NZ630568A - Methods and means for the production of ch3 domain-comprising molecules - Google Patents

Methods and means for the production of ch3 domain-comprising molecules

Info

Publication number
NZ630568A
NZ630568A NZ630568A NZ63056813A NZ630568A NZ 630568 A NZ630568 A NZ 630568A NZ 630568 A NZ630568 A NZ 630568A NZ 63056813 A NZ63056813 A NZ 63056813A NZ 630568 A NZ630568 A NZ 630568A
Authority
NZ
New Zealand
Prior art keywords
domain
amino acid
polypeptide chain
acid residue
molecule
Prior art date
Application number
NZ630568A
Inventor
Kruif Cornelis Adriaan De
Linda Johanna Aleida Hendriks
Ton Logtenberg
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv filed Critical Merus Nv
Publication of NZ630568A publication Critical patent/NZ630568A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is an in vitro method for producing a heterodimeric CH3 domain-comprising molecule from a single cell, wherein said molecule comprises two CH3 domains that are capable of forming an interface, said method comprising providing in said cell a. A first nucleic acid molecule encoding a 1st CH3 domain-comprising polypeptide chain, b. A second nucleic acid molecule encoding a 2nd CH3 domain-comprising polypeptide chain, wherein said first CH3 domain-comprising polypeptide chain comprises at least one substitution of a neutral amino acid residue by a positively charged amino acid residue and wherein said second CH3 domain-comprising polypeptide chain comprises at least one substitution of a neutral amino acid residue by a negatively charged amino acid residue, said method further comprising the step of culturing said host cell and allowing for expression of said two nucleic acid molecules and harvesting said heterodimeric CH3 domain-comprising molecule from the culture.
NZ630568A 2012-04-20 2013-04-19 Methods and means for the production of ch3 domain-comprising molecules NZ630568A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261635935P 2012-04-20 2012-04-20
PCT/NL2013/050294 WO2013157954A1 (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules

Publications (1)

Publication Number Publication Date
NZ630568A true NZ630568A (en) 2017-06-30

Family

ID=48289584

Family Applications (4)

Application Number Title Priority Date Filing Date
NZ799532A NZ799532A (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules
NZ630568A NZ630568A (en) 2012-04-20 2013-04-19 Methods and means for the production of ch3 domain-comprising molecules
NZ630551A NZ630551A (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules
NZ772318A NZ772318A (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ799532A NZ799532A (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules

Family Applications After (2)

Application Number Title Priority Date Filing Date
NZ630551A NZ630551A (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules
NZ772318A NZ772318A (en) 2012-04-20 2013-04-19 Methods and means for the production of ig-like molecules

Country Status (24)

Country Link
US (11) US20150196637A1 (en)
EP (4) EP3594232A1 (en)
JP (7) JP6272299B2 (en)
KR (8) KR102171431B1 (en)
CN (5) CN114163530A (en)
AU (4) AU2013249986B2 (en)
CA (2) CA2870821C (en)
CY (2) CY1122153T1 (en)
DK (2) DK2838918T3 (en)
EA (3) EA035344B1 (en)
ES (2) ES2740749T3 (en)
HK (2) HK1206039A1 (en)
HR (2) HRP20191409T1 (en)
HU (2) HUE045945T2 (en)
LT (2) LT2838917T (en)
MX (4) MX360110B (en)
NZ (4) NZ799532A (en)
PL (2) PL2838918T3 (en)
PT (2) PT2838918T (en)
RS (2) RS59260B1 (en)
SG (6) SG10201913634VA (en)
SI (2) SI2838918T1 (en)
WO (2) WO2013157954A1 (en)
ZA (2) ZA201407835B (en)

