucleic acids
US6492497B1 (en) 1999-04-30 2002-12-10 Cambridge Antibody Technology Limited Specific binding members for TGFbeta1
US20020102613A1 (en) 1999-05-18 2002-08-01 Hoogenboom Hendricus Renerus Jacobus Mattheus Novel Fab fragment libraries and methods for their use
DK2067788T3 (en) 1999-05-18 2015-10-19 Dyax Corp Fab fragment libraries and methods for using them
AU2001234125A1 (en) 2000-02-22 2001-09-03 Medical And Biological Laboratories Co., Ltd. Antibody library
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
UA81743C2 (en) 2000-08-07 2008-02-11 Центокор, Инк. HUMAN MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TUMOR NECROSIS FACTOR ALFA (TNFα), PHARMACEUTICAL MIXTURE CONTAINING THEREOF, AND METHOD FOR TREATING ARTHRITIS
CN1306272C (en) 2000-11-17 2007-03-21 罗切斯特大学 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
ES2390425T3 (en) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Use of repulsive targeting molecules (RGM) and their modulators
CN100374457C (en) 2001-11-14 2008-03-12 森托科尔公司 Anti-IL-6 antibodies, compositions, methods and uses
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
JO3058B1 (en) 2005-04-29 2017-03-15 Applied Molecular Evolution Inc Anti-IL-6 Antibodies,Compositions,Methods and uses
JP2009501006A (en) 2005-06-30 2009-01-15 セントカー・インコーポレーテツド Anti-IL-23 antibodies, compositions, methods and uses
US7700739B2 (en) 2005-06-30 2010-04-20 Abbott Laboratories IL-12/p40 binding proteins
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP2500356A3 (en) 2005-08-19 2012-10-24 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
RU2515108C2 (en) 2005-08-19 2014-05-10 Эббви Инк Immunoglobulin with double variable domains and its applications
US8906864B2 (en) 2005-09-30 2014-12-09 AbbVie Deutschland GmbH & Co. KG Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use
KR101439828B1 (en) 2005-11-30 2014-09-17 애브비 인코포레이티드 Monoclonal antibodies against amyloid beta protein and uses thereof
AU2006319358B2 (en) 2005-11-30 2012-01-19 AbbVie Deutschland GmbH & Co. KG Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
HUE034269T2 (en) 2005-12-29 2018-02-28 Janssen Biotech Inc Human anti-il-23 antibodies, compositions, methods and uses
ES2902063T3 (en) 2006-09-08 2022-03-24 Abbvie Bahamas Ltd Interleukin-13 binding proteins
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
WO2008104386A2 (en) 2007-02-27 2008-09-04 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
WO2009055656A2 (en) 2007-10-26 2009-04-30 Centocor, Inc. Vectors, host cells, and methods of production and uses
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
MY159667A (en) 2008-05-09 2017-01-13 Abbvie Inc Antibodies to receptor of advanced glycation end products (rage) and uses thereof
RU2010153578A (en) 2008-06-03 2012-07-20 Эбботт Лэборетриз (Us) IMMUNOGLOBULINS WITH DOUBLE VARIABLE DOMAINS AND THEIR APPLICATION
CA2726087A1 (en) 2008-06-03 2009-12-10 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
MX2010014358A (en) 2008-06-20 2011-07-04 Wyeth Llc Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains.
RU2011104348A (en) 2008-07-08 2012-08-20 Эбботт Лэборетриз (Us) IMMUNOGLOBULINS WITH DOUBLE VARIABLE DOMAIN AGAINST PROSTAGLANDINE E2 AND THEIR APPLICATION
TW201014602A (en) 2008-07-08 2010-04-16 Abbott Lab Prostaglandin E2 binding proteins and uses thereof
US8563697B2 (en) 2008-08-14 2013-10-22 Cephalon Australia Pty. Ltd. Anti-IL-12/IL-23 antibodies
KR20110110349A (en) 2009-01-29 2011-10-06 아보트 러보러터리즈 Il-1 binding proteins
US8030026B2 (en) 2009-02-24 2011-10-04 Abbott Laboratories Antibodies to troponin I and methods of use thereof
EP2810652A3 (en) 2009-03-05 2015-03-11 AbbVie Inc. IL-17 binding proteins
US8685896B2 (en) 2009-05-29 2014-04-01 Morphosys Ag Collection and methods for its use
EP3029070A1 (en) 2009-08-29 2016-06-08 AbbVie Inc. Therapeutic dll4 binding proteins
KR20120060877A (en) 2009-09-01 2012-06-12 아보트 러보러터리즈 Dual variable domain immunoglobulins and uses thereof
AU2010306677B2 (en) 2009-10-15 2013-05-23 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
WO2011053707A1 (en) 2009-10-31 2011-05-05 Abbott Laboratories Antibodies to receptor for advanced glycation end products (rage) and uses thereof
