HRP20192134T1 - Molekule za vezanje na antigen koji veže egfr, vektori koji ih kodiraju, te njihove primjene - Google Patents
Molekule za vezanje na antigen koji veže egfr, vektori koji ih kodiraju, te njihove primjene Download PDFInfo
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- HRP20192134T1 HRP20192134T1 HRP20192134TT HRP20192134T HRP20192134T1 HR P20192134 T1 HRP20192134 T1 HR P20192134T1 HR P20192134T T HRP20192134T T HR P20192134TT HR P20192134 T HRP20192134 T HR P20192134T HR P20192134 T1 HRP20192134 T1 HR P20192134T1
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- 239000013598 vector Substances 0.000 title claims 4
- 108060006698 EGF receptor Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 102000045108 human EGFR Human genes 0.000 claims 3
- 230000004807 localization Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 230000025545 Golgi localization Effects 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010054377 Mannosidases Proteins 0.000 claims 1
- 102000001696 Mannosidases Human genes 0.000 claims 1
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical group CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000005889 cellular cytotoxicity Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000004041 dendritic cell maturation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 108010083819 mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase Proteins 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (20)
1. Humanizirano protutijelo anti-EGFR koje se specifično veže na ljudski EGFR, naznačeno time, da navedeno protutijelo obuhvaća sljedeće:
(a) varijabilno područje teškog lanca koje obuhvaća sekvencu od SEQ ID NO: 15; i
(b) varijabilno područje lakog lanca koje obuhvaća sekvencu od SEQ ID NO:45;
i pritom navedeno protutijelo obuhvaća ljudsko Fc područje proizvedeno glikoinženjeringom, koje posjeduje smanjeni broj fukoznih ostataka u usporedbi s oblikom protutijela koji nije proizveden glikoinženjeringom.
2. Protutijelo prema patentnom zahtjevu 1, naznačeno time, da je navedeno Fc područje proizvedeno glikoinženjeringom:
(a) kako bi imalo najmanje 70% ne-fukoziliranih oligosaharida;
(b) kako bi imalo povećani omjer GlcNAc ostataka naspram fukoznih ostataka u usporedbi s oblikom protutijela koji nije proizveden glikoinženjeringom;
(c) kako bi imalo povećani afinitet vezanja Fc receptora u usporedbi s oblikom protutijela koji nije proizveden glikoinženjeringom;
(d) kako bi imalo povećanu efektorsku funkciju u usporedbi s oblikom protutijela koji nije proizveden glikoinženjeringom.
3. Protutijelo prema patentnom zahtjevu 2, naznačeno time, da je navedena efektorska funkcija odabrana iz skupine koja se sastoji od povećane Fc-posredovane stanične citotoksičnosti, povećanog vezanja na NK-stanice, povećanog vezanja na makrofage, povećanog vezanja na polimorfonuklearne stanice, povećanog vezanja na monocite, povećanog izravnog signaliziranja induciranog apoptozom, povećane maturacije dendritičke stanice i povećane pripreme za aktivaciju T-stanice.
4. Polipeptid, naznačen time, da on obuhvaća aminokiselinsku sekvencu od varijabilnog područja teškog lanca i lakog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 3.
5. Polinukleotid, naznačen time, da on kodira varijabilno područje teškog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 4 i varijabilno područje lakog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 4.
6. Vektor, naznačen time, da obuhvaća polinukleotid koji kodira varijabilno područje teškog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 4 i polinukleotid koji kodira varijabilno područje lakog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 4.
7. Vektor prema patentnom zahtjevu 6, naznačen time, da je on policistronički.
8. Stanica domaćina, naznačena time, da ona obuhvaća polinukleotid koji kodira varijabilno područje teškog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 4 i polinukleotid koji kodira varijabilno područje lakog lanca od protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 4, ili vektor prema patentnom zahtjevu 6 ili 7.
9. Stanica domaćina prema patentnom zahtjevu 8, naznačena time, da je spomenuta stanica domaćina modificirana inženjeringom kako bi eksprimirala najmanje jednu nukleinsku kiselinu koja kodira polipeptid s aktivitetom β(1,4)-N-acetilglukozaminiltransferaze III.
10. Stanica domaćina prema patentnom zahtjevu 9, naznačena time, da je spomenuta stanica domaćina i dalje modificirana inženjeringom kako bi eksprimirala nukleinsku kiselinu koja kodira polipeptid s aktivitetom Golgi-manosidaze II.
11. Stanica domaćina prema patentnom zahtjevu 9, naznačena time, da je navedeni polipeptid koji ima aktivitet β(1,4)-N-acetilglukozaminiltransferaze III, fuzijski polipeptid koji dodatno sadrži lokalizacijsku Golgi-domenu od heterolognog polipeptida koji je stanovnik Golgi-trakta.
12. Stanica domaćina prema patentnom zahtjevu 11, naznačena time, da je navedena lokalizacijska Golgi-domena odabrana od lokalizacijske domene manosidaze II, lokalizacijske domene β(1,2)-N-acetilglukozaminiltransferaze I, β(1,2)-N-acetilglukozaminiltransferaze II, manosidaze I ili α1-6-jezgra-fukoziltransferaze.