Families Citing this family (387)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
ES2368733T3 (en) 2002-07-18 2011-11-21 Merus B.V. RECOMBINANT PRODUCTION OF MIXTURES OF ANTIBODIES.
EP1639009B1 (en) 2003-05-30 2013-02-27 Merus B.V. Fab library for the preparation of a mixture of antibodies
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CA2603408C (en) 2005-03-31 2018-08-21 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
EP3345616A1 (en) 2006-03-31 2018-07-11 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
ES2568436T3 (en) 2006-03-31 2016-04-29 Chugai Seiyaku Kabushiki Kaisha Procedure to control the blood pharmacokinetics of antibodies
WO2008027986A2 (en) 2006-09-01 2008-03-06 Therapeutic Human Polyclonals, Inc. Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
PL2059532T3 (en) 2006-09-07 2013-05-31 Crucell Holland Bv Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
BRPI0817294A2 (en) 2007-09-26 2015-03-17 Chugai Pharmaceutical Co Ltd Method of modifying antibody isoelectric point via amino acid substitution in cdr.
EP2194066B1 (en) 2007-09-26 2016-03-09 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant region
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
TWI544077B (en) 2009-03-19 2016-08-01 Chugai Pharmaceutical Co Ltd Antibody constant region change body
JP5717624B2 (en) 2009-03-19 2015-05-13 中外製薬株式会社 Antibody constant region variants
CA2757931C (en) 2009-04-07 2019-03-26 Roche Glycart Ag Trivalent, bispecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
NZ598962A (en) 2009-09-16 2014-12-24 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
EP2481752B1 (en) 2009-09-24 2016-11-09 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant regions
EP2501817B2 (en) 2010-02-08 2021-04-21 Regeneron Pharmaceuticals, Inc. Common light chain mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US10435458B2 (en) 2010-03-04 2019-10-08 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variants with reduced Fcgammar binding
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
WO2012016227A2 (en) 2010-07-29 2012-02-02 Xencor, Inc. Antibodies with modified isoelectric points
TR201802772T4 (en) 2010-11-17 2018-03-21 Chugai Pharmaceutical Co Ltd Multi-specific antigen binding molecule with alternative function for the function of blood coagulation factor VIII.
CN103502271B (en) 2011-02-28 2016-10-26 霍夫曼-拉罗奇有限公司 Antigen-binding proteins
MX342034B (en) 2011-02-28 2016-09-12 Hoffmann La Roche Monovalent antigen binding proteins.
CN103533951B (en) 2011-04-08 2017-04-19 安姆根有限公司 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
JP6510234B2 (en) 2011-08-05 2019-05-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Humanized universal light chain mouse
JP6159724B2 (en) 2011-08-23 2017-07-05 ロシュ グリクアート アーゲー Bispecific antibodies and tumor antigens specific for T cell activating antigens and methods of use
CA2791109C (en) 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
BR112014010257A2 (en) 2011-10-31 2017-04-18 Chugai Pharmaceutical Co Ltd antigen binding molecule having regulated conjugation between heavy and light chains
EA201491413A1 (en) 2012-01-26 2015-03-31 Эмджен Инк. POLYPEPTIDE GROWTH FACTOR AND DIFFERENTIATION 15 (GDF-15)
EA035344B1 (en) * 2012-04-20 2020-05-29 Мерюс Н.В. Method for producing two antibodies from a single host cell
EP2869845B1 (en) 2012-07-06 2019-08-28 Genmab B.V. Dimeric protein with triple mutations
PL2900694T3 (en) 2012-09-27 2018-12-31 Merus N.V. Bispecific igg antibodies as t cell engagers
US10087250B2 (en) 2012-10-08 2018-10-02 Roche Glycart Ag Fc-free antibodies comprising two fab-fragments and methods of use
US9951145B2 (en) 2012-11-27 2018-04-24 Ajou University Industry—Academic Cooperation Foundation CH3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
AU2014205086B2 (en) 2013-01-14 2019-04-18 Xencor, Inc. Novel heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
EP2945969A1 (en) 2013-01-15 2015-11-25 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
BR112015015824B1 (en) 2013-02-26 2020-09-24 Roche Glycart Ag MOLECULE THAT BINDES THE BIESPECIFIC ANTIGEN THAT ACTIVATES T CELLS, ISOLATED POLYNUCLEOTIDE OR POLYNUCLEOTIDE PLURALITY, VECTOR, METHOD TO PRODUCE A MOLECULE, PHARMACEUTICAL COMPOSITION AND USE OF THE MOLECULE
EP2961773B1 (en) 2013-02-26 2019-03-20 Roche Glycart AG Bispecific t cell activating antigen binding molecules
US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
EP2970486B1 (en) 2013-03-15 2018-05-16 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
TW201920285A (en) 2013-04-29 2019-06-01 瑞士商赫孚孟拉羅股份公司 FcRn-binding abolished anti-IGF-1R antibodies and their use in the treatment of vascular eye diseases
KR102266819B1 (en) 2013-04-29 2021-06-18 에프. 호프만-라 로슈 아게 Fc-receptor binding modified asymmetric antibodies and methods of use
ES2746136T3 (en) 2013-04-29 2020-03-04 Hoffmann La Roche Modified Human FcRn Binding Antibodies and Methods of Use
JP6509852B2 (en) 2013-07-31 2019-05-08 アムジエン・インコーポレーテツド Constructs of growth differentiation factor 15 (GDF-15)
BR112016006197B1 (en) 2013-09-27 2023-04-11 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A BISPECIFIC POLYPEPTIDE ANTIBODY
MX2016003593A (en) 2013-10-11 2016-06-02 Hoffmann La Roche Multispecific domain exchanged common variable light chain antibodies.
AU2014368696A1 (en) 2013-12-20 2016-06-02 F. Hoffmann-La Roche Ag Humanized anti-Tau(pS422) antibodies and methods of use
JP6476194B2 (en) 2014-01-03 2019-02-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Bispecific anti-hapten / anti-blood brain barrier receptor antibodies, complexes thereof, and their use as blood brain barrier shuttles
ES2864160T3 (en) 2014-01-06 2021-10-13 Hoffmann La Roche Monovalent Blood Brain Barrier Shuttle Modules
MX2016008539A (en) 2014-01-15 2016-09-26 Hoffmann La Roche Fc-region variants with modified fcrn- and maintained protein a-binding properties.
ES2826774T3 (en) 2014-02-28 2021-05-19 Merus Nv Antibody that binds to ERBB-2 and ERBB-3
JP6771385B2 (en) 2014-02-28 2020-10-21 メルス ナムローゼ フェンノートシャップ Bispecific antibody and pharmaceutical composition
AU2015230938C1 (en) 2014-03-21 2021-10-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
RS59907B1 (en) 2014-03-28 2020-03-31 Xencor Inc Bispecific antibodies that bind to cd38 and cd3
UA117289C2 (en) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Multispecific antibodies
CN113092788A (en) 2014-04-02 2021-07-09 豪夫迈·罗氏有限公司 Method for detecting light chain mismatch of multispecific antibody
AR100978A1 (en) 2014-06-26 2016-11-16 Hoffmann La Roche ANTI-Tau HUMANIZED ANTIBODY BRAIN LAUNCHERS (pS422) AND USES OF THE SAME
JP6654581B2 (en) 2014-06-26 2020-02-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Anti-BRDU antibodies and methods of use
FI3608337T3 (en) 2014-08-04 2024-06-13 Hoffmann La Roche Bispecific t cell activating antigen binding molecules
EP2982692A1 (en) 2014-08-04 2016-02-10 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
AU2015329965A1 (en) 2014-10-09 2017-04-27 Engmab Sàrl Bispecific antibodies against CD3epsilon and ROR1
MX2017005150A (en) 2014-11-06 2017-08-08 Hoffmann La Roche Fc-region variants with modified fcrn- and protein a-binding properties.
EP3215528B1 (en) 2014-11-06 2019-08-07 F.Hoffmann-La Roche Ag Fc-region variants with modified fcrn-binding and methods of use
EP3023437A1 (en) 2014-11-20 2016-05-25 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
CN107206072B (en) 2014-11-20 2022-01-21 豪夫迈·罗氏有限公司 Combination therapy of the T cell activating bispecific antigen binding molecule CD3 ABD folate receptor 1(FolR1) and a PD-1 axis binding antagonist
CA2968878A1 (en) 2014-11-26 2016-06-02 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cd38
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
RS62332B1 (en) 2014-11-26 2021-10-29 Xencor Inc Heterodimeric antibodies that bind cd3 and cd20
CN107001482B (en) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 Multispecific antibodies
WO2016105450A2 (en) 2014-12-22 2016-06-30 Xencor, Inc. Trispecific antibodies
CN110655582B (en) * 2015-01-08 2022-12-16 江苏康宁杰瑞生物制药有限公司 Bispecific antibodies or antibody mixtures with a common light chain
WO2016141387A1 (en) 2015-03-05 2016-09-09 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
WO2016149678A1 (en) 2015-03-19 2016-09-22 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
EP3274457A4 (en) * 2015-03-26 2018-08-08 Acceleron Pharma Inc. Follistatin-related fusion proteins and uses thereof
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
EP3744732A1 (en) 2015-06-24 2020-12-02 F. Hoffmann-La Roche AG Humanized anti-tau(ps422) antibodies and methods of use
HUE049072T2 (en) 2015-07-10 2020-09-28 Genmab As Axl-specific antibody-drug conjugates for cancer treatment
WO2017010874A1 (en) 2015-07-10 2017-01-19 Merus N.V. Human cd3 binding antibody
NZ739028A (en) 2015-07-15 2023-05-26 Genmab As Humanized or chimeric cd3 antibodies
JP6622396B2 (en) 2015-08-26 2019-12-18 バイソン セラピュイティクス インコーポレイテッド Multispecific antibody platform and related methods
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
WO2017055404A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific antibodies specific for pd1 and tim3
WO2017055393A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules
WO2017055388A2 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific t cell activating antigen binding molecules
EP3150637A1 (en) 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Multispecific antibodies
WO2017055395A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-cd3xrob04 bispecific t cell activating antigen binding molecules
WO2017055392A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules
EP3913000A1 (en) 2015-10-02 2021-11-24 F. Hoffmann-La Roche AG Bispecific anti-cd19xcd3 t cell activating antigen binding molecules
AR106365A1 (en) 2015-10-02 2018-01-10 Hoffmann La Roche BISPECIFIC MOLECULES OF ANTIGEN BINDING TO T-CELL ACTIVATORS
EP3356410B1 (en) 2015-10-02 2021-10-20 F. Hoffmann-La Roche AG Bispecific anti-ceaxcd3 t cell activating antigen binding molecules
WO2017055385A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-cd3xgd2 bispecific t cell activating antigen binding molecules
CN108139394B (en) 2015-10-02 2020-10-30 豪夫迈·罗氏有限公司 Cell-based FRET assay for determining simultaneous binding
KR101851380B1 (en) 2015-10-12 2018-04-23 아주대학교산학협력단 Method to generate CH3 domain mutant pairs of heterodimeric Fc using yeast mating and CH3 domain mutant pairs thereby
SG11201803359VA (en) 2015-10-23 2018-05-30 Merus Nv Binding molecules that inhibit cancer growth
EP3368568B1 (en) 2015-10-29 2022-04-06 F. Hoffmann-La Roche AG Anti-variant fc-region antibodies and methods of use
