HUP9802401A2 - Az emberi gp39-protein különböző epitópjaira specifikus monoklonális antitestek, valamint eljárások az ilyen antitestek diagnosztikai és terápiás alkalmazására - Google Patents

Az emberi gp39-protein különböző epitópjaira specifikus monoklonális antitestek, valamint eljárások az ilyen antitestek diagnosztikai és terápiás alkalmazására

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Publication number
HUP9802401A2
HUP9802401A2 HU9802401A HUP9802401A HUP9802401A2 HU P9802401 A2 HUP9802401 A2 HU P9802401A2 HU 9802401 A HU9802401 A HU 9802401A HU P9802401 A HUP9802401 A HU P9802401A HU P9802401 A2 HUP9802401 A2 HU P9802401A2
Authority
HU
Hungary
Prior art keywords
subject
human
protein
monoclonal antibodies
different epitopes
Prior art date
Application number
HU9802401A
Other languages
English (en)
Inventor
Alejandro A. Aruffo
Jurgen Bajorath
Lisa K. Gilliland
Marcia L. Gordon
Linda J. Harris
Diane Hollenbaugh
Anthony W. Siadak
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HUP9802401A2 publication Critical patent/HUP9802401A2/hu
Publication of HUP9802401A3 publication Critical patent/HUP9802401A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány tárgyát mőnőklőnális antitestek képezik, amelyek az emberigp39- prőtein legalább 12 különböző epitópjáhőz képesek kötődni. Atalálmány tárgyát képezik tővábbá a találmány szerinti mőnőklő-nálisantitestekből származó antigénkötő fragmensek és rekőmbinánskötőprőteinek, melyek szintén képesen a gp39-prőteinhez kötődni.Ugyancsak a találmány tárgyát képezik a találmny szerinti mőnőklőnálisantitesteket szekretáló specifikűs hibridómák. A találmány tárgyátképezi tővábbá: eljárás X-krőmőszómával kapcsőlatős hiper- IgM-szindróma detektálására izőlált és tisztítőtt nűkleinsavszekvencia,amely az emberi gp39- prőtein epitópjait felismerőimműnglőbűlinmőlekűlák könnyű és nehéz láncainak aminősavszekvenciájátkódőlja, gyógyászati készítmények, amelyek a találmány szerintimőnőklinális antitesteket, antigén-kötő fragmenseket vagy rekőmbinánskötőprőteineket tartalmazzák, tővábbá az ilyen készítményekalkalmazási eljárásai. ŕ
HU9802401A 1995-01-26 1996-01-26 Monoclonal antibodies specific for different epitopes of human gp39 and methods for their use in diagnosis and therapy HUP9802401A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/379,057 US5876950A (en) 1995-01-26 1995-01-26 Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy

Publications (2)

Publication Number Publication Date
HUP9802401A2 true HUP9802401A2 (hu) 1999-01-28
HUP9802401A3 HUP9802401A3 (en) 2003-03-28

Family

ID=23495642

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802401A HUP9802401A3 (en) 1995-01-26 1996-01-26 Monoclonal antibodies specific for different epitopes of human gp39 and methods for their use in diagnosis and therapy

Country Status (15)

Country Link
US (1) US5876950A (hu)
EP (2) EP0807175A2 (hu)
JP (1) JPH10513348A (hu)
AU (1) AU692074B2 (hu)
CA (1) CA2210419A1 (hu)
CZ (1) CZ233997A3 (hu)
ES (1) ES2391101T3 (hu)
FI (1) FI973120A (hu)
HU (1) HUP9802401A3 (hu)
IL (1) IL116882A (hu)
MX (1) MX9705610A (hu)
NO (1) NO973447L (hu)
NZ (1) NZ303375A (hu)
PL (1) PL182868B1 (hu)
WO (1) WO1996023071A2 (hu)

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Also Published As

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PL182868B1 (pl) 2002-03-29
EP1728864B1 (en) 2012-08-01
WO1996023071A2 (en) 1996-08-01
CA2210419A1 (en) 1996-08-01
HUP9802401A3 (en) 2003-03-28
NO973447L (no) 1997-09-26
EP1728864A1 (en) 2006-12-06
WO1996023071A3 (en) 1996-09-26
MX9705610A (es) 1997-10-31
JPH10513348A (ja) 1998-12-22
IL116882A0 (en) 1996-05-14
NZ303375A (en) 2000-01-28
NO973447D0 (no) 1997-07-25
EP0807175A2 (en) 1997-11-19
IL116882A (en) 2001-09-13
CZ233997A3 (en) 1997-11-12
AU692074B2 (en) 1998-05-28
AU4966996A (en) 1996-08-14
FI973120A0 (fi) 1997-07-25
PL323565A1 (en) 1998-04-14
FI973120A (fi) 1997-07-25
US5876950A (en) 1999-03-02
ES2391101T3 (es) 2012-11-21

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