ATE528397T1 - Bei krebs überexprimiertes gen - Google Patents

Bei krebs überexprimiertes gen

Info

Publication number
ATE528397T1
ATE528397T1 AT04771625T AT04771625T ATE528397T1 AT E528397 T1 ATE528397 T1 AT E528397T1 AT 04771625 T AT04771625 T AT 04771625T AT 04771625 T AT04771625 T AT 04771625T AT E528397 T1 ATE528397 T1 AT E528397T1
Authority
AT
Austria
Prior art keywords
gene
cancer
nucleotide sequence
protein
seq
Prior art date
Application number
AT04771625T
Other languages
English (en)
Inventor
Hiroyuki Aburatani
Yoshitaka Hippo
Hirokazu Taniguchi
Yong Xin Chen
Shumpei Ishikawa
Shin-Ichi Fukumoto
Takahiro Shimamura
Naoko Kamimura
Ying Qiu Guo
Shogo Yamamoto
Yukio Ito
Hirotaka Ito
Toshihiko Ohtomo
Original Assignee
Perseus Proteomics Inc
Chugai Pharmaceutical Co Ltd
Hiroyuki Aburatani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseus Proteomics Inc, Chugai Pharmaceutical Co Ltd, Hiroyuki Aburatani filed Critical Perseus Proteomics Inc
Application granted granted Critical
Publication of ATE528397T1 publication Critical patent/ATE528397T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
AT04771625T 2003-08-08 2004-08-06 Bei krebs überexprimiertes gen ATE528397T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003290704 2003-08-08
PCT/JP2004/011650 WO2005014818A1 (ja) 2003-08-08 2004-08-06 癌高発現遺伝子

Publications (1)

Publication Number Publication Date
ATE528397T1 true ATE528397T1 (de) 2011-10-15

Family

ID=34131599

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04771625T ATE528397T1 (de) 2003-08-08 2004-08-06 Bei krebs überexprimiertes gen

Country Status (5)

Country Link
US (1) US20080153104A1 (de)
EP (2) EP2311468B1 (de)
JP (2) JP4643450B2 (de)
AT (1) ATE528397T1 (de)
WO (1) WO2005014818A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097204A1 (ja) * 2004-04-09 2005-10-20 Takeda Pharmaceutical Company Limited 癌の予防・治療剤
AU2006203884B2 (en) * 2005-01-06 2012-02-16 Genentech, Inc. Cancer prognostic, diagnostic and treatment methods
EP2177614B1 (de) 2005-05-02 2014-12-31 Toray Industries, Inc. Zusammensetzung und Verfahren zur Diagnose von Speiseröhrenkrebs sowie der Metastasierung von Speiseröhrenkrebs
WO2007005635A2 (en) * 2005-07-01 2007-01-11 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mitotic spindle protein aspm as a diagnostic marker for neoplasia and uses therefor
JP2008118915A (ja) * 2006-11-10 2008-05-29 Kazuto Nishio 胃癌高発現遺伝子特定による胃癌診断および創薬への利用
CA2672581A1 (en) * 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same
EP2060583A1 (de) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identifikation Tumor-assoziierter Marker für Diagnose und Therapie
EP2095821A1 (de) * 2008-02-29 2009-09-02 Rheinische Friedrich-Wilhelms-Universität Bonn Antikrebsmittel
JP2009276153A (ja) * 2008-05-13 2009-11-26 Sumitomo Bakelite Co Ltd 胃癌の判定方法
FR2958936A1 (fr) * 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
US9119869B2 (en) * 2010-04-29 2015-09-01 Ronald J. Shebuski Mucin derived polypeptides
US9056096B2 (en) * 2010-06-04 2015-06-16 Kao Corporation Hyaluronic acid decomposition-promoting factor and inhibitor thereof
CA2809369A1 (en) * 2010-08-27 2012-03-01 Stem Centrx, Inc. Notum protein modulators and methods of use
BR112013012858B1 (pt) 2010-11-24 2021-12-07 Lexicon Pharmaceuticals, Inc Anticorpo monoclonal que se liga a pectinacetilesterase de notum, composição farmacêutica, molécula de ácido nucleico, célula hospedeira e método para produzir o dito anticorpo
US20190382853A1 (en) * 2011-02-25 2019-12-19 Korea Institute Of Ocean And Science & Technology Mest as biomarker for cancer diagnosis and prognosis and method for using thereof
WO2013067054A1 (en) * 2011-11-01 2013-05-10 Bionomics, Inc. Antibodies and methods of treating cancer
US10598653B2 (en) 2011-11-01 2020-03-24 Bionomics Inc. Methods of blocking cancer stem cell growth
WO2013104103A1 (zh) * 2012-01-09 2013-07-18 苏州工业园区为真生物医药科技有限公司 诊断和预示肠癌的标志物
WO2013104102A1 (zh) * 2012-01-09 2013-07-18 苏州工业园区为真生物医药科技有限公司 乳腺癌诊断和预示的标志物
CN103901206B (zh) * 2013-05-07 2016-03-16 上海良润生物医药科技有限公司 半胱氨酸蛋白酶抑制剂sn与糖类抗原19-9的联合应用
CN103940996B (zh) * 2013-05-07 2016-03-16 上海良润生物医药科技有限公司 Cystatin SN和AFP在制备诊断和预示肝癌标志物中的应用
AU2015240599B2 (en) 2014-04-04 2020-11-19 Bionomics, Inc. Humanized antibodies that bind LGR5
WO2015172201A1 (en) * 2014-05-16 2015-11-19 Peter Maccallum Cancer Institute Biomarker of gastric cancer
EP3432925A4 (de) 2016-03-22 2019-11-06 Bionomics Limited Verabreichung eines monoklonalen anti-lgr5-antikörpers
UY38041A (es) * 2017-12-29 2019-06-28 Amgen Inc Construcción de anticuerpo biespecífico dirigida a muc17 y cd3
TWI883585B (zh) * 2022-10-08 2025-05-11 臺北醫學大學 用於靜默紡錘體微管(spindle microtubule)組裝因子(assembly factor)轉錄變異體1的多核苷酸及其應用
WO2025169993A1 (ja) * 2024-02-07 2025-08-14 国立大学法人京都大学 大腸がん患者の予後予測方法

