ATE152918T1 - Technetium-99m-markierte peptide zur bilderzeugung - Google Patents
Technetium-99m-markierte peptide zur bilderzeugungInfo
- Publication number
- ATE152918T1 ATE152918T1 AT93915221T AT93915221T ATE152918T1 AT E152918 T1 ATE152918 T1 AT E152918T1 AT 93915221 T AT93915221 T AT 93915221T AT 93915221 T AT93915221 T AT 93915221T AT E152918 T1 ATE152918 T1 AT E152918T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- technetium
- linker moiety
- binding
- polyvalent linker
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 229940056501 technetium 99m Drugs 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 125000005647 linker group Chemical group 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 230000009870 specific binding Effects 0.000 abstract 3
- 230000027455 binding Effects 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/893,981 US5508020A (en) | 1992-06-05 | 1992-06-05 | Technetium-99M labeled peptides for imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE152918T1 true ATE152918T1 (de) | 1997-05-15 |
Family
ID=25402435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93915221T ATE152918T1 (de) | 1992-06-05 | 1993-06-04 | Technetium-99m-markierte peptide zur bilderzeugung |
Country Status (11)
Country | Link |
---|---|
US (4) | US5508020A (de) |
EP (1) | EP0644778B1 (de) |
JP (1) | JP2954354B2 (de) |
AT (1) | ATE152918T1 (de) |
AU (1) | AU688264B2 (de) |
CA (1) | CA2137009C (de) |
DE (1) | DE69310733T2 (de) |
DK (1) | DK0644778T3 (de) |
ES (1) | ES2105292T3 (de) |
HK (1) | HK1007685A1 (de) |
WO (1) | WO1993025244A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
ES2141102T3 (es) * | 1991-02-08 | 2000-03-16 | Diatide Inc | Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
EP0630265B1 (de) * | 1992-03-13 | 2003-04-16 | Diatide, Inc. | Technetium-99-markierte peptide zur visualisierung vom entzuendungen |
AU709306B2 (en) * | 1992-04-30 | 1999-08-26 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
JPH08502261A (ja) * | 1992-10-02 | 1996-03-12 | ダイアテク,インコーポレイテッド | 多重多価抗血栓症剤 |
DE69431052T2 (de) * | 1993-04-08 | 2003-03-13 | Diatide Inc | Radiomarkierte verbindungen zur thrombus-bilderzeugung |
ZA945587B (en) * | 1993-07-28 | 1995-05-15 | Diatech Inc | Radiolabeled glucans. |
DE69526203T2 (de) * | 1994-01-12 | 2002-11-28 | Amersham Plc Little Chalfont | Biologische zielgerichtete mittel |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
DK0750610T3 (da) * | 1994-03-18 | 2002-03-11 | Diatide Inc | Piperidyl-4-substituerede tyrosinderivater som scintigrafiske billedfrembringende midler til diagnose af thrombose |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
ATE380038T1 (de) | 1996-07-12 | 2007-12-15 | Immunomedics Inc | Radiometall-bindende peptide analoge |
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
EP1905357B1 (de) | 1997-04-30 | 2012-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Verfahren zur In-vivo-Zelltodabbildung |
US5886142A (en) * | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
US6028056A (en) * | 1998-02-06 | 2000-02-22 | Diatide, Inc. | Pharmaceutical compositions for imaging and treating thrombi |
US6022857A (en) * | 1998-06-19 | 2000-02-08 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
EP1441773A1 (de) * | 2001-10-19 | 2004-08-04 | Thomas Jefferson University | Pacap-zusammensetzungen und verfahren für die tumordarsetllung und -therapie |
WO2003090121A1 (en) * | 2002-04-22 | 2003-10-30 | Thomson Licensing S.A. | A web browser for use with a television display for preventing screen burn |
US20060029544A1 (en) * | 2004-08-06 | 2006-02-09 | The Regents Of The University Of California Office Of Technology Transfer | Receptor-binding cyclic peptides and methods of use |
KR101430627B1 (ko) | 2008-05-13 | 2014-08-14 | 유니버시티 오브 캔사스 | 금속 추출 펩타이드(map) 태그 및 관련된 방법 |
WO2013023795A1 (en) | 2011-08-17 | 2013-02-21 | Piramal Imaging Sa | Compounds for binding to the platelet specific glycoprotein iib/iiia and their use for imaging of thrombi |
US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
WO2014124943A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
DE102013113156A1 (de) * | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
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US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
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US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