SG181563A1 (en) 2009-12-08 2012-07-30 Abbott Gmbh & Co Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
CN102933231B (en) 2010-02-10 2015-07-29 伊缪诺金公司 CD20 antibody and uses thereof
TW202348631A (en) 2010-02-24 2023-12-16 美商免疫遺傳股份有限公司 Folate receptor 1 antibodies and immunoconjugates and uses thereof
EP2542582A4 (en) 2010-03-02 2013-12-04 Abbvie Inc Therapeutic dll4 binding proteins
SI2552961T1 (en) 2010-03-30 2018-02-28 Janssen Biotech, Inc. Humanized il-25 antibodies
CA2796339C (en) 2010-04-15 2020-03-31 Abbott Laboratories Amyloid-beta binding proteins
SI2571532T1 (en) 2010-05-14 2017-10-30 Abbvie Inc. Il-1 binding proteins
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (en) 2010-07-09 2012-01-31 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
KR20130100118A (en) 2010-08-03 2013-09-09 아비에 인코포레이티드 Dual variable domain immunoglobulins and uses therof
EP3533803B1 (en) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antibodies
HUE058226T2 (en) 2010-08-19 2022-07-28 Zoetis Belgium S A Anti-ngf antibodies and their use
CA2809433A1 (en) 2010-08-26 2012-03-01 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
EP2640742B1 (en) 2010-11-19 2018-08-15 MorphoSys AG A collection of antibody sequences its use
US20120275996A1 (en) 2010-12-21 2012-11-01 Abbott Laboratories IL-1 Binding Proteins
KR20130133247A (en) 2010-12-21 2013-12-06 애브비 인코포레이티드 Il-1-alpha and -beta bispecific dual variable domain immunoglobulins and their use
MX344595B (en) 2010-12-31 2016-12-20 Bioatla Llc Express humanization of antibodies.
EP2734236A4 (en) 2011-07-13 2015-04-15 Abbvie Inc Methods and compositions for treating asthma using anti-il-13 antibodies
MX2014004977A (en) 2011-10-24 2014-09-11 Abbvie Inc Immunobinders directed against sclerostin.
US9220775B2 (en) 2011-11-23 2015-12-29 Medimmune Llc Binding molecules specific for HER3 and uses thereof
TW201333035A (en) 2011-12-30 2013-08-16 Abbvie Inc Dual specific binding proteins directed against IL-13 and/or IL-17
MY176695A (en) 2012-01-27 2020-08-19 Abbvie Inc Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration
EP3296320A1 (en) 2012-03-08 2018-03-21 Halozyme, Inc. Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
EP2859018B1 (en) 2012-06-06 2021-09-22 Zoetis Services LLC Caninized anti-ngf antibodies and methods thereof
WO2014011955A2 (en) 2012-07-12 2014-01-16 Abbvie, Inc. Il-1 binding proteins
NZ726258A (en) 2012-08-31 2019-07-26 Immunogen Inc Antibodies and uses thereof to detect folate receptor 1
CA2890263C (en) 2012-11-01 2020-03-10 Abbvie Inc. Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
US9550986B2 (en) 2012-12-21 2017-01-24 Abbvie Inc. High-throughput antibody humanization
JP6739329B2 (en) 2013-03-14 2020-08-12 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCV core lipid binding domain monoclonal antibody
EP2968526A4 (en) 2013-03-14 2016-11-09 Abbott Lab Hcv antigen-antibody combination assay and methods and compositions for use therein
JP2016512241A (en) 2013-03-14 2016-04-25 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCVNS3 recombinant antigen for improved antibody detection and mutants thereof
WO2014144280A2 (en) 2013-03-15 2014-09-18 Abbvie Inc. DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17
KR102585409B1 (en) 2013-08-30 2023-10-05 이뮤노젠 아이엔씨 Antibodies and assays for detection of folate receptor 1
MX2016003256A (en) 2013-09-12 2016-06-07 Halozyme Inc Modified anti-epidermal growth factor receptor antibodies and methods of use thereof.
PL3712174T3 (en) 2013-12-24 2022-07-04 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
KR102546611B1 (en) 2014-04-08 2023-06-22 보스턴 파마슈티칼즈, 아이엔씨. Binding molecules specific for il-21 and uses of thereof
US10160812B2 (en) 2014-04-11 2018-12-25 Medimmune, Llc Bispecific HER2 antibodies
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates
AU2015345202B2 (en) 2014-11-10 2021-05-13 Medimmune Limited Binding molecules specific for CD73 and uses thereof
JP6847037B2 (en) 2014-11-11 2021-03-24 メディミューン リミテッド Concomitant therapeutic agents containing anti-CD73 antibody and A2A receptor inhibitor and their use
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
CA2973978A1 (en) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Inc. Treatment of cancer with anti-lap monoclonal antibodies
