ES2092514T3 - Conjugados de anticuerpos de dominio variable. - Google Patents
Conjugados de anticuerpos de dominio variable.Info
- Publication number
- ES2092514T3 ES2092514T3 ES90917572T ES90917572T ES2092514T3 ES 2092514 T3 ES2092514 T3 ES 2092514T3 ES 90917572 T ES90917572 T ES 90917572T ES 90917572 T ES90917572 T ES 90917572T ES 2092514 T3 ES2092514 T3 ES 2092514T3
- Authority
- ES
- Spain
- Prior art keywords
- variable domain
- domain antibodies
- conjugates
- linker
- specific binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Weting (AREA)
Abstract
PEQUEÑAS MOLECULAS LIGADORAS ESPECIFICAS, COMO ANTICUERPOS DE DOMINIO UNICO VARIABLE (DABS) Y FRAGMENTOS DE FV, PUEDEN ACOPLARSE A SUPERFICIES DE PLASTICOS SOLIDOS O A INDICADORES COMO ENZIMAS POR MEDIO DE LIGADORES QUE INCLUYEN POLIPEPTIDOS QUE CONTIENEN ENTRE 5 Y 20 AMINOACIDOS Y QUE SON HIDROFOBICOS Y/O CONTIENEN POR LO MENOS UN RESIDUO DE LISINA. EL ACOPLAMIENTO PUEDE REALIZARSE SIN UNA PERDIDA SIGNIFICATIVA DE ACTIVIDAD LIGADORA ESPECIFICA. EL COMBINADO DAB/LIGADOR O FU/LIGADOR PUEDE PREPARARSE MEDIANTE LA EXPRESION EN ORGANISMOS MODIFICADOS GENETICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898927230A GB8927230D0 (en) | 1989-12-01 | 1989-12-01 | Reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2092514T3 true ES2092514T3 (es) | 1996-12-01 |
Family
ID=10667290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90917572T Expired - Lifetime ES2092514T3 (es) | 1989-12-01 | 1990-11-27 | Conjugados de anticuerpos de dominio variable. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0456790B1 (es) |
JP (1) | JPH0833397B2 (es) |
AT (1) | ATE141415T1 (es) |
AU (1) | AU650857B2 (es) |
DE (1) | DE69028094T2 (es) |
ES (1) | ES2092514T3 (es) |
GB (1) | GB8927230D0 (es) |
WO (1) | WO1991008482A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
GB9226535D0 (en) * | 1992-12-21 | 1993-02-17 | Unilever Plc | Foodstuffs and other compositions |
DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
EP0736770A3 (fr) * | 1995-04-05 | 1997-05-02 | Anda Biolog Sa | Conjugué immunoréactif, procédé d'obtention de ce conjugué, anticorps dirigés contre ledit conjugué, composition pharmaceutique et dispositif de diagnostic les comprenant |
BR9907950A (pt) * | 1998-02-19 | 2001-12-18 | Xcyte Therapies Inc | Composições e processos para regulagem deativação de linfócitos |
AU776824B2 (en) | 1999-04-22 | 2004-09-23 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins |
WO2001040310A2 (en) * | 1999-11-29 | 2001-06-07 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
DK1233987T3 (da) * | 1999-11-29 | 2009-09-28 | Bac Ip B V | Immobiliserede enkelt-domæne antigenbindende molekyler |
DK2330121T3 (en) | 2004-06-02 | 2014-12-15 | Adalta Pty Ltd | Binding moieties based on shark IgNar domains |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
EP0134307B1 (de) * | 1983-07-29 | 1989-04-19 | Henning Berlin GmbH Chemie und Pharmawerk | Voraktivierte Kunststoffoberflächen zur Immobilisierung von organisch-chemischen und biologischen Materialien, Verfahren zur Herstellung und Verwendung derselben |
DE3640412A1 (de) * | 1986-11-26 | 1988-06-09 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung einer spezifisch bindefaehigen substanz |
SE8701962D0 (sv) * | 1987-05-13 | 1987-05-13 | Bo Hakan Nygren | Sett att isolera och/eller bestemma halten av ett organiskt emne genom kovalent koppling av en for emnet specifik motreaktant till ytadsorberad, hydrofoberad vattenloslig polymer |
WO1988009344A1 (en) * | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
IT1223320B (it) * | 1987-10-23 | 1990-09-19 | Eniricerche Spa | Sensore con membrana immunochimica legata chimicamente a un dispositivo semiconduttore |
US4952519A (en) * | 1988-05-02 | 1990-08-28 | E. I. Du Pont De Nemours And Company | Protein immobilization with poly(ethyleneimine) derivatized with a hydroprobic group |
-
1989
- 1989-12-01 GB GB898927230A patent/GB8927230D0/en active Pending
-
1990
- 1990-11-27 EP EP90917572A patent/EP0456790B1/en not_active Expired - Lifetime
- 1990-11-27 JP JP3500229A patent/JPH0833397B2/ja not_active Expired - Lifetime
- 1990-11-27 DE DE69028094T patent/DE69028094T2/de not_active Expired - Fee Related
- 1990-11-27 AT AT90917572T patent/ATE141415T1/de not_active IP Right Cessation
- 1990-11-27 ES ES90917572T patent/ES2092514T3/es not_active Expired - Lifetime
- 1990-11-27 AU AU68775/91A patent/AU650857B2/en not_active Ceased
- 1990-11-27 WO PCT/GB1990/001839 patent/WO1991008482A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JPH04504309A (ja) | 1992-07-30 |
EP0456790B1 (en) | 1996-08-14 |
AU650857B2 (en) | 1994-07-07 |
WO1991008482A1 (en) | 1991-06-13 |
AU6877591A (en) | 1991-06-26 |
ATE141415T1 (de) | 1996-08-15 |
JPH0833397B2 (ja) | 1996-03-29 |
DE69028094D1 (de) | 1996-09-19 |
GB8927230D0 (en) | 1990-01-31 |
DE69028094T2 (de) | 1997-02-20 |
EP0456790A1 (en) | 1991-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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