WO2009041613A1 - 抗体定常領域改変体 - Google Patents

抗体定常領域改変体 Download PDF

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Publication number
WO2009041613A1
WO2009041613A1 PCT/JP2008/067483 JP2008067483W WO2009041613A1 WO 2009041613 A1 WO2009041613 A1 WO 2009041613A1 JP 2008067483 W JP2008067483 W JP 2008067483W WO 2009041613 A1 WO2009041613 A1 WO 2009041613A1
Authority
WO
WIPO (PCT)
Prior art keywords
constant region
antibody constant
succeeded
stability
finding
Prior art date
Application number
PCT/JP2008/067483
Other languages
English (en)
French (fr)
Inventor
Tomoyuki Igawa
Hirotake Shiraiwa
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40511493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009041613(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DK08834649.9T priority Critical patent/DK2194066T3/en
Priority to ES08834649.9T priority patent/ES2566957T3/es
Priority to EP15200628.4A priority patent/EP3059246B1/en
Priority to KR1020107008918A priority patent/KR101680906B1/ko
Priority to AU2008304748A priority patent/AU2008304748C1/en
Priority to KR1020167032250A priority patent/KR101922788B1/ko
Priority to KR1020187033614A priority patent/KR102119108B1/ko
Priority to PL15200628T priority patent/PL3059246T3/pl
Priority to RU2010116278/10A priority patent/RU2526512C2/ru
Priority to MX2013009569A priority patent/MX342551B/es
Priority to CA2700394A priority patent/CA2700394C/en
Priority to KR1020217006046A priority patent/KR102339457B1/ko
Priority to EP18181757.8A priority patent/EP3415529B1/en
Priority to CN2008801185811A priority patent/CN101874041B/zh
Priority to EP20198500.9A priority patent/EP3789400A1/en
Priority to BRPI0817273-0A priority patent/BRPI0817273A2/pt
Priority to MX2010003450A priority patent/MX2010003450A/es
Priority to EP08834649.9A priority patent/EP2194066B1/en
Priority to PH12018501459A priority patent/PH12018501459A1/en
Priority to US12/680,082 priority patent/US9688762B2/en
Priority to KR1020207015247A priority patent/KR102225009B1/ko
Priority to JP2009534420A priority patent/JP5484060B2/ja
Priority to KR1020217040531A priority patent/KR102467302B1/ko
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of WO2009041613A1 publication Critical patent/WO2009041613A1/ja
Priority to IL204537A priority patent/IL204537A0/en
Priority to ZA2010/02422A priority patent/ZA201002422B/en
Priority to HK11100811.4A priority patent/HK1146728A1/xx
Priority to PH12014502106A priority patent/PH12014502106B1/en
Priority to US15/614,842 priority patent/US11332533B2/en
Priority to US17/720,937 priority patent/US20220251225A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

　本発明者らは、抗体の定常領域において、酸性条件下での安定性、ヒンジ領域のジスルフィドに由来するヘテロジェニティー、H鎖C末端に由来するヘテロジェニティー、高濃度製剤における安定性を改善させることに成功した。さらに新しいT-cellエピトープペプチドの出現を最小限にしつつ、Fcγレセプターに結合を低下させた新規な定常領域配列を見出すことに成功した。これにより、物性（安定性および均一性）、免疫原性、安全性、且つ、薬物動態を改善させた抗体定常領域を見出すことに成功した。
PCT/JP2008/067483 2007-09-26 2008-09-26 抗体定常領域改変体 WO2009041613A1 (ja)

Priority Applications (29)

Application Number Priority Date Filing Date Title
ES08834649.9T ES2566957T3 (es) 2007-09-26 2008-09-26 Región constante de anticuerpo modificado
MX2010003450A MX2010003450A (es) 2007-09-26 2008-09-26 Region constante de anticuerpo modificada.
EP20198500.9A EP3789400A1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
KR1020107008918A KR101680906B1 (ko) 2007-09-26 2008-09-26 항체 정상영역 개변체
AU2008304748A AU2008304748C1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
KR1020167032250A KR101922788B1 (ko) 2007-09-26 2008-09-26 항체 정상영역 개변체
KR1020187033614A KR102119108B1 (ko) 2007-09-26 2008-09-26 항체 정상영역 개변체
PL15200628T PL3059246T3 (pl) 2007-09-26 2008-09-26 Zmodyfikowany region stały przeciwciała
RU2010116278/10A RU2526512C2 (ru) 2007-09-26 2008-09-26 Модифицированная константная область антитела
MX2013009569A MX342551B (es) 2007-09-26 2008-09-26 Region constante de anticuerpo modificada.
CA2700394A CA2700394C (en) 2007-09-26 2008-09-26 Modified antibody constant region
KR1020217006046A KR102339457B1 (ko) 2007-09-26 2008-09-26 항체 정상영역 개변체
EP18181757.8A EP3415529B1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
CN2008801185811A CN101874041B (zh) 2007-09-26 2008-09-26 抗体恒定区修饰体
EP15200628.4A EP3059246B1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
DK08834649.9T DK2194066T3 (en) 2007-09-26 2008-09-26 Modified constant region of an antibody
BRPI0817273-0A BRPI0817273A2 (pt) 2007-09-26 2008-09-26 Região constante de anticorpo modificada
EP08834649.9A EP2194066B1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
PH12018501459A PH12018501459A1 (en) 2007-09-26 2008-09-26 Modified antibody constant region
US12/680,082 US9688762B2 (en) 2007-09-26 2008-09-26 Modified antibody constant region
KR1020207015247A KR102225009B1 (ko) 2007-09-26 2008-09-26 항체 정상영역 개변체
JP2009534420A JP5484060B2 (ja) 2007-09-26 2008-09-26 抗体定常領域改変体
KR1020217040531A KR102467302B1 (ko) 2007-09-26 2008-09-26 항체 정상영역 개변체
IL204537A IL204537A0 (en) 2007-09-26 2010-03-16 Modified antibody constant region
ZA2010/02422A ZA201002422B (en) 2007-09-26 2010-04-07 Modified antibody constant region
HK11100811.4A HK1146728A1 (en) 2007-09-26 2011-01-26 Modified antibody constant region
PH12014502106A PH12014502106B1 (en) 2007-09-26 2014-09-22 Modified antibody constant region
US15/614,842 US11332533B2 (en) 2007-09-26 2017-06-06 Modified antibody constant region
US17/720,937 US20220251225A1 (en) 2007-09-26 2022-04-14 Modified antibody constant region

