HRP20190656T1 - Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava - Google Patents

Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava Download PDF

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Publication number
HRP20190656T1
HRP20190656T1 HRP20190656TT HRP20190656T HRP20190656T1 HR P20190656 T1 HRP20190656 T1 HR P20190656T1 HR P20190656T T HRP20190656T T HR P20190656TT HR P20190656 T HRP20190656 T HR P20190656T HR P20190656 T1 HRP20190656 T1 HR P20190656T1
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HR
Croatia
Prior art keywords
antibody
cancer
antibody fragment
fragment according
treatment
Prior art date
Application number
HRP20190656TT
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English (en)
Inventor
Zurit Levine
Avi Rosenberg
Galit Rotman
Amit Novik
Amir Toporik
Yaron Kinar
Sergey Nemzer
Cynthia Koifman
Merav Beiman
Liat Dassa
Shira Walach
Eve Montia
Shirley Sameach-Greenwald
Tania Pergam
Dalit Milo
Anat Cohen-Dayag
Ofer Levy
Marina Bubis
Original Assignee
Compugen Ltd.
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Publication date
Application filed by Compugen Ltd. filed Critical Compugen Ltd.
Publication of HRP20190656T1 publication Critical patent/HRP20190656T1/hr

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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Claims (15)

1. Monoklonsko ili poliklonsko protutijelo ili njegov fragment koji veže ektodomenu C1ORF32 ili njihove dijelove ili varijante i blokira interakciju C1 ORF32 s njegovim protu-receptorom, naznačeno time što je ektodomena odabrana od polipeptida iz SEQ ID NO 147, 148 i 299 i njihova varijanta ima najmanje 80% identičnosti sekvence za uporabu u terapiji.
2. Monoklonsko ili poliklonsko protutijelo ili njegov fragment koji veže ektodomenu C1ORF32 ili njihove dijelove ili varijante i blokira interakciju C1ORF32 s njegovim protu-receptorom, naznačeno time što je ektodomena odabrana od polipeptida iz SEQ ID NO 147, 148 i 299 i njihova varijanta ima najmanje 80% identičnosti sekvence za uporabu za liječenje raka.
3. Protutijelo ili fragment prema zahtjevu 2 za uporabu za liječenje raka, naznačeno time što je rak odabran od raka pluća, raka jajnika, raka debelog crijeva, hematoloških malignih bolesti i raka dojke, prostate, slezene, bubrega, mjehura, glave i vrata, maternice, testisa, želuca, vrata maternice, jetre, kosti, kože, gušterače ili mozga.
4. Protutijelo ili fragment protutijela prema zahtjevu 1 za uporabu u terapiji ili protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu za liječenje raka, naznačeno time što je sadržano u farmaceutskom pripravku.
5. Protutijelo ili fragment protutijela prema zahtjevu 1 za uporabu u terapiji ili protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu za liječenje raka, naznačeno time što je navedeno protutijelo ili fragment protutijela vezan za enzim, toksin, terapeutsko sredstvo, ili kemoterapijsko sredstvo.
6. Protutijelo ili fragment protutijela prema zahtjevu 1 za uporabu u terapiji ili protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu za liječenje raka, naznačeno time što je navedeno protutijelo ili fragment protutijela vezan na radioizotop, metalni kelator, fluorescentni spoj, bioluminiscentni spoj ili kemiluminiscentni spoj.
7. Protutijelo ili fragment protutijela prema zahtjevu 1 za uporabu u terapiji ili protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu za liječenje raka, naznačeno time što je protutijelo ljudsko anti-C10RF32 protutijelo i pri čemu se navedeno protutijelo daje s najmanje jednim terapeutskim sredstvom odabranim iz skupine koja se sastoji od citotoksičnog sredstva, radiotoksičnog sredstva i imunosupresivnog sredstva.