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
JPS58201994A (ja) 1982-05-21 1983-11-25 Hideaki Hagiwara 抗原特異的ヒト免疫グロブリンの生産方法
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
ES2096590T3 (es) 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ アンティボディー テクノロジー リミティド 特異的な結合ペアーの構成員の製造方法
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
JPH06507398A (ja) 1991-05-14 1994-08-25 リプリジェン コーポレーション Hiv感染治療のための異種複合抗体
ATE181571T1 (de) 1991-09-23 1999-07-15 Medical Res Council Methoden zur herstellung humanisierter antikörper
ATE463573T1 (de) 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
EP0746609A4 (de) 1991-12-17 1997-12-17 Genpharm Int Heterologe antikörper produzierende transgene nicht-humane tiere
EP0656941B1 (de) 1992-03-24 2005-06-01 Cambridge Antibody Technology Limited Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
JPH07509137A (ja) 1992-07-24 1995-10-12 セル ジェネシス,インク. 異種抗体の生産
DE69308573T2 (de) 1992-08-17 1997-08-07 Genentech Inc Bispezifische immunoadhesine
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (de) 1993-12-03 1996-09-18 Medical Research Council Rekombinante indungsproteine und -peptide
KR100261941B1 (ko) 1994-07-13 2000-07-15 나가야마 오사무 사람의 인터루킨-8에 대한 재구성 사람항체
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
JPH08334280A (ja) 1995-04-07 1996-12-17 Fuji Koki Seisakusho:Kk 膨張弁及び冷凍システム
EP0822830B1 (de) 1995-04-27 2008-04-02 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6337195B1 (en) 1995-06-06 2002-01-08 Human Genome Sciences, Inc. Colon specific genes and proteins
WO1997010333A1 (fr) * 1995-09-14 1997-03-20 Sumitomo Electric Industries, Ltd. Nouvelles proteines s'exprimant specifiquement dans le cancer du foie, genes codant ces proteines, anticorps actifs contre ces proteines et procede de detection de l'expression de ces proteines
JPH09203734A (ja) * 1996-01-26 1997-08-05 Sumitomo Electric Ind Ltd 抗血清、抗体、リガンド及びそれらの検出方法
GB9607441D0 (en) 1996-04-10 1996-06-12 Univ Manitoba Human hyaluronan receptor
SK40599A3 (en) 1996-09-26 2000-06-12 Chugai Pharmaceutical Co Ltd Antibody against human parathormone related peptides
US6800746B2 (en) 1997-02-25 2004-10-05 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
EP0972201B1 (de) 1997-02-25 2005-08-17 Corixa Corporation Verbindungen zur immundiagnose von prostatakrebs und deren verwendung
WO1998042738A1 (en) * 1997-03-21 1998-10-01 Human Genome Sciences, Inc. 87 human secreted proteins
WO2000006698A1 (en) 1998-07-30 2000-02-10 Human Genome Sciences, Inc. 98 human secreted proteins
EP1016717A4 (de) * 1997-06-26 2004-11-17 Sumitomo Electric Industries Neues protein exprimiert in leberkrebs, gen kodierend dafür, antikörper dagegen und ein verfahren zum nachweis der expression dieses proteins
EP1025231B1 (de) 1997-10-20 2003-07-16 The Regents of the University of California Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung
EP1037925A2 (de) 1997-12-09 2000-09-27 Children's Medical Center Corporation Antagonisten für die neuropilin rezeptorfunktion und deren verwendung
US6362321B1 (en) 1998-03-27 2002-03-26 The General Hospital Corporation Taxol resistance associated gene
JP2002523088A (ja) 1998-08-31 2002-07-30 バイエル コーポレイション 結腸癌において示差的に発現されるヒト遺伝子
WO2001064835A2 (en) 2000-02-28 2001-09-07 Hyseq, Inc. Novel nucleic acids and polypeptides
EP1135494A2 (de) 1998-12-11 2001-09-26 Incyte Pharmaceuticals, Inc. Mit neuronen assoziierte proteine
US6468546B1 (en) 1998-12-17 2002-10-22 Corixa Corporation Compositions and methods for therapy and diagnosis of ovarian cancer