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-250147 2007-09-26
JP2007250147 2007-09-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/680,082 A-371-Of-International US9688762B2 (en) 2007-09-26 2008-09-26 Modified antibody constant region
US15/614,842 Division US11332533B2 (en) 2007-09-26 2017-06-06 Modified antibody constant region

Publications (1)

Publication Number Publication Date
WO2009041613A1 true WO2009041613A1 (ja) 2009-04-02

Family

ID=40511493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067483 WO2009041613A1 (ja) 2007-09-26 2008-09-26 抗体定常領域改変体

Country Status (24)

Country Link
US (3) US9688762B2 (ja)
EP (4) EP3789400A1 (ja)
JP (8) JP5484060B2 (ja)
KR (6) KR102467302B1 (ja)
CN (1) CN101874041B (ja)
AR (4) AR068563A1 (ja)
AU (1) AU2008304748C1 (ja)
BR (1) BRPI0817273A2 (ja)
CA (5) CA2978687C (ja)
CL (1) CL2008002886A1 (ja)
DK (2) DK3059246T3 (ja)
ES (2) ES2687808T3 (ja)
HK (1) HK1146728A1 (ja)
IL (1) IL204537A0 (ja)
MX (2) MX342551B (ja)
MY (3) MY180713A (ja)
PE (1) PE20090711A1 (ja)
PH (2) PH12018501459A1 (ja)
PL (1) PL3059246T3 (ja)
RU (2) RU2526512C2 (ja)
SG (2) SG193868A1 (ja)
TW (2) TWI464262B (ja)
WO (1) WO2009041613A1 (ja)
ZA (1) ZA201002422B (ja)

Cited By (93)

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WO2010064697A1 (ja) * 2008-12-05 2010-06-10 中外製薬株式会社 抗nr10抗体、およびその利用
WO2010107108A1 (ja) * 2009-03-19 2010-09-23 中外製薬株式会社 関節リウマチ治療剤
WO2010107109A1 (ja) * 2009-03-19 2010-09-23 中外製薬株式会社 抗体定常領域改変体
WO2010106812A1 (en) * 2009-03-19 2010-09-23 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical formulation containing improved antibody molecules
WO2010107110A1 (ja) * 2009-03-19 2010-09-23 中外製薬株式会社 抗体定常領域改変体
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WO2011037158A1 (ja) 2009-09-24 2011-03-31 中外製薬株式会社 抗体定常領域改変体
WO2011055550A1 (ja) 2009-11-05 2011-05-12 国立大学法人大阪大学 自己免疫疾患又はアレルギー治療剤とそのスクリーニング方法
WO2011090088A1 (ja) 2010-01-20 2011-07-28 中外製薬株式会社 安定化抗体含有溶液製剤
WO2011092989A1 (ja) 2010-01-29 2011-08-04 東レ株式会社 ポリ乳酸系樹脂シート
JPWO2010064697A1 (ja) * 2008-12-05 2012-05-10 中外製薬株式会社 抗ｎｒ１０抗体、およびその利用
WO2012067176A1 (ja) 2010-11-17 2012-05-24 中外製薬株式会社 血液凝固第viii因子の機能を代替する機能を有する多重特異性抗原結合分子
WO2012073985A1 (ja) * 2010-11-30 2012-06-07 中外製薬株式会社 細胞傷害誘導治療剤
WO2012115241A1 (ja) 2011-02-25 2012-08-30 中外製薬株式会社 FcγRIIb特異的Fc抗体
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WO2013187495A1 (ja) 2012-06-14 2013-12-19 中外製薬株式会社 改変されたFc領域を含む抗原結合分子
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WO2014104165A1 (ja) 2012-12-27 2014-07-03 中外製薬株式会社 ヘテロ二量化ポリペプチド
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