8. Protutijelo ili fragment protutijela prema zahtjevu 1 za uporabu u terapiji ili protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu za liječenje raka, naznačeno time što je navedeno protutijelo ili fragment protutijela konjugirano na terapeutski dio odabran od citotoksina, lijeka ili radiotoksina, pri čemu je citotoksin odabran iz skupine koja sadrži taksol, citokalasin B, gramicidin D, etidij bromid, emetin, mitomicin, etopozid, tenopozid, vinkristin, vinblastin, kolhicin, doksorubicin, daunorubicin, dihidroksi antracin dion, mitoksantron, mitramicin, aktinomicin D, 1-dehidrotestosteron, glukokortikoide, prokain, tetrakain, lidokain, propranolol, puromicin i njegove analoge ili homologe, antimetabolite, alkilirajuća sredstva, antracikline, antibiotike, anti-mitotička sredstva, duokarmicine, kalikeamicine, maitanzine i auristatine.
9. Protutijelo ili fragment protutijela prema zahtjevu 8 za uporabu u terapiji ili za uporabu za liječenje raka, naznačeno time što je navedeno protutijelo ili fragment protutijela konjugiran na citotoksin odabran iz skupine koju čine metotreksat, 6-merkaptopurin, 6-tioguanin, citarabin, 5-fluorouracil dekarbazin, mekloretamin, tioepa klorambucil, melfalan, karmustin (BSNU), lomustin (CCNU), ciklotosfamid, busulfan, dibromomanitol, streptozotocin, mitomicin C, cis-diklorodiamin platina (II) (DDP, cisplatin), daunorubicin, doksorubicin, daktinomicin, bleomicin, mitramicin, antramicin (AMC), vinkristin i vinblastin.
10. Uporaba poliklonskog ili monoklonskog protutijela ili njegovog fragmenta koji veže ektodomenu od C1ORF32 ili njegovih dijelova ili varijanti, naznačena time što je ektodomena odabrana od polipeptida iz SEQ ID NO 147, 148 i 299 i njihovih varijanti koje imaju najmanje 80% identičnosti sekvence u dijagnostici karcinoma koji diferencijalno eksprimiraju antigen C1ORF32, pri čemu je terapeutski poželjna modulacija B7-povezane imuno ko-stimulacije koja obuhvaća antigen C1ORF32.
11. Uporaba prema zahtjevu 10, naznačena time što su karcinomi odabrani od raka pluća, raka jajnika, raka debelog crijeva, hematoloških malignih bolesti i raka dojke, prostate, spleen, slezene, bubrega, mjehura, glave i vrata, maternice, testisa, želuca, vrata maternice, jetre, kosti, kože, gušterače ili mozga.
12. Protutijelo ili fragment protutijela prema zahtjevu 3 za uporabu u liječenju raka ili za uporabu prema zahtjevu 11, naznačeno time što su navedene hematološke maligne bolesti odabrane iz skupine koju čine akutna limfocitna leukemija, kronična limfocitna leukemija, akutna mijelogena leukemija, kronična mijelogena leukemija, multipli mijelom, Hodgkinov limfom i ne-Hodgkinov limfom.
13. Protutijelo ili fragment protutijela prema zahtjevu 3 za uporabu za liječenje raka ili uporaba prema zahtjevu 11, naznačeno time što je rak pluća odabran iz skupine koju čine karcinom pluća skvamoznih stanica, adenokarcinom pluća, karcinoid, karcinom pluća malih stanica ili karcinom pluća ne-malih stanica.
14. Protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu u liječenju raka ili za uporabu prema zahtjevu 10, naznačeno time što je rak ne-metastazirajući, invazivan ili metastazirajući.
15. Protutijelo ili fragment protutijela prema zahtjevu 1 za uporabu u terapiji, ili protutijelo ili fragment protutijela prema zahtjevu 2 za uporabu za liječenje raka, ili uporaba prema zahtjevu 10, naznačeno time što varijante ektodomena posjeduju najmanje 90%, najmanje 95, 96, 97, 98 ili 99% identičnosti sekvence s polipeptidima iz SEQ ID NO 147, 148 i 299.
HRP20190656TT 2007-09-04 2019-04-05 Polipeptidi i polinukleotidi, te njihova uporaba kao ciljnih molekula za proizvodnju lijekova i bioloških sredstava HRP20190656T1 (hr)

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