DE602004021773D1 - Herstellung eines einkettigen fv Antikörperfragments - Google Patents

Herstellung eines einkettigen fv Antikörperfragments

Info

Publication number
DE602004021773D1
DE602004021773D1 DE602004021773T DE602004021773T DE602004021773D1 DE 602004021773 D1 DE602004021773 D1 DE 602004021773D1 DE 602004021773 T DE602004021773 T DE 602004021773T DE 602004021773 T DE602004021773 T DE 602004021773T DE 602004021773 D1 DE602004021773 D1 DE 602004021773D1
Authority
DE
Germany
Prior art keywords
chain
preparation
antibody fragment
methods
antibody fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004021773T
Other languages
English (en)
Inventor
Tobias Raum
Julia Henckel
Eva Krinner
Silke Mittelstrass
Andreas Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Research Munich GmbH
Original Assignee
Micromet GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet GmbH filed Critical Micromet GmbH
Publication of DE602004021773D1 publication Critical patent/DE602004021773D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE602004021773T 2004-05-05 2004-05-05 Herstellung eines einkettigen fv Antikörperfragments Expired - Lifetime DE602004021773D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04010702A EP1593690B1 (de) 2004-05-05 2004-05-05 Herstellung eines einkettigen fv Antikörperfragments

Publications (1)

Publication Number Publication Date
DE602004021773D1 true DE602004021773D1 (de) 2009-08-13

Family

ID=34924877

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004021773T Expired - Lifetime DE602004021773D1 (de) 2004-05-05 2004-05-05 Herstellung eines einkettigen fv Antikörperfragments

Country Status (8)

Country Link
US (2) US8247194B2 (de)
EP (2) EP1593690B1 (de)
AT (1) ATE435238T1 (de)
AU (1) AU2005238203B2 (de)
CA (1) CA2562604C (de)
DE (1) DE602004021773D1 (de)
DK (1) DK1593690T3 (de)
WO (1) WO2005105844A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004021773D1 (de) * 2004-05-05 2009-08-13 Micromet Ag Herstellung eines einkettigen fv Antikörperfragments
ME02191B (me) * 2005-04-18 2016-02-20 Amgen Res Munich Gmbh Protutijela koja neutraliziraju ljudski čimbenik stimuliranja kolonija makrofaga
EP3620171B1 (de) 2005-05-18 2022-04-20 MorphoSys AG Anti-gm-csf-antikörper und verwendungen dafür
JP4736037B2 (ja) 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
LT1981909T (lt) * 2006-02-08 2017-01-10 Morphotek, Inc. Antigeniniai gm-csf peptidai ir gm-csf antikūnai
AU2013201228B2 (en) * 2006-02-08 2016-01-21 Eisai, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
CN101605814B (zh) * 2006-12-14 2014-02-19 默沙东公司 经工程改造的抗tslp抗体
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
KR20100102108A (ko) 2007-11-13 2010-09-20 에베크 인코포레이티드 ｈＧＭ-ＣＳＦ에 결합하는 모노클로날 항체 및 이를 포함하는 의약 조성물
WO2010056898A2 (en) * 2008-11-12 2010-05-20 University Of Maryland, Baltimore Rapid expression cloning of human monoclonal antibodies from memory b cells
CN108014335A (zh) 2008-12-22 2018-05-11 墨尔本大学 粒细胞巨噬细胞集落刺激因子的拮抗剂的用途
CA2746827C (en) 2008-12-22 2018-01-23 The University Of Melbourne Osteoarthritis treatment
MY162511A (en) 2009-11-04 2017-06-15 Merck Sharp & Dohme Engineered anti-tslp antibody
US20140004121A1 (en) 2012-06-27 2014-01-02 Amgen Inc. Anti-mesothelin binding proteins
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
US9833410B2 (en) 2012-10-31 2017-12-05 Takeda Gmbh Lyophilized formulation comprising GM-CSF neutralizing compound
EP3039039B1 (de) 2013-08-30 2021-03-10 Takeda GmbH Gm-csf-neutralisierende antikörper zur verwendung bei der behandlung von rheumatoider arthritis und als analgetika
BR112016030740A2 (pt) 2014-07-01 2018-02-20 Pfizer Inc. diacorpos heterodiméricos biespecíficos e seus usos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
DE602004021773D1 (de) * 2004-05-05 2009-08-13 Micromet Ag Herstellung eines einkettigen fv Antikörperfragments

Also Published As

Publication number Publication date
US20080193978A1 (en) 2008-08-14
AU2005238203A1 (en) 2005-11-10
DK1593690T3 (da) 2009-11-09
US9279017B2 (en) 2016-03-08
EP1742967A2 (de) 2007-01-17
EP1593690A1 (de) 2005-11-09
WO2005105844A3 (en) 2006-01-26
ATE435238T1 (de) 2009-07-15
AU2005238203B2 (en) 2010-09-02
EP1593690B1 (de) 2009-07-01
CA2562604C (en) 2014-02-18
US20130171165A1 (en) 2013-07-04
WO2005105844A2 (en) 2005-11-10
CA2562604A1 (en) 2005-11-10
US8247194B2 (en) 2012-08-21

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