MX342131B - Eliminacion selectiva de celulas erosivas. - Google Patents

Eliminacion selectiva de celulas erosivas.

Info

Publication number
MX342131B
MX342131B MX2013014203A MX2013014203A MX342131B MX 342131 B MX342131 B MX 342131B MX 2013014203 A MX2013014203 A MX 2013014203A MX 2013014203 A MX2013014203 A MX 2013014203A MX 342131 B MX342131 B MX 342131B
Authority
MX
Mexico
Prior art keywords
selective elimination
erosive
cells
treatment
erosive cells
Prior art date
Application number
MX2013014203A
Other languages
English (en)
Other versions
MX2013014203A (es
Inventor
Söderström Kalle
Douglas Galsgaard Elizabeth
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2013014203A publication Critical patent/MX2013014203A/es
Publication of MX342131B publication Critical patent/MX342131B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un anticuerpo anti-NXG2A, o un fragmento de enlace a antígeno del mismo, para usarse en el tratamiento de un paciente que tiene destrucción de cartílago y/o erosión ósea, en donde el anticuerpo anti-NKG2A estimula la eliminación selectiva de células destructivas de cartílago y/o reduce la formación de células que erosinan el hueso.
MX2013014203A 2011-06-17 2012-06-18 Eliminacion selectiva de celulas erosivas. MX342131B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11170402 2011-06-17
US201161501533P 2011-06-27 2011-06-27
PCT/EP2012/061583 WO2012172102A1 (en) 2011-06-17 2012-06-18 Selective elimination of erosive cells

Publications (2)

Publication Number Publication Date
MX2013014203A MX2013014203A (es) 2014-01-20
MX342131B true MX342131B (es) 2016-09-14

Family

ID=44904625

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014203A MX342131B (es) 2011-06-17 2012-06-18 Eliminacion selectiva de celulas erosivas.

Country Status (11)

Country Link
US (4) US9512228B2 (es)
EP (1) EP2721068B1 (es)
JP (1) JP6334395B2 (es)
KR (1) KR102047248B1 (es)
CN (1) CN103635487B (es)
AU (1) AU2012268939B2 (es)
BR (1) BR112013032217B1 (es)
CA (1) CA2838220C (es)
MX (1) MX342131B (es)
RU (1) RU2617056C2 (es)
WO (1) WO2012172102A1 (es)

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* Cited by examiner, † Cited by third party
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US8993319B2 (en) 2004-12-28 2015-03-31 Innate Pharma S.A. Monoclonal antibodies against NKG2A
RS61082B1 (sr) 2010-02-26 2020-12-31 Novo Nordisk As Stabilno antitelo koje sadrži kompozicije
AU2012268939B2 (en) 2011-06-17 2017-05-04 Novo Nordisk A/S Selective elimination of erosive cells
HUE051193T2 (hu) 2014-09-16 2021-03-01 Innate Pharma Gátlási reakcióút semlegesítése limfocitákban
JP2017538660A (ja) 2014-09-16 2017-12-28 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． 抗ｎｋｇ２ａ抗体を使用した治療計画
WO2016062851A1 (en) * 2014-10-23 2016-04-28 Innate Pharma Treatment of cancers using anti-nkg2a agents
JP7301538B2 (ja) 2016-01-21 2023-07-03 イナート・ファルマ・ソシエテ・アノニム リンパ球における阻害経路の中和
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
EA202092147A1 (ru) 2018-03-13 2021-03-04 Иннейт Фарма Лечение рака головы и шеи
US20220185895A1 (en) * 2019-03-29 2022-06-16 Dren Bio, Inc. Methods of reducing large granular lymphocyte and natural killer cell levels
KR20230005952A (ko) * 2020-05-04 2023-01-10 임뮤노라이즌 엘티디. 전구체 삼중-특이적 항체 구조체 및 그의 이용 방법
AU2021352981A1 (en) 2020-09-30 2023-06-08 Dren Bio, Inc. Anti-cd94 antibodies and methods of use thereof
CN114524876A (zh) * 2020-11-23 2022-05-24 南京北恒生物科技有限公司 靶向nkg2a的抗体及其用途

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KR20170051462A (ko) 2014-08-28 2017-05-11 아카데미슈 지켄후이스 라이덴 Ｃｄ９４／ｎｋｇ２ａ 및／또는 ｃｄ９４／ｎｋｇ２ｂ 항체, 백신 조합물
JP2017538660A (ja) 2014-09-16 2017-12-28 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． 抗ｎｋｇ２ａ抗体を使用した治療計画
HUE051193T2 (hu) 2014-09-16 2021-03-01 Innate Pharma Gátlási reakcióút semlegesítése limfocitákban
WO2016062851A1 (en) 2014-10-23 2016-04-28 Innate Pharma Treatment of cancers using anti-nkg2a agents
JP7301538B2 (ja) 2016-01-21 2023-07-03 イナート・ファルマ・ソシエテ・アノニム リンパ球における阻害経路の中和

Also Published As

Publication number Publication date
CN103635487B (zh) 2016-10-12
US20200109206A1 (en) 2020-04-09
MX2013014203A (es) 2014-01-20
US20170073417A1 (en) 2017-03-16
BR112013032217B1 (pt) 2021-01-19
CA2838220A1 (en) 2012-12-20
WO2012172102A1 (en) 2012-12-20
KR20140037918A (ko) 2014-03-27
CN103635487A (zh) 2014-03-12
AU2012268939B2 (en) 2017-05-04
EP2721068A1 (en) 2014-04-23
US20140161802A1 (en) 2014-06-12
BR112013032217A2 (pt) 2016-11-22
JP2014519522A (ja) 2014-08-14
RU2013158625A (ru) 2015-07-27
EP2721068B1 (en) 2018-12-05
US20230416374A1 (en) 2023-12-28
US9512228B2 (en) 2016-12-06
US11697687B2 (en) 2023-07-11
JP6334395B2 (ja) 2018-05-30
CA2838220C (en) 2020-07-21
KR102047248B1 (ko) 2019-11-21
RU2617056C2 (ru) 2017-04-19

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