CR20230076A - Anticuerpos que se unen a células cancerosas y dirigen radionucleótidos a dichas células - Google Patents
Anticuerpos que se unen a células cancerosas y dirigen radionucleótidos a dichas célulasInfo
- Publication number
- CR20230076A CR20230076A CR20230076A CR20230076A CR20230076A CR 20230076 A CR20230076 A CR 20230076A CR 20230076 A CR20230076 A CR 20230076A CR 20230076 A CR20230076 A CR 20230076A CR 20230076 A CR20230076 A CR 20230076A
- Authority
- CR
- Costa Rica
- Prior art keywords
- cells
- antibodies
- bind
- target
- terminus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0495—Pretargeting
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La presente invención se refiere a un conjunto de anticuerpos que se unen a antígenos en células diana y que dirigen radionúclidos a dichas células, y a métodos para usarlos. Cada anticuerpo comprende un Fab que se une al antígeno diana fusionado en el extremo C del VH al extremo N del Fc y un VH o VL que se une a un compuesto radiomarcado. VH o VL se fusionan en el extremo C al extremo N del Fc. VH y VL forman un sitio de unión al antígeno cuando el anticuerpo se une mediante el scFv al antígeno diana.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2020/069561 WO2021009047A1 (en) | 2019-07-12 | 2020-07-10 | Antibodies which bind to cancer cells and target radionuclides to said cells |
EP21151246 | 2021-01-12 | ||
PCT/EP2021/069072 WO2022008688A1 (en) | 2020-07-10 | 2021-07-08 | Antibodies which bind to cancer cells and target radionuclides to said cells |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20230076A true CR20230076A (es) | 2023-03-13 |
Family
ID=74175695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20230076A CR20230076A (es) | 2020-07-10 | 2021-07-08 | Anticuerpos que se unen a células cancerosas y dirigen radionucleótidos a dichas células |
Country Status (15)
Country | Link |
---|---|
US (1) | US20230272116A1 (es) |
EP (1) | EP4178985A1 (es) |
JP (1) | JP2023533533A (es) |
KR (1) | KR20230037578A (es) |
CN (1) | CN115867583A (es) |
AU (1) | AU2021303508A1 (es) |
BR (1) | BR112023000204A2 (es) |
CA (1) | CA3187277A1 (es) |
CO (1) | CO2023001413A2 (es) |
CR (1) | CR20230076A (es) |
IL (1) | IL298921A (es) |
MX (1) | MX2023000339A (es) |
PE (1) | PE20230434A1 (es) |
TW (1) | TW202216789A (es) |
WO (1) | WO2022008688A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3206466A1 (en) * | 2021-01-12 | 2022-07-21 | Christian Klein | Split antibodies which bind to cancer cells and target radionuclides to said cells |
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-
2021
- 2021-07-08 US US18/014,729 patent/US20230272116A1/en active Pending
- 2021-07-08 AU AU2021303508A patent/AU2021303508A1/en active Pending
- 2021-07-08 BR BR112023000204A patent/BR112023000204A2/pt unknown
- 2021-07-08 EP EP21740081.1A patent/EP4178985A1/en active Pending
- 2021-07-08 PE PE2023000024A patent/PE20230434A1/es unknown
- 2021-07-08 CN CN202180048696.3A patent/CN115867583A/zh active Pending
- 2021-07-08 MX MX2023000339A patent/MX2023000339A/es unknown
- 2021-07-08 KR KR1020237003528A patent/KR20230037578A/ko unknown
- 2021-07-08 JP JP2023501057A patent/JP2023533533A/ja active Pending
- 2021-07-08 CA CA3187277A patent/CA3187277A1/en active Pending
- 2021-07-08 CR CR20230076A patent/CR20230076A/es unknown
- 2021-07-08 IL IL298921A patent/IL298921A/en unknown
- 2021-07-08 WO PCT/EP2021/069072 patent/WO2022008688A1/en active Application Filing
- 2021-07-09 TW TW110125254A patent/TW202216789A/zh unknown
-
2023
- 2023-02-09 CO CONC2023/0001413A patent/CO2023001413A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20230434A1 (es) | 2023-03-08 |
KR20230037578A (ko) | 2023-03-16 |
WO2022008688A1 (en) | 2022-01-13 |
AU2021303508A1 (en) | 2023-02-02 |
TW202216789A (zh) | 2022-05-01 |
JP2023533533A (ja) | 2023-08-03 |
EP4178985A1 (en) | 2023-05-17 |
CN115867583A (zh) | 2023-03-28 |
CA3187277A1 (en) | 2022-01-13 |
US20230272116A1 (en) | 2023-08-31 |
BR112023000204A2 (pt) | 2023-01-31 |
CO2023001413A2 (es) | 2023-05-19 |
MX2023000339A (es) | 2023-02-09 |
IL298921A (en) | 2023-02-01 |
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