DE69028094D1 - Konjugate von antikörpern mit variablen domänen - Google Patents
Konjugate von antikörpern mit variablen domänenInfo
- Publication number
- DE69028094D1 DE69028094D1 DE69028094T DE69028094T DE69028094D1 DE 69028094 D1 DE69028094 D1 DE 69028094D1 DE 69028094 T DE69028094 T DE 69028094T DE 69028094 T DE69028094 T DE 69028094T DE 69028094 D1 DE69028094 D1 DE 69028094D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- conjugates
- linker
- specific binding
- variable domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Weting (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898927230A GB8927230D0 (en) | 1989-12-01 | 1989-12-01 | Reagents |
PCT/GB1990/001839 WO1991008482A1 (en) | 1989-12-01 | 1990-11-27 | Antibody variable domain conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69028094D1 true DE69028094D1 (de) | 1996-09-19 |
DE69028094T2 DE69028094T2 (de) | 1997-02-20 |
Family
ID=10667290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69028094T Expired - Fee Related DE69028094T2 (de) | 1989-12-01 | 1990-11-27 | Konjugate von antikörpern mit variablen domänen |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0456790B1 (de) |
JP (1) | JPH0833397B2 (de) |
AT (1) | ATE141415T1 (de) |
AU (1) | AU650857B2 (de) |
DE (1) | DE69028094T2 (de) |
ES (1) | ES2092514T3 (de) |
GB (1) | GB8927230D0 (de) |
WO (1) | WO1991008482A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
GB9226535D0 (en) * | 1992-12-21 | 1993-02-17 | Unilever Plc | Foodstuffs and other compositions |
US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
EP0736770A3 (de) * | 1995-04-05 | 1997-05-02 | Anda Biolog Sa | Immunoreaktives Konjugat, Verfahren zu seiner Herstellung, gegen dieses gerichtete Antikörper und sie enthaltende pharmazeutische Zusammensetzung und diagnostische Vorrichtung |
BR9907950A (pt) * | 1998-02-19 | 2001-12-18 | Xcyte Therapies Inc | Composições e processos para regulagem deativação de linfócitos |
BR0009866A (pt) | 1999-04-22 | 2002-01-08 | Unilever Nv | Método de inibição de infecção viral, uso de uma proteìna de ligação de antìgeno monovalente, produto alimentìcio, composição farmacêutica ou cosmética, proteìna de ligação de antìgeno monovalente, sequência de nucleotìdeos, vetor de expressão, célula hospedeira, e, métodos de seleção e de indentificação de uma proteìna de ligação de antìgeno |
DE60042789D1 (de) * | 1999-11-29 | 2009-10-01 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
WO2001040310A2 (en) * | 1999-11-29 | 2001-06-07 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
EP1751181B1 (de) | 2004-06-02 | 2012-08-15 | AdAlta Pty Ltd | Auf haifisch-ignar-domänen basierende bindungseinheiten |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
DE3379659D1 (en) * | 1983-07-29 | 1989-05-24 | Henning Berlin Gmbh | Preactivated surfaces of synthetic materials for immobilizing organochemical and biological substances, process for preparing them and their use |
DE3640412A1 (de) * | 1986-11-26 | 1988-06-09 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung einer spezifisch bindefaehigen substanz |
SE8701962D0 (sv) * | 1987-05-13 | 1987-05-13 | Bo Hakan Nygren | Sett att isolera och/eller bestemma halten av ett organiskt emne genom kovalent koppling av en for emnet specifik motreaktant till ytadsorberad, hydrofoberad vattenloslig polymer |
EP0623679B1 (de) * | 1987-05-21 | 2003-06-25 | Micromet AG | Multifunktionelle Proteine mit vorbestimmter Zielsetzung |
IT1223320B (it) * | 1987-10-23 | 1990-09-19 | Eniricerche Spa | Sensore con membrana immunochimica legata chimicamente a un dispositivo semiconduttore |