CN113862300A (en) * 2015-10-29 2021-12-31 豪夫迈·罗氏有限公司 Transgenic rabbits with common light chain
EP3387013B1 (en) 2015-12-07 2022-06-08 Xencor, Inc. Heterodimeric antibodies that bind cd3 and psma
EP3178848A1 (en) 2015-12-09 2017-06-14 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
EP4026848A1 (en) 2015-12-09 2022-07-13 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody for reducing the cytokine release syndrome
CN106883297B (en) * 2015-12-16 2019-12-13 苏州康宁杰瑞生物科技有限公司 CH3 domain-based heterodimer molecule, preparation method and application thereof
AU2016381992B2 (en) 2015-12-28 2024-01-04 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of Fc region-containing polypeptide
ES2837428T3 (en) 2016-01-08 2021-06-30 Hoffmann La Roche CEA-Positive Cancer Treatment Procedures Using PD-1 Axis Binding Antagonists and Anti-CEA / Anti-CD3 Bispecific Antibodies
AU2017233658B2 (en) 2016-03-14 2023-09-21 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
CA3016563A1 (en) 2016-03-21 2017-09-28 Elstar Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
SI3433280T1 (en) 2016-03-22 2023-07-31 F. Hoffmann-La Roche Ag Protease-activated t cell bispecific molecules
WO2017186853A1 (en) * 2016-04-27 2017-11-02 Bcrt Holding Bv T cell-based bi-specific immunotherapeutics
BR112018069890A2 (en) 2016-05-02 2019-02-05 Hoffmann La Roche target-specific fusion polypeptide, dimeric fusion polypeptide, isolated nucleic acid, isolated nucleic acid pair, host cell, method for producing a fusion polypeptide, immunoconjugate, pharmaceutical formulation, fusion polypeptide and use of the fusion polypeptide
JP7301540B2 (en) * 2016-05-26 2023-07-03 チールー ピュージェット サウンド バイオセラピューティクス コーポレイション mixture of antibodies
TW201902512A (en) 2016-06-02 2019-01-16 瑞士商赫孚孟拉羅股份公司 treatment method
EP3252078A1 (en) 2016-06-02 2017-12-06 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
US10787518B2 (en) 2016-06-14 2020-09-29 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
WO2018005706A1 (en) 2016-06-28 2018-01-04 Xencor, Inc. Heterodimeric antibodies that bind somatostatin receptor 2
CN109415435B (en) 2016-07-04 2024-01-16 豪夫迈·罗氏有限公司 Novel antibody forms
CN117247458A (en) 2016-07-14 2023-12-19 健玛保 Multispecific antibodies to CD40 and CD137
BR112019002394B1 (en) 2016-08-10 2021-12-21 Ajou University Industry-Academic Cooperation Foundation HETERODIMERIC PROTEIN FLUTED WITH CF AND ITS USE
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
MX2019003241A (en) 2016-09-23 2019-11-12 Merus Nv Binding molecules that modulate a biological activity expressed by a cell.
BR112019006074A2 (en) * 2016-09-29 2019-06-18 Beijing Hanmi Pharmaceutical Co Ltd heterodimer, method of producing the heterodimer, methods of producing a heterodimer, nucleic acid, vector or vector system, cell, pharmaceutical composition and method of treating or preventing a disease or disorder in a subject in need thereof
CN109791149A (en) 2016-09-30 2019-05-21 豪夫迈·罗氏有限公司 The dual combination measuring method based on SPR for functional analysis multispecific molecule
CN109843926B (en) 2016-09-30 2023-01-20 豪夫迈·罗氏有限公司 Bispecific antibodies against CD3
US10550185B2 (en) 2016-10-14 2020-02-04 Xencor, Inc. Bispecific heterodimeric fusion proteins containing IL-15-IL-15Rα Fc-fusion proteins and PD-1 antibody fragments
KR20240000650A (en) * 2016-10-19 2024-01-02 인벤라 인코포레이티드 Antibody constructs
KR20190070977A (en) 2016-11-01 2019-06-21 젠맵 비. 브이 Polypeptide variants and uses thereof
TW201829463A (en) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 Anti-hla-g antibodies and use thereof
CA3043652A1 (en) 2016-11-18 2018-05-24 Beijing Hanmi Pharmaceutical Co., Ltd. Anti-pd-1/anti-her2 natural antibody structural heterodimeric bispecific antibody and method of preparing the same
EP3565833A1 (en) 2017-01-09 2019-11-13 Torch Therapeutics Conditionally effective bispecific therapeutics
CN110944651A (en) 2017-02-08 2020-03-31 蜻蜓疗法股份有限公司 Multispecific binding proteins for natural killer cell activation and therapeutic uses thereof for treating cancer
KR20240101717A (en) 2017-02-10 2024-07-02 젠맵 비. 브이 Polypeptide variants and uses thereof
US20200291089A1 (en) 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
ES2955074T3 (en) 2017-02-20 2023-11-28 Dragonfly Therapeutics Inc Proteins that bind to HER2, NKG2D and CD16
EP3586872A4 (en) * 2017-02-24 2020-12-30 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition, antigen-binding molecules, treatment method, and screening method
SG11201908088RA (en) 2017-03-09 2019-10-30 Genmab As Antibodies against pd-l1
SG11201908127WA (en) 2017-03-10 2019-10-30 Hoffmann La Roche Method for producing multispecific antibodies
EP3601354A1 (en) 2017-03-31 2020-02-05 Genmab Holding B.V. Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
WO2018182422A1 (en) 2017-03-31 2018-10-04 Merus N.V. Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
AU2018246872C1 (en) 2017-03-31 2023-05-18 Merus N.V. ErbB-2 targeting agent and a bispecific antibody with antigen-binding sites that bind an epitope on an extracellular part of erb-2 and erbB-3, for treatment of an individual with an erbB-2, erbB-2/erbB-3 positive tumour
US20200291130A1 (en) 2017-03-31 2020-09-17 Merus N.V. Antibodies for the treatment of erbb-2/erbb-3 positive tumors
MX2019011748A (en) * 2017-04-01 2020-01-23 Beijing hanmi pharm co ltd Anti-pd-l1/anti-pd-1 natural antibody structure-like heterodimeric bispecific antibody and preparation thereof.
MA49289A (en) 2017-04-03 2020-02-12 Hoffmann La Roche ANTIBODIES BINDING TO STEAP-1
EP4201953A1 (en) 2017-04-03 2023-06-28 F. Hoffmann-La Roche AG Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
JP7148539B2 (en) 2017-04-03 2022-10-05 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト immunoconjugate
CA3052532A1 (en) 2017-04-05 2018-10-11 F. Hoffmann-La Roche Ag Bispecific antibodies specifically binding to pd1 and lag3
JOP20190222A1 (en) 2017-04-11 2019-09-24 Zymeworks Inc Anti-pd-l1-anti-tim-3 bispecific antibodies
BR112019021411A2 (en) 2017-04-13 2020-05-05 Hoffmann La Roche methods to treat or slow the progression of cancer and to improve function, uses of an immunoconjugate, an agonist, an antagonist, compositions, kit and invention
MX2019013804A (en) 2017-05-17 2020-02-24 Merus Nv Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer.
WO2018222901A1 (en) 2017-05-31 2018-12-06 Elstar Therapeutics, Inc. Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
EP3635005A1 (en) 2017-06-07 2020-04-15 Genmab B.V. Therapeutic antibodies based on mutated igg hexamers
WO2018228442A1 (en) * 2017-06-14 2018-12-20 Dingfu Biotarget Co., Ltd. Proteinaceous heterodimer and use thereof
GB201709970D0 (en) 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
JP2020529832A (en) 2017-06-30 2020-10-15 ゼンコア インコーポレイテッド Targeted heterodimer Fc fusion protein containing IL-15 / IL-15Rα and antigen binding domain
CA3068933A1 (en) 2017-07-06 2019-01-10 Merus N.V. Antibodies that modulate a biological activity expressed by a cell
BR112020000209A8 (en) * 2017-07-06 2020-08-11 Merus Nv binding molecules that modulate a biological activity expressed by a cell
EA202090004A1 (en) 2017-07-06 2020-06-18 Мерус Н.В. BSPECIFIC ANTIBODIES AGAINST PD-1 AND AGAINST TIM-3
AR112603A1 (en) 2017-07-10 2019-11-20 Lilly Co Eli BIS SPECIFIC ANTIBODIES CONTROL POINT INHIBITORS
WO2019014912A1 (en) * 2017-07-21 2019-01-24 赵磊 Heterodimeric protein and preparation method thereof
MX2020001198A (en) 2017-08-04 2020-09-07 Genmab As Binding agents binding to pd-l1 and cd137 and use thereof.
TW201910354A (en) 2017-08-09 2019-03-16 荷蘭商美勒斯公司 Antibodies that bind to epidermal growth factor receptor (EGFR) and cMET
US20200317783A1 (en) 2017-10-06 2020-10-08 Ono Pharmaceutical Co., Ltd. Bispecific antibody
WO2019077092A1 (en) 2017-10-20 2019-04-25 F. Hoffmann-La Roche Ag Method for generating multispecific antibodies from monospecific antibodies
TWI832824B (en) 2017-10-30 2024-02-21 瑞士商赫孚孟拉羅股份公司 Method for in vivo generation of multispecific antibodies from monospecific antibodies
WO2019086394A1 (en) 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag The compbody - a multivalent target binder
US20210324108A1 (en) 2017-11-01 2021-10-21 Hoffmann-La Roche Inc. Bispecific 2+1 contorsbodies
EP3703746A1 (en) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Novel tnf family ligand trimer-containing antigen binding molecules
JP7092881B2 (en) 2017-11-01 2022-06-28 エフ．ホフマン－ラ ロシュ アーゲー TriFab Contour Body
US10981992B2 (en) 2017-11-08 2021-04-20 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
WO2019094637A1 (en) 2017-11-08 2019-05-16 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-pd-1 sequences
CN111432838A (en) 2017-12-01 2020-07-17 美勒斯公司 Combination therapy with bispecific antibody and I L-15
BR112020011295A2 (en) 2017-12-04 2020-11-24 Beijing Hanmi Pharmaceutical Co., Ltd. bispecific anti-pd-l1 / anti-cd47 antibody with structure similar to the natural antibody and in the form of heterodimer and preparation thereof
CN111655718A (en) 2017-12-19 2020-09-11 Xencor股份有限公司 Engineered IL-2 FC fusion proteins
CN111527107A (en) 2017-12-21 2020-08-11 豪夫迈·罗氏有限公司 Antibodies that bind HLA-A2/WT1
CN111491951B (en) 2017-12-22 2024-05-24 豪夫迈·罗氏有限公司 Antibody variants depleted of light chain mismatches by hydrophobic interaction chromatography
EP3743440A1 (en) 2018-01-24 2020-12-02 Genmab B.V. Polypeptide variants and uses thereof
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
CN111699004A (en) 2018-02-06 2020-09-22 豪夫迈·罗氏有限公司 Treatment of ophthalmic disorders
WO2019153200A1 (en) 2018-02-08 2019-08-15 北京韩美药品有限公司 Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody in heterodimeric form and preparation thereof
EP3749346B1 (en) 2018-02-08 2024-07-10 Dragonfly Therapeutics, Inc. Antibody variable domain combinations targeting the nkg2d receptor
AR115360A1 (en) 2018-02-08 2021-01-13 Genentech Inc ANTIGEN BINDING MOLECULES AND METHODS OF USE
TWI804572B (en) 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 Bispecific antibody
TWI829667B (en) 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 Antibodies binding to gprc5d
CA3090878A1 (en) * 2018-02-11 2019-08-15 Beijing Hanmi Pharmaceutical Co., Ltd. Anti-pd-1/anti-vegf natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof
WO2019178364A2 (en) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
US20210238280A1 (en) 2018-03-14 2021-08-05 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
EA202091871A1 (en) * 2018-03-30 2021-06-22 Мерус Н.В. POLISHING ANTIBODY
AU2019247415A1 (en) 2018-04-04 2020-10-22 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
