ATE528397T1 - Bei krebs überexprimiertes gen - Google Patents

Bei krebs überexprimiertes gen

Info

Publication number
ATE528397T1
ATE528397T1 AT04771625T AT04771625T ATE528397T1 AT E528397 T1 ATE528397 T1 AT E528397T1 AT 04771625 T AT04771625 T AT 04771625T AT 04771625 T AT04771625 T AT 04771625T AT E528397 T1 ATE528397 T1 AT E528397T1
Authority
AT
Austria
Prior art keywords
gene
cancer
nucleotide sequence
protein
seq
Prior art date
Application number
AT04771625T
Other languages
English (en)
Inventor
Hiroyuki Aburatani
Yoshitaka Hippo
Hirokazu Taniguchi
Yong Xin Chen
Shumpei Ishikawa
Shin-Ichi Fukumoto
Takahiro Shimamura
Naoko Kamimura
Ying Qiu Guo
Shogo Yamamoto
Yukio Ito
Hirotaka Ito
Toshihiko Ohtomo
Original Assignee
Perseus Proteomics Inc
Chugai Pharmaceutical Co Ltd
Hiroyuki Aburatani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseus Proteomics Inc, Chugai Pharmaceutical Co Ltd, Hiroyuki Aburatani filed Critical Perseus Proteomics Inc
Application granted granted Critical
Publication of ATE528397T1 publication Critical patent/ATE528397T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
AT04771625T 2003-08-08 2004-08-06 Bei krebs überexprimiertes gen ATE528397T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003290704 2003-08-08
PCT/JP2004/011650 WO2005014818A1 (ja) 2003-08-08 2004-08-06 癌高発現遺伝子

Publications (1)

Publication Number Publication Date
ATE528397T1 true ATE528397T1 (de) 2011-10-15

Family

ID=34131599

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04771625T ATE528397T1 (de) 2003-08-08 2004-08-06 Bei krebs überexprimiertes gen

Country Status (5)

Country Link
US (1) US20080153104A1 (de)
EP (2) EP2311468B1 (de)
JP (2) JP4643450B2 (de)
AT (1) ATE528397T1 (de)
WO (1) WO2005014818A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005097204A1 (ja) * 2004-04-09 2008-02-28 武田薬品工業株式会社 癌の予防・治療剤
JP5007238B2 (ja) * 2005-01-06 2012-08-22 ジェネンテック， インコーポレイテッド 癌の予後予測、診断および治療に有用な方法および組成物
EP1897940A4 (de) 2005-05-02 2009-04-15 Toray Industries Zusammensetzung und verfahren zur diagnose von speiseröhrenkrebs sowie der metastasierung von speiseröhrenkrebs
WO2007005635A2 (en) * 2005-07-01 2007-01-11 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mitotic spindle protein aspm as a diagnostic marker for neoplasia and uses therefor
JP2008118915A (ja) * 2006-11-10 2008-05-29 Kazuto Nishio 胃癌高発現遺伝子特定による胃癌診断および創薬への利用
US20100111852A1 (en) * 2006-12-14 2010-05-06 Forerunner Pharma Research Co., Ltd. Anti-Claudin 3 Monoclonal Antibody and Treatment and Diagnosis of Cancer Using the Same
EP2060583A1 (de) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identifikation Tumor-assoziierter Marker für Diagnose und Therapie
EP2095821A1 (de) * 2008-02-29 2009-09-02 Rheinische Friedrich-Wilhelms-Universität Bonn Antikrebsmittel
JP2009276153A (ja) * 2008-05-13 2009-11-26 Sumitomo Bakelite Co Ltd 胃癌の判定方法
FR2958936A1 (fr) * 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
US9119869B2 (en) * 2010-04-29 2015-09-01 Ronald J. Shebuski Mucin derived polypeptides
JP5855849B2 (ja) * 2010-06-04 2016-02-09 花王株式会社 新規ヒアルロン酸分解促進因子及びその阻害剤
AU2011293127B2 (en) * 2010-08-27 2016-05-12 Abbvie Stemcentrx Llc Notum protein modulators and methods of use
ES2718849T3 (es) 2010-11-24 2019-07-04 Lexicon Pharmaceuticals Inc Anticuerpos contra notum pectinacetilesterasa
US20190382853A1 (en) * 2011-02-25 2019-12-19 Korea Institute Of Ocean And Science & Technology Mest as biomarker for cancer diagnosis and prognosis and method for using thereof
ES2697674T3 (es) 2011-11-01 2019-01-25 Bionomics Inc Procedimientos para bloquear el crecimiento de células madre cancerosas
AU2012332587B2 (en) * 2011-11-01 2017-02-23 Bionomics, Inc. Antibodies and methods of treating cancer
WO2013104103A1 (zh) * 2012-01-09 2013-07-18 苏州工业园区为真生物医药科技有限公司 诊断和预示肠癌的标志物
JP6138154B2 (ja) * 2012-01-09 2017-05-31 スージョウ マイクロダイアグ バイオメディスン カンパニー リミテッド 乳癌の予測および診断のためのバイオマーカー
CN103901206B (zh) * 2013-05-07 2016-03-16 上海良润生物医药科技有限公司 半胱氨酸蛋白酶抑制剂sn与糖类抗原19-9的联合应用
CN103940996B (zh) * 2013-05-07 2016-03-16 上海良润生物医药科技有限公司 Cystatin SN和AFP在制备诊断和预示肝癌标志物中的应用
WO2015153916A1 (en) 2014-04-04 2015-10-08 Bionomics, Inc. Humanized antibodies that bind lgr5
WO2015172201A1 (en) * 2014-05-16 2015-11-19 Peter Maccallum Cancer Institute Biomarker of gastric cancer
WO2017161414A1 (en) 2016-03-22 2017-09-28 Bionomics Limited Administration of an anti-lgr5 monoclonal antibody
WO2024076781A1 (en) * 2022-10-08 2024-04-11 Taipei Medical University Polynucleotides for silencing transcript variant 1 of assembly factor for spindle microtubules and applications thereof

