MX357166B - Anticuerpos que se unen a notum pectinacetilesterasa. - Google Patents

Anticuerpos que se unen a notum pectinacetilesterasa.

Info

Publication number
MX357166B
MX357166B MX2013005906A MX2013005906A MX357166B MX 357166 B MX357166 B MX 357166B MX 2013005906 A MX2013005906 A MX 2013005906A MX 2013005906 A MX2013005906 A MX 2013005906A MX 357166 B MX357166 B MX 357166B
Authority
MX
Mexico
Prior art keywords
antibodies
notum pectinacetylesterase
pectinacetylesterase
notum
neutralize
Prior art date
Application number
MX2013005906A
Other languages
English (en)
Other versions
MX2013005906A (es
Inventor
Reed Powell David
Hong Seokjoo
Feng Xiao
Joseph Brommage Robert Jr
Landes Gregory
Liu Jeff
George Potter David
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of MX2013005906A publication Critical patent/MX2013005906A/es
Publication of MX357166B publication Critical patent/MX357166B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a anticuerpos que neutralizan Notum Pectinacetilesterasa, así como composiciones que los comprenden, y métodos de uso para tratar enfermedades y trastornos que afectan los huesos.
MX2013005906A 2010-11-24 2011-11-22 Anticuerpos que se unen a notum pectinacetilesterasa. MX357166B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41692710P 2010-11-24 2010-11-24
PCT/US2011/061785 WO2012071381A1 (en) 2010-11-24 2011-11-22 Antibodies to notum pectinacetylesterase

Publications (2)

Publication Number Publication Date
MX2013005906A MX2013005906A (es) 2013-06-28
MX357166B true MX357166B (es) 2018-06-28

Family

ID=46146184

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018001218A MX385858B (es) 2010-11-24 2011-11-22 Anticuerpos que se unen a notum pectinacetilesterasa.
MX2013005906A MX357166B (es) 2010-11-24 2011-11-22 Anticuerpos que se unen a notum pectinacetilesterasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018001218A MX385858B (es) 2010-11-24 2011-11-22 Anticuerpos que se unen a notum pectinacetilesterasa.

Country Status (21)

Country Link
US (3) US20130302346A1 (es)
EP (1) EP2643019B1 (es)
JP (1) JP6033229B2 (es)
KR (2) KR20140026334A (es)
CN (1) CN103298490B (es)
AU (1) AU2011332007C1 (es)
BR (1) BR112013012858B1 (es)
CA (1) CA2817415C (es)
CO (1) CO6721048A2 (es)
DK (1) DK2643019T3 (es)
ES (1) ES2718849T3 (es)
HU (1) HUE043576T2 (es)
IL (1) IL225876A0 (es)
MX (2) MX385858B (es)
NZ (1) NZ609501A (es)
PL (1) PL2643019T3 (es)
PT (1) PT2643019T (es)
RU (1) RU2013123793A (es)
SG (1) SG189982A1 (es)
WO (1) WO2012071381A1 (es)
ZA (1) ZA201302983B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103260646B (zh) * 2010-08-27 2016-01-13 施特姆森特克斯股份有限公司 Notum蛋白调节剂和使用方法
MX385858B (es) 2010-11-24 2025-03-18 Lexicon Pharmaceuticals Inc Anticuerpos que se unen a notum pectinacetilesterasa.
CA3027071A1 (en) 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
US8802365B2 (en) * 2011-03-22 2014-08-12 Whitehead Institute For Biomedical Research Methods for identifying candidate modulators of NOTUM activity
EP2890711B1 (en) * 2012-08-31 2017-01-04 Argen-X Nv Method for producing antibody molecules having inter-species, intra-target cross-reactivity
MX374853B (es) 2015-02-19 2025-03-06 Compugen Ltd Anticuerpos anti-proteína que contiene domino de inmunologlubina relacionado con el receptor de poliovirus (pvrig) y metodos de uso.
WO2020150282A1 (en) * 2019-01-18 2020-07-23 Askgene Pharma Inc. Pd-l1 specific monoclonal antibodies for disease treatment and diagnosis
CN110317271B (zh) * 2019-07-02 2021-04-30 武汉云克隆科技股份有限公司 一种pinp重组抗体的重/轻链可变区及编码基因和重组抗体
EP4263613A4 (en) * 2020-12-16 2024-11-20 Memorial Sloan-Kettering Cancer Center CD40-BINDING MOLECULES AND USES THEREOF

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US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
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DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
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TW313568B (es) 1994-12-20 1997-08-21 Hoffmann La Roche
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EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
GB0201808D0 (en) * 2002-01-25 2002-03-13 European Molecular Biology Lab Embl Protein
US20040063924A1 (en) * 2002-01-28 2004-04-01 Y Tom Tang Secreted proteins
JP4643450B2 (ja) * 2003-08-08 2011-03-02 株式会社ペルセウスプロテオミクス 癌高発現遺伝子
CN103260646B (zh) * 2010-08-27 2016-01-13 施特姆森特克斯股份有限公司 Notum蛋白调节剂和使用方法
MX385858B (es) 2010-11-24 2025-03-18 Lexicon Pharmaceuticals Inc Anticuerpos que se unen a notum pectinacetilesterasa.

Also Published As

Publication number Publication date
JP2014501513A (ja) 2014-01-23
KR20180069083A (ko) 2018-06-22
RU2013123793A (ru) 2014-12-27
DK2643019T3 (en) 2019-04-15
US20130302346A1 (en) 2013-11-14
AU2011332007B2 (en) 2016-11-10
CA2817415A1 (en) 2012-05-31
JP6033229B2 (ja) 2016-11-30
EP2643019A4 (en) 2014-12-31
CN103298490B (zh) 2017-04-26
MX2013005906A (es) 2013-06-28
SG189982A1 (en) 2013-06-28
US11059907B2 (en) 2021-07-13
BR112013012858A2 (pt) 2018-09-04
NZ609501A (en) 2014-12-24
EP2643019B1 (en) 2019-01-02
IL225876A0 (en) 2013-06-27
MX385858B (es) 2025-03-18
US20190241677A1 (en) 2019-08-08
WO2012071381A1 (en) 2012-05-31
HUE043576T2 (hu) 2019-08-28
US20160152731A1 (en) 2016-06-02
ES2718849T3 (es) 2019-07-04
ZA201302983B (en) 2017-06-28
PT2643019T (pt) 2019-04-23
CN103298490A (zh) 2013-09-11
AU2011332007A1 (en) 2013-05-09
KR20140026334A (ko) 2014-03-05
PL2643019T3 (pl) 2019-07-31
AU2011332007C1 (en) 2017-03-02
BR112013012858B1 (pt) 2021-12-07
CA2817415C (en) 2020-05-12
CO6721048A2 (es) 2013-07-31
EP2643019A1 (en) 2013-10-02

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