BR112020020823A2 (en) 2018-04-09 2021-01-19 Amgen Inc. GROWTH DIFFERENTIATION FACTOR FUSION PROTEINS 15
WO2019204522A1 (en) * 2018-04-17 2019-10-24 Invenra Inc. Binding molecules
WO2019204655A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
AR115052A1 (en) 2018-04-18 2020-11-25 Hoffmann La Roche MULTI-SPECIFIC ANTIBODIES AND THE USE OF THEM
MX2020010910A (en) 2018-04-18 2021-02-09 Xencor Inc Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof.
EP3788074A1 (en) 2018-05-03 2021-03-10 Genmab B.V. Antibody variant combinations and uses thereof
US12012461B2 (en) 2018-05-16 2024-06-18 Janssen Biotech, Inc. Methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics
SG11202011461TA (en) 2018-06-01 2020-12-30 Compugen Ltd Anti-pvrig/anti-tigit bispecific antibodies and methods of use
MX2020013348A (en) 2018-06-09 2021-03-09 Boehringer Ingelheim Int Dll3-cd3 bispecific antibodies.
WO2019243636A1 (en) 2018-06-22 2019-12-26 Genmab Holding B.V. Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof
EP3818083A2 (en) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
MA53123A (en) 2018-07-13 2021-05-19 Genmab As TROGOCYTOSIS MEDIATION THERAPY USING CD38 ANTIBODIES
KR20210031932A (en) 2018-07-13 2021-03-23 젠맵 에이/에스 Variants of CD38 antibody and uses thereof
GB2576914A (en) 2018-09-06 2020-03-11 Kymab Ltd Antigen-binding molecules comprising unpaired variable domains produced in mammals
CA3113605A1 (en) 2018-09-19 2020-03-26 Lava Therapeutics B.V. Novel bispecific antibodies for use in the treatment of hematological malignancies
JP2022503959A (en) 2018-10-03 2022-01-12 ゼンコア インコーポレイテッド IL-12 heterodimer FC-fusion protein
WO2020070313A1 (en) 2018-10-04 2020-04-09 Genmab Holding B.V. Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
SG11202104136YA (en) 2018-10-23 2021-05-28 Dragonfly Therapeutics Inc Heterodimeric fc-fused proteins
UA128258C2 (en) 2018-10-29 2024-05-22 Ф. Хоффманн-Ля Рош Аг Antibody formulation
US20210369842A1 (en) 2018-11-06 2021-12-02 Genmab A/S Antibody formulation
WO2020115115A1 (en) 2018-12-05 2020-06-11 Morphosys Ag Multispecific antigen-binding molecules
GB201820687D0 (en) 2018-12-19 2019-01-30 Kymab Ltd Antagonists
TW202034952A (en) 2018-12-20 2020-10-01 荷蘭商美勒斯公司 Clec12axcd3 bispecific antibodies and methods for the treatment of disease
AR117727A1 (en) 2018-12-21 2021-08-25 Hoffmann La Roche ANTIBODIES THAT JOIN CD3
HRP20220088T1 (en) 2018-12-21 2022-04-15 Kymab Limited Fixaxfx bispecific antibody with common light chain
CN113412123A (en) 2018-12-28 2021-09-17 豪夫迈·罗氏有限公司 peptide-MHC-I-antibody fusion proteins for therapeutic use in patients with enhanced immune response
BR112021013009A2 (en) 2018-12-31 2021-09-14 Merus N.V. MIXED CONNECTION DOMAINS
CN113439089A (en) 2018-12-31 2021-09-24 美勒斯公司 Truncated multivalent multimers
EP3908311A1 (en) 2019-01-10 2021-11-17 Janssen Biotech, Inc. Prostate neoantigens and their uses
NL2022494B1 (en) 2019-02-01 2020-08-19 Lava Therapeutics B V Novel CD40-binding antibodies
JP2022519082A (en) 2019-02-01 2022-03-18 ラヴァ・セラピューティクス・ベー・フェー New CD40 binding antibody
CN114409798A (en) * 2019-02-14 2022-04-29 美勒斯公司 Preparation of a composition comprising two or more antibodies
BR112021016094A2 (en) 2019-02-14 2021-10-26 Merus N.V. COMBINATIONS OF BINDING PORTIONS THAT BIND TO EGFR, HER2 AND HER3
KR20210126699A (en) 2019-02-14 2021-10-20 메뤼스 엔.페. Preparation of Compositions Comprising Two or More Antibodies
SG11202109056TA (en) 2019-02-21 2021-09-29 Marengo Therapeutics Inc Multifunctional molecules that bind to calreticulin and uses thereof
SG11202109122SA (en) 2019-02-21 2021-09-29 Marengo Therapeutics Inc Anti-tcr antibody molecules and uses thereof
CA3130628A1 (en) 2019-02-21 2020-08-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
AU2020226893A1 (en) 2019-02-21 2021-09-23 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
EP3927747A1 (en) 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
US11472890B2 (en) 2019-03-01 2022-10-18 Xencor, Inc. Heterodimeric antibodies that bind ENPP3 and CD3
KR20210144837A (en) * 2019-03-28 2021-11-30 에이비 스튜디오 인코포레이티드 Heteromultimeric proteins and methods of use thereof
CN113646622A (en) 2019-03-29 2021-11-12 豪夫迈·罗氏有限公司 Spr-based binding assay for functional analysis of multivalent molecules
CN113677701A (en) 2019-03-29 2021-11-19 豪夫迈·罗氏有限公司 Method for generating affinity binding multispecific antibodies
TW202039578A (en) 2019-03-29 2020-11-01 荷蘭商美勒斯公司 Cd3 binding molecules
EP3959244A1 (en) 2019-04-25 2022-03-02 F. Hoffmann-La Roche AG Generation of antibody-derived polypeptides by polypeptide chain exchange
BR112021021210A2 (en) 2019-04-25 2021-12-21 Hoffmann La Roche Set of polypeptides, method for generating a heterodimeric polypeptide, first heterodimeric precursor polypeptide, second heterodimeric precursor polypeptide, and pharmaceutical composition
CA3132494A1 (en) 2019-04-25 2020-10-29 Ulrich Brinkmann Therapeutic multispecific polypeptides activated by polypeptide chain exchange
CN114702587A (en) * 2019-05-09 2022-07-05 美勒斯公司 Variant domains and their isolation for multimerizing proteins
JP2022531894A (en) 2019-05-09 2022-07-12 ゲンマブ ビー．ブイ． Administration regimen of anti-DR5 antibody combination for use in the treatment of cancer
JP7273195B2 (en) 2019-05-13 2023-05-12 エフ． ホフマン－ラ ロシュ アーゲー Interference suppression pharmacokinetic immunoassay
JP7317353B2 (en) * 2019-06-18 2023-07-31 株式会社プロテイン・エクスプレス Production of heterodimeric proteins by Brevibacillus
KR20220010024A (en) 2019-06-19 2022-01-25 에프. 호프만-라 로슈 아게 Method for generation of protein-expressing cells by targeted integration using CRE mRNA
BR112021026286A2 (en) 2019-06-26 2022-03-03 Hoffmann La Roche Method for increasing the heterologous polypeptide titer and/or reducing lactate production of a recombinant mammalian cell and methods for producing a heterologous polypeptide and a recombinant mammalian cell
EP3994169A1 (en) 2019-07-02 2022-05-11 F. Hoffmann-La Roche AG Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody
WO2021006199A1 (en) 2019-07-05 2021-01-14 小野薬品工業株式会社 Treatment of hematologic cancer with pd-1/cd3 dual specificity protein
AR119393A1 (en) 2019-07-15 2021-12-15 Hoffmann La Roche ANTIBODIES THAT BIND NKG2D
CR20220025A (en) 2019-07-26 2022-05-04 Janssen Biotech Inc Proteins comprising kallikrein related peptidase 2 antigen binding domains and their uses
JP6856183B1 (en) 2019-07-30 2021-04-07 小野薬品工業株式会社 Bispecific antibody
CN114174338A (en) 2019-07-31 2022-03-11 豪夫迈·罗氏有限公司 Antibodies that bind to GPRC5D
AU2020323686B2 (en) 2019-07-31 2024-03-21 F. Hoffmann-La Roche Ag Antibodies binding to GPRC5D
WO2021025140A1 (en) 2019-08-08 2021-02-11 小野薬品工業株式会社 Dual-specific protein
MX2022001799A (en) 2019-08-15 2022-03-11 Janssen Biotech Inc Materials and methods for improved single chain variable fragments.
CA3151641A1 (en) 2019-08-19 2021-02-25 Merus N.V. Treatment of cancer with a combination of an antibody that binds lgr5 and egfr and a topoisomerase i inhibitor
EP3792283A1 (en) 2019-09-16 2021-03-17 Lava Therapeutics B.V. Treatment of cancer comprising administration of vgamma9vdelta2 t cell receptor binding antibodies
EP4048702A1 (en) 2019-10-24 2022-08-31 Merus N.V. Means and methods for treating subjects with her2 and her3 positive cancer
EP4051233A1 (en) 2019-11-01 2022-09-07 InnoCore Technologies Holding B.V. Dosage form for extended release of an antibody or large protein
EP4055046A1 (en) 2019-11-06 2022-09-14 Genmab B.V. Antibody variant combinations and uses thereof
US20220409732A1 (en) 2019-12-02 2022-12-29 Regeneron Pharmaceuticals, Inc. Peptide-mhc ii protein constructs and uses thereof
WO2021122733A1 (en) 2019-12-18 2021-06-24 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
WO2021122875A1 (en) 2019-12-18 2021-06-24 F. Hoffmann-La Roche Ag Antibodies binding to hla-a2/mage-a4
EP4085251B1 (en) 2020-01-02 2024-07-31 F. Hoffmann-La Roche AG Method for determining the amount of a therapeutic antibody in the brain
WO2021138407A2 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof
PE20230113A1 (en) 2020-01-16 2023-01-27 Genmab As FORMULATIONS OF ANTI-CD38 ANTIBODIES AND USES THEREOF
EP4097131A1 (en) 2020-01-29 2022-12-07 Merus N.V. Means and method for modulating immune cell engaging effects
IL295129A (en) 2020-01-30 2022-09-01 Umoja Biopharma Inc Bispecific transduction enhancer
WO2021155916A1 (en) 2020-02-04 2021-08-12 BioNTech SE Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
TW202144389A (en) 2020-02-14 2021-12-01 美商健生生物科技公司 Neoantigens expressed in multiple myeloma and their uses
TW202144388A (en) 2020-02-14 2021-12-01 美商健生生物科技公司 Neoantigens expressed in ovarian cancer and their uses
KR20230051616A (en) 2020-03-13 2023-04-18 얀센 바이오테크 인코포레이티드 Materials and methods for binding siglec-3/cd33
AR121599A1 (en) 2020-03-18 2022-06-22 Genmab As ANTIBODIES
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
US20230203466A1 (en) * 2020-04-03 2023-06-29 Medgenome Inc. Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment
US20230192795A1 (en) 2020-04-15 2023-06-22 Hoffmann-La Roche Inc. Immunoconjugates
CA3180321A1 (en) 2020-04-24 2021-10-28 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cell related cancer cells and uses thereof
EP4139357A1 (en) 2020-04-24 2023-03-01 Merus N.V. Treatment of cancers with an antibody that binds lgr5 and egfr
KR20230007384A (en) 2020-04-30 2023-01-12 브리스톨-마이어스 스큅 컴퍼니 treatment method
MX2022014134A (en) 2020-05-11 2022-11-30 Hoffmann La Roche Combination therapy with modified pbmcs and an immunoconjugate.
US11919956B2 (en) 2020-05-14 2024-03-05 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
JP2023526630A (en) * 2020-05-21 2023-06-22 メルス ナムローゼ フェンノートシャップ Methods and means for the production of IG-like molecules
US20220411504A1 (en) 2020-05-27 2022-12-29 Janssen Biotech, Inc. Proteins comprising cd3 antigen binding domains and uses thereof
CN115916826A (en) 2020-06-19 2023-04-04 豪夫迈·罗氏有限公司 Antibodies that bind to CD3 and FolR1
BR112022025574A2 (en) 2020-06-19 2023-01-03 Hoffmann La Roche ANTIBODIES THAT BINDS CD3, POLYNUCLEOTIDE ISOLATED, HOST CELL, METHOD FOR PRODUCING AN ANTIBODY THAT BINDS CD3 AND FOR TREAT A DISEASE IN AN INDIVIDUAL, PHARMACEUTICAL COMPOSITION, ANTIBODY FOR USE AND INVENTION
PE20231080A1 (en) 2020-06-19 2023-07-17 Hoffmann La Roche ANTIBODIES THAT BIND CD3 AND CD19
PE20230470A1 (en) 2020-06-19 2023-03-14 Hoffmann La Roche BINDING MOLECULES TO THE FC DOMAIN OF IMMUNE ACTIVATION
WO2021255146A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and cea
AU2021305396A1 (en) 2020-07-08 2023-02-09 LAVA Therapeutics N.V. Antibodies that bind PSMA and gamma-delta t cell receptors