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
JPS58201994A (ja) 1982-05-21 1983-11-25 Hideaki Hagiwara 抗原特異的ヒト免疫グロブリンの生産方法
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DK0479909T3 (da) 1989-06-29 1997-04-07 Medarex Inc Bispecifikke reagenser til AIDS-behandling
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
EP0586505A1 (de) 1991-05-14 1994-03-16 Repligen Corporation Heterokonjugat-antikörper zur behandlung von hiv-infektionen
EP0605522B1 (de) 1991-09-23 1999-06-23 Medical Research Council Methoden zur Herstellung humanisierter Antikörper
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
EP0656941B1 (de) 1992-03-24 2005-06-01 Cambridge Antibody Technology Limited Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
CA2140280A1 (en) 1992-08-17 1994-03-03 Avi J. Ashkenazi Bispecific immunoadhesins
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (de) 1993-12-03 1996-09-18 Medical Research Council Rekombinante indungsproteine und -peptide
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
JPH08334280A (ja) 1995-04-07 1996-12-17 Fuji Koki Seisakusho:Kk 膨張弁及び冷凍システム
DE69637481T2 (de) 1995-04-27 2009-04-09 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6337195B1 (en) 1995-06-06 2002-01-08 Human Genome Sciences, Inc. Colon specific genes and proteins
WO1997010333A1 (fr) * 1995-09-14 1997-03-20 Sumitomo Electric Industries, Ltd. Nouvelles proteines s'exprimant specifiquement dans le cancer du foie, genes codant ces proteines, anticorps actifs contre ces proteines et procede de detection de l'expression de ces proteines
JPH09203734A (ja) * 1996-01-26 1997-08-05 Sumitomo Electric Ind Ltd 抗血清、抗体、リガンド及びそれらの検出方法
GB9607441D0 (en) 1996-04-10 1996-06-12 Univ Manitoba Human hyaluronan receptor
CZ106299A3 (cs) 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
US6800746B2 (en) 1997-02-25 2004-10-05 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
AR012035A1 (es) 1997-02-25 2000-09-27 Corixa Corp Metodo para detectar el cancer de prostata, metodo para monitorear el desarrollo del cancer de prostata, anticuerpo monoclonal que se une a un polipeptido, una cantidad terapeutica eficaz de anticuerpos monoclonales para preparar medicamentos y equipo para diagnostico
WO2000006698A1 (en) 1998-07-30 2000-02-10 Human Genome Sciences, Inc. 98 human secreted proteins
CA2284550A1 (en) * 1997-03-21 1998-10-01 Human Genome Sciences, Inc. 87 human secreted proteins
EP1016717A4 (de) * 1997-06-26 2004-11-17 Sumitomo Electric Industries Neues protein exprimiert in leberkrebs, gen kodierend dafür, antikörper dagegen und ein verfahren zum nachweis der expression dieses proteins
JP2003517262A (ja) 1997-10-20 2003-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経誘導に含まれるポリペプチド及び核酸のファミリーであるｒｏｂｏ
EP1037925A2 (de) 1997-12-09 2000-09-27 Children's Medical Center Corporation Antagonisten für die neuropilin rezeptorfunktion und deren verwendung
US6362321B1 (en) 1998-03-27 2002-03-26 The General Hospital Corporation Taxol resistance associated gene
WO2000037643A2 (en) 1998-12-23 2000-06-29 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
