MA40972B1 - Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 - Google Patents
Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3Info
- Publication number
- MA40972B1 MA40972B1 MA40972A MA40972A MA40972B1 MA 40972 B1 MA40972 B1 MA 40972B1 MA 40972 A MA40972 A MA 40972A MA 40972 A MA40972 A MA 40972A MA 40972 B1 MA40972 B1 MA 40972B1
- Authority
- MA
- Morocco
- Prior art keywords
- binding molecules
- bispecific antigen
- antigen binding
- cells targeting
- activating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne de manière générale de nouvelles molécules bispécifiques de liaison à l'antigène destinées à activer les lymphocytes t et à les rediriger vers des cellules cibles spécifiques. De plus, la présente invention concerne des polynucléotides codant pour ces molécules bispécifiques de liaison à l'antigène, ainsi que des vecteurs et des cellules hôtes comprenant ces polynucléotides. L'invention concerne par ailleurs des méthodes pour produire les molécules bispécifiques de liaison à l'antigène précitées, et des méthodes pour les utiliser dans le traitement de maladies.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14194147 | 2014-11-20 | ||
PCT/EP2015/076739 WO2016079076A1 (fr) | 2014-11-20 | 2015-11-17 | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA40972B1 true MA40972B1 (fr) | 2020-11-30 |
Family
ID=52100988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA40972A MA40972B1 (fr) | 2014-11-20 | 2015-11-17 | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 |
Country Status (33)
Country | Link |
---|---|
US (3) | US20160208019A1 (fr) |
EP (1) | EP3221356B1 (fr) |
JP (2) | JP7146395B2 (fr) |
KR (1) | KR102648966B1 (fr) |
CN (1) | CN107074955B (fr) |
AR (1) | AR102732A1 (fr) |
AU (1) | AU2015348595B2 (fr) |
BR (1) | BR112017007086A2 (fr) |
CA (1) | CA2960929A1 (fr) |
CL (1) | CL2017000954A1 (fr) |
CO (1) | CO2017003048A2 (fr) |
CR (1) | CR20170203A (fr) |
DK (1) | DK3221356T3 (fr) |
EA (1) | EA201791121A1 (fr) |
ES (1) | ES2829829T3 (fr) |
HR (1) | HRP20201747T1 (fr) |
HU (1) | HUE051715T2 (fr) |
IL (1) | IL251292A0 (fr) |
LT (1) | LT3221356T (fr) |
MA (1) | MA40972B1 (fr) |
MX (1) | MX2017006571A (fr) |
MY (1) | MY184889A (fr) |
PE (1) | PE20170585A1 (fr) |
PH (1) | PH12017500939A1 (fr) |
PL (1) | PL3221356T3 (fr) |
PT (1) | PT3221356T (fr) |
RS (1) | RS61010B1 (fr) |
SG (1) | SG11201702976TA (fr) |
SI (1) | SI3221356T1 (fr) |
TW (2) | TWI756164B (fr) |
UA (1) | UA122676C2 (fr) |
WO (1) | WO2016079076A1 (fr) |
ZA (1) | ZA201701843B (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
MX341921B (es) | 2011-02-28 | 2016-09-07 | Hoffmann La Roche | Proteinas de union a antigeno. |
WO2012116927A1 (fr) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Protéines monovalentes de liaison à l'antigène |
WO2013026839A1 (fr) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Anticorps bispécifiques spécifiques pour les antigènes d'activation des lymphocytes t et un antigène tumoral et procédés d'utiliation correspondants |
CN104704004B (zh) | 2012-10-08 | 2019-12-31 | 罗切格利卡特公司 | 包含两个Fab片段的无Fc的抗体及使用方法 |
WO2014131694A1 (fr) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
JP6133444B2 (ja) | 2013-02-26 | 2017-05-24 | ロシュ グリクアート アーゲー | 二重特異性t細胞活性化抗原結合分子 |
CA2922912A1 (fr) * | 2013-10-11 | 2015-04-16 | F. Hoffmann-La Roche Ag | Anticorps a chaine legere variable commune echangee a domaine multispecifique |
