HRP20150512T1 - Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava - Google Patents
Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava Download PDFInfo
- Publication number
- HRP20150512T1 HRP20150512T1 HRP20150512TT HRP20150512T HRP20150512T1 HR P20150512 T1 HRP20150512 T1 HR P20150512T1 HR P20150512T T HRP20150512T T HR P20150512TT HR P20150512 T HRP20150512 T HR P20150512T HR P20150512 T1 HRP20150512 T1 HR P20150512T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- polypeptide
- antibody
- acid sequence
- c1orf32
- Prior art date
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- 229920001184 polypeptide Polymers 0.000 title claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 19
- 239000003814 drug Substances 0.000 title claims 2
- 108091033319 polynucleotide Proteins 0.000 title claims 2
- 102000040430 polynucleotide Human genes 0.000 title claims 2
- 239000002157 polynucleotide Substances 0.000 title claims 2
- 229960000074 biopharmaceutical Drugs 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003596 drug target Substances 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 6
- 102000037865 fusion proteins Human genes 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07—ORGANIC CHEMISTRY
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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Claims (15)
1. Farmaceutski pripravak naznačen time da sadrži barem jedan C1ORF32 polipeptid ektodomene odabran iz skupine koja sadrži:
i. C1ORF32 polipeptid ektodomene koji sadrži sekvencu amino kiseline iz SEQ ID NO: 299;
ii. C1ORF32 polipeptid ektodomene koji sadrži sekvencu amino kiseline iz SEQ ID NO: 147;
iii. C1ORF32 polipeptid ektodomene koji sadrži sekvencu amino kiseline iz SEQ ID NO: 148;
iv. C1ORF32 varijantu polipeptida ektodomene koji sadrži barem 95% identičnosti sekvence sa sekvencama amino kiseline u SEQ ID NO: 299, SEQ ID NO: 147 ili SEQ ID NO: 148;
i farmaceutski prihvatljivo sredstvo za razrjeđivanje ili nosač.
2. Pripravak prema zahtjevu 1, naznačen time da navedeni polipeptid sadrži sekvencu amino kiseline iz SEQ ID NO: 147, SEQ ID NO:148 ili SEQ ID NO:299.
3. Izolirani polinukleotid naznačen time da kodira polipeptid prema zahtjevima 1 ili 2.
4. Ekspresijski vektor naznačen time da sadrži barem jednu sekvencu nukleinske kiseline prema zahtjevu 3.
5. Rekombinantna stanica koja sadrži ekspresijski vektor ili virus koji sadrži sekvencu nukleinske kiseline prema zahtjevu 3, naznačen time da stanica konstitutivno ili induktivno eksprimira polipeptid koji je kodiran sa segmentom DNA.
6. Postupak proizvodnje C1ORF32 polipeptida ektodomene, ili njegovog fragmenta ili konjugata, koji se sastoji od kultiviranja rekombinantne stanice prema zahtjevu 5, pod uvjetima gdje stanica eksprimira polipeptid kodiran sa DNA segmentom ili nukleinskom kiselinom i od izdvajanja navedenog polipeptida.
7. Protutijelo ili fragment protutijela koji sadrži mjesto vezivanja antigena koji se veže specifično na polipeptid odabran iz skupine koja sadrži:
i) C1ORF32 polipeptid ektodomene koji sadrži sekvencu amino kiseline iz SEQ ID NO: 299;
ii) C1ORF32 polipeptid ektodomene koji sadrži sekvencu amino kiseline iz SEQ ID NO: 147;
iii) G1ORF32 polipeptid ektodomene koji sadrži sekvencu amino kiseline iz SEQ ID NO: 148.
8. Protutijelo ili fragment prema zahtjevu 7, naznačeno time da je protutijelo u cijelosti ljudsko protutijelo, kimerno protutijelo, humanizirano ili primatizirano protutijelo; Fab, Fab', F(ab')2, F(ab'), F(ab), Fv ili fragment scFv i minimalna jedinica prepoznavanja.
9. Protutijelo ili fragment prema zahtjevu 7 ili 8, naznačeno time da je protutijelo spojeno na skupinu koja je odabrana od: enzima, toksina, terapijskog sredstva, kemoterapijskog sredstva, ili oznake koja se može detektirati; te pri čemu oznaka koja se može detektirati je radioizotop, kelator metala, enzim, fluorescentni spoj, bioluminescentni spoj ili kemiluminescentni spoj.
10. Farmaceutski pripravak naznačen time da sadrži protutijelo prema bilo kojem od zahtjeva 7-9.
11. Fuzijski protein naznačen time da sadrži izolirani topivi C1ORF32 polipeptid ektodomene sparen na sekvencu proteina ne-C1ORF32.
12. Fuzijski protein prema zahtjevu 11, naznačen time da je sekvenca proteina ne- C1ORF32 barem dio molekule imunoglobulina.
13. Fuzijski protein prema zahtjevu 11 ili 12, naznačen time da je C1ORF32 polipeptid ektodomene odabran od polipeptida koji sadrži sekvencu amino kiseline prema SEQ ID NO: 147, SEQ ID NO:148 ili SEQ ID NO:299
14. Fuzijski protein prema najmanje jednom od patentnih zahtjeva 11 do 13, naznačen time da fuzijski protein sadrži Fc fragment.
15. Fuzijski protein prema najmanje jednom od patentnih zahtjeva 11 do 14, naznačen time da ima sekvencu kao što je navedeno u SEQ ID NO: 105.
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PCT/US2008/075122 WO2009032845A2 (en) | 2007-09-04 | 2008-09-03 | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
EP08829443.4A EP2190469B1 (en) | 2007-09-04 | 2008-09-03 | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
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HRP20150512TT HRP20150512T1 (hr) | 2007-09-04 | 2015-05-13 | Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava |
HRP20190656TT HRP20190656T1 (hr) | 2007-09-04 | 2019-04-05 | Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava |
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