HUE048284T2 (en) 2015-05-29 2020-07-28 Abbvie Inc Anti-cd40 antibodies and uses thereof
TW201710286A (en) 2015-06-15 2017-03-16 艾伯維有限公司 Binding proteins against VEGF, PDGF, and/or their receptors
JP7026509B2 (en) 2015-06-24 2022-02-28 ヤンセン ファーマシューティカ エヌブイ Anti-VISTA antibody and fragment
HUE053619T2 (en) 2015-06-29 2021-07-28 Immunogen Inc Anti-cd123 antibodies and conjugates and derivatives thereof
RU2710194C9 (en) 2015-11-10 2020-09-14 МЕДИММЬЮН, ЭлЭлСи Binding molecules specific for asct2, and their use
CN116920085A (en) 2016-02-12 2023-10-24 詹森药业有限公司 anti-VISTA (B7H 5) antibodies
WO2017156488A2 (en) 2016-03-10 2017-09-14 Acceleron Pharma, Inc. Activin type 2 receptor binding proteins and uses thereof
WO2017161206A1 (en) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
AU2017241776A1 (en) 2016-03-29 2018-10-11 Janssen Biotech, Inc. Treating psoriasis with increased interval dosing of anti-IL12 and/or -23 antibody
WO2017175058A1 (en) 2016-04-07 2017-10-12 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3448391A4 (en) 2016-04-27 2019-12-18 AbbVie Inc. Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
MY194619A (en) 2016-06-02 2022-12-07 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
CA3027103A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
WO2017214335A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
CN109563167A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti- B7-H3 antibody and antibody drug conjugates
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
MX2019003703A (en) 2016-09-30 2020-08-13 Janssen Biotech Inc Safe and effective method of treating psoriasis with anti-il23 specific antibody.
AU2017362222A1 (en) 2016-11-16 2019-05-30 Janssen Biotech, Inc. Method of treating psoriasis with anti-IL-23 specific antibody
WO2018098370A1 (en) 2016-11-23 2018-05-31 Immunoah Therapeutics, Inc. 4-1bb binding proteins and uses thereof
JP7227146B2 (en) 2016-11-23 2023-02-21 バイオベラティブ セラピューティクス インコーポレイテッド A bispecific antibody that binds to coagulation factor IX and coagulation factor X
TW201825515A (en) 2017-01-04 2018-07-16 美商伊繆諾金公司 Met antibodies and immunoconjugates and uses thereof
EP3565845A4 (en) 2017-01-06 2020-10-07 Biosion, Inc. Erbb2 antibodies and uses therefore
CA3052095A1 (en) 2017-01-30 2018-08-02 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
MA47442A (en) 2017-02-07 2019-12-18 Janssen Biotech Inc ANTI-TNF ANTIBODIES, COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACTIVE ANKYLOSING SPONDYLARTHRITIS
JP6889328B2 (en) 2017-07-31 2021-06-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Humanization method based on three-dimensional structure
TW201922780A (en) 2017-09-25 2019-06-16 美商健生生物科技公司 Safe and effective method of treating Lupus with anti-IL12/IL23 antibody
WO2019075090A1 (en) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
WO2019150309A1 (en) 2018-02-02 2019-08-08 Hammack Scott Modulators of gpr68 and uses thereof for treating and preventing diseases
EP3752195A4 (en) 2018-02-14 2021-11-17 Viela Bio, Inc. Antibodies to feline mcdonough sarcoma (fms)-like tyrosine kinase 3 receptor ligand (flt3l) and uses thereof for treating autoimmune and inflammatory diseases
JP2021515770A (en) 2018-03-05 2021-06-24 ヤンセン バイオテツク，インコーポレーテツド Treatment of Crohn's disease using anti-IL-23 specific antibody
WO2019177690A1 (en) 2018-03-12 2019-09-19 Zoetis Services Llc Anti-ngf antibodies and methods thereof
KR102480493B1 (en) 2018-06-08 2022-12-21 크리스탈 바이오사이언스 주식회사 Transgenic animals to produce different antibodies with the same light chain I
WO2020014306A1 (en) 2018-07-10 2020-01-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
WO2020016838A2 (en) 2018-07-18 2020-01-23 Janssen Biotech, Inc. Sustained response predictors after treatment with anti-il23 specific antibody
DK3883606T5 (en) 2018-09-24 2024-01-02 Janssen Biotech Inc SAFE AND EFFECTIVE METHOD FOR TREATMENT OF ULCERATIVE COLITIS WITH ANTI-IL12/IL23 ANTIBODY
JP2022504839A (en) 2018-10-10 2022-01-13 ティロス・セラピューティクス・インコーポレイテッド Anti-LAP antibody mutants and their use
WO2020106358A1 (en) 2018-11-20 2020-05-28 Takeda Vaccines, Inc. Novel anti-zika virus antibodies and uses thereof
