DE69119211D1 - Cdr-gepfropfte anti-cea-antikörper und ihre herstellung - Google Patents

Cdr-gepfropfte anti-cea-antikörper und ihre herstellung

Info

Publication number
DE69119211D1
DE69119211D1 DE69119211T DE69119211T DE69119211D1 DE 69119211 D1 DE69119211 D1 DE 69119211D1 DE 69119211 T DE69119211 T DE 69119211T DE 69119211 T DE69119211 T DE 69119211T DE 69119211 D1 DE69119211 D1 DE 69119211D1
Authority
DE
Germany
Prior art keywords
hams
cdr
derived
production
humanized antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69119211T
Other languages
English (en)
Other versions
DE69119211T2 (de
Inventor
John Adair
Mark Bodmer
Andrew St Michael S C Mountain
Raymond Owens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1990/002017 external-priority patent/WO1991009967A1/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of DE69119211D1 publication Critical patent/DE69119211D1/de
Application granted granted Critical
Publication of DE69119211T2 publication Critical patent/DE69119211T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69119211T 1990-07-05 1991-07-05 Cdr-gepfropfte anti-cea-antikörper und ihre herstellung Expired - Fee Related DE69119211T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909014932A GB9014932D0 (en) 1990-07-05 1990-07-05 Recombinant dna product and method
PCT/GB1990/002017 WO1991009967A1 (en) 1989-12-21 1990-12-21 Humanised antibodies
PCT/GB1991/001108 WO1992001059A1 (en) 1990-07-05 1991-07-05 Cdr grafted anti-cea antibodies and their production

Publications (2)

Publication Number Publication Date
DE69119211D1 true DE69119211D1 (de) 1996-06-05
DE69119211T2 DE69119211T2 (de) 1996-12-19

Family

ID=10678718

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69119211T Expired - Fee Related DE69119211T2 (de) 1990-07-05 1991-07-05 Cdr-gepfropfte anti-cea-antikörper und ihre herstellung

Country Status (10)

Country Link
US (1) US5877293A (de)
EP (1) EP0491031B1 (de)
JP (1) JPH05502587A (de)
KR (1) KR920702425A (de)
AT (1) ATE137534T1 (de)
AU (1) AU651984B2 (de)
CA (1) CA2065325C (de)
DE (1) DE69119211T2 (de)
GB (2) GB9014932D0 (de)
WO (1) WO1992001059A1 (de)

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* Cited by examiner, † Cited by third party
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KR920702425A (ko) 1992-09-04
AU8200591A (en) 1992-02-04
CA2065325C (en) 2002-09-24
EP0491031A1 (de) 1992-06-24
EP0491031B1 (de) 1996-05-01
GB2251859A (en) 1992-07-22
CA2065325A1 (en) 1992-01-06
GB2251859B (en) 1995-01-11
AU651984B2 (en) 1994-08-11
GB9014932D0 (en) 1990-08-22
JPH05502587A (ja) 1993-05-13
US5877293A (en) 1999-03-02
WO1992001059A1 (en) 1992-01-23
DE69119211T2 (de) 1996-12-19
GB9204803D0 (en) 1992-04-29
ATE137534T1 (de) 1996-05-15

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