MX359769B - Metodos para descelularizar huesos. - Google Patents

Metodos para descelularizar huesos.

Info

Publication number
MX359769B
MX359769B MX2014015270A MX2014015270A MX359769B MX 359769 B MX359769 B MX 359769B MX 2014015270 A MX2014015270 A MX 2014015270A MX 2014015270 A MX2014015270 A MX 2014015270A MX 359769 B MX359769 B MX 359769B
Authority
MX
Mexico
Prior art keywords
methods
bone
decellularizing
decellularizing bone
human
Prior art date
Application number
MX2014015270A
Other languages
English (en)
Other versions
MX2014015270A (es
Inventor
Ross Jeffrey
Porter Blaise
Original Assignee
Miromatrix Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miromatrix Medical Inc filed Critical Miromatrix Medical Inc
Publication of MX2014015270A publication Critical patent/MX2014015270A/es
Publication of MX359769B publication Critical patent/MX359769B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4646—Devices for cleaning bone graft

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Pens And Brushes (AREA)
  • Mattresses And Other Support Structures For Chairs And Beds (AREA)
  • Seats For Vehicles (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método para descelularizar un hueso de mamífero nativo que tiene células, caracterizado porque comprende: a) proporcionar un hueso de mamífero nativo que tiene células y una cavidad central, que se modifica para incluir al menos una apertura introducida exógenamente que se extiende desde el exterior del huso hacia adentro de la cavidad central, en donde la apertura se fija con un aparato que proporciona un sello hermético al agua y uno o más conductos; y b) introducir un medio de interrupción celular a través de al menos un conducto del aparato a través de la apertura en la cavidad del hueso, en donde el medio es perfundido a través de la apertura bajo una presión de al menos 200 mm de Hg o hasta 2000 mm de Hg para proporcionar descelularización del hueso.
MX2014015270A 2012-06-13 2013-06-12 Metodos para descelularizar huesos. MX359769B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261659046P 2012-06-13 2012-06-13
PCT/US2013/045387 WO2013188525A1 (en) 2012-06-13 2013-06-12 Methods of decellularizing bone

Publications (2)

Publication Number Publication Date
MX2014015270A MX2014015270A (es) 2015-08-12
MX359769B true MX359769B (es) 2018-10-10

Family

ID=48703894

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015270A MX359769B (es) 2012-06-13 2013-06-12 Metodos para descelularizar huesos.

Country Status (13)

Country Link
US (1) US9290738B2 (es)
EP (1) EP2861721A1 (es)
JP (2) JP2015524680A (es)
KR (1) KR20150033644A (es)
CN (1) CN104937094B (es)
AU (1) AU2013274322B2 (es)
BR (1) BR112014031224A2 (es)
CA (1) CA2876648C (es)
HK (1) HK1209159A1 (es)
IN (1) IN2014DN11201A (es)
MX (1) MX359769B (es)
SG (1) SG11201408337PA (es)
WO (1) WO2013188525A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system

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AU2006282783B2 (en) 2005-08-26 2013-06-06 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
ES2562707T3 (es) 2010-09-01 2016-03-07 Regents Of The University Of Minnesota Métodos de recelularización de un tejido u órgano para una mejor capacidad de trasplante
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
MX376437B (es) 2013-03-15 2025-03-04 Miromatrix Medical Inc Uso de hígado descelularizado por perfusión para recelularización de células de islote.
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
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ES2749160T3 (es) 2015-09-11 2020-03-19 Massachusetts Gen Hospital Regeneración de un lecho vascular pulmonar funcional
CN107456603A (zh) * 2016-06-03 2017-12-12 香港大学深圳医院 一种富集镁离子的骨支架材料及制备方法
CN106075583B (zh) * 2016-07-07 2020-07-14 中国人民解放军第二军医大学 一种采用灌注-压差法制备脱细胞基质生物材料的方法
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering
CN110227182B (zh) * 2019-01-17 2020-12-15 浙江大学医学院附属邵逸夫医院 一种梯度矿化骨细胞外基质材料的制备方法
JP7336242B2 (ja) * 2019-04-05 2023-08-31 株式会社三共 スロットマシン
CN110237303B (zh) * 2019-06-27 2021-06-29 浙江大学医学院附属邵逸夫医院 天然组织来源的脱细胞骨膜基质凝胶材料的制备方法
KR20230015192A (ko) * 2021-07-22 2023-01-31 한스바이오메드 주식회사 무세포 진피층 이식재의 제조 방법

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system

Also Published As

Publication number Publication date
HK1209159A1 (en) 2016-03-24
AU2013274322B2 (en) 2017-03-09
US9290738B2 (en) 2016-03-22
MX2014015270A (es) 2015-08-12
CA2876648C (en) 2020-09-22
IN2014DN11201A (es) 2015-10-02
CN104937094A (zh) 2015-09-23
CA2876648A1 (en) 2013-12-19
KR20150033644A (ko) 2015-04-01
EP2861721A1 (en) 2015-04-22
AU2013274322A1 (en) 2015-01-29
SG11201408337PA (en) 2015-01-29
JP2019072524A (ja) 2019-05-16
US20130337560A1 (en) 2013-12-19
JP2015524680A (ja) 2015-08-27
CN104937094B (zh) 2018-06-01
BR112014031224A2 (pt) 2017-06-27
WO2013188525A1 (en) 2013-12-19

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