PE20231300A1 - Anticuerpos anti-notch2 y metodos de uso - Google Patents

Anticuerpos anti-notch2 y metodos de uso

Info

Publication number
PE20231300A1
PE20231300A1 PE2023000052A PE2023000052A PE20231300A1 PE 20231300 A1 PE20231300 A1 PE 20231300A1 PE 2023000052 A PE2023000052 A PE 2023000052A PE 2023000052 A PE2023000052 A PE 2023000052A PE 20231300 A1 PE20231300 A1 PE 20231300A1
Authority
PE
Peru
Prior art keywords
cdr
amino acid
acid sequence
sequence seq
chain variable
Prior art date
Application number
PE2023000052A
Other languages
English (en)
Inventor
Cecilia Pui Chi Chiu
Yan Wu
Adel Mahmoud Elsohly
Daniel George Lafkas
Jian Mehr-Dean Payandeh
Siao-Ping Tsai
Hoangdung Dang Ho
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20231300A1 publication Critical patent/PE20231300A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invencion se refiere a un anticuerpo aislado que se une a Notch2 humana, donde dicho anticuerpo comprende: a) un dominio variable de la cadena pesada (VH) que comprende: CDR-H1 que comprende la secuencia de aminoacidos SEQ ID NO: 4, CDR-H2 que comprende la secuencia de aminoacidos SEQ ID NO: 6 o 7, CDR-H3 que comprende la secuencia de aminoacidos SEQ ID NO: 8, 9, 10, 11 o 12, y un dominio variable de la cadena ligera (VL) que comprende: CDR-L1 que comprende la secuencia de aminoacidos SEQ ID NO: 1, CDR-L2 que comprende la secuencia de aminoacidos SEQ ID NO: 2, CDR-L3 que comprende la secuencia de aminoacidos SEQ ID NO: 3; b) un dominio variable de la cadena pesada (VH) que comprende: CDR-H1 que comprende la secuencia de aminoacidos SEQ ID NO: 36, CDR-H2 que comprende la secuencia de aminoacidos SEQ ID NO: 37, CDR-H3 que comprende la secuencia de aminoacidos SEQ ID NO: 38, y un dominio variable de la cadena ligera (VL) que comprende: CDR-L1 que comprende la secuencia de aminoacidos SEQ ID NO: 33, CDR-L2 que comprende la secuencia de aminoacidos SEQ ID NO: 34, CDR-L3 que comprende la secuencia de aminoacidos SEQ ID NO: 35; entre otros. Tambien se refiere a un acido nucleico aislado, una celula huesped, un metodo de produccion y una composicion farmaceutica. Dicho anticuerpo inhibe la senalizacion mediada por Jagged1, pero no inhibe la senalizacion mediada por DLL1; ademas, dicho anticuerpo se une a un epitopo dentro de la repeticion de EGF7 de Notch2 dentro de los aminoacidos 260-296 de Notch2, siendo util en el tratamiento de una enfermedad pulmonar mucoobstructiva, tal como fibrosis quistica, bronquiolitis, bronquioectasia, entre otros.
PE2023000052A 2020-07-17 2021-07-16 Anticuerpos anti-notch2 y metodos de uso PE20231300A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063053034P 2020-07-17 2020-07-17
PCT/US2021/041935 WO2022016037A1 (en) 2020-07-17 2021-07-16 Anti-notch2 antibodies and methods of use

Publications (1)

Publication Number Publication Date
PE20231300A1 true PE20231300A1 (es) 2023-08-24

Family

ID=77338798

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2023000052A PE20231300A1 (es) 2020-07-17 2021-07-16 Anticuerpos anti-notch2 y metodos de uso

Country Status (17)

Country Link
US (1) US20230303682A1 (es)
EP (1) EP4182348A1 (es)
JP (1) JP2023534458A (es)
KR (1) KR20230038735A (es)
CN (1) CN116406377A (es)
AR (1) AR123001A1 (es)
AU (1) AU2021308653A1 (es)
BR (1) BR112023000839A2 (es)
CA (1) CA3185122A1 (es)
CL (2) CL2023000129A1 (es)
CO (1) CO2023000505A2 (es)
CR (1) CR20230087A (es)
IL (1) IL299799A (es)
MX (1) MX2023000617A (es)
PE (1) PE20231300A1 (es)
TW (1) TW202216780A (es)
WO (1) WO2022016037A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023141445A1 (en) * 2022-01-19 2023-07-27 Genentech, Inc. Anti-notch2 antibodies and conjugates and methods of use

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