JP2002523088A (ja) 1998-08-31 2002-07-30 バイエル コーポレイション 結腸癌において示差的に発現されるヒト遺伝子
WO2001064835A2 (en) 2000-02-28 2001-09-07 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2373800A (en) 1998-12-11 2000-06-26 Incyte Pharmaceuticals, Inc. Neuron-associated proteins
US6468546B1 (en) 1998-12-17 2002-10-22 Corixa Corporation Compositions and methods for therapy and diagnosis of ovarian cancer
CA2296792A1 (en) 1999-02-26 2000-08-26 Genset S.A. Expressed sequence tags and encoded human proteins
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
EP1163524A2 (de) 1999-03-15 2001-12-19 EOS Biotechnology, Inc. Screeningverfahren für modulatoren von darmkrebs
CA2383592A1 (en) 1999-03-31 2000-10-05 Curagen Corporation 2384891 acids including open reading frames encoding polypeptides; orfx
ES2420835T3 (es) 1999-04-09 2013-08-27 Kyowa Hakko Kirin Co., Ltd. Procedimiento para controlar la actividad de las moléculas inmunofuncionales
EP1268758A2 (de) 1999-06-01 2003-01-02 Incyte Genomics, Inc. Moleküle für diagnostik und therapie
JP2004500029A (ja) 1999-06-30 2004-01-08 コリクサ　コーポレイション 肺癌の治療および診断のための組成物および方法
AU6181300A (en) 1999-07-29 2001-02-19 Helix Research Institute Liver cancer-associated genes
WO2001021653A2 (en) 1999-09-23 2001-03-29 Corixa Corporation Ovarian tumor antigen and methods of use therefor
US20030003538A1 (en) * 1999-09-23 2003-01-02 Dietrich Paul Shartzer Neuropathic pain genes; compositions thereof; related reagents
EP1265582A2 (de) 1999-09-29 2002-12-18 Human Genome Sciences, Inc. MIT DEM DICKDARM UND DICKDARMKREBS ZUSAMMENHäNGENDE POLYNUKLEOTIDE UND POLYPEPTIDE
WO2001051513A2 (en) 2000-01-14 2001-07-19 Corixa Corporation Ovarian tumor-associated sequences
AU2001229340A1 (en) 2000-01-14 2001-07-24 Millennium Pharmaceuticals, Inc. Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US20020090615A1 (en) * 2000-01-31 2002-07-11 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20030139327A9 (en) 2000-01-31 2003-07-24 Rosen Craig A. Nucleic acids, proteins, and antibodies
WO2001055447A1 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
DE10004102A1 (de) 2000-01-31 2002-06-20 Metagen Pharmaceuticals Gmbh Nachweis von differenzieller Genexpression
EP1255832A1 (de) 2000-02-08 2002-11-13 Millennium Pharmaceuticals, Inc. Protein 18057, ein 7-transmembranprotein
AU2001241541A1 (en) 2000-02-17 2001-08-27 Millennium Predictive Medicine, Inc. Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
AU4347701A (en) 2000-03-01 2001-09-12 Corixa Corp Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
JP2001245671A (ja) 2000-03-07 2001-09-11 Chiba Prefecture ヒト神経芽細胞腫においてクローニングされた新規遺伝子及び新規遺伝子の断片
WO2001070976A2 (en) 2000-03-21 2001-09-27 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian and endometrial cancer
WO2001073027A2 (en) 2000-03-24 2001-10-04 Corixa Corporation Compositions and methods for therapy and diagnosis of colon cancer
AU2001253140A1 (en) 2000-04-03 2001-10-15 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Tumor markers in ovarian cancer
AU2001259062A1 (en) 2000-04-11 2001-10-23 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