EP4185388A1 (en) 2020-07-23 2023-05-31 Genmab B.V. A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
US11827708B2 (en) 2020-07-29 2023-11-28 Janssen Biotech, Inc. Proteins comprising HLA-G antigen binding domains and their uses
US20230272052A1 (en) 2020-07-31 2023-08-31 CureVac SE Nucleic acid encoded antibody mixtures
CA3187061A1 (en) 2020-08-06 2022-02-10 Karsten Beckmann Binding agents for coronavirus s protein
WO2022040482A1 (en) 2020-08-19 2022-02-24 Xencor, Inc. Anti-cd28 and/or anti-b7h3 compositions
CA3190755A1 (en) 2020-08-26 2022-03-03 Andreas Loew Multifunctional molecules that bind to calreticulin and uses thereof
CA3190573A1 (en) 2020-08-26 2022-03-03 Andreas Loew Methods of detecting trbc1 or trbc2
KR20230074144A (en) 2020-08-26 2023-05-26 마렝고 테라퓨틱스, 인크. Antibody molecules that bind to NKp30 and uses thereof
US20230312757A1 (en) 2020-09-10 2023-10-05 Genmab A/S Bispecific antibodies against cd3 and cd20 for treating chronic lymphocytic leukemia
AU2021340232A1 (en) 2020-09-10 2023-04-13 Genmab A/S Bispecific antibody against CD3 and CD20 in combination therapy for treating diffuse large B-cell lymphoma
WO2022063877A1 (en) 2020-09-24 2022-03-31 F. Hoffmann-La Roche Ag Mammalian cell lines with gene knockout
KR20230080437A (en) 2020-10-02 2023-06-07 젠맵 에이/에스 Antibodies capable of binding ROR2 and bispecific antibodies binding ROR2 and CD3
TW202231292A (en) 2020-10-13 2022-08-16 美商健生生物科技公司 Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv and/or viii
CA3199319A1 (en) 2020-10-22 2022-04-28 Janssen Biotech, Inc. Proteins comprising delta-like ligand 3 (dll3) antigen binding domains and their uses
CN117487015A (en) 2020-11-04 2024-02-02 美勒斯公司 Means and methods for treating subjects with ERBB3 mutation positive cancers
JP2023548249A (en) 2020-11-10 2023-11-15 上海齊魯制藥研究中心有限公司 Bispecific antibodies against claudin 18A2 and CD3 and uses thereof
IL303045A (en) 2020-12-10 2023-07-01 Lava Therapeutics N V Antibodies that bind gamma-delta t cell receptors
WO2022131912A1 (en) 2020-12-15 2022-06-23 Merus N.V. Treatment of cancers with an antibody that binds lgr5 and egfr
CA3204702A1 (en) 2020-12-17 2022-06-23 F. Hoffmann-La Roche Ag Anti-hla-g antibodies and use thereof
WO2022129313A1 (en) 2020-12-18 2022-06-23 F. Hoffmann-La Roche Ag Precursor proteins and kit for targeted therapy
AU2021401712A1 (en) 2020-12-18 2023-07-06 Merus N.V. Antibody composition
WO2022136140A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Oligonucleotides targeting xbp1
EP4274658A1 (en) 2021-01-06 2023-11-15 F. Hoffmann-La Roche AG Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody
WO2022148853A1 (en) 2021-01-11 2022-07-14 F. Hoffmann-La Roche Ag Immunoconjugates
JP2024512240A (en) 2021-02-18 2024-03-19 エフ． ホフマン－ラ ロシュ アーゲー Methods for elucidating complex multistep antibody interactions
JP2024507937A (en) 2021-02-26 2024-02-21 ラヴァ・セラピューティクス・エヌ・ヴイ Antibodies that bind to CD123 and gamma delta T cell receptors
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
AU2022232375A1 (en) 2021-03-09 2023-09-21 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
EP4305065A1 (en) 2021-03-10 2024-01-17 Xencor, Inc. Heterodimeric antibodies that bind cd3 and gpc3
MX2023011266A (en) 2021-03-24 2023-12-07 Janssen Biotech Inc Proteins comprising cd3 antigen binding domains and uses thereof.
CA3237992A1 (en) 2021-03-31 2022-10-06 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Truncated taci polypeptide and fusion protein and use thereof
BR112023020141A2 (en) 2021-03-31 2023-11-28 Merus Nv MULTI-SPECIFIC ANTIBODIES
KR20240004462A (en) 2021-04-08 2024-01-11 마렝고 테라퓨틱스, 인크. Multifunctional molecules that bind to TCR and their uses
CA3213632A1 (en) 2021-04-30 2022-11-03 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
IL307821A (en) 2021-04-30 2023-12-01 Hoffmann La Roche Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
AU2022268652A1 (en) 2021-05-07 2023-10-05 Genmab A/S PHARMACEUTICAL COMPOSITIONS COMPRISING BISPECIFIC ANTIBODIES BINDING TO B7H4 and CD3
US20240254245A1 (en) 2021-05-12 2024-08-01 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Antigen binding molecule specifically binding to rankl and ngf, and medical use thereof
AU2022273737A1 (en) 2021-05-14 2023-11-16 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Antigen-binding molecule
CA3221735A1 (en) 2021-06-18 2022-12-22 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
JP2024523438A (en) 2021-06-21 2024-06-28 ジェンマブ エー／エス Combination Dosing Regimen of CD137-Binding Agent and PD-L1-Binding Agent
EP4363449A2 (en) 2021-07-02 2024-05-08 Genentech, Inc. Methods and compositions for treating cancer
MX2024000501A (en) 2021-07-14 2024-01-31 Jiangsu Hengrui Pharmaceuticals Co Ltd Antigen-binding molecule specifically binding to hgfr and eger, and pharmaceutical use thereof.
JP2024528631A (en) 2021-07-22 2024-07-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Heterodimeric Fc domain antibodies
WO2023006809A1 (en) 2021-07-27 2023-02-02 Morphosys Ag Combinations of antigen binding molecules
EP4377338A2 (en) 2021-07-27 2024-06-05 Novab, Inc. Engineered vlrb antibodies with immune effector functions
MX2024001214A (en) 2021-07-28 2024-02-12 Hoffmann La Roche Methods and compositions for treating cancer.
KR102351147B1 (en) * 2021-08-02 2022-01-14 주식회사 바이오뱅크힐링 Blautia obeum strain, and vesicles from thereof and anti-inflammation and anti-bacteria uses of thereof
CA3231003A1 (en) 2021-09-06 2023-03-09 Genmab A/S Antibodies capable of binding to cd27, variants thereof and uses thereof
WO2023037333A1 (en) 2021-09-13 2023-03-16 Janssen Biotech, Inc CD33 X Vδ2 MULTISPECIFIC ANTIBODIES FOR THE TREATMENT OF CANCER
TW202323277A (en) 2021-09-23 2023-06-16 大陸商江蘇恆瑞醫藥股份有限公司 Anti-klb antibodies and uses
WO2023046322A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceutica Nv Proteins comprising cd20 binding domains, and uses thereof
KR20240067099A (en) 2021-09-30 2024-05-16 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Anti-IL23 antibody fusion protein and uses
AU2022359551A1 (en) 2021-10-06 2024-04-11 Merus N.V. Treatment of immune checkpoint inhibitor-treated cancers with high egfr expression using an antibody that binds at least egfr
MX2024003615A (en) 2021-10-08 2024-04-09 Genmab As Antibodies binding to cd30 and cd3.
WO2023062048A1 (en) 2021-10-14 2023-04-20 F. Hoffmann-La Roche Ag Alternative pd1-il7v immunoconjugates for the treatment of cancer
MX2024004451A (en) 2021-10-14 2024-05-08 F Hoffmann La Roche Ag New interleukin-7 immunoconjugates.
WO2023067138A1 (en) 2021-10-21 2023-04-27 LAVA Therapeutics N.V. Uses of gamma delta t cell activating antibodies
TW202328180A (en) 2021-11-19 2023-07-16 荷蘭商美勒斯公司 Multispecific binding moieties comprising pd-1 and tgf-brii binding domains
IL312968A (en) 2021-11-22 2024-07-01 Janssen Biotech Inc Compositions comprising enhanced multispecific binding agents for an immune response
WO2023094282A1 (en) 2021-11-25 2023-06-01 F. Hoffmann-La Roche Ag Quantification of low amounts of antibody sideproducts
AR127887A1 (en) 2021-12-10 2024-03-06 Hoffmann La Roche ANTIBODIES THAT BIND CD3 AND PLAP
TW202346353A (en) 2022-03-07 2023-12-01 荷蘭商美勒斯公司 Treatment with an antibody that binds egfr and cmet
TW202337909A (en) 2022-03-07 2023-10-01 荷蘭商美勒斯公司 Combination therapy including antibodies that bind egfr and cmet
WO2023174521A1 (en) 2022-03-15 2023-09-21 Genmab A/S Binding agents binding to epcam and cd137
US20230414750A1 (en) 2022-03-23 2023-12-28 Hoffmann-La Roche Inc. Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
JP2024517042A (en) 2022-04-13 2024-04-19 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Pharmaceutical compositions and methods of use of anti-CD20/anti-CD3 bispecific antibodies
WO2023202967A1 (en) 2022-04-19 2023-10-26 F. Hoffmann-La Roche Ag Improved production cells
TW202413412A (en) 2022-05-12 2024-04-01 丹麥商珍美寶股份有限公司 Binding agents capable of binding to cd27 in combination therapy
WO2023218051A1 (en) 2022-05-12 2023-11-16 Genmab A/S Binding agents capable of binding to cd27 in combination therapy
EP4285926A1 (en) 2022-05-30 2023-12-06 LAVA Therapeutics N.V. Combination treatment for chronic lymphocytic leukemia
WO2023232961A1 (en) 2022-06-03 2023-12-07 F. Hoffmann-La Roche Ag Improved production cells
EP4292609A1 (en) 2022-06-15 2023-12-20 LAVA Therapeutics N.V. Compositions comprising antibodies that bind gamma-delta t cell receptors
EP4292610A1 (en) 2022-06-15 2023-12-20 LAVA Therapeutics N.V. Variant antibodies that bind gamma-delta t cell receptors
NL2032398B1 (en) 2022-07-06 2024-01-23 Academisch Ziekenhuis Leiden Bispecific antibody and uses thereof
WO2024030027A1 (en) 2022-08-05 2024-02-08 Merus N.V. Means and methods for treating castration-resistant prostate cancer
WO2024079010A1 (en) 2022-10-10 2024-04-18 F. Hoffmann-La Roche Ag Combination therapy of a gprc5d tcb and cd38 antibodies
WO2024079015A1 (en) 2022-10-10 2024-04-18 F. Hoffmann-La Roche Ag Combination therapy of a gprc5d tcb and imids
WO2024079009A1 (en) 2022-10-10 2024-04-18 F. Hoffmann-La Roche Ag Combination therapy of a gprc5d tcb and proteasome inhibitors
WO2024079069A1 (en) 2022-10-12 2024-04-18 F. Hoffmann-La Roche Ag Method for classifying cells
WO2024094660A1 (en) 2022-10-31 2024-05-10 Genmab A/S Cd38 antibodies and uses thereof
WO2024095173A1 (en) 2022-11-02 2024-05-10 Janssen Biotech, Inc. Methods of treating cancers
WO2024100170A1 (en) 2022-11-11 2024-05-16 F. Hoffmann-La Roche Ag Antibodies binding to hla-a*02/foxp3
WO2024104933A1 (en) 2022-11-15 2024-05-23 F. Hoffmann-La Roche Ag Antigen binding molecules
WO2024104988A1 (en) 2022-11-15 2024-05-23 F. Hoffmann-La Roche Ag Recombinant binding proteins with activatable effector domain
WO2024133330A1 (en) 2022-12-20 2024-06-27 Merus N.V. FAP BINDING DOMAINS AND BISPECIFIC BINDING MOIETIES THAT BIND FAP AND TGF-βRII
WO2024136658A1 (en) 2022-12-23 2024-06-27 Merus N.V. Combination treatment of cancers using an antibody that binds at least egfr and an immune checkpoint inhibitor
WO2024143442A1 (en) * 2022-12-27 2024-07-04 中外製薬株式会社 Polypeptide with controlled association
WO2024144401A1 (en) 2022-12-28 2024-07-04 Merus N.V. Treatment of cancer with a combination of an antibody that binds egfr and cytotoxic drugs
WO2024153722A1 (en) 2023-01-20 2024-07-25 F. Hoffmann-La Roche Ag Immunoconjugates
WO2024156672A1 (en) 2023-01-25 2024-08-02 F. Hoffmann-La Roche Ag Antibodies binding to csf1r and cd3
WO2024163009A1 (en) 2023-01-31 2024-08-08 Genentech, Inc. Methods and compositions for treating urothelial bladder cancer
WO2024163494A1 (en) 2023-01-31 2024-08-08 F. Hoffmann-La Roche Ag Methods and compositions for treating non-small cell lung cancer and triple-negative breast cancer

