DE69028094T2 - Konjugate von antikörpern mit variablen domänen - Google Patents

Konjugate von antikörpern mit variablen domänen

Info

Publication number
DE69028094T2
DE69028094T2 DE69028094T DE69028094T DE69028094T2 DE 69028094 T2 DE69028094 T2 DE 69028094T2 DE 69028094 T DE69028094 T DE 69028094T DE 69028094 T DE69028094 T DE 69028094T DE 69028094 T2 DE69028094 T2 DE 69028094T2
Authority
DE
Germany
Prior art keywords
antibodies
conjugates
linker
specific binding
variable domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69028094T
Other languages
English (en)
Other versions
DE69028094D1 (de
Inventor
Paul Davis
Martine Verhoeyen
Winter Ronald De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere Switzerland GmbH
Original Assignee
Unilever NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever NV filed Critical Unilever NV
Application granted granted Critical
Publication of DE69028094D1 publication Critical patent/DE69028094D1/de
Publication of DE69028094T2 publication Critical patent/DE69028094T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69028094T 1989-12-01 1990-11-27 Konjugate von antikörpern mit variablen domänen Expired - Fee Related DE69028094T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927230A GB8927230D0 (en) 1989-12-01 1989-12-01 Reagents
PCT/GB1990/001839 WO1991008482A1 (en) 1989-12-01 1990-11-27 Antibody variable domain conjugates

Publications (2)

Publication Number Publication Date
DE69028094D1 DE69028094D1 (de) 1996-09-19
DE69028094T2 true DE69028094T2 (de) 1997-02-20

Family

ID=10667290

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028094T Expired - Fee Related DE69028094T2 (de) 1989-12-01 1990-11-27 Konjugate von antikörpern mit variablen domänen

Country Status (8)

Country Link
EP (1) EP0456790B1 (de)
JP (1) JPH0833397B2 (de)
AT (1) ATE141415T1 (de)
AU (1) AU650857B2 (de)
DE (1) DE69028094T2 (de)
ES (1) ES2092514T3 (de)
GB (1) GB8927230D0 (de)
WO (1) WO1991008482A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9021671D0 (en) * 1990-10-05 1990-11-21 Unilever Plc Delivery of agents
GB9012995D0 (en) * 1990-06-11 1990-08-01 Celltech Ltd Multivalent antigen-binding proteins
GB9226535D0 (en) * 1992-12-21 1993-02-17 Unilever Plc Foodstuffs and other compositions
DK0698097T3 (da) 1993-04-29 2001-10-08 Unilever Nv Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
EP0736770A3 (de) * 1995-04-05 1997-05-02 Anda Biolog Sa Immunoreaktives Konjugat, Verfahren zu seiner Herstellung, gegen dieses gerichtete Antikörper und sie enthaltende pharmazeutische Zusammensetzung und diagnostische Vorrichtung
KR20010034512A (ko) * 1998-02-19 2001-04-25 베렌슨, 론 림프구 활성화 조절을 위한 조성물 및 그 방법
CN100434441C (zh) 1999-04-22 2008-11-19 荷兰联合利华有限公司 利用单价抗原-结合蛋白抑制病毒感染
EP1242460B1 (de) * 1999-11-29 2006-10-18 Unilever Plc Immobilisierung von proteinen mit hilfe eines polypeptidsegments
ATE440111T1 (de) * 1999-11-29 2009-09-15 Bac Ip B V Immobilisierte antigenbindende moleküle aus einer domäne
CA2567655C (en) 2004-06-02 2015-06-30 Diatech Pty Ltd Binding moieties based on shark ignar domains

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769326A (en) * 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
EP0134307B1 (de) * 1983-07-29 1989-04-19 Henning Berlin GmbH Chemie und Pharmawerk Voraktivierte Kunststoffoberflächen zur Immobilisierung von organisch-chemischen und biologischen Materialien, Verfahren zur Herstellung und Verwendung derselben
DE3640412A1 (de) * 1986-11-26 1988-06-09 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
SE8701962D0 (sv) * 1987-05-13 1987-05-13 Bo Hakan Nygren Sett att isolera och/eller bestemma halten av ett organiskt emne genom kovalent koppling av en for emnet specifik motreaktant till ytadsorberad, hydrofoberad vattenloslig polymer
EP0623679B1 (de) * 1987-05-21 2003-06-25 Micromet AG Multifunktionelle Proteine mit vorbestimmter Zielsetzung
IT1223320B (it) * 1987-10-23 1990-09-19 Eniricerche Spa Sensore con membrana immunochimica legata chimicamente a un dispositivo semiconduttore
US4952519A (en) * 1988-05-02 1990-08-28 E. I. Du Pont De Nemours And Company Protein immobilization with poly(ethyleneimine) derivatized with a hydroprobic group

Also Published As

Publication number Publication date
JPH04504309A (ja) 1992-07-30
EP0456790A1 (de) 1991-11-21
JPH0833397B2 (ja) 1996-03-29
AU6877591A (en) 1991-06-26
AU650857B2 (en) 1994-07-07
EP0456790B1 (de) 1996-08-14
ATE141415T1 (de) 1996-08-15
ES2092514T3 (es) 1996-12-01
WO1991008482A1 (en) 1991-06-13
DE69028094D1 (de) 1996-09-19
GB8927230D0 (en) 1990-01-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: INVERNESS MEDICAL SWITZERLAND GMBH, ZUG, CH

8339 Ceased/non-payment of the annual fee