EA038958B1 (ru) | 2014-08-04 | 2021-11-15 | Ф. Хоффманн-Ля Рош Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
SI3221355T1 (sl) | 2014-11-20 | 2021-01-29 | F. Hoffmann-La Roche Ag | Kombinirano zdravljenje z bispecifičnimi molekulami CD3, ki aktivirajo celice T in vežejo antigene in folatni receptor 1 (FoIR1) ter antagonisti za vezavo osi PD-1 |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
AR106201A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | Moléculas biespecíficas de unión a antígeno activadoras de células t |
CN108290954B (zh) | 2015-12-09 | 2022-07-26 | 豪夫迈·罗氏有限公司 | Ii型抗cd20抗体用于降低抗药物抗体形成 |
US10596257B2 (en) | 2016-01-08 | 2020-03-24 | Hoffmann-La Roche Inc. | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
PL3433280T3 (pl) | 2016-03-22 | 2023-07-31 | F. Hoffmann-La Roche Ag | Dwuswoiste cząsteczki limfocytów T aktywowane przez proteazy |
EP3519437B1 (fr) * | 2016-09-30 | 2021-09-08 | F. Hoffmann-La Roche AG | Anticorps bispécifiques dirigés contre p95her2 |
ES2898025T3 (es) * | 2016-11-02 | 2022-03-03 | Jounce Therapeutics Inc | Anticuerpos contra PD-1 y sus usos |
WO2018108759A1 (fr) * | 2016-12-13 | 2018-06-21 | F. Hoffmann-La Roche Ag | Procédé de détermination de la présence d'un antigène cible dans un échantillon de tumeur |
MX2019006955A (es) * | 2016-12-19 | 2019-08-01 | Hoffmann La Roche | Terapia de combinacion con agonistas de 4-1bb orientados (cd137). |
TWI690538B (zh) | 2017-04-05 | 2020-04-11 | 瑞士商赫孚孟拉羅股份公司 | 特異性結合至pd1至lag3的雙特異性抗體 |
EP3638697A4 (fr) | 2017-06-12 | 2021-07-07 | Bluefin Biomedicine, Inc. | Anticorps anti-il1rap et conjugués anticorps-médicament |
KR20200026995A (ko) | 2017-07-14 | 2020-03-11 | 이매틱스 바이오테크놀로지스 게엠베하 | 향상된 이중 특이성 폴리펩티드 분자 |
MX2020004573A (es) * | 2017-11-01 | 2020-09-25 | Hoffmann La Roche | Terapia de combinacion con agonistas de ox40 dirigidos. |
EP3502140A1 (fr) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t |
US20200339685A1 (en) * | 2017-12-27 | 2020-10-29 | Teneobio, Inc. | Cd3-delta/epsilon heterodimer specific antibodies |
CN111712261A (zh) | 2018-02-08 | 2020-09-25 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
WO2019177854A1 (fr) * | 2018-03-13 | 2019-09-19 | Phanes Therapeutics, Inc. | Anticorps anti-récepteur 1 aux folates et leurs utilisations |
US20200407434A1 (en) * | 2018-03-13 | 2020-12-31 | Vascular Biogenics Ltd. | Bispecific antibodies to mospd2 and t cell- or nk cell-specific molecules |
CA3105415A1 (fr) * | 2018-07-09 | 2020-01-23 | Multitude Inc. | Anticorps specifiques du recepteur alpha du folate |
WO2020028269A2 (fr) * | 2018-07-30 | 2020-02-06 | Invenra Inc. | Molécules multispécifiques de liaison aux treg |
JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
CN116121302A (zh) * | 2018-09-27 | 2023-05-16 | 公益财团法人实验动物中央研究所 | 免疫缺陷小鼠 |
WO2020127618A1 (fr) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Molécules de liaison à l'antigène cd28 agonistes de ciblage de tumeurs |
US11672858B2 (en) | 2018-12-21 | 2023-06-13 | Hoffmann-La Roche Inc. | Bispecific antibody molecules binding to CD3 and TYRP-1 |
JPWO2020246563A1 (fr) * | 2019-06-05 | 2020-12-10 | ||
CA3140192A1 (fr) | 2019-06-19 | 2020-12-24 | Johannes Auer | Procede de generation d'une cellule exprimant un anticorps multivalent, multispecifique par integration ciblee de multiples cassettes d'expression dans une organisation definie |
