RU94045249A - Мономерное антитело, способ получения антитела, димерный слитый белок, способ получения белка, набор конструкций - Google Patents

Мономерное антитело, способ получения антитела, димерный слитый белок, способ получения белка, набор конструкций

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Publication number
RU94045249A
RU94045249A RU94045249/13A RU94045249A RU94045249A RU 94045249 A RU94045249 A RU 94045249A RU 94045249/13 A RU94045249/13 A RU 94045249/13A RU 94045249 A RU94045249 A RU 94045249A RU 94045249 A RU94045249 A RU 94045249A
Authority
RU
Russia
Prior art keywords
antibody
preparing
protein
antibodies
fragments
Prior art date
Application number
RU94045249/13A
Other languages
English (en)
Other versions
RU2128709C1 (ru
Inventor
Плюктун Андреас
De]
Пак Петер
Original Assignee
Мерк Патент ГмбХ (DE)
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент ГмбХ (DE), Мерк Патент Гмбх filed Critical Мерк Патент ГмбХ (DE)
Publication of RU94045249A publication Critical patent/RU94045249A/ru
Application granted granted Critical
Publication of RU2128709C1 publication Critical patent/RU2128709C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Abstract

Настоящее изобретение описывает новый класс молекул, связывающих антигены, который содержит Fv-фрагменты антитела, но не использует константные области антитела. Они также могут димеризоваться с фрагментами молекул других антител или с фрагментами молекул неантител с образованием би- или мультифункциональных слитых белков фрагмента антитела и так называемых миниантител соответственно. Новые слитые белки могут быть использованы в широкой области диагностики и терапевтической медицины.

Claims (1)

  1. Настоящее изобретение описывает новый класс молекул, связывающих антигены, который содержит Fv-фрагменты антитела, но не использует константные области антитела. Они также могут димеризоваться с фрагментами молекул других антител или с фрагментами молекул неантител с образованием би- или мультифункциональных слитых белков фрагмента антитела и так называемых миниантител соответственно. Новые слитые белки могут быть использованы в широкой области диагностики и терапевтической медицины.
RU94045249A 1992-01-23 1993-01-15 Способ получения димерного одноцепочечного слитого белка (варианты) RU2128709C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP92101069 1992-01-23
EP92101069.0 1992-01-23
DE92101069.0 1992-01-23
PCT/EP1993/000082 WO1993015210A1 (en) 1992-01-23 1993-01-15 Monomeric and dimeric antibody-fragment fusion proteins

Publications (2)

Publication Number Publication Date
RU94045249A true RU94045249A (ru) 1996-05-27
RU2128709C1 RU2128709C1 (ru) 1999-04-10

Family

ID=8209260

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045249A RU2128709C1 (ru) 1992-01-23 1993-01-15 Способ получения димерного одноцепочечного слитого белка (варианты)

Country Status (16)

Country Link
US (1) US5910573A (ru)
EP (1) EP0654085B1 (ru)
JP (2) JP3490437B2 (ru)
KR (1) KR100254759B1 (ru)
AT (1) ATE151113T1 (ru)
AU (1) AU676150B2 (ru)
CA (1) CA2128511C (ru)
CZ (1) CZ287296B6 (ru)
DE (1) DE69309472T2 (ru)
DK (1) DK0654085T3 (ru)
ES (1) ES2102007T3 (ru)
GR (1) GR3023860T3 (ru)
HU (1) HU215180B (ru)
NO (1) NO942750L (ru)
RU (1) RU2128709C1 (ru)
WO (1) WO1993015210A1 (ru)

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