13. Postupak proizvodnje humaniziranog anti-EGFR protutijela podvrgnutog glikoinženjeringu koje ima ljudsko Fc područje modificirano glikoinženjeringom, čime je osposobljeno za natjecanje s protutijelom štakora ICR62 u vezanju na ljudski EGFR, pri čemu spomenuto protutijelo štakora ICR62 obuhvaća varijabilno područje teškog lanca od SEQ ID NO:1 i varijabilno područje lakog lanca od SEQ ID NO:43, naznačen time, da navedeni postupak obuhvaća sljedeće:
(a) kultiviranje stanice domaćina prema bilo kojem od patentnih zahtjeva 8 do 12, pod uvjetima koji dopuštaju proizvodnju navedenog protutijela; i
(b) izoliranje spomenutog protutijela.
14. Protutijelo koje se specifično veže na ljudski EGFR, naznačeno time, da se navedeno protutijelo može dobiti putem postupka u skladu s patentnim zahtjevom 13 ili se može dobiti pomoću stanice domaćina u skladu s bilo kojim od patentnih zahtjeva 8 do 12.
15. Farmaceutski pripravak, naznačen time, da obuhvaća protutijelo u skladu s bilo kojim od patentnih zahtjeva 1 do 3 ili 14, te farmaceutski prihvatljiv nosač.
16. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 3 ili 14, naznačeno time, da se ono upotrebljava kao lijek.
17. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 3 ili 14, naznačeno time, da se ono upotrebljava u liječenju ili profilaksi raka.
18. Uporaba protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 3 ili 14, naznačena time, da je za proizvodnju farmaceutskog pripravka za liječenje ili profilaksu raka.
19. Protutijelo prema patentnom zahtjevu 17 ili uporaba prema patentnom zahtjevu 18, naznačeno time, da se navedeno protutijelo upotrebljava u terapeutski učinkovitoj količini koja iznosi od 1,0 mg/kg do 15 mg/kg.
20. Protutijelo prema bilo kojem od patentnih zahtjeva 17 do 19 ili uporaba prema patentnom zahtjevu 18 ili 19, naznačeno(a) time, da je navedeni rak odabran iz skupine koja se sastoji od sljedećih: rak mjehura, rak mozga, rak glave i vrata, rak gušterače, rak pluća, rak dojke, rak jajnika, rak debelog crijeva, rak prostate, rak kože i rak bubrega.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65011505P | 2005-02-07 | 2005-02-07 | |
| PCT/IB2006/000238 WO2006082515A2 (en) | 2005-02-07 | 2006-02-07 | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
| EP06710336.6A EP1871805B1 (en) | 2005-02-07 | 2006-02-07 | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20192134T1 true HRP20192134T1 (hr) | 2020-02-21 |
Family
ID=36777599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192134TT HRP20192134T1 (hr) | 2005-02-07 | 2019-11-27 | Molekule za vezanje na antigen koji veže egfr, vektori koji ih kodiraju, te njihove primjene |
Country Status (28)
| Country | Link |
|---|---|
| US (8) | US7722867B2 (hr) |
| EP (4) | EP1871805B1 (hr) |
| JP (2) | JP5336089B2 (hr) |
| KR (2) | KR101569300B1 (hr) |
| CN (2) | CN103981190A (hr) |
| AR (1) | AR052285A1 (hr) |
| AU (1) | AU2006211037B2 (hr) |
| BR (1) | BRPI0607315B1 (hr) |
| CA (1) | CA2596835C (hr) |
| CR (2) | CR9236A (hr) |
| DK (1) | DK1871805T3 (hr) |
| ES (1) | ES2755976T3 (hr) |
| HK (2) | HK1199470A1 (hr) |
| HR (1) | HRP20192134T1 (hr) |
| IL (1) | IL184498A (hr) |
| LT (1) | LT1871805T (hr) |
| MA (1) | MA29279B1 (hr) |
| MX (1) | MX2007008619A (hr) |
| NO (1) | NO20073662L (hr) |
| NZ (1) | NZ556286A (hr) |
| PL (1) | PL1871805T3 (hr) |
| PT (1) | PT1871805T (hr) |
| RS (1) | RS59761B1 (hr) |
| RU (2) | RU2488597C2 (hr) |
| SI (1) | SI1871805T1 (hr) |
| TW (1) | TWI387602B (hr) |
| UA (1) | UA95068C2 (hr) |
| WO (1) | WO2006082515A2 (hr) |
Families Citing this family (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE458007T1 (de) * | 1998-04-20 | 2010-03-15 | Glycart Biotechnology Ag | Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität |
| CA2838062C (en) | 2001-08-03 | 2015-12-22 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| AR052285A1 (es) | 2005-02-07 | 2007-03-07 | Glycart Biotechnology Ag | Moleculas de union al antigeno que fijan egfr, vectores que las codifican y usos de las mismas |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| KR101169243B1 (ko) | 2007-06-06 | 2012-08-02 | 에프. 호프만-라 로슈 아게 | 종양 항원에 결합하는 비-표지된 제 1 단클론 항체 및 ｎｉｒ 형광 표지로 표지된 비-교차 반응성 제 2 단클론 항체로 이루어진 조성물 |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
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