ATE152918T1 - Technetium-99m-markierte peptide zur bilderzeugung - Google Patents

Technetium-99m-markierte peptide zur bilderzeugung

Info

Publication number
ATE152918T1
ATE152918T1 AT93915221T AT93915221T ATE152918T1 AT E152918 T1 ATE152918 T1 AT E152918T1 AT 93915221 T AT93915221 T AT 93915221T AT 93915221 T AT93915221 T AT 93915221T AT E152918 T1 ATE152918 T1 AT E152918T1
Authority
AT
Austria
Prior art keywords
peptides
technetium
linker moiety
binding
polyvalent linker
Prior art date
Application number
AT93915221T
Other languages
English (en)
Inventor
Richard T Dean
John Lister-James
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25402435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE152918(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of ATE152918T1 publication Critical patent/ATE152918T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
AT93915221T 1992-06-05 1993-06-04 Technetium-99m-markierte peptide zur bilderzeugung ATE152918T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/893,981 US5508020A (en) 1992-06-05 1992-06-05 Technetium-99M labeled peptides for imaging

Publications (1)

Publication Number Publication Date
ATE152918T1 true ATE152918T1 (de) 1997-05-15

Family

ID=25402435

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93915221T ATE152918T1 (de) 1992-06-05 1993-06-04 Technetium-99m-markierte peptide zur bilderzeugung

Country Status (11)