WO2020104943A2 (en) 2018-11-20 2020-05-28 Janssen Biotech, Inc. Safe and effective method of treating psoriasis with anti-il-23 specific antibody
US20200197517A1 (en) 2018-12-18 2020-06-25 Janssen Biotech, Inc. Safe and Effective Method of Treating Lupus with Anti-IL12/IL23 Antibody
US20220090125A1 (en) 2018-12-21 2022-03-24 Compass Therapeutics Llc Transgenic mouse expressing common human light chain
BR112021013903A2 (en) 2019-01-15 2021-09-21 Janssen Biotech, Inc. COMPOSITIONS AND METHODS OF ANTI-TNF ANTIBODIES FOR THE TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS
WO2020152544A1 (en) 2019-01-23 2020-07-30 Janssen Biotech, Inc. Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis
EP3938391A1 (en) 2019-03-14 2022-01-19 Janssen Biotech, Inc. Methods for producing anti-tnf antibody compositions
CN113840838A (en) 2019-03-14 2021-12-24 詹森生物科技公司 Methods of manufacture of compositions for the production of anti-TNF antibodies
JP2022525145A (en) 2019-03-14 2022-05-11 ヤンセン バイオテツク，インコーポレーテツド A production method for producing an anti-IL12 / IL23 antibody composition.
EP3938392A1 (en) 2019-03-14 2022-01-19 Janssen Biotech, Inc. Methods for producing anti-tnf antibody compositions
KR20210141583A (en) 2019-03-18 2021-11-23 얀센 바이오테크 인코포레이티드 Methods of Treating Psoriasis in Children Using Anti-IL-12/IL-23 Antibodies
JP2022534020A (en) 2019-05-23 2022-07-27 ヤンセン バイオテツク，インコーポレーテツド Methods of treating inflammatory bowel disease with combination therapy of antibodies against IL-23 and TNF-alpha
EP3976648A1 (en) 2019-06-03 2022-04-06 Janssen Biotech, Inc. Anti-tnf antibody compositions, and methods for the treatment of psoriatic arthritis
MX2021014882A (en) 2019-06-03 2022-03-25 Janssen Biotech Inc Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis.
WO2021028752A1 (en) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anti-tfn antibodies for treating type i diabetes
CA3167027A1 (en) 2020-02-05 2021-08-12 Larimar Therapeutics, Inc. Tat peptide binding proteins and uses thereof
US20230272056A1 (en) 2020-04-09 2023-08-31 Merck Sharp & Dohme Llc Affinity matured anti-lap antibodies and uses thereof
BR112023004415A2 (en) 2020-09-11 2023-05-09 Medimmune Ltd B7-H4 BINDING THERAPEUTIC MOLECULES
EP4211663A2 (en) 2020-09-12 2023-07-19 MedImmune Limited A scoring method for an anti-b7h4 antibody-drug conjugate therapy
UY39610A (en) 2021-01-20 2022-08-31 Abbvie Inc ANTI-EGFR ANTIBODY-DRUG CONJUGATES
IL305802A (en) 2021-03-12 2023-11-01 Janssen Biotech Inc Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
EP4305062A1 (en) 2021-03-12 2024-01-17 Janssen Biotech, Inc. Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody
CA3208011A1 (en) 2021-03-17 2022-09-22 Sarah Harris Methods of treating atopic dermatitis with anti il-13 antibodies
BR112023018331A2 (en) 2021-03-18 2023-12-12 Medimmune Ltd THERAPEUTIC BINDING MOLECULE THAT BINDS TO CCR9
WO2022241057A1 (en) 2021-05-12 2022-11-17 Applied Biomedical Science Institute Binding polypeptides against sars cov-2 and uses thereof
AU2022306144A1 (en) 2021-07-09 2024-02-22 Janssen Biotech, Inc. Manufacturing methods for producing anti-tnf antibody compositions
US20230042465A1 (en) 2021-07-09 2023-02-09 Janssen Biotech, Inc. Manufacturing Methods for Producing Anti-TNF Antibody Compositions
AU2022306973A1 (en) 2021-07-09 2024-02-22 Janssen Biotech, Inc. Manufacturing methods for producing anti-il12/il23 antibody compositions
US11807685B2 (en) 2021-08-05 2023-11-07 The Uab Research Foundation Anti-CD47 antibody and uses thereof
WO2023073615A1 (en) 2021-10-29 2023-05-04 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
WO2023084488A1 (en) 2021-11-15 2023-05-19 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
US20230159633A1 (en) 2021-11-23 2023-05-25 Janssen Biotech, Inc. Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody
TW202348252A (en) 2022-02-16 2023-12-16 英商梅迪繆思有限公司 Combination therapies for treatment of cancer with therapeutic binding molecules
WO2023187707A1 (en) 2022-03-30 2023-10-05 Janssen Biotech, Inc. Method of treating mild to moderate psoriasis with il-23 specific antibody
WO2023223265A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Method for evaluating and treating psoriatic arthritis with il23 antibody

