WO2008114733A1 - 抗Claudin-4抗体 - Google Patents

抗Claudin-4抗体 Download PDF

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Publication number
WO2008114733A1
WO2008114733A1 PCT/JP2008/054769 JP2008054769W WO2008114733A1 WO 2008114733 A1 WO2008114733 A1 WO 2008114733A1 JP 2008054769 W JP2008054769 W JP 2008054769W WO 2008114733 A1 WO2008114733 A1 WO 2008114733A1
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WO
WIPO (PCT)
Prior art keywords
antibody
cldn4
extracellular domain
fragment
claudin
Prior art date
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PCT/JP2008/054769
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English (en)
French (fr)
Inventor
So Ohta
Hiroshi Ando
Masayo Suzuki
Shinobu Kawamoto
Mariko Nakano
Kazuyasu Nakamura
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Priority to JP2009505202A priority Critical patent/JPWO2008114733A1/ja
Priority to EP08722165A priority patent/EP2138576A4/en
Publication of WO2008114733A1 publication Critical patent/WO2008114733A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　本発明の目的は、Claudin-4（以下、CLDN4と表記する）遺伝子によりコードされるポリペプチドおよび/または、Claudin-3（以下、CLDN3と表記する）遺伝子によりコードされるポリペプチドが関与する疾患に対する治療薬及び診断に有用なモノクローナル抗体またはその使用方法を提供することにある。 　本発明は、CLDN4の細胞外領域の立体構造を特異的に認識し、かつ細胞外領域に結合するモノクローナル抗体または該抗体断片、CLDN4およびCLDN3の細胞外領域の立体構造を特異的に認識し、かつ該細胞外領域に結合するモノクローナル抗体または該抗体断片、該抗体を産生するハイブリドーマ、該抗体をコードするDNA、該DNAを含んでなるベクター、該ベクターを形質転換して得られる形質転換体、該ハイブリドーマまたは形質転換体を用いる抗体または抗体断片の製造方法、ならびに該抗体または抗体断片を用いるCLDN4および/またはCLDM3遺伝子によりコードされるポリペプチドが関与する疾患の診断薬または治療薬を提供する。
PCT/JP2008/054769 2007-03-16 2008-03-14 抗Claudin-4抗体 WO2008114733A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009505202A JPWO2008114733A1 (ja) 2007-03-16 2008-03-14 抗Ｃｌａｕｄｉｎ−４抗体
EP08722165A EP2138576A4 (en) 2007-03-16 2008-03-14 ANTI-CLAUDIN-4 ANTIBODY

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-068064 2007-03-16
JP2007068064 2007-03-16
JP2007-223803 2007-08-30
JP2007223803 2007-08-30

Publications (1)

Publication Number Publication Date
WO2008114733A1 true WO2008114733A1 (ja) 2008-09-25

Family

ID=39765841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054769 WO2008114733A1 (ja) 2007-03-16 2008-03-14 抗Claudin-4抗体

Country Status (4)

Country Link
US (1) US8076458B2 (ja)
EP (1) EP2138576A4 (ja)
JP (1) JPWO2008114733A1 (ja)
WO (1) WO2008114733A1 (ja)

Cited By (11)

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Publication number Priority date Publication date Assignee Title
EP2322555A1 (en) * 2009-11-11 2011-05-18 Ganymed Pharmaceuticals AG Antibodies specific for claudin 6 (CLDN6)
WO2014132647A1 (ja) * 2013-03-01 2014-09-04 公益財団法人ヒューマンサイエンス振興財団 抗体、フラグメント、医薬組成物、分子及び腫瘍マーカー
US9321842B2 (en) 2011-05-13 2016-04-26 Ganymed Pharmaceuticals Ag Antibodies for treatment of cancer
US9487584B2 (en) 2009-11-11 2016-11-08 Ganymed Pharmaceuticals Ag Antibodies specific for claudin 6 (CLDN6)
CN106459165A (zh) * 2014-04-01 2017-02-22 拜恩科技细胞&基因治疗有限公司 密封蛋白‑6特异性免疫受体和t细胞表位
US9718886B2 (en) 2010-07-06 2017-08-01 Ganymed Pharmaceuticals Ag Cancer therapy using CLDN6 target-directed antibodies in vivo
US9809815B2 (en) 2009-02-20 2017-11-07 Ganymed Pharmaceuticals Ag Methods and compositions for diagnosis and treatment of cancer
WO2018105560A1 (ja) * 2016-12-07 2018-06-14 国立大学法人大阪大学 Ｃｌａｕｄｉｎ ５抗体、及びその抗体を含有する医薬
WO2018207638A1 (ja) * 2017-05-08 2018-11-15 国立大学法人大阪大学 抗ｃｌｄｎ－５抗体、及びその抗体を含有する医薬
US10604568B2 (en) 2013-07-31 2020-03-31 BioN Tech AG Diagnosis and therapy of cancer involving cancer stem cells
WO2024085166A1 (ja) * 2022-10-19 2024-04-25 アステラス製薬株式会社 がん治療におけるｐｄ－１シグナル阻害剤との組み合わせによる抗ｃｌｄｎ４－抗ｃｄ１３７二重特異性抗体の使用

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JP5624276B2 (ja) 2006-03-31 2014-11-12 中外製薬株式会社 抗体の血中動態を制御する方法
AR061317A1 (es) 2006-06-08 2008-08-20 Chugai Pharmaceutical Co Ltd Agentes para prevenir o tratar enfermedades inflamatorias
KR102225009B1 (ko) 2007-09-26 2021-03-08 추가이 세이야쿠 가부시키가이샤 항체 정상영역 개변체
JP5334319B2 (ja) 2007-09-26 2013-11-06 中外製薬株式会社 Ｃｄｒのアミノ酸置換により抗体の等電点を改変する方法
BRPI0821110B8 (pt) * 2007-12-05 2021-05-25 Chugai Pharmaceutical Co Ltd anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
EP2409990A4 (en) 2009-03-19 2013-01-23 Chugai Pharmaceutical Co Ltd VARIANT OF A CONSTANT ANTIBODY REGION
EP2409991B1 (en) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
RU2596925C2 (ru) 2009-09-06 2016-09-10 Протаб Лтд. Гуманизированные антитела, специфические для пептида-6, полученного из hsp65, способы их использования
US9505847B2 (en) * 2011-08-22 2016-11-29 Cnj Holdings Inc Clostridium difficile antibodies
CA2928671A1 (en) 2013-11-06 2015-05-14 Stemcentrx, Inc. Novel anti-claudin antibodies and methods of use
BR112017022101A2 (ja) 2015-04-14 2018-07-31 Chugai Seiyaku Kabushiki Kaisha An object for prevention and/or a medicine constituent for medical treatment of atopic dermatitis which contain IL-31 antagonist as an active ingredient
US20210130418A1 (en) * 2019-10-19 2021-05-06 Enrique GAMERO-ESTEVEZ Claudin-targeting agents and uses thereof
AR120512A1 (es) 2019-11-20 2022-02-16 Chugai Pharmaceutical Co Ltd Formulaciones que contienen anticuerpos
WO2024039670A1 (en) 2022-08-15 2024-02-22 Dana-Farber Cancer Institute, Inc. Antibodies against cldn4 and methods of use thereof

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