WO2001092578A2 (en) 2000-05-26 2001-12-06 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
EP1358349A2 (de) 2000-06-05 2003-11-05 Avalon Pharmaceuticals Bestimmung von krebsgenen und therapeutisches screeningverfahren das signaturen von gensätzen verwendet
WO2002000677A1 (en) 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US6974667B2 (en) 2000-06-14 2005-12-13 Gene Logic, Inc. Gene expression profiles in liver cancer
US6774223B2 (en) 2000-06-28 2004-08-10 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating colon cancer
WO2002000889A1 (fr) 2000-06-29 2002-01-03 Seikagaku Corporation Sulfate transferase et adn codant cette enzyme
EP1343886A2 (de) 2000-07-11 2003-09-17 Corixa Corporation Zusammensetzungen und verfahren zur behandlung und diagnose von lungenkrebs
AU2001285568A1 (en) 2000-07-28 2002-03-22 Michael Andrew Mcguckin Mucin
AU2001283062A1 (en) 2000-08-02 2002-02-13 The Johns Hopkins University Endothelial cell expression patterns
WO2002012280A2 (en) 2000-08-03 2002-02-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
WO2002026982A2 (en) * 2000-09-29 2002-04-04 Incyte Genomics, Inc. Secreted human proteins
AU2001294943A1 (en) 2000-10-02 2002-04-15 Bayer Corporation Nucleic acid sequences differentially expressed in cancer tissue
CN103333860B (zh) 2000-10-06 2015-07-08 协和发酵麒麟株式会社 产生抗体组合物的细胞
US20020150922A1 (en) 2000-11-20 2002-10-17 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
WO2002046415A2 (en) * 2000-12-08 2002-06-13 Incyte Genomics, Inc. Polynucleotide and polypeptide sequences of putative transporters and ion channells
WO2002068579A2 (en) * 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US20030073144A1 (en) 2001-01-30 2003-04-17 Corixa Corporation Compositions and methods for the therapy and diagnosis of pancreatic cancer
US6743619B1 (en) * 2001-01-30 2004-06-01 Nuvelo Nucleic acids and polypeptides
WO2002064797A2 (en) 2001-02-16 2002-08-22 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Mitochondrial topoisomerase i
EP1293569A3 (de) * 2001-09-14 2004-03-31 Research Association for Biotechnology Vollständige cDNA-Sequenzen
US20040038223A1 (en) * 2001-10-02 2004-02-26 Glennda Smithson Novel proteins and nucleic acids encoding same
AU2003214048A1 (en) * 2002-01-25 2003-09-02 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Proteins involved in the regulation of energy homeostasis and organelle metabolism
JP2006513702A (ja) * 2002-09-09 2006-04-27 ヌラ インコーポレーティッド Ｇタンパク質共役受容体およびその使用
WO2004080148A2 (en) * 2002-10-02 2004-09-23 Nuvelo, Inc. Novel nucleic acids and polypeptides
US20070020637A1 (en) * 2003-01-21 2007-01-25 Research Association For Biotechnology Full-length cDNA
WO2004087874A2 (en) * 2003-03-28 2004-10-14 Nuvelo, Inc. Novel nucleic acids and polypeptides

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EP1652923A4 (de) 2006-07-26
EP2311468A1 (de) 2011-04-20
JP2011015681A (ja) 2011-01-27
WO2005014818A1 (ja) 2005-02-17
EP2311468B1 (de) 2014-01-15
US20080153104A1 (en) 2008-06-26
JPWO2005014818A1 (ja) 2006-10-05
EP1652923A1 (de) 2006-05-03
JP4643450B2 (ja) 2011-03-02
EP1652923B1 (de) 2011-10-12

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