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006630A1 (en) * 1987-03-02 1988-09-07 Genex Corporation Method for the preparation of binding molecules
WO1988009344A1 (en) * 1987-05-21 1988-12-01 Creative Biomolecules, Inc. Targeted multifunctional proteins
WO1989001526A1 (en) * 1987-08-07 1989-02-23 Genelabs Incorporated Coincidence cloning method and library

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006630A1 (en) * 1987-03-02 1988-09-07 Genex Corporation Method for the preparation of binding molecules
WO1988009344A1 (en) * 1987-05-21 1988-12-01 Creative Biomolecules, Inc. Targeted multifunctional proteins
WO1989001526A1 (en) * 1987-08-07 1989-02-23 Genelabs Incorporated Coincidence cloning method and library

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 3, 15 May 1989, DULUTH, MINNESOTA US pages 1250 - 1256; Larrick, J.W. et al.: 'Rapid cloning of rearranged Immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction.' *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 10, 15 May 1989, WASHINGTON US pages 3833 - 3837; Orlandi, R. et al.: 'Cloning Immunoglobulin variable domains for expression by the polymerase chain reaction.' *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 86, August 1989, WASHINGTON US pages 5728 - 5732; Sastry, L. et al.: 'Cloning of the immunological repertoire in Esherichia coli for generation of monoclonal catalytic antibodies : construction of a heavy chain variable region-specific cDNA library' *
SCIENCE. vol. 246, 8 December 1989, LANCASTER, PA US pages 1275 - 1281; Huse, W.D. et al.: 'Generation of a large combinatorial library of the Immunoglobulin repertoire in Phage lambda.' *
See also references of WO9014443A1 *

