PE20120835A1 - Anticuerpos anti-tnf-alfa y sus usos - Google Patents
Anticuerpos anti-tnf-alfa y sus usosInfo
- Publication number
- PE20120835A1 PE20120835A1 PE2011001810A PE2011001810A PE20120835A1 PE 20120835 A1 PE20120835 A1 PE 20120835A1 PE 2011001810 A PE2011001810 A PE 2011001810A PE 2011001810 A PE2011001810 A PE 2011001810A PE 20120835 A1 PE20120835 A1 PE 20120835A1
- Authority
- PE
- Peru
- Prior art keywords
- cdr
- seq
- antibody
- cdrs
- refers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN ANTICUERPO MONOCLONAL HUMANIZADO ANTI-TNFa O UN FRAGMENTO DE UNION ANTI-TNFa DE UN ANTICUERPO QUE COMPRENDE LAS REGIONES DETERMINANTES DE LA COMPLEMENTARIEDAD (CDR) DEL ANTICUERPO D2E7: i) CDR-H1 DE SEQ ID Nº: 5, ii) CDR-H2 DE SEQ ID Nº: 6, iii) CDR-H3 DE SEQ ID Nº: 7, iv) CDR-L1 DE SEQ ID Nº: 8, v) CDR-L2 DE SEQ ID Nº: 9 Y vi) CDR-H3 DE SEQ ID Nº: 10; EN DONDE DICHAS CDRs TIENEN EN CONJUNTO HASTA 17 SUSTITUCIONES DE AMINOACIDOS EN COMPARACION CON LAS SECUENCIAS DE LAS CDRs DEL ANTICUERPO D2E7. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE LUPUS SISTEMICO ERITEMATOSO, ARTRITIS REUMATOIDE, DIABETES MELLITUS, ENFERMEDAD DE CROHN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17005309P | 2009-04-16 | 2009-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120835A1 true PE20120835A1 (es) | 2012-07-23 |
Family
ID=42470707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001810A PE20120835A1 (es) | 2009-04-16 | 2010-04-16 | Anticuerpos anti-tnf-alfa y sus usos |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8722860B2 (es) |
| EP (2) | EP2419448A1 (es) |
| JP (1) | JP5795759B2 (es) |
| KR (1) | KR20110138412A (es) |
| CN (1) | CN102439040B (es) |
| AU (1) | AU2010236256C1 (es) |
| BR (1) | BRPI1012524A2 (es) |
| CA (1) | CA2758964A1 (es) |
| CL (1) | CL2011002567A1 (es) |
| CO (1) | CO6450656A2 (es) |
| CR (1) | CR20110526A (es) |
| DO (1) | DOP2011000316A (es) |
| EC (1) | ECSP11011450A (es) |
| GT (1) | GT201100260A (es) |
| IL (1) | IL215649A (es) |
| MX (1) | MX2011010908A (es) |
| NZ (1) | NZ595687A (es) |
| PE (1) | PE20120835A1 (es) |
| RU (1) | RU2595379C2 (es) |
| SG (1) | SG175181A1 (es) |
| TW (1) | TWI559930B (es) |
| WO (1) | WO2010121140A1 (es) |
| ZA (1) | ZA201107486B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2758964A1 (en) | 2009-04-16 | 2010-10-21 | Abbott Biotherapeutics Corp. | Anti-tnf-.alpha. antibodies and their uses |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| CN102539778A (zh) * | 2010-12-24 | 2012-07-04 | 北京义翘神州生物技术有限公司 | 一种检测人肿瘤坏死因子-α的酶联免疫试剂盒 |
| CN102998457B (zh) * | 2012-07-12 | 2015-08-26 | 电子科技大学 | 草鱼肿瘤坏死因子alpha的竞争抑制酶联免疫检测方法 |
| RU2648141C2 (ru) | 2012-09-19 | 2018-03-22 | Эббви Биотерапьютикс Инк. | Способы идентификации антител с пониженной иммуногенностью |
| CN105051064A (zh) * | 2013-01-24 | 2015-11-11 | 葛兰素史克知识产权开发有限公司 | 抗TNF-α抗原结合蛋白 |
| CA2904528C (en) | 2013-03-15 | 2021-01-19 | Abbvie Biotherapeutics Inc. | Fc variants |
| CN104341502B (zh) * | 2013-08-09 | 2016-04-27 | 北京天成新脉生物技术有限公司 | 低免疫原性抗TNF-α全人源单抗及其应用 |
| WO2015035044A2 (en) | 2013-09-04 | 2015-03-12 | Abbvie Biotherapeutics Inc. | Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
| CA2943445A1 (en) | 2014-03-26 | 2015-10-01 | Cell Medica Switzerland Ag | Binding members to tnf alpha |
| AR102417A1 (es) | 2014-11-05 | 2017-03-01 | Lilly Co Eli | Anticuerpos biespecíficos anti-tnf- / anti-il-23 |
| WO2016081836A1 (en) * | 2014-11-21 | 2016-05-26 | Ehrenpreis Eli D | Combination therapy for administration of monoclonal antibodies |
| WO2016130451A1 (en) * | 2015-02-09 | 2016-08-18 | Dnx Biotech, Llc | Increasing the half-life of a full-length or a functional fragment of variant anti-human tnf-alpha antibody |
