MX342131B - Eliminacion selectiva de celulas erosivas. - Google Patents

Eliminacion selectiva de celulas erosivas.

Info

Publication number
MX342131B
MX342131B MX2013014203A MX2013014203A MX342131B MX 342131 B MX342131 B MX 342131B MX 2013014203 A MX2013014203 A MX 2013014203A MX 2013014203 A MX2013014203 A MX 2013014203A MX 342131 B MX342131 B MX 342131B
Authority
MX
Mexico
Prior art keywords
selective elimination
erosive
cells
treatment
erosive cells
Prior art date
Application number
MX2013014203A
Other languages
English (en)
Other versions
MX2013014203A (es
Inventor
Söderström Kalle
Douglas Galsgaard Elizabeth
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2013014203A publication Critical patent/MX2013014203A/es
Publication of MX342131B publication Critical patent/MX342131B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un anticuerpo anti-NXG2A, o un fragmento de enlace a antígeno del mismo, para usarse en el tratamiento de un paciente que tiene destrucción de cartílago y/o erosión ósea, en donde el anticuerpo anti-NKG2A estimula la eliminación selectiva de células destructivas de cartílago y/o reduce la formación de células que erosinan el hueso.
MX2013014203A 2011-06-17 2012-06-18 Eliminacion selectiva de celulas erosivas. MX342131B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11170402 2011-06-17
US201161501533P 2011-06-27 2011-06-27
PCT/EP2012/061583 WO2012172102A1 (en) 2011-06-17 2012-06-18 Selective elimination of erosive cells

Publications (2)

Publication Number Publication Date
MX2013014203A MX2013014203A (es) 2014-01-20
MX342131B true MX342131B (es) 2016-09-14

Family

ID=44904625

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014203A MX342131B (es) 2011-06-17 2012-06-18 Eliminacion selectiva de celulas erosivas.

Country Status (11)

Country Link
US (4) US9512228B2 (es)
EP (1) EP2721068B1 (es)
JP (1) JP6334395B2 (es)
KR (1) KR102047248B1 (es)
CN (1) CN103635487B (es)
AU (1) AU2012268939B2 (es)
BR (1) BR112013032217B1 (es)
CA (1) CA2838220C (es)
MX (1) MX342131B (es)
RU (1) RU2617056C2 (es)
WO (1) WO2012172102A1 (es)

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EP3026063A1 (en) 2004-12-28 2016-06-01 Innate Pharma S.A. Monoclonal antibodies against nkg2a
BR112012021576A2 (pt) 2010-02-26 2016-10-25 Novo Nordisk As composições estáveis contendo anticorpo.
CN103635487B (zh) 2011-06-17 2016-10-12 诺沃—诺迪斯克有限公司 选择性消除侵蚀性细胞
CN113929782B (zh) 2014-09-16 2024-06-21 依奈特制药公司 对淋巴细胞中抑制途径的中和
DK3193929T3 (da) * 2014-09-16 2019-08-19 Innate Pharma Behandlingsregimer ved anvendelse af anti-nkg2a-antistoffer
RU2721271C2 (ru) 2014-10-23 2020-05-18 Иннейт Фарма Лечение раковых заболеваний с применением анти-nkg2a средств
RS61901B1 (sr) 2016-01-21 2021-06-30 Innate Pharma Neutralizacija inhibitornih puteva u limfocitima
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
KR20200133233A (ko) 2018-03-13 2020-11-26 이나뜨 파르마 두부경부암의 치료
AU2019270277B9 (en) 2018-05-15 2024-12-05 Innate Pharma Treatment of cancer
JP2022528000A (ja) * 2019-03-29 2022-06-07 ドレン バイオ， インコーポレイテッド 大顆粒リンパ球およびナチュラルキラー細胞レベルを低減する方法
IL297412A (en) * 2020-05-04 2022-12-01 Immunorizon Ltd Precursor tri-specific antibody constructs and methods of use thereof
US11795228B2 (en) 2020-09-30 2023-10-24 Dren Bio, Inc. Anti-CD94 antibodies and methods of use thereof
CN114524876B (zh) * 2020-11-23 2025-12-05 南京北恒生物科技有限公司 靶向nkg2a的抗体及其用途

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DK3193929T3 (da) 2014-09-16 2019-08-19 Innate Pharma Behandlingsregimer ved anvendelse af anti-nkg2a-antistoffer
RU2721271C2 (ru) 2014-10-23 2020-05-18 Иннейт Фарма Лечение раковых заболеваний с применением анти-nkg2a средств
RS61901B1 (sr) 2016-01-21 2021-06-30 Innate Pharma Neutralizacija inhibitornih puteva u limfocitima

Also Published As

Publication number Publication date
WO2012172102A1 (en) 2012-12-20
BR112013032217B1 (pt) 2021-01-19
KR20140037918A (ko) 2014-03-27
US20230416374A1 (en) 2023-12-28
BR112013032217A2 (pt) 2016-11-22
EP2721068B1 (en) 2018-12-05
US20140161802A1 (en) 2014-06-12
JP2014519522A (ja) 2014-08-14
MX2013014203A (es) 2014-01-20
RU2013158625A (ru) 2015-07-27
CN103635487B (zh) 2016-10-12
US11697687B2 (en) 2023-07-11
CN103635487A (zh) 2014-03-12
US20200109206A1 (en) 2020-04-09
JP6334395B2 (ja) 2018-05-30
US9512228B2 (en) 2016-12-06
US20170073417A1 (en) 2017-03-16
CA2838220C (en) 2020-07-21
CA2838220A1 (en) 2012-12-20
KR102047248B1 (ko) 2019-11-21
RU2617056C2 (ru) 2017-04-19
AU2012268939B2 (en) 2017-05-04
EP2721068A1 (en) 2014-04-23

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