KR20220024637A (ko) | 2019-06-19 | 2022-03-03 | 에프. 호프만-라 로슈 아게 | 정의된 조직의 다수 발현 카세트들의 표적화 통합에 의한 3가 항체 발현 세포의 생성 방법 |
WO2020260326A1 (fr) | 2019-06-27 | 2020-12-30 | F. Hoffmann-La Roche Ag | Nouveaux anticorps anti-icos et molécules de liaison à un antigène ciblant les tumeurs les comprenant |
US20220348648A1 (en) * | 2019-07-11 | 2022-11-03 | Memorial Sloan Kettering Cancer Center | Dll3-targeting antibodies and uses thereof |
CN111018969A (zh) * | 2019-12-27 | 2020-04-17 | 上海药明生物技术有限公司 | 采用轻链select联合层析色谱纯化双特异性抗体的方法 |
AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
AU2021291005A1 (en) | 2020-06-19 | 2023-01-05 | F. Hoffmann-La Roche Ag | Antibodies binding to CD3 and FolR1 |
MX2022015204A (es) * | 2020-06-19 | 2023-01-05 | Hoffmann La Roche | Anticuerpos que se unen a cd3. |
WO2021255146A1 (fr) * | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Anticorps se liant à cd3 et cea |
MX2022016069A (es) * | 2020-06-19 | 2023-02-02 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y cd19. |
EP4225786A2 (fr) * | 2020-10-07 | 2023-08-16 | Amgen Inc. | Sélection rationnelle de blocs de construction pour l'assemblage d'anticorps multispécifiques |
TW202233684A (zh) * | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
WO2023079493A1 (fr) * | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Liants de cd16a bispécifiques |
WO2023161457A1 (fr) | 2022-02-27 | 2023-08-31 | Evobright Gmbh | Anticorps bispécifiques dirigés contre cd277 et un antigène tumoral |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011010158A (es) | 2009-04-07 | 2011-10-17 | Roche Glycart Ag | Anticuerpos biespecificos anti-erbb-2/anti-c-met. |
PL3321286T3 (pl) * | 2011-08-23 | 2021-05-31 | Roche Glycart Ag | Dwuswoiste cząsteczki wiążące antygen aktywujące limfocyty T |
RS60217B1 (sr) * | 2012-08-31 | 2020-06-30 | Immunogen Inc | Dijagnostički testovi i kompleti za detekciju folatnog receptora 1 |
WO2014087863A1 (fr) * | 2012-12-07 | 2014-06-12 | 協和発酵キリン株式会社 | Anticorps anti-folr1 |
US9522196B2 (en) | 2012-12-25 | 2016-12-20 | Kagoshima University | Antibody recognizing folate receptors α and β |
WO2014131694A1 (fr) * | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
CA2903258C (fr) * | 2013-03-15 | 2019-11-26 | Amgen Inc. | Anticorps heterodimeres bispecifiques |
KR20150130349A (ko) * | 2013-03-15 | 2015-11-23 | 메르크 파텐트 게엠베하 | 4가 이중특이적 항체 |
UA118028C2 (uk) * | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
US20160257748A1 (en) * | 2013-09-25 | 2016-09-08 | Amgen Inc. | V-c-fc-v-c antibody |
-
2015
- 2015-11-17 HU HUE15797970A patent/HUE051715T2/hu unknown
- 2015-11-17 UA UAA201706105A patent/UA122676C2/uk unknown
- 2015-11-17 AU AU2015348595A patent/AU2015348595B2/en active Active
- 2015-11-17 SI SI201531404T patent/SI3221356T1/sl unknown
- 2015-11-17 ES ES15797970T patent/ES2829829T3/es active Active
- 2015-11-17 MX MX2017006571A patent/MX2017006571A/es unknown
- 2015-11-17 CA CA2960929A patent/CA2960929A1/fr active Pending
- 2015-11-17 SG SG11201702976TA patent/SG11201702976TA/en unknown
- 2015-11-17 EA EA201791121A patent/EA201791121A1/ru unknown
- 2015-11-17 WO PCT/EP2015/076739 patent/WO2016079076A1/fr active Application Filing
- 2015-11-17 PT PT157979709T patent/PT3221356T/pt unknown
- 2015-11-17 PE PE2017000543A patent/PE20170585A1/es unknown
- 2015-11-17 EP EP15797970.9A patent/EP3221356B1/fr active Active
- 2015-11-17 BR BR112017007086A patent/BR112017007086A2/pt active Search and Examination
