ATE435238T1 - Herstellung eines einkettigen fv antikörperfragments - Google Patents

Herstellung eines einkettigen fv antikörperfragments

Info

Publication number
ATE435238T1
ATE435238T1 AT04010702T AT04010702T ATE435238T1 AT E435238 T1 ATE435238 T1 AT E435238T1 AT 04010702 T AT04010702 T AT 04010702T AT 04010702 T AT04010702 T AT 04010702T AT E435238 T1 ATE435238 T1 AT E435238T1
Authority
AT
Austria
Prior art keywords
preparation
antibody fragment
single chain
methods
antibody fragments
Prior art date
Application number
AT04010702T
Other languages
English (en)
Inventor
Tobias Raum
Julia Henckel
Eva Krinner
Silke Mittelstrass
Andreas Wolf
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of ATE435238T1 publication Critical patent/ATE435238T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT04010702T 2004-05-05 2004-05-05 Herstellung eines einkettigen fv antikörperfragments ATE435238T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04010702A EP1593690B1 (de) 2004-05-05 2004-05-05 Herstellung eines einkettigen fv Antikörperfragments

Publications (1)

Publication Number Publication Date
ATE435238T1 true ATE435238T1 (de) 2009-07-15

Family

ID=34924877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04010702T ATE435238T1 (de) 2004-05-05 2004-05-05 Herstellung eines einkettigen fv antikörperfragments

Country Status (8)

Country Link
US (2) US8247194B2 (de)
EP (2) EP1593690B1 (de)
AT (1) ATE435238T1 (de)
AU (1) AU2005238203B2 (de)
CA (1) CA2562604C (de)
DE (1) DE602004021773D1 (de)
DK (1) DK1593690T3 (de)
WO (1) WO2005105844A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1593690B1 (de) * 2004-05-05 2009-07-01 Micromet AG Herstellung eines einkettigen fv Antikörperfragments
RU2458071C2 (ru) 2005-04-18 2012-08-10 Микромет Аг Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека
HUE058876T2 (hu) 2005-05-18 2022-09-28 Morphosys Ag Anti-GM-CSF antitestek és felhasználásuk
JP4736037B2 (ja) * 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
AU2013201228B2 (en) * 2006-02-08 2016-01-21 Eisai, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
CN101501070B (zh) * 2006-02-08 2013-12-25 诺福泰克公司 抗原性gm-csf肽和针对gm-csf的抗体
US8232372B2 (en) * 2006-12-14 2012-07-31 Schering Corp. Engineered anti-TSLP antibody
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
MX2010005291A (es) 2007-11-13 2010-11-12 Evec Inc Anticuerpos monoclonales que se unen a hgm-csf y composiciones medicas que comprenden los mismos.
US8840890B2 (en) * 2008-11-12 2014-09-23 University Of Maryland, Baltimore Rapid expression cloning of human monoclonal antibodies from memory B cells
EP3381471B1 (de) 2008-12-22 2024-03-20 The University of Melbourne Schmerzbehandlung
RU2712273C2 (ru) 2008-12-22 2020-01-28 Де Юниверсити Оф Мельбурн Лечение остеоартрита
KR101898739B1 (ko) 2009-11-04 2018-09-13 머크 샤프 앤드 돔 코포레이션 조작된 항－ｔｓｌｐ 항체
US20140004121A1 (en) 2012-06-27 2014-01-02 Amgen Inc. Anti-mesothelin binding proteins
EP2914289B1 (de) 2012-10-31 2019-05-22 Takeda GmbH Lyophilisierte formulierung mit einer gm-csf-neutralisierenden verbindung
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
CN118178647A (zh) 2013-08-30 2024-06-14 武田药品工业株式会社 用于治疗类风湿性关节炎或作为镇痛药的中和gm-csf的抗体
CN106661119A (zh) 2014-07-01 2017-05-10 辉瑞公司 双特异性异二聚化双抗体及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
EP1593690B1 (de) * 2004-05-05 2009-07-01 Micromet AG Herstellung eines einkettigen fv Antikörperfragments

Also Published As

Publication number Publication date
EP1593690A1 (de) 2005-11-09
US8247194B2 (en) 2012-08-21
CA2562604A1 (en) 2005-11-10
DE602004021773D1 (de) 2009-08-13
AU2005238203A1 (en) 2005-11-10
WO2005105844A3 (en) 2006-01-26
AU2005238203B2 (en) 2010-09-02
CA2562604C (en) 2014-02-18
EP1742967A2 (de) 2007-01-17
WO2005105844A2 (en) 2005-11-10
US20080193978A1 (en) 2008-08-14
US9279017B2 (en) 2016-03-08
US20130171165A1 (en) 2013-07-04
EP1593690B1 (de) 2009-07-01
DK1593690T3 (da) 2009-11-09

Similar Documents

Publication Publication Date Title
ATE435238T1 (de) Herstellung eines einkettigen fv antikörperfragments
NL300911I2 (nl) sarilumab
WO2008097817A3 (en) Multivariable antigens complexed with targeting humanized monoclonal antibody
NO2017032I1 (no) bezlotoksumab
ATE452147T1 (de) Antikörper mit korrigierten cdr
WO2005069970A3 (en) Antibody specificity transfer using minimal essential binding determinants
CR20150102A (es) Anticuerpos que se unen a il-4 y/o il-13 (divisional 2)
WO2007137984A3 (en) Modified humanised anti-interleukin-18 antibodies
NZ607711A (en) Antibodies directed to her-3 and uses thereof
EP1912674B8 (de) Bispezifische einzelketten-fv-antikörper-moleküle und anwendungsverfahren dafür
BRPI0908508A2 (pt) anticorpo monoclonal nkg2a anti-humano humanizado
NZ623706A (en) Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof
IL197459A0 (en) Humanized proteins, including antibodies and methods for producing the same
EP2162469A4 (de) Neue verfahren zur humanisierung von kaninchenantikörpern und humanisierte kaninchenantikörper
ES2572231T3 (es) Anticuerpos monoclonales anti-IL-21 humana
WO2007063415A3 (en) Methods of producing stable b-lymphocytes
BRPI0509495A2 (pt) anticorpo humanizado
WO2008052108A3 (en) Methods for use in human-adapting monoclonal antibodies
WO2011112850A3 (en) Humanized and chimeric anti-properdin antibodies
NZ594668A (en) Humanised antibodies with anti-tumour activity
NZ607881A (en) Humanized antibody against amyloid beta
WO2008068359A3 (es) Método para producir anticuerpos mediante inmunización con haptenos unidos a partículas de óxidos metálicos
NZ708488A (en) Method of providing disease-specific binding molecules and targets
AU2004902842A0 (en) Monoclonal antibody against ABCA1

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1593690

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 1593690

Country of ref document: EP