Country Link
US (4) US5508020A (de)
EP (1) EP0644778B1 (de)
JP (1) JP2954354B2 (de)
AT (1) ATE152918T1 (de)
AU (1) AU688264B2 (de)
CA (1) CA2137009C (de)
DE (1) DE69310733T2 (de)
DK (1) DK0644778T3 (de)
ES (1) ES2105292T3 (de)
HK (1) HK1007685A1 (de)
WO (1) WO1993025244A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
ES2141102T3 (es) * 1991-02-08 2000-03-16 Diatide Inc Polipeptidos marcados con tecnecio-99m para la generacion de imagenes.
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
EP0630265B1 (de) * 1992-03-13 2003-04-16 Diatide, Inc. Technetium-99-markierte peptide zur visualisierung vom entzuendungen
AU709306B2 (en) * 1992-04-30 1999-08-26 Cis Bio International Radiolabeled compounds for thrombus imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
JPH08502261A (ja) * 1992-10-02 1996-03-12 ダイアテク,インコーポレイテッド 多重多価抗血栓症剤
DE69431052T2 (de) * 1993-04-08 2003-03-13 Diatide Inc Radiomarkierte verbindungen zur thrombus-bilderzeugung
ZA945587B (en) * 1993-07-28 1995-05-15 Diatech Inc Radiolabeled glucans.
DE69526203T2 (de) * 1994-01-12 2002-11-28 Amersham Plc Little Chalfont Biologische zielgerichtete mittel
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
DK0750610T3 (da) * 1994-03-18 2002-03-11 Diatide Inc Piperidyl-4-substituerede tyrosinderivater som scintigrafiske billedfrembringende midler til diagnose af thrombose
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
ATE380038T1 (de) 1996-07-12 2007-12-15 Immunomedics Inc Radiometall-bindende peptide analoge
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
EP1905357B1 (de) 1997-04-30 2012-11-28 The Board Of Trustees Of The Leland Stanford Junior University Verfahren zur In-vivo-Zelltodabbildung
US5886142A (en) * 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
US6028056A (en) * 1998-02-06 2000-02-22 Diatide, Inc. Pharmaceutical compositions for imaging and treating thrombi
US6022857A (en) * 1998-06-19 2000-02-08 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
EP1441773A1 (de) * 2001-10-19 2004-08-04 Thomas Jefferson University Pacap-zusammensetzungen und verfahren für die tumordarsetllung und -therapie
WO2003090121A1 (en) * 2002-04-22 2003-10-30 Thomson Licensing S.A. A web browser for use with a television display for preventing screen burn
US20060029544A1 (en) * 2004-08-06 2006-02-09 The Regents Of The University Of California Office Of Technology Transfer Receptor-binding cyclic peptides and methods of use
KR101430627B1 (ko) 2008-05-13 2014-08-14 유니버시티 오브 캔사스 금속 추출 펩타이드(map) 태그 및 관련된 방법
WO2013023795A1 (en) 2011-08-17 2013-02-21 Piramal Imaging Sa Compounds for binding to the platelet specific glycoprotein iib/iiia and their use for imaging of thrombi
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
WO2014124943A1 (en) 2013-02-12 2014-08-21 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
DE102013113156A1 (de) * 2013-11-28 2015-05-28 Freie Universität Berlin Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4571430A (en) * 1982-11-08 1986-02-18 Medi-Physics, Inc. Homocysteine and homocysteinamide derivatives
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
EP0188256B1 (de) * 1985-01-14 1991-08-21 NeoRx Metall-Radionuklid markiertes Protein für Diagnose und Therapie
US4748022A (en) 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
GB8525974D0 (en) * 1985-10-22 1985-11-27 Nyegaard & Co As Chemical substance
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
WO1989000051A1 (en) * 1987-07-07 1989-01-12 Cytrx Biopool Ltd. Fibrin-binding compound and method
CA1335725C (en) * 1987-09-25 1995-05-30 Stephen W. Hadley Method of diagnosing blood clots using fibrin-binding proteins
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
US5648471A (en) * 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
EP0731110A1 (de) * 1987-12-10 1996-09-11 La Jolla Cancer Research Foundation Verfahren zur Herstellung von konformationell stabilisierten Zelladhäsionspeptiden
WO1989007456A1 (en) * 1988-02-09 1989-08-24 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
AU3778989A (en) * 1988-04-29 1989-11-29 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
AU628357B2 (en) * 1988-05-02 1992-09-17 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
US5302700A (en) * 1988-05-23 1994-04-12 Duke University Radiohalogenation conjugate technology
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
AU3876789A (en) * 1988-06-20 1990-01-12 Washington University Use of modified tpa to detect blood clots
AU616284B2 (en) 1988-06-23 1991-10-24 E.I. Du Pont De Nemours And Company Catalyzed hydrofluorination process
WO1990001169A1 (en) * 1988-07-26 1990-02-08 Szekely Levente Device for measuring and recording acceleration data
US4925648A (en) * 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
DE68928842T2 (de) 1988-08-03 1999-04-29 Univ California Sonde für hohe auflösung nmr mit wiederorientierung der muster
US5169933A (en) * 1988-08-15 1992-12-08 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
NZ230897A (en) * 1988-10-04 1993-02-25 Cancer Res Campaign Tech Targeting agents against malignant melanoma comprising peptides from #alpha#-melanocyte stimulating hormone n-linked to moiety active against melanomas
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
DE69023394T2 (de) * 1989-06-16 1996-07-04 Merck Frosst Canada Inc Chelat-Derivate von atrialnatriurethischem Faktor (ANF).
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
EP0436005B1 (de) * 1989-07-20 1995-03-29 Sandoz Ltd. Markierte polypeptidderivate
FR2650672A1 (fr) * 1989-08-02 1991-02-08 Medgenix Group Sa Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues
US4961869A (en) * 1989-08-03 1990-10-09 E. I. Du Pont De Nemours And Company Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
IL97459A0 (en) * 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5273743A (en) * 1990-03-09 1993-12-28 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
GB9012995D0 (en) * 1990-06-11 1990-08-01 Celltech Ltd Multivalent antigen-binding proteins
WO1992005154A1 (en) * 1990-09-14 1992-04-02 Mallinckrodt Medical, Inc. Novel nitrogen-sulfur ligands useful in radiographic imaging agents
ES2141102T3 (es) * 1991-02-08 2000-03-16 Diatide Inc Polipeptidos marcados con tecnecio-99m para la generacion de imagenes.
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5300280A (en) * 1992-02-14 1994-04-05 Mallinckrodt Medical, Inc. Stabilized radiopharmaceutical kits
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
EP0630265B1 (de) * 1992-03-13 2003-04-16 Diatide, Inc. Technetium-99-markierte peptide zur visualisierung vom entzuendungen
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
EP0641222B1 (de) * 1992-05-21 2000-09-06 Diatide, Inc. Technetium-99m markierte peptide zur bilderzeugung von thrombus
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
JPH08502261A (ja) * 1992-10-02 1996-03-12 ダイアテク,インコーポレイテッド 多重多価抗血栓症剤
DE69431052T2 (de) * 1993-04-08 2003-03-13 Diatide Inc Radiomarkierte verbindungen zur thrombus-bilderzeugung
US5951964A (en) * 1993-06-04 1999-09-14 Diatide, Inc. Technetium-99m labeled peptides for imaging
JPH09512555A (ja) * 1994-05-02 1997-12-16 ダイアテック・インコーポレイテッド テクネチウム−99m標識イメージング剤

Also Published As

Publication number Publication date
AU688264B2 (en) 1998-03-12
WO1993025244A1 (en) 1993-12-23
EP0644778B1 (de) 1997-05-14
EP0644778A1 (de) 1995-03-29
US5508020A (en) 1996-04-16
HK1007685A1 (en) 1999-04-23
US6667389B1 (en) 2003-12-23
JPH07506592A (ja) 1995-07-20
ES2105292T3 (es) 1997-10-16
JP2954354B2 (ja) 1999-09-27
CA2137009A1 (en) 1993-12-23
US6113878A (en) 2000-09-05
DK0644778T3 (da) 1997-11-03
DE69310733T2 (de) 1997-10-30
DE69310733D1 (de) 1997-06-19
CA2137009C (en) 2001-11-27
AU4528793A (en) 1994-01-04
US5976494A (en) 1999-11-02

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