JP5904552B2 - 膵癌治療剤 - Google Patents
膵癌治療剤 Download PDFInfo
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- JP5904552B2 JP5904552B2 JP2012517325A JP2012517325A JP5904552B2 JP 5904552 B2 JP5904552 B2 JP 5904552B2 JP 2012517325 A JP2012517325 A JP 2012517325A JP 2012517325 A JP2012517325 A JP 2012517325A JP 5904552 B2 JP5904552 B2 JP 5904552B2
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- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
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- YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Description
〔1〕代謝拮抗剤を含有する、または、代謝拮抗剤と併用して投与する、IL-6阻害剤を含む膵癌治療用組成物。
〔2〕IL-6阻害剤がIL-6受容体に結合する物質である〔1〕に記載の治療用組成物。
〔3〕IL-6受容体に結合する物質が抗IL-6受容体抗体である〔2〕に記載の治療用組成物。
〔4〕抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である請求項3に記載の治療用組成物。
〔5〕代謝拮抗剤がシトシン類縁体である〔1〕〜〔4〕いずれかに記載の治療用組成物。
〔6〕シトシン類縁体がゲムシタビンまたはその塩である〔5〕に記載の治療用組成物。
〔7〕ゲムシタビンまたはその塩がゲムシタビン塩酸塩である〔6〕に記載の治療用組成物。
〔8〕IL-6阻害剤と代謝拮抗剤とを対象に投与する工程を含む、膵癌の治療方法。
〔9〕IL-6阻害剤がIL-6受容体に結合する物質である〔8〕に記載の方法。
〔10〕IL-6受容体に結合する物質が抗IL-6受容体抗体である〔9〕に記載の方法。
〔11〕抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である〔10〕に記載の方法。
〔12〕代謝拮抗剤がシトシン類縁体である〔8〕〜〔11〕いずれかに記載の方法。
〔13〕シトシン類縁体がゲムシタビンまたはその塩である〔12〕に記載の方法。
〔14〕ゲムシタビンまたはその塩がゲムシタビン塩酸塩である〔13〕に記載の方法。
〔15〕代謝拮抗剤と併用投与して膵癌を治療する方法に使用するための、IL-6阻害剤。
〔16〕IL-6阻害剤がIL-6受容体に結合する物質である〔15〕に記載の阻害剤。
〔17〕IL-6受容体に結合する物質が抗IL-6受容体抗体である〔16〕に記載の阻害剤。
〔18〕抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である〔17〕に記載の阻害剤。
〔19〕代謝拮抗剤がシトシン類縁体である〔15〕〜〔18〕いずれかに記載の阻害剤。
〔20〕シトシン類縁体がゲムシタビンまたはその塩である〔19〕に記載の阻害剤。
〔21〕ゲムシタビンまたはその塩がゲムシタビン塩酸塩である〔20〕に記載の阻害剤。
げられる。動物を使用する場合、哺乳類動物、昆虫を用いる産生系などがある。
実施例1 膵癌に対する塩酸ゲムシタビンとトシリズマブの併用投与効果
CRP>=2.0 mg/dL(CRP:C反応性蛋白:炎症反応の強さに相関する)の化学療法未施行の進行・転移性膵癌患者を対象に塩酸ゲムシタビンとヒト化抗IL-6レセプター抗体(トシリズマブ)による治療を行った。
1) Sobin LH, Wittekind CL, editors. TNM classification of malignant tumors, 6th edition. New York: John Wiley & Sons, 2002.
2) 光永修一,池田公史,仲地耕平,ほか:切除不能膵癌患者における悪液質の指標としての血清CRP値の有効性. 第40回日本膵臓学会学術総会,2009.
Claims (3)
- ゲムシタビンまたはその塩を含有する、または、ゲムシタビンまたはその塩と併用して投与する、抗IL-6受容体抗体を含む膵癌治療用組成物。
- 抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である請求項1に記載の治療用組成物。
- ゲムシタビンまたはその塩がゲムシタビン塩酸塩である請求項1または2に記載の治療用組成物。
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2011
- 2011-05-27 JP JP2012517325A patent/JP5904552B2/ja active Active
- 2011-05-27 EP EP11786743.2A patent/EP2578233B1/en active Active
- 2011-05-27 WO PCT/JP2011/062191 patent/WO2011149046A1/ja active Application Filing
- 2011-05-27 US US13/700,594 patent/US20130149302A1/en not_active Abandoned
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2015
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JP2007518709A (ja) * | 2003-12-19 | 2007-07-12 | アンティセンス ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物 |
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EP2578233A1 (en) | 2013-04-10 |
US11285208B2 (en) | 2022-03-29 |
US20180236068A1 (en) | 2018-08-23 |
US20220175919A1 (en) | 2022-06-09 |
EP2578233A4 (en) | 2014-01-22 |
US20130149302A1 (en) | 2013-06-13 |
EP2578233B1 (en) | 2017-04-26 |
JP2016074703A (ja) | 2016-05-12 |
US20160022812A1 (en) | 2016-01-28 |
WO2011149046A1 (ja) | 2011-12-01 |
JPWO2011149046A1 (ja) | 2013-07-25 |
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