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
EP0187045B1 (en) 1984-12-28 1991-07-31 Elf Atochem S.A. Radiation curable macromonomer printing inks
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
DE3785186T2 (en) 1986-09-02 1993-07-15 Enzon Lab Inc BINDING MOLECULE WITH SINGLE POLYPEPTIDE CHAIN.
US4801687A (en) 1986-10-27 1989-01-31 Bioprobe International, Inc. Monoclonal antibody purification process using protein A
EP0307667B1 (en) 1987-08-24 1994-04-20 Wacom Company, Ltd. Coordinate input system with input pen
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
NZ226694A (en) 1987-10-28 1994-04-27 Oncogen Human immunoglobulin produced by recombinant dna techniques
ATE81724T1 (en) 1987-11-09 1992-11-15 Becton Dickinson Co PROCEDURE FOR ANALYZING HAEMATOPOIETIC CELLS IN A SAMPLE.
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
WO1990002809A1 (en) 1988-09-02 1990-03-22 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8909218D0 (en) 1989-04-22 1989-06-07 Medical Res Council Improvements in or relating to enhancers
ES2062364T3 (en) 1989-06-08 1994-12-16 Wistar Inst A METHOD OF PREPARING A COMPOSITION FOR TREATMENT AFTER EXPOSURE TO RABIES INFECTION.
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
US5030002A (en) 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5151504A (en) 1989-11-17 1992-09-29 E. R. Squibb & Sons, Inc. Method for purification of monoclonal antibodies
ES2090299T3 (en) 1989-12-01 1996-10-16 Pharming Bv PRODUCTION OF RECOMBINANT POLYPEPTIDES THROUGH BOVINE SPECIES AND TRANSGENIC METHODS.
ES2087997T3 (en) 1990-01-12 1996-08-01 Cell Genesys Inc GENERATION OF XENOGENIC ANTIBODIES.
DE4006630A1 (en) 1990-03-03 1991-09-12 Behringwerke Ag HUMANE MONOCLONAL ANTIBODIES AGAINST RABBIT VIRUSES, THEIR PRODUCTION AND USE
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
EP0469897A3 (en) 1990-07-31 1992-11-19 The Wistar Institute Engineered antibodies
IE76732B1 (en) 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
JP2938569B2 (en) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド Method for producing xenogeneic immunoglobulin and transgenic mouse
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
WO1992015677A1 (en) 1991-03-01 1992-09-17 Protein Engineering Corporation Process for the development of binding mini-proteins
JP3438889B2 (en) 1991-03-29 2003-08-18 ジェネンテク，インコーポレイテッド Method for selecting a recombinant host cell that expresses a desired protein at a high level
ATE269401T1 (en) 1991-04-10 2004-07-15 Scripps Research Inst LIBRARIES OF HETERODIMERIC RECEPTORS USING PHAGEMIDS
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
WO1993002190A1 (en) 1991-07-15 1993-02-04 The Wellcome Foundation Limited Production of antibodies
CA2124967C (en) 1991-12-17 2008-04-08 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
US7067284B1 (en) 1992-01-27 2006-06-27 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
SE9201984D0 (en) 1992-06-29 1992-06-29 Pharmacia Biosensor Ab IMPROVEMENT IN OPTICAL ASSAYS
AU687010B2 (en) 1992-07-17 1998-02-19 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
AU675661B2 (en) 1992-07-24 1997-02-13 Abgenix, Inc. Generation of xenogeneic antibodies
KR100335584B1 (en) 1992-10-28 2002-11-29 제넨테크, 인코포레이티드 Antagonists Against Vascular Endothelial Growth Factor
DE669986T1 (en) 1992-11-13 1996-10-10 Idec Pharma Corp COMPLETELY FUNCTIONAL CONSENSUS-KOZAK SEQUENCES FOR MAMMAL EXPRESSION.
AU6498294A (en) 1993-04-07 1994-10-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Dna sequence which acts as a chromatin insulator element to protect expressed genes from (cis)-acting regulatory sequences in mammalian cells
US6838254B1 (en) 1993-04-29 2005-01-04 Conopco, Inc. Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae
US5693506A (en) 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
AU1595195A (en) 1993-12-23 1995-07-10 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
PT744958E (en) 1994-01-31 2003-11-28 Univ Boston BANKS OF POLYCLONE ANTIBODIES
FR2717187B1 (en) 1994-03-10 1996-05-31 Transgene Sa Combined use of two expression cassettes for the production of a protein of interest.
US6080560A (en) 1994-07-25 2000-06-27 Monsanto Company Method for producing antibodies in plant cells
JPH08116978A (en) 1994-10-18 1996-05-14 Nisshinbo Ind Inc Preparation of antibody fab library
DE69535557T2 (en) 1994-12-30 2008-04-30 Planet Biotechnology, Inc., San Diego PROCESS FOR THE PREPARATION OF PROTECTED PROTEINS AND THEIR USE OF IMMUNOGLOBULINE
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
US5885827A (en) 1996-01-23 1999-03-23 The Regents Of The Universtiy Of California Eukaryotic high rate mutagenesis system
US6300065B1 (en) 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6825396B2 (en) 1996-06-12 2004-11-30 Board Of Trustees Operating Michigan State University Methods for tissue specific synthesis of protein in eggs of transgenic hens
ATE230850T1 (en) 1996-10-08 2003-01-15 Bisys B V U METHOD AND MEANS FOR SELECTING PEPTIDES AND PROTEINS WITH SPECIFIC AFFINITY FOR A TARGET MOLECULE
GB9621113D0 (en) 1996-10-10 1996-11-27 Univ Southampton Transgenic fish
CA2273192A1 (en) 1996-12-02 1998-06-11 Wake Forest University Inactivation of hiv co-receptors as therapy for hiv infection
ES2373110T3 (en) 1997-01-21 2012-01-31 The General Hospital Corporation SELECTION OF PROTEINS USING ARN-PROTEIN FUSIONS.
NZ337495A (en) 1997-03-06 2001-06-29 Infigen Inc Bovine primordial germ cells and their use in cloning
CZ293355B6 (en) 1997-03-14 2004-04-14 Idec Pharmaceuticals Corporation Method for integrating genes at specific sites in mammalian cells via homologous recombination and appropriate vectors for accomplishing the same
US6080912A (en) 1997-03-20 2000-06-27 Wisconsin Alumni Research Foundation Methods for creating transgenic animals
EP1650220B1 (en) 1997-04-07 2007-09-05 Genentech, Inc. Anti-VEGF antibodies
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
US20030207346A1 (en) 1997-05-02 2003-11-06 William R. Arathoon Method for making multispecific antibodies having heteromultimeric and common components
ES2246069T3 (en) 1997-05-02 2006-02-01 Genentech, Inc. PROCEDURE FOR THE PREPARATION OF MULTI-SPECIFIC ANTIBODIES THAT HAVE COMMON AND MULTIMERIC COMPONENTS.
DE69833755T2 (en) 1997-05-21 2006-12-28 Biovation Ltd. METHOD FOR PRODUCING NON-IMMUNOGENOUS PROTEINS
WO1999015684A2 (en) 1997-09-23 1999-04-01 Oxford Biomedica (Uk) Limited Expression of genes in hematopoietic stem cells in hischaemic conditions
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
EP1027439B1 (en) 1997-10-27 2010-03-17 Bac Ip B.V. Multivalent antigen-binding proteins
EP0968694B1 (en) 1997-11-26 2004-05-06 Mitsubishi Precision Co., Ltd. Information guidance system
IL138579A0 (en) 1998-03-30 2001-10-31 Res Dev Foundation Corticotropin releasing factor receptor 1-deficient mice
US6413776B1 (en) 1998-06-12 2002-07-02 Galapagos Geonomics N.V. High throughput screening of gene function using adenoviral libraries for functional genomics applications
GB9823930D0 (en) 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
WO2000044777A1 (en) 1999-01-29 2000-08-03 Imclone Systems Incorporated Antibodies specific to kdr and uses thereof
ATE447617T1 (en) 1999-04-15 2009-11-15 Crucell Holland Bv USE OF RECOMBINANT PROTEINS IN HUMAN CELLS
PT2067788E (en) 1999-05-18 2015-10-29 Dyax Corp Fab fragment libraries and methods for their use
US6472147B1 (en) 1999-05-25 2002-10-29 The Scripps Research Institute Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
DE60042648D1 (en) 1999-06-25 2009-09-10 Genentech Inc HUMANIZED ANTI-ERBB2 ANTIBODIES AND TREATMENT WITH ANTI-ERBB2 ANTIBODIES
WO2001019394A2 (en) 1999-09-15 2001-03-22 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds
US6180357B1 (en) 1999-10-08 2001-01-30 Arius Research, Inc. Individualized patient-specific anti-cancer antibodies
AU7676300A (en) 1999-10-12 2001-04-23 Cambridge Antibody Technology Limited Human anti-adipocyte monoclonal antibodies and their use
EP2278022A3 (en) 1999-11-01 2011-05-18 Novartis Vaccines and Diagnostics, Inc. Expression vectors, transfection systems, and method of use thereof
GB9928787D0 (en) 1999-12-03 2000-02-02 Medical Res Council Direct screening method
WO2001048485A2 (en) 1999-12-27 2001-07-05 Crucell Holland B.V. Selecting library members capable of binding to epitopes
EP1268832A4 (en) 2000-02-29 2003-04-02 Univ Auburn Production of antibodies in transgenic plastids
AU5720601A (en) 2000-04-26 2001-11-07 Elusys Therapeutics Inc Bispecific molecules and uses thereof
PT1297016E (en) 2000-05-12 2006-07-31 Vlaams Interuniv Inst Biotech USE OF PLACENTARY GROWTH FACTOR INHIBITORS FOR THE TREATMENT OF PATHOLOGICAL ANGIOGENESIS, PATHOLOGICAL ARTERIOGENESIS, INFLAMMATION, FORMATION OF TUMORS AND / OR VASCULAR FIGURES
CA2419148C (en) 2000-05-16 2011-07-12 Thomas Jefferson University Rabies virus-specific neutralizing human monoclonal antibodies and nucleic acids and related methods
CZ2003291A3 (en) 2000-06-29 2003-05-14 Abbott Laboratories Dual specific antibodies, processes of their preparation and use
EP1184458A1 (en) 2000-08-28 2002-03-06 U-BISys B.V. Differentially expressed CD46 epitopes, proteinaceous molecules capable of binding thereto, and uses thereof
EP1188771A1 (en) 2000-09-15 2002-03-20 U-BISys B.V. Libraries of human heavy chain variable fragments in a functional format
US7737258B2 (en) 2000-10-18 2010-06-15 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
TWI313299B (en) 2000-11-30 2009-08-11 Medarex Inc Transgenic transchromosomal rodents for making human antibodies