- 2015-11-17 RS RS20201312A patent/RS61010B1/sr unknown
- 2015-11-17 DK DK15797970.9T patent/DK3221356T3/da active
- 2015-11-17 KR KR1020177013403A patent/KR102648966B1/ko active IP Right Grant
- 2015-11-17 LT LTEP15797970.9T patent/LT3221356T/lt unknown
- 2015-11-17 MY MYPI2017701790A patent/MY184889A/en unknown
- 2015-11-17 CR CR20170203A patent/CR20170203A/es unknown
- 2015-11-17 PL PL15797970T patent/PL3221356T3/pl unknown
- 2015-11-17 CN CN201580059475.0A patent/CN107074955B/zh active Active
- 2015-11-17 MA MA40972A patent/MA40972B1/fr unknown
- 2015-11-17 JP JP2017527224A patent/JP7146395B2/ja active Active
- 2015-11-19 TW TW104138283D patent/TWI756164B/zh active
- 2015-11-19 TW TW104138283A patent/TW201632556A/zh unknown
- 2015-11-20 AR ARP150103792A patent/AR102732A1/es unknown
- 2015-11-20 US US14/947,657 patent/US20160208019A1/en not_active Abandoned
-
2017
- 2017-03-15 ZA ZA2017/01843A patent/ZA201701843B/en unknown
- 2017-03-20 IL IL251292A patent/IL251292A0/en active IP Right Grant
- 2017-03-29 CO CONC2017/0003048A patent/CO2017003048A2/es unknown
- 2017-04-18 CL CL2017000954A patent/CL2017000954A1/es unknown
- 2017-05-19 PH PH12017500939A patent/PH12017500939A1/en unknown
-
2018
- 2018-06-22 US US16/016,209 patent/US20190031784A1/en not_active Abandoned
-
2020
- 2020-10-29 HR HRP20201747TT patent/HRP20201747T1/hr unknown
- 2020-12-02 JP JP2020200433A patent/JP2021058189A/ja active Pending
-
2022
- 2022-01-20 US US17/580,248 patent/US20220220224A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA40972B1 (fr) | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 | |
MA40510A (fr) | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t | |
MA35448B1 (fr) | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t | |
MA38308A1 (fr) | Molécules de liaison à l'antigène bispécifiques activant des lymphocytes t | |
PH12019500545A1 (en) | Cd3 binding antibodies | |
EA201890285A1 (ru) | Антитела против pd-1, активируемые антитела против pd-1 и способы их применения | |
PH12018501220A1 (en) | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof | |
UA118332C2 (uk) | Білок, що зв'язує антиген cd27l | |
EA201992131A1 (ru) | Высокоаффинные специфичные к mage-a1 tcr и их применение | |
PH12018500062A1 (en) | Antibodies specific for hyperphosphorylated tau and methods of use thereof | |
MX2018016404A (es) | Anticuerpos de union a cd3. | |
MY193112A (en) | Anti pd-1 and anti-lag3 antibodies for cancer treatment | |
MA39250B1 (fr) | Protéines hybrides de l'interleukine-2 et leurs utilisations | |
EP4249066A3 (fr) | Anticorps contre tigit | |
EA201792420A1 (ru) | Композиции и способы перепрограммирования tcr с помощью гибридных белков | |
JOP20180117B1 (ar) | أجسام مضادة انتقائية لـ tau فائق المعالجة بفوسفوريلات وطرق لاستخدامها | |
BR112012022102A2 (pt) | polipeptídeos de ligação a a-beta. | |
UA116614C2 (uk) | Антитіло до фактора d і його застосування | |
BR112019024654A2 (pt) | proteína de ligação nkg2d, cd16 e ror1 ou ror2 | |
PH12019500571A1 (en) | Anti-pd-1 antibodies | |
MX2020003503A (es) | Proteinas de union al antigeno del receptor de oncostatina m. | |
PH12016501366A1 (en) | Novel anti-baff antibodies | |
EA201591791A1 (ru) | Антитела pac1 человека | |
EA201591191A1 (ru) | Антитела против ntb-a и связанные с ними композиции и способы | |
EA201992206A1 (ru) | Моноклональное антитело к pd-l1 |