EA201791121A1 - Активирующие т-клетки биспецифические антигенсвязывающие молекулы против folri и cd3 - Google Patents

Активирующие т-клетки биспецифические антигенсвязывающие молекулы против folri и cd3

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Publication number
EA201791121A1
EA201791121A1 EA201791121A EA201791121A EA201791121A1 EA 201791121 A1 EA201791121 A1 EA 201791121A1 EA 201791121 A EA201791121 A EA 201791121A EA 201791121 A EA201791121 A EA 201791121A EA 201791121 A1 EA201791121 A1 EA 201791121A1
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EA
Eurasian Patent Office
Prior art keywords
binding molecules
bispecific antigen
folri
activating
molecules against
Prior art date
Application number
EA201791121A
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English (en)
Inventor
Марина Бакак
Петер Брюнкер
Анне Фраймозер-Грундшобер
Ральф Хоссе
Кристиан Кляйн
Эккехард Мёсснер
Пабло Умана
Тина Вайнцирль
Original Assignee
Ф. Хоффманн-Ля Рош Аг
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Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201791121A1 publication Critical patent/EA201791121A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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  • Health & Medical Sciences (AREA)
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Abstract

В заявке описаны новые биспецифические антигенсвязывающие молекулы для активации T-клеток и перенаправления их к специфическим клеткам-мишеням. Кроме того, в заявке описаны полинуклеотиды, кодирующие такие биспецифические антигенсвязывающие молекулы, и векторы и клетки-хозяева, содержащие такие полинуклеотиды. В заявке описаны также способы получения биспецифических антигенсвязывающих молекул, предлагаемых в изобретении, и способы применения указанных биспецифических антигенсвязывающих молекул для лечения заболевания.
EA201791121A 2014-11-20 2015-11-17 Активирующие т-клетки биспецифические антигенсвязывающие молекулы против folri и cd3 EA201791121A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14194147 2014-11-20
PCT/EP2015/076739 WO2016079076A1 (en) 2014-11-20 2015-11-17 T cell activating bispecific antigen binding molecules agiant folr1 and cd3

Publications (1)

Publication Number Publication Date
EA201791121A1 true EA201791121A1 (ru) 2018-04-30

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EA201791121A EA201791121A1 (ru) 2014-11-20 2015-11-17 Активирующие т-клетки биспецифические антигенсвязывающие молекулы против folri и cd3

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US (3) US20160208019A1 (ru)
EP (1) EP3221356B1 (ru)
JP (2) JP7146395B2 (ru)
KR (1) KR102648966B1 (ru)
CN (1) CN107074955B (ru)
AR (1) AR102732A1 (ru)
AU (1) AU2015348595B2 (ru)
CA (1) CA2960929A1 (ru)
CL (1) CL2017000954A1 (ru)
CO (1) CO2017003048A2 (ru)
CR (1) CR20170203A (ru)
DK (1) DK3221356T3 (ru)
EA (1) EA201791121A1 (ru)
ES (1) ES2829829T3 (ru)
HR (1) HRP20201747T1 (ru)
HU (1) HUE051715T2 (ru)
IL (1) IL251292A0 (ru)
LT (1) LT3221356T (ru)
MA (1) MA40972B1 (ru)
MX (1) MX2017006571A (ru)
MY (1) MY184889A (ru)
PE (1) PE20170585A1 (ru)
PH (1) PH12017500939A1 (ru)
PL (1) PL3221356T3 (ru)
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RS (1) RS61010B1 (ru)
SG (1) SG11201702976TA (ru)
SI (1) SI3221356T1 (ru)
TW (2) TWI756164B (ru)
UA (1) UA122676C2 (ru)
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ZA (1) ZA201701843B (ru)

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