FR2817875B1 (en) 2000-12-07 2005-03-18 Technopharm PROCESS FOR THE PREPARATION OF A HUMAN MONOCLONAL ANTIBODY, FRAGMENTS THEREOF OR ANTIBODIES COMPRISING SUCH FRAGMENTS, THE ANTIBODIES THUS OBTAINED AND THEIR USE
JP2004525624A (en) 2001-01-25 2004-08-26 エボルバ バイオテック アクティーゼルスカブ Cell collection library
EP1395669B1 (en) 2001-01-26 2009-07-22 Selexis S.A. Matrix attachment regions and methods for use thereof
WO2002096948A2 (en) 2001-01-29 2002-12-05 Idec Pharmaceuticals Corporation Engineered tetravalent antibodies and methods of use
WO2002076196A1 (en) 2001-03-22 2002-10-03 Abbott Gmbh & Co. Kg Transgenic animals expressing antibodies specific for genes of interest and uses thereof
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
US7247301B2 (en) 2001-06-13 2007-07-24 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
CA2449071C (en) 2001-06-15 2008-12-16 Crucell Holland B.V. Chimaeric phages
AU2002319402B2 (en) 2001-06-28 2008-09-11 Domantis Limited Dual-specific ligand and its use
ATE466944T1 (en) 2001-07-04 2010-05-15 Chromagenics Bv DNS SEQUENCES WITH ANTI-REPRESSOR ACTIVITY
NZ531291A (en) 2001-08-21 2006-02-24 Univ Jefferson Recombinant anti rabies antibodies MAb JB.1 and Mab 57 and compositions and methods for making and using the same
WO2003018771A2 (en) 2001-08-27 2003-03-06 Genentech, Inc. A system for antibody expression and assembly
CA2467363A1 (en) 2001-11-16 2003-06-12 Idec Pharmaceuticals Corporation Polycistronic expression of antibodies
US20060088520A1 (en) 2001-11-30 2006-04-27 Crucell Holland B.V. Antigen presenting cell targeting conjugate, an antigen presenting cell contacted with such conjugate, their use for vaccination or as medicament, and methods for their production or generation
NZ532838A (en) 2001-11-30 2008-05-30 Ca Nat Research Council Multimeric complex preferably pentamer molecules derived from the AB5 toxin family i.e. verotoxin and their use in medical treatment
GB0130267D0 (en) 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
US7244592B2 (en) 2002-03-07 2007-07-17 Dyax Corp. Ligand screening and discovery
GB2387030A (en) 2002-03-26 2003-10-01 Thales Plc Compensation of mutual coupling in array antenna systems
EP1510943A4 (en) 2002-05-31 2007-05-09 Celestar Lexico Sciences Inc Interaction predicting device
AU2003239966B9 (en) 2002-06-03 2010-08-26 Genentech, Inc. Synthetic antibody phage libraries
WO2003106684A2 (en) 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
WO2003106674A2 (en) 2002-06-14 2003-12-24 Chromagenics B.V. Means and methods for regulating gene expression
AU2002368062A1 (en) 2002-06-26 2004-01-19 Imclone Systems Incorporated Bispecific antibodies that bind to vegf receptors
US20080241166A1 (en) 2002-06-28 2008-10-02 Domantis Limited Ligands that bind a receptor
EP1521887B1 (en) 2002-07-10 2010-07-28 Agostino Di Trapani Building block
ES2368733T3 (en) 2002-07-18 2011-11-21 Merus B.V. RECOMBINANT PRODUCTION OF MIXTURES OF ANTIBODIES.
CA2512647C (en) 2003-01-07 2013-10-08 Symphogen A/S Method for manufacturing recombinant polyclonal proteins
EP1439234A1 (en) 2003-01-08 2004-07-21 ARTEMIS Pharmaceuticals GmbH Targeted transgenesis using the rosa26 locus
EP1639009B1 (en) 2003-05-30 2013-02-27 Merus B.V. Fab library for the preparation of a mixture of antibodies
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1636265A2 (en) 2003-06-25 2006-03-22 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
SG128680A1 (en) 2003-07-22 2007-01-30 Crucell Holland Bv Binding molecules against sars-coronavirus and uses thereof
ATE536376T1 (en) 2003-12-23 2011-12-15 Crucell Holland Bv HUMAN BINDING MOLECULE AGAINST CD1A
NZ548828A (en) 2004-01-20 2009-07-31 Merus B V Mixtures of binding proteins
CN1961002B (en) 2004-05-27 2011-05-18 克鲁塞尔荷兰公司 Binding molecules capable of neutralizing rabies virus and uses thereof
MXPA06014075A (en) 2004-06-03 2007-03-15 Novimmune Sa Anti-cd3 antibodies and methods of use thereof.
CA2577082A1 (en) 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
JP4487068B2 (en) 2004-10-12 2010-06-23 国立大学法人 岡山大学 Method for producing mutant protein by controlling gene mutation function of cell
WO2006040322A1 (en) 2004-10-12 2006-04-20 Crucell Holland B.V. Binding molecules for treatment and detection of cancer
CA2582057C (en) 2004-11-11 2015-08-11 Crucell Holland B.V. Compositions against sars-coronavirus and uses thereof
CA2603408C (en) 2005-03-31 2018-08-21 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
CA2604440A1 (en) 2005-04-29 2006-11-09 Inserm (Institut De La Sante Et De La Recherche Medicale) Transgenic animals and methods of making recombinant antibodies
CA2608058C (en) 2005-05-12 2013-09-10 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
EP1893645A1 (en) 2005-06-23 2008-03-05 Crucell Holland B.V. Optimization of west nile virus antibodies
CA2622603C (en) 2005-09-15 2014-06-17 Crucell Holland B.V. Method for preparing immunoglobulin libraries
WO2007059782A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
ZA200804337B (en) * 2005-11-28 2009-11-25 Genmab As Recombinant monovalent antibodies and methods for production thereof
JP5474531B2 (en) 2006-03-24 2014-04-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Engineered heterodimeric protein domains
CA2638774C (en) 2006-03-31 2015-11-24 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
DK2041177T3 (en) 2006-06-02 2012-02-27 Regeneron Pharma High affinity antibodies to human IL-6 receptor
EP3018142A1 (en) 2006-06-06 2016-05-11 Crucell Holland B.V. Human binding molecules having killing activity against staphylococci and uses thereof
CN101460518B (en) 2006-06-06 2012-08-22 克鲁塞尔荷兰公司 Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof
JP2009541275A (en) 2006-06-22 2009-11-26 ノボ・ノルデイスク・エー／エス Production of bispecific antibodies
EP2471816A1 (en) 2006-08-30 2012-07-04 Genentech, Inc. Multispecific antibodies
PL2059532T3 (en) 2006-09-07 2013-05-31 Crucell Holland Bv Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
DK2069403T3 (en) 2006-10-02 2014-07-28 Regeneron Pharma High-affinity human antibodies for human IL-4 receptor
US8290739B2 (en) 2006-10-20 2012-10-16 Amfit, Inc. Method for determining relative mobility of regions of an object
RU2448979C2 (en) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Human antibodies to delta-like human ligand-4
NZ614857A (en) 2007-03-29 2015-04-24 Genmab As Bispecific antibodies and methods for production thereof
ITMI20071522A1 (en) 2007-07-27 2009-01-28 Areta Internat S R L IDIOTYPIC VACCINE
BRPI0815416A2 (en) 2007-08-15 2014-10-21 Amunix Inc COMPOSITIONS AND METHODS FOR MODIFYING PROPERTIES OF BIOLOGICALLY ACTIVE POLYPEPTIDES
CA2964398C (en) 2007-09-14 2023-03-07 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2211903A4 (en) 2007-10-17 2011-07-06 Nuvelo Inc Antibodes to cll-1
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8592562B2 (en) 2008-01-07 2013-11-26 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
AU2009211148B2 (en) 2008-02-05 2014-08-28 Zymeworks Inc. Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics
DK2147594T3 (en) 2008-06-27 2014-02-10 Merus B V Antibody-producing non-human mammals
CN102365296A (en) * 2009-01-26 2012-02-29 根马布股份公司 Methods for producing mixtures of antibodies
TW201438739A (en) 2009-03-20 2014-10-16 Genentech Inc Anti-HER antibodies
WO2010129304A2 (en) 2009-04-27 2010-11-11 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
AU2010247530B2 (en) 2009-05-11 2016-10-13 Janssen Vaccines & Prevention B.V. Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof
SI2975051T1 (en) 2009-06-26 2021-08-31 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format
US8765900B2 (en) 2009-08-27 2014-07-01 Bayer Materialscience Llc Aliphatic moisture-curable resins, coating compositions, and related processes
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
JP2013511281A (en) 2009-11-23 2013-04-04 アムジェン インコーポレイテッド Monomeric antibody Fc
US20120021409A1 (en) 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
EP2501817B2 (en) 2010-02-08 2021-04-21 Regeneron Pharmaceuticals, Inc. Common light chain mouse
CA2797981C (en) * 2010-05-14 2019-04-23 Rinat Neuroscience Corporation Heterodimeric proteins and methods for producing and purifying them
US20130177555A1 (en) * 2010-08-13 2013-07-11 Medimmune Limited Monomeric Polypeptides Comprising Variant FC Regions And Methods Of Use
CA2808482C (en) 2010-08-16 2021-10-26 Novimmune S.A. Methods for the generation of multispecific and multivalent antibodies
CA2815266C (en) * 2010-11-05 2023-09-05 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
ES2805364T3 (en) 2011-02-25 2021-02-11 Regeneron Pharma ADAM6 mice
CN108285488B (en) 2011-03-25 2023-01-24 伊克诺斯科学公司 Heterodimeric immunoglobulins
JP2013004215A (en) 2011-06-14 2013-01-07 Hitachi Ltd Lithium-ion secondary battery
CA2791109C (en) 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
WO2013134263A1 (en) 2012-03-06 2013-09-12 Regeneron Pharmaceuticals, Inc. Common light chain mouse
EA035344B1 (en) 2012-04-20 2020-05-29 Мерюс Н.В. Method for producing two antibodies from a single host cell
SG11201407644UA (en) 2012-06-05 2014-12-30 Regeneron Pharma Methods for making fully human bispecific antibodies using a common light chain
PL2900694T3 (en) * 2012-09-27 2018-12-31 Merus N.V. Bispecific igg antibodies as t cell engagers
UY35148A (en) * 2012-11-21 2014-05-30 Amgen Inc HETERODIMERIC IMMUNOGLOBULINS
US10798961B2 (en) 2013-03-15 2020-10-13 Altria Client Services Llc Functional food and beverage compositions with improved taste through the use of sensates
WO2017010874A1 (en) 2015-07-10 2017-01-19 Merus N.V. Human cd3 binding antibody