EP0188256B1 (de) * | 1985-01-14 | 1991-08-21 | NeoRx | Metall-Radionuklid markiertes Protein für Diagnose und Therapie |
US4748022A (en) | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
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EP0731110A1 (de) * | 1987-12-10 | 1996-09-11 | La Jolla Cancer Research Foundation | Verfahren zur Herstellung von konformationell stabilisierten Zelladhäsionspeptiden |
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US5302700A (en) * | 1988-05-23 | 1994-04-12 | Duke University | Radiohalogenation conjugate technology |
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DE68928842T2 (de) | 1988-08-03 | 1999-04-29 | Univ California | Sonde für hohe auflösung nmr mit wiederorientierung der muster |
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US5180816A (en) * | 1988-08-24 | 1993-01-19 | Centocor | One vial method for labeling protein/linker conjugates with technetium-99M |
NZ230897A (en) * | 1988-10-04 | 1993-02-25 | Cancer Res Campaign Tech | Targeting agents against malignant melanoma comprising peptides from #alpha#-melanocyte stimulating hormone n-linked to moiety active against melanomas |
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US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
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FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
US4961869A (en) * | 1989-08-03 | 1990-10-09 | E. I. Du Pont De Nemours And Company | Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol |
US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
WO1992005154A1 (en) * | 1990-09-14 | 1992-04-02 | Mallinckrodt Medical, Inc. | Novel nitrogen-sulfur ligands useful in radiographic imaging agents |
ES2141102T3 (es) * | 1991-02-08 | 2000-03-16 | Diatide Inc | Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
EP0630265B1 (de) * | 1992-03-13 | 2003-04-16 | Diatide, Inc. | Technetium-99-markierte peptide zur visualisierung vom entzuendungen |
US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
EP0641222B1 (de) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | Technetium-99m markierte peptide zur bilderzeugung von thrombus |
US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
JPH08502261A (ja) * | 1992-10-02 | 1996-03-12 | ダイアテク,インコーポレイテッド | 多重多価抗血栓症剤 |
DE69431052T2 (de) * | 1993-04-08 | 2003-03-13 | Diatide Inc | Radiomarkierte verbindungen zur thrombus-bilderzeugung |
US5951964A (en) * | 1993-06-04 | 1999-09-14 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
JPH09512555A (ja) * | 1994-05-02 | 1997-12-16 | ダイアテック・インコーポレイテッド | テクネチウム−99m標識イメージング剤 |
-
1992
- 1992-06-05 US US07/893,981 patent/US5508020A/en not_active Expired - Lifetime
-
1993
- 1993-06-04 JP JP6501622A patent/JP2954354B2/ja not_active Expired - Lifetime
- 1993-06-04 DK DK93915221.1T patent/DK0644778T3/da active
- 1993-06-04 WO PCT/US1993/005372 patent/WO1993025244A1/en active IP Right Grant
- 1993-06-04 DE DE69310733T patent/DE69310733T2/de not_active Expired - Fee Related
- 1993-06-04 EP EP93915221A patent/EP0644778B1/de not_active Revoked
- 1993-06-04 AT AT93915221T patent/ATE152918T1/de not_active IP Right Cessation
- 1993-06-04 ES ES93915221T patent/ES2105292T3/es not_active Expired - Lifetime
- 1993-06-04 AU AU45287/93A patent/AU688264B2/en not_active Ceased
- 1993-06-04 CA CA002137009A patent/CA2137009C/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/469,858 patent/US5976494A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,567 patent/US6113878A/en not_active Expired - Fee Related
-
1997
- 1997-07-08 US US08/889,212 patent/US6667389B1/en not_active Expired - Fee Related
-
1998
- 1998-06-26 HK HK98106974A patent/HK1007685A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU688264B2 (en) | 1998-03-12 |
WO1993025244A1 (en) | 1993-12-23 |
EP0644778B1 (de) | 1997-05-14 |
EP0644778A1 (de) | 1995-03-29 |
US5508020A (en) | 1996-04-16 |
HK1007685A1 (en) | 1999-04-23 |
US6667389B1 (en) | 2003-12-23 |
JPH07506592A (ja) | 1995-07-20 |
ES2105292T3 (es) | 1997-10-16 |
JP2954354B2 (ja) | 1999-09-27 |
CA2137009A1 (en) | 1993-12-23 |
US6113878A (en) | 2000-09-05 |
DK0644778T3 (da) | 1997-11-03 |
DE69310733T2 (de) | 1997-10-30 |
DE69310733D1 (de) | 1997-06-19 |
CA2137009C (en) | 2001-11-27 |
AU4528793A (en) | 1994-01-04 |
US5976494A (en) | 1999-11-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |