PE20121646A1 - Anticuerpo anti-tslp modificado por tecnicas de ingeneria genetica - Google Patents

Anticuerpo anti-tslp modificado por tecnicas de ingeneria genetica

Info

Publication number
PE20121646A1
PE20121646A1 PE2012000607A PE2012000607A PE20121646A1 PE 20121646 A1 PE20121646 A1 PE 20121646A1 PE 2012000607 A PE2012000607 A PE 2012000607A PE 2012000607 A PE2012000607 A PE 2012000607A PE 20121646 A1 PE20121646 A1 PE 20121646A1
Authority
PE
Peru
Prior art keywords
seq
cdr
antibody
genetic engineering
engineering techniques
Prior art date
Application number
PE2012000607A
Other languages
English (en)
Inventor
Leonard G Presta
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20121646A1 publication Critical patent/PE20121646A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN ANTICUERPO QUE SE UNE ESPECIFICAMENTE A TSLP HUMANA QUE COMPRENDE SEC ID NO:11 Y SEC ID NO:12; EL ANTICUERPO COMPRENDE: A) UNA REGION VARIABLE DE CADENA PESADA CON UNA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 7; CON CDR-H1 DE SEC ID NO:1, CDR-H2 DE SEC ID NO:2, Y CDR-H3 DE SEC ID NO:3 Y B) UNA REGION VARIABLE DE CADENA LIGERA CON UNA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 8; CON CDR-L1 DE SEC ID NO:4, CDR-L2 DE SEC ID NO:5, Y CDR-L3 DE SEC ID NO:6. DICHO ANTICUERPO ES HUMANIZADO O ES UN FRAGMENTO DE UNION QUE SE SELECCIONA DE Fab, Fab´, Fv, scFv, ENTRE OTROS. REFERIDO ADEMAS A UN ACIDO NUCLEICO, UN VECTOR, UNA CELULA HUESPED, UN METODO DE PRODUCCION Y UNA COMPOSICION FARMACEUTICA. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS Y RESPUESTAS INFLAMATORIAS ALERGICAS
PE2012000607A 2009-11-04 2010-11-02 Anticuerpo anti-tslp modificado por tecnicas de ingeneria genetica PE20121646A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25805109P 2009-11-04 2009-11-04
US29700810P 2010-01-21 2010-01-21

Publications (1)

Publication Number Publication Date
PE20121646A1 true PE20121646A1 (es) 2012-12-02

Family

ID=43970291

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000607A PE20121646A1 (es) 2009-11-04 2010-11-02 Anticuerpo anti-tslp modificado por tecnicas de ingeneria genetica

Country Status (20)

Country Link
US (2) US8637019B2 (es)
EP (2) EP2496707B1 (es)
JP (2) JP6077856B2 (es)
KR (1) KR101898739B1 (es)
CN (1) CN102782149B (es)
AR (1) AR078899A1 (es)
AU (1) AU2010315304B2 (es)
BR (1) BR112012010707B1 (es)
CA (1) CA2779384C (es)
CL (1) CL2012001179A1 (es)
CO (1) CO6531489A2 (es)
EC (1) ECSP12011879A (es)
ES (1) ES2784123T3 (es)
IL (1) IL219204A0 (es)
MX (1) MX2012005180A (es)
MY (1) MY162511A (es)
NZ (1) NZ599761A (es)
PE (1) PE20121646A1 (es)
PH (1) PH12012500843A1 (es)
WO (1) WO2011056772A1 (es)

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WO2013063062A2 (en) * 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp. Il-19 as a biomarker of tslp treatment
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US20140227250A1 (en) 2012-08-23 2014-08-14 Merck Sharp & Dohme Corp. Stable formulations of antibodies to tslp
UA117466C2 (uk) 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
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WO2015187519A1 (en) * 2014-06-06 2015-12-10 Merck Sharp & Dohme Corp. Tslp assay
AU2016320748B2 (en) * 2015-09-09 2019-05-02 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies
PT3347377T (pt) * 2015-09-09 2021-04-30 Novartis Ag Anticorpos que se ligam à linfopoietina do estroma tímico (tslp) e métodos de utilização dos anticorpos
US10617650B2 (en) 2015-10-16 2020-04-14 Merck Sharp & Dohme Corp. Process for preparing formulations for gastrointestinal-targeted therapies
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CN113501878B (zh) * 2021-02-03 2022-12-02 北京智仁美博生物科技有限公司 针对人tslp的多种抗体及其用途
KR20230140571A (ko) * 2021-02-04 2023-10-06 스테이드슨 (베이징) 바이오팔마슈티칼스 캄퍼니 리미티드 흉선 기질 림포포이에틴을 특이적으로 인식하는 항체 및 이의 용도
CN113069543B (zh) * 2021-06-07 2021-08-06 迈威(上海)生物科技股份有限公司 包含抗胸腺基质淋巴细胞生成素的单克隆抗体的液体组合物
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