Also Published As

Publication number Publication date
EP0478627A1 (en) 1992-04-08
AU652539B2 (en) 1994-09-01
WO1990014443A1 (en) 1990-11-29
AU5834490A (en) 1990-12-18
CA2057923A1 (en) 1990-11-17
FI915411A0 (en) 1991-11-15

Similar Documents

Publication Publication Date Title
EP0478627A4 (en) Co-expression of heteromeric receptors
GB2135311B (en) Novel xanthine-type adenosine receptor antagonists
EP0432600A3 (en) Derivatives of 2-iminopyridine
HUT59733A (en) Group of bore rod details
IL96306A0 (en) Preparation of deoxyfluoronucleosides
EP0405560A3 (en) Preparation of tertiary-hydrocarbylsilyl compounds
GB2226095B (en) Mounting of tubular elements
EP0416406A3 (en) Process for the preparation of alkylhalosilanes
GB2249492B (en) Crystallisation of materials
YU53490A (en) Derivatives of tetrahydronaphtaline
GR3000924T3 (en) Shower rod
GB2222678B (en) Apparatus for the determination of crystalline structure
NO173997C (en) Analogous Procedure for Preparation of Selective Adenosine Receptor Compounds
GB8918517D0 (en) Location of tubular members
EP0419288A3 (en) Electrophotographic receptor
IL95024A0 (en) Preparation of 2-diazo-3-trisubstituted silyloxy-3-butenoates
RU1816810C (en) Device for electroplating of hollow parts
IL96055A0 (en) Continuous process for the preparation of ketals
GB8918394D0 (en) Preparation of polyhemiacetals
GB8924760D0 (en) Preparation of heterocyclic compounds
IE893845L (en) Manufacture of support structure for elongate components
IL89362A0 (en) Preparation of tetrabromotetralin
GB8917201D0 (en) N-imidazolyl-and n-imidazolylmethyl-derivatives of exo-alkylidene substituted bicyclic compounds
IE872439L (en) 23-imino derivatives of 23-keto c-076 compounds
IL105198A0 (en) Trifluoromethylsulfonate derivatives of estr-tri-and tetra-enes

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19911211

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

R17P Request for examination filed (corrected)

Effective date: 19911211

A4 Supplementary search report drawn up and despatched

Effective date: 19920703

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19940506

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19951130