| KR20170138426A (ko) * | 2015-03-13 | 2017-12-15 | 삼성바이오에피스 주식회사 | 항-tnf-알파 폴리펩티드 조성물 및 그 용도 |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| CA2990565A1 (en) | 2015-06-24 | 2016-12-29 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein containing bdnf and anti-human transferrin receptor antibody |
| TWI769982B (zh) * | 2015-06-24 | 2022-07-11 | 日商Ｊｃｒ製藥股份有限公司 | 通過血腦障壁之抗人類運鐵蛋白受體抗體 |
| JP7210276B2 (ja) | 2015-07-31 | 2023-01-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 抗体変異体 |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| BR112018014810A2 (pt) | 2016-01-22 | 2018-12-11 | Merck Sharp & Dohme Corp. | anticorpos anti-fator xi de coagulação |
| CN116425879A (zh) | 2016-06-14 | 2023-07-14 | 默沙东有限责任公司 | 抗-凝血因子xi抗体 |
| EP3257866A1 (en) | 2016-06-17 | 2017-12-20 | Academisch Medisch Centrum | Modified anti-tnf antibody and use thereof in the treatment of ibd |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN109983031B (zh) | 2016-12-26 | 2022-11-25 | Jcr制药股份有限公司 | 通过血脑屏障的新的抗人转铁蛋白受体抗体 |
| KR102573622B1 (ko) | 2016-12-26 | 2023-08-31 | 제이씨알 파마 가부시키가이샤 | Bdnf를 포함하는 융합 단백질 |
| JOP20190162A1 (ar) * | 2016-12-30 | 2019-06-27 | Biocad Joint Stock Co | تركيبة صيدلانية مائية من جسم مضاد لـ tnf? أحادي النسيلة معاود الارتباط الجيني |
| RU2665966C2 (ru) * | 2016-12-30 | 2018-09-05 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция рекомбинантного моноклонального антитела к ФНОα |
| AU2019211910B2 (en) | 2018-01-25 | 2022-09-22 | Fujimoto Co., Ltd | Thiophene derivative and use thereof |
| WO2019183131A1 (en) * | 2018-03-19 | 2019-09-26 | Bioventures, Llc | Periostin antibodies and methods of using the same |
| CN111909267B (zh) * | 2019-05-07 | 2022-03-25 | 北京天成新脉生物技术有限公司 | 低免疫原性抗TNF-α人源化单克隆抗体TCX063及其应用 |
| CN111909268B (zh) * | 2019-05-07 | 2022-04-19 | 北京天成新脉生物技术有限公司 | 低免疫原性低ADCC/CDC功能抗TNF-α人源化单克隆抗体TCX060及其应用 |
| CN114401988A (zh) * | 2019-07-09 | 2022-04-26 | 国家生物技术研究所公司 | 具有降低的免疫原性的抗体 |
| FR3104582A1 (fr) | 2019-12-17 | 2021-06-18 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Variants de l’adalimumab au potentiel immunogène réduit |
| WO2025049345A1 (en) | 2023-08-25 | 2025-03-06 | Proteologix Us Inc. | Anti-il-13 multispecific antibody constructs and uses thereof |
| WO2025264860A2 (en) | 2024-06-18 | 2025-12-26 | Yale University | Methods of treating post-covid airway disease |
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2010
- 2010-04-16 CA CA2758964A patent/CA2758964A1/en not_active Abandoned
- 2010-04-16 CN CN201080020704.5A patent/CN102439040B/zh not_active Expired - Fee Related
- 2010-04-16 EP EP10719448A patent/EP2419448A1/en not_active Withdrawn
- 2010-04-16 EP EP14196416.3A patent/EP2918602A1/en not_active Withdrawn
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- 2010-04-16 BR BRPI1012524-8A patent/BRPI1012524A2/pt not_active IP Right Cessation
- 2010-04-16 PE PE2011001810A patent/PE20120835A1/es not_active Application Discontinuation
- 2010-04-16 TW TW099112215A patent/TWI559930B/zh not_active IP Right Cessation
- 2010-04-16 SG SG2011074259A patent/SG175181A1/en unknown
- 2010-04-16 US US13/264,983 patent/US20120135005A1/en not_active Abandoned
- 2010-04-16 JP JP2012505960A patent/JP5795759B2/ja not_active Expired - Fee Related
- 2010-04-16 RU RU2011145428/10A patent/RU2595379C2/ru not_active IP Right Cessation
- 2010-04-16 AU AU2010236256A patent/AU2010236256C1/en not_active Ceased
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- 2010-04-16 MX MX2011010908A patent/MX2011010908A/es active IP Right Grant
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