DK3433280T3 - Protease-aktiverede T-celle-bispecifikke molekyler - Google Patents
Protease-aktiverede T-celle-bispecifikke molekyler Download PDFInfo
- Publication number
- DK3433280T3 DK3433280T3 DK17711223.2T DK17711223T DK3433280T3 DK 3433280 T3 DK3433280 T3 DK 3433280T3 DK 17711223 T DK17711223 T DK 17711223T DK 3433280 T3 DK3433280 T3 DK 3433280T3
- Authority
- DK
- Denmark
- Prior art keywords
- protease
- activated
- bispecific molecules
- cell bispecific
- cell
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16161740 | 2016-03-22 | ||
US201662433327P | 2016-12-13 | 2016-12-13 | |
PCT/EP2017/056556 WO2017162587A1 (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
DK3433280T3 true DK3433280T3 (da) | 2023-06-19 |
DK3433280T5 DK3433280T5 (da) | 2024-09-16 |
Family
ID=65529185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17711223.2T DK3433280T5 (da) | 2016-03-22 | 2017-03-20 | Protease-aktiverede T-celle-bispecifikke molekyler |
Country Status (19)
Country | Link |
---|---|
US (3) | US11242390B2 (da) |
JP (1) | JP7015244B2 (da) |
CL (1) | CL2018002507A1 (da) |
DK (1) | DK3433280T5 (da) |
ES (1) | ES2947230T3 (da) |
FI (1) | FI3433280T3 (da) |
HR (1) | HRP20230528T1 (da) |
HU (1) | HUE061946T2 (da) |
IL (1) | IL260637B2 (da) |
LT (1) | LT3433280T (da) |
MX (1) | MX2018011542A (da) |
PE (1) | PE20231511A1 (da) |
PH (1) | PH12018502035A1 (da) |
PL (1) | PL3433280T3 (da) |
RS (1) | RS64266B1 (da) |
RU (1) | RU2018136567A (da) |
SI (1) | SI3433280T1 (da) |
UA (1) | UA127308C2 (da) |
ZA (1) | ZA201804973B (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2017291262A1 (en) * | 2016-06-30 | 2019-01-03 | F. Hoffmann-La Roche Ag | Improved adoptive T-cell therapy |
JP7141407B2 (ja) * | 2016-12-13 | 2022-09-22 | エフ.ホフマン-ラ ロシュ アーゲー | 腫瘍試料における標的抗原の存在を決定する方法 |
WO2020028832A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
CN113603783B (zh) * | 2018-12-21 | 2022-07-12 | 浙江时迈药业有限公司 | 蛋白酶可切割的双特异性抗体及其用途 |
CA3134680C (en) * | 2019-03-29 | 2024-02-06 | Green Cross Corporation | Fusion protein comprising anti-mesothelin antibody, anti-cd3 antibody or anti-egfr antibody, bispecific or trispecific antibody comprising same, and uses thereof |
EP4168444A1 (en) * | 2020-06-19 | 2023-04-26 | F. Hoffmann-La Roche AG | Protease-activated t cell bispecific antibodies |
CA3202358A1 (en) * | 2020-12-16 | 2022-06-23 | Andreas BOSSHART | Novel slow-release prodrugs |
US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
WO2023283629A1 (en) * | 2021-07-09 | 2023-01-12 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations thereof for treating facioscapulohumeral muscular dystrophy |
CN118355035A (zh) * | 2021-07-09 | 2024-07-16 | 达因疗法公司 | 肌肉靶向复合物及其用于治疗肌养蛋白病的用途 |
WO2023283624A2 (en) * | 2021-07-09 | 2023-01-12 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
EP4392452A1 (en) * | 2021-08-23 | 2024-07-03 | Concept to Medicine Biotech Co., Ltd. | Antibody prodrugs with constant domains |
US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
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-
2017
- 2017-03-20 DK DK17711223.2T patent/DK3433280T5/da active
- 2017-03-20 JP JP2018549865A patent/JP7015244B2/ja active Active
- 2017-03-20 ES ES17711223T patent/ES2947230T3/es active Active
- 2017-03-20 RS RS20230438A patent/RS64266B1/sr unknown
- 2017-03-20 HR HRP20230528TT patent/HRP20230528T1/hr unknown
- 2017-03-20 MX MX2018011542A patent/MX2018011542A/es unknown
- 2017-03-20 UA UAA201810280A patent/UA127308C2/uk unknown
- 2017-03-20 HU HUE17711223A patent/HUE061946T2/hu unknown
- 2017-03-20 LT LTEPPCT/EP2017/056556T patent/LT3433280T/lt unknown
- 2017-03-20 PE PE2023001613A patent/PE20231511A1/es unknown
- 2017-03-20 FI FIEP17711223.2T patent/FI3433280T3/fi active
- 2017-03-20 RU RU2018136567A patent/RU2018136567A/ru unknown
- 2017-03-20 PL PL17711223.2T patent/PL3433280T3/pl unknown
- 2017-03-20 SI SI201731359T patent/SI3433280T1/sl unknown
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2018
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- 2018-07-24 ZA ZA2018/04973A patent/ZA201804973B/en unknown
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2022
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PH12018502035A1 (en) | 2019-07-08 |
US11242390B2 (en) | 2022-02-08 |
US20230119537A1 (en) | 2023-04-20 |
RU2018136567A3 (da) | 2021-02-19 |
HRP20230528T1 (hr) | 2023-08-04 |
IL260637A (da) | 2018-09-20 |
RU2018136567A (ru) | 2020-04-22 |
PE20231511A1 (es) | 2023-09-26 |
JP2019514850A (ja) | 2019-06-06 |
CL2018002507A1 (es) | 2018-12-21 |
HUE061946T2 (hu) | 2023-09-28 |
FI3433280T3 (fi) | 2023-06-06 |
US20220275087A1 (en) | 2022-09-01 |
RS64266B1 (sr) | 2023-07-31 |
PL3433280T3 (pl) | 2023-07-31 |
MX2018011542A (es) | 2019-02-07 |
DK3433280T5 (da) | 2024-09-16 |
ES2947230T3 (es) | 2023-08-03 |
ZA201804973B (en) | 2023-02-22 |
US20190119383A1 (en) | 2019-04-25 |
IL260637B1 (en) | 2023-04-01 |
UA127308C2 (uk) | 2023-07-19 |
IL260637B2 (en) | 2023-08-01 |
LT3433280T (lt) | 2023-07-10 |
JP7015244B2 (ja) | 2022-02-02 |
SI3433280T1 (sl) | 2023-07-31 |
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