MX9705610A - Anticuerpos monoclonales especificos para diferentes epitopos de la gp39 humana y metodos para su uso en diagnostico y terapia. - Google Patents

Anticuerpos monoclonales especificos para diferentes epitopos de la gp39 humana y metodos para su uso en diagnostico y terapia.

Info

Publication number
MX9705610A
MX9705610A MX9705610A MX9705610A MX9705610A MX 9705610 A MX9705610 A MX 9705610A MX 9705610 A MX9705610 A MX 9705610A MX 9705610 A MX9705610 A MX 9705610A MX 9705610 A MX9705610 A MX 9705610A
Authority
MX
Mexico
Prior art keywords
antibodies
bind
monoclonal antibodies
epitopes
present
Prior art date
Application number
MX9705610A
Other languages
English (en)
Inventor
Anthony W Siadak
Diane Hollenbaugh
Lisa K Gilliland
Marcial L Gordon
Jurgen Bajorath
Alejandro A Aruffo
Linda J Harris
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX9705610A publication Critical patent/MX9705610A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invencion proporciona anticuerpos monoclonales, fragmentos de union de antígeno y proteínas de union recombinantes específicas para la gp39 humana. Esos anticuerpos son específicos para al menos 12 epitopos diferentes sobre la gp39. También se proporcionan los hibridomas que secretan anticuerpos específicos los cuales se unen a esos epitopos. Además, la presente invencion describe la ausencia de aminoácidos de las regiones variables de cadena pesada y ligera de la inmunoglobulina las cuales se unen a los epitopos de la gp39 y proporciona anticuerpos sFv humanizadas los cuales se unen a la gp39. También, se proporcionan composiciones farmacéuticas que comprenden los anticuerpos monoclonales, fragmentos de union de antígeno y proteínas de union recombinantes que se unen al gp39 y los métodos para usar esas composiciones en diagnostico de estados de enfermedad, inhibicion de la activacion de las células B y para tratar padecimientos inmunologicos, tales como enfermedades autoinmunes, respuestas alérgicas, rechazo de organos y enfermedad injerto versus huésped. Los anticuerpos de la presente invencion también pueden usarse para formar las imágenes de las células que expresan la gp39 sobre us superficie, tales como células tumorales (por ejemplo, linfoma) y para que los agentes terapéuticos hagan blanco en las células objetivo.
MX9705610A 1995-01-26 1996-01-26 Anticuerpos monoclonales especificos para diferentes epitopos de la gp39 humana y metodos para su uso en diagnostico y terapia. MX9705610A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/379,057 US5876950A (en) 1995-01-26 1995-01-26 Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
PCT/US1996/001119 WO1996023071A2 (en) 1995-01-26 1996-01-26 MONOCLONAL ANTIBODIES SPECIFIC FOR DIFFERENT EPITOPES OF HUMAN gp39 AND METHODS FOR THEIR USE IN DIAGNOSIS AND THERAPY

Publications (1)

Publication Number Publication Date
MX9705610A true MX9705610A (es) 1997-10-31

Family

ID=23495642

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705610A MX9705610A (es) 1995-01-26 1996-01-26 Anticuerpos monoclonales especificos para diferentes epitopos de la gp39 humana y metodos para su uso en diagnostico y terapia.

Country Status (15)

Country Link
US (1) US5876950A (es)
EP (2) EP1728864B1 (es)
JP (1) JPH10513348A (es)
AU (1) AU692074B2 (es)
CA (1) CA2210419A1 (es)
CZ (1) CZ233997A3 (es)
ES (1) ES2391101T3 (es)
FI (1) FI973120A0 (es)
HU (1) HUP9802401A3 (es)
IL (1) IL116882A (es)
MX (1) MX9705610A (es)
NO (1) NO973447L (es)
NZ (1) NZ303375A (es)
PL (1) PL182868B1 (es)
WO (1) WO1996023071A2 (es)

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Also Published As

Publication number Publication date
AU4966996A (en) 1996-08-14
FI973120A (fi) 1997-07-25
WO1996023071A2 (en) 1996-08-01
HUP9802401A2 (hu) 1999-01-28
IL116882A0 (en) 1996-05-14
EP0807175A2 (en) 1997-11-19
JPH10513348A (ja) 1998-12-22
ES2391101T3 (es) 2012-11-21
IL116882A (en) 2001-09-13
AU692074B2 (en) 1998-05-28
HUP9802401A3 (en) 2003-03-28
FI973120A0 (fi) 1997-07-25
US5876950A (en) 1999-03-02
PL323565A1 (en) 1998-04-14
PL182868B1 (pl) 2002-03-29
EP1728864B1 (en) 2012-08-01
NO973447D0 (no) 1997-07-25
NZ303375A (en) 2000-01-28
WO1996023071A3 (en) 1996-09-26
NO973447L (no) 1997-09-26
EP1728864A1 (en) 2006-12-06
CZ233997A3 (en) 1997-11-12
CA2210419A1 (en) 1996-08-01

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