Also Published As

Publication number Publication date
US20170327860A1 (en) 2017-11-16
KR102171431B1 (en) 2020-10-30
MX2018012766A (en) 2021-11-16
AU2018201325A1 (en) 2018-03-15
KR102545770B1 (en) 2023-06-21
SG10201607371UA (en) 2016-10-28
PL2838917T3 (en) 2019-12-31
MX360110B (en) 2018-10-23
JP2018099119A (en) 2018-06-28
SG11201406770WA (en) 2014-11-27
KR20230093359A (en) 2023-06-27
KR20200015756A (en) 2020-02-12
KR20220046711A (en) 2022-04-14
HUE045945T2 (en) 2020-02-28
JP6781740B2 (en) 2020-11-04
ES2743399T3 (en) 2020-02-19
JP2023060019A (en) 2023-04-27
EP2838918B1 (en) 2019-06-05
US20140072579A1 (en) 2014-03-13
CA2870821A1 (en) 2013-10-24
US10337045B2 (en) 2019-07-02
AU2018201326A1 (en) 2018-03-15
SI2838918T1 (en) 2019-11-29
US20210071222A1 (en) 2021-03-11
US9248181B2 (en) 2016-02-02
SG10201607369QA (en) 2016-10-28
EA201491909A1 (en) 2015-03-31
KR20200126007A (en) 2020-11-05
US20150139996A1 (en) 2015-05-21
AU2013249986A1 (en) 2014-11-06
MX2014012701A (en) 2014-12-05
JP6639464B2 (en) 2020-02-05
HRP20191446T1 (en) 2019-11-15
US20130336981A1 (en) 2013-12-19
KR20230091201A (en) 2023-06-22
US20160177364A1 (en) 2016-06-23
CN107383197B (en) 2021-12-10
EP2838918A1 (en) 2015-02-25
US11926859B2 (en) 2024-03-12
CN108586610A (en) 2018-09-28
LT2838918T (en) 2019-09-10
AU2013249986B2 (en) 2017-11-23
ES2740749T3 (en) 2020-02-06
MX2014012700A (en) 2014-12-05
MX360109B (en) 2018-10-23
SG10201913634VA (en) 2020-03-30
AU2013249985A1 (en) 2014-11-06
WO2013157954A1 (en) 2013-10-24
CN104520319A (en) 2015-04-15
PT2838918T (en) 2019-08-23
EA035344B1 (en) 2020-05-29
DK2838918T3 (en) 2019-08-12
CA2871068C (en) 2022-06-14
ZA201407835B (en) 2015-12-23
US20150196637A1 (en) 2015-07-16
JP6272299B2 (en) 2018-01-31
KR20150035534A (en) 2015-04-06
RS59263B1 (en) 2019-10-31
PL2838918T3 (en) 2019-11-29
NZ630551A (en) 2017-11-24
ZA201407834B (en) 2015-12-23
KR20150035535A (en) 2015-04-06
CN104520320A (en) 2015-04-15
JP2020089366A (en) 2020-06-11
CN114163530A (en) 2022-03-11
KR102104601B1 (en) 2020-06-01
HK1206039A1 (en) 2015-12-31
DK2838917T3 (en) 2019-08-26
AU2013249985B2 (en) 2017-11-23
EP2838917A1 (en) 2015-02-25
US10329596B2 (en) 2019-06-25
EA201491908A1 (en) 2015-03-31
EP3594233A1 (en) 2020-01-15
CN107383197A (en) 2017-11-24
CY1122153T1 (en) 2020-11-25
US20230340556A1 (en) 2023-10-26
JP2015514417A (en) 2015-05-21
HRP20191409T1 (en) 2019-11-15
HK1206041A1 (en) 2015-12-31
CA2870821C (en) 2022-06-14
EP3594232A1 (en) 2020-01-15
NZ728228A (en) 2021-02-26
JP2015515275A (en) 2015-05-28
CN104520319B (en) 2017-08-25
JP6393255B2 (en) 2018-09-19
SG11201406772YA (en) 2014-11-27
CY1122118T1 (en) 2020-11-25
NZ772318A (en) 2023-06-30
AU2018201326B2 (en) 2020-02-06
SI2838917T1 (en) 2019-11-29
HUE045944T2 (en) 2020-02-28
SG10201913376XA (en) 2020-02-27
PT2838917T (en) 2019-09-12
KR20200047724A (en) 2020-05-07
US9758805B2 (en) 2017-09-12
LT2838917T (en) 2019-09-25
MX2018012769A (en) 2021-11-16
CA2871068A1 (en) 2013-10-24
AU2018201325B2 (en) 2020-02-06
EA202090591A2 (en) 2020-08-31
CN104520320B (en) 2018-05-01
US10752929B2 (en) 2020-08-25
US9248182B2 (en) 2016-02-02
JP2019022489A (en) 2019-02-14
RS59260B1 (en) 2019-10-31
US9358286B2 (en) 2016-06-07
KR102382304B1 (en) 2022-04-04
EA202090591A3 (en) 2020-12-30
JP2020202854A (en) 2020-12-24
US20140140999A1 (en) 2014-05-22
WO2013157953A1 (en) 2013-10-24
KR102269650B1 (en) 2021-06-28
US20170369923A1 (en) 2017-12-28
US20200017897A1 (en) 2020-01-16
NZ799532A (en) 2023-07-28
EP2838917B1 (en) 2019-06-05

Similar Documents

Publication Publication Date Title
NZ630568A (en) Methods and means for the production of ch3 domain-comprising molecules
MX353144B (en) Heterodimeric antibody fc-containing proteins and methods for production thereof.
SG10201805291TA (en) Production of heterodimeric proteins
MX2019003427A (en) Cell culture compositions and methods for polypeptide production.
MX2021000211A (en) Methods and products for transfecting cells.
MX2015017110A (en) Targeted integration.
WO2011134919A3 (en) Cho cells cultivation process 0
MX2018014043A (en) Cell culture compositions with antioxidants and methods for polypeptide production.
IN2014DN03419A (en)
WO2015162274A3 (en) Mirnas enhancing cell productivity
NZ715246A (en) Improved process for production of monoclonal antibodies
MX366112B (en) Cell culture media and methods of antibody production.
WO2015004403A3 (en) Uncoupled cell culture method
MX2020001357A (en) Microbial production of fatty amines.
MX2018004580A (en) Method for producing fusion protein having igg fc domain.
FI20115328A0 (en) New cutinases, their production and uses
MX2016001917A (en) Method for preparing lipid-rich compositions of microalga flour with optimised organoleptic properties.
EA200900984A1 (en) IMPROVEMENT OF CELL GROWTH
WO2012125626A3 (en) Decorin compositions and use thereof
SG11201902998SA (en) PROMOTER OF Hspa5 GENE
EA201300884A1 (en) METHOD OF OBTAINING A NEW ANTI-BACTERIAL MEDICINE ON THE BASIS OF A RECOMBINANT POLYPEPE
ES2523016A1 (en) Alphaviral vectors and cell lines for producing recombinant proteins
WO2012129449A3 (en) High level production of recombinant proteins
AU2016219622A1 (en) Heterodimeric antibody FC-containing proteins and methods for production thereof
MX346721B (en) Biotechnological process for the production of three galphimine anxiolytic compounds from galphimia glauca in vitro culture.

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 19 APR 2020 BY AJ PARK

Effective date: 20171130

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2021 BY DENNEMEYER + CO

Effective date: 20200401

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2022 BY DENNEMEYER+CO

Effective date: 20210413

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2023 BY DENNEMEYER + CO

Effective date: 20220412

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2024 BY DENNEMEYER + CO

Effective date: 20230410