US4952519A (en) * | 1988-05-02 | 1990-08-28 | E. I. Du Pont De Nemours And Company | Protein immobilization with poly(ethyleneimine) derivatized with a hydroprobic group |
-
1989
- 1989-12-01 GB GB898927230A patent/GB8927230D0/en active Pending
-
1990
- 1990-11-27 EP EP90917572A patent/EP0456790B1/de not_active Expired - Lifetime
- 1990-11-27 JP JP3500229A patent/JPH0833397B2/ja not_active Expired - Lifetime
- 1990-11-27 AU AU68775/91A patent/AU650857B2/en not_active Ceased
- 1990-11-27 ES ES90917572T patent/ES2092514T3/es not_active Expired - Lifetime
- 1990-11-27 AT AT90917572T patent/ATE141415T1/de not_active IP Right Cessation
- 1990-11-27 DE DE69028094T patent/DE69028094T2/de not_active Expired - Fee Related
- 1990-11-27 WO PCT/GB1990/001839 patent/WO1991008482A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
GB8927230D0 (en) | 1990-01-31 |
AU6877591A (en) | 1991-06-26 |
EP0456790A1 (de) | 1991-11-21 |
AU650857B2 (en) | 1994-07-07 |
WO1991008482A1 (en) | 1991-06-13 |
JPH04504309A (ja) | 1992-07-30 |
DE69028094T2 (de) | 1997-02-20 |
ES2092514T3 (es) | 1996-12-01 |
JPH0833397B2 (ja) | 1996-03-29 |
ATE141415T1 (de) | 1996-08-15 |
EP0456790B1 (de) | 1996-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1993021331A3 (en) | Polysaccharide binding fusion proteins and conjugates | |
DE68927523T2 (de) | Modifikation der Domäne der Konstantregion der Antikörpern | |
ATE58297T1 (de) | Kupplungsmittel zum radiomarkieren von proteinen. | |
AU7261994A (en) | Hydrazino-type radionuclide chelators having an n3s configuration | |
IL152886A0 (en) | B-7 related nucleic acids and polypeptides and pharmaceutical compositions containing the same | |
ES2171705T3 (es) | Complejos de polipeptido-dendrimero. | |
NZ330897A (en) | Human trk receptors and neurotropic factor inhibitors | |
AU6113396A (en) | Novel high affinity human antibodies to tumor antigens | |
PT1135498E (pt) | Variantes de anticorpos com maior afinidade de ligação em comparação com os anticorpos parentais | |
DE69434384D1 (de) | Metalkomplexbildner | |
DE69942802D1 (de) | Trifunktionales reagenz zur verbindung von biomolekülen | |
BR9509172A (pt) | Proteina de via de complemento nativa sequéncia de dna construção de dna conjugado uso de uma proteína processo para reduzir proteina de via de complemento em um mamifero e formulação farmacéutica | |
ES2090052T3 (es) | Anticuerpos monoclonales (mak) contra antigenos asociados a tumores, su preparacion y uso. | |
DE69028094D1 (de) | Konjugate von antikörpern mit variablen domänen | |
CA2200855A1 (en) | Radioactive phosphorous labeling of proteins for targeted radiotherapy | |
DE69317886D1 (de) | Neue propoxyphenderivate sowie deren protein-und polypeptidlabels und-konjugate | |
ATE196767T1 (de) | Neue cocain-derivate und protein- und polypeptid- cocain-derivate, konjugate und markierte verbindungen | |
ES8604228A1 (es) | Procedimiento para la obtencion de un conjugado entre un io-nofero carboxilico monovalente y una macromolecula | |
ATE66534T1 (de) | Nortriptylinderivate, verfahren zu ihrer herstellung, deren konjugate mit antigenischen proteinen und enzymen, antikoerper davon und verwandte verfahren zur bestimmung. | |
DE69631624D1 (de) | Antikörper gegen menschliches restrictin | |
PT524421E (pt) | Herpesvirus humano tipo 6 proteina p 100, sequencias de adn correspondentes, preparacao e utilizacao | |
ATE125306T1 (de) | Monoklonale antikörper, die einen unterschied zwischen nativproteinen und proteinen mit einer modifizierten sequenz machen. | |
MX9701904A (es) | Proteinas de enlace de pka novedosas y usos de las mismas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: INVERNESS MEDICAL SWITZERLAND GMBH, ZUG, CH |
|
8339 | Ceased/non-payment of the annual fee |