HK1041025A1 (zh) 1998-12-23 2002-06-28 Corixa Corporation 用於結腸癌的免疫治療和診斷的化合物及其使用方法
CA2296792A1 (en) 1999-02-26 2000-08-26 Genset S.A. Expressed sequence tags and encoded human proteins
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
WO2000055633A2 (en) 1999-03-15 2000-09-21 Eos Biotechnology, Inc. Methods of screening for colorectal cancer modulators
EP1165784A2 (de) 1999-03-31 2002-01-02 Curagen Corporation Nukleinsäuren mit offener leserahmen, die polypeptiden kodieren; "orfx"
EP1176195B1 (de) 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Verfahren zur kontrolle der aktivität von immunologisch funktionellem molekül
WO2000073509A2 (en) 1999-06-01 2000-12-07 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics
CA2380873A1 (en) 1999-06-30 2001-01-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
AU6181300A (en) 1999-07-29 2001-02-19 Helix Research Institute Liver cancer-associated genes
AU7832700A (en) 1999-09-23 2001-04-24 Corixa Corporation Ovarian tumor antigen and methods of use therefor
US20030003538A1 (en) * 1999-09-23 2003-01-02 Dietrich Paul Shartzer Neuropathic pain genes; compositions thereof; related reagents
AU7721500A (en) 1999-09-29 2001-04-30 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
WO2001051513A2 (en) 2000-01-14 2001-07-19 Corixa Corporation Ovarian tumor-associated sequences
AU2001229340A1 (en) 2000-01-14 2001-07-24 Millennium Pharmaceuticals, Inc. Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US20020090615A1 (en) * 2000-01-31 2002-07-11 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020168711A1 (en) 2000-01-31 2002-11-14 Rosen Craig A. Nucleic acids, proteins, and antibodies
WO2001055309A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
DE10004102A1 (de) 2000-01-31 2002-06-20 Metagen Pharmaceuticals Gmbh Nachweis von differenzieller Genexpression
EP1255832A1 (de) 2000-02-08 2002-11-13 Millennium Pharmaceuticals, Inc. Protein 18057, ein 7-transmembranprotein
WO2001060860A2 (en) 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
AU4347701A (en) 2000-03-01 2001-09-12 Corixa Corp Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
JP2001245671A (ja) 2000-03-07 2001-09-11 Chiba Prefecture ヒト神経芽細胞腫においてクローニングされた新規遺伝子及び新規遺伝子の断片
WO2001070976A2 (en) 2000-03-21 2001-09-27 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian and endometrial cancer
US20010055596A1 (en) 2000-03-24 2001-12-27 Meagher Madeleine Joy Compositions and methods for therapy and diagnosis of colon cancer
US7279294B2 (en) 2000-04-03 2007-10-09 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services, Nih Tumor markers in ovarian cancer
WO2001077168A2 (en) 2000-04-11 2001-10-18 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
JP2004509608A (ja) 2000-05-26 2004-04-02 ボード オブ トラスティーズ オブ ザ ユニヴァースティ オブ イリノイ レチノイドにより調節される遺伝子の発現を同定する試薬及び方法
JP2004509612A (ja) 2000-06-05 2004-04-02 アバロン ファーマシューティカルズ ガン遺伝子決定および特徴的な遺伝子群を用いた治療用スクリーニング
AU2001266787A1 (en) 2000-06-07 2002-01-08 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US6974667B2 (en) 2000-06-14 2005-12-13 Gene Logic, Inc. Gene expression profiles in liver cancer
AU2001271621A1 (en) 2000-06-28 2002-01-08 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating colon cancer
JP4791676B2 (ja) 2000-06-29 2011-10-12 生化学工業株式会社 硫酸基転移酵素及び該酵素をコードするdna
EP1343886A2 (de) 2000-07-11 2003-09-17 Corixa Corporation Zusammensetzungen und verfahren zur behandlung und diagnose von lungenkrebs
WO2002020598A1 (en) 2000-07-28 2002-03-14 Michael Andrew Mcguckin Mucin
US7402660B2 (en) 2000-08-02 2008-07-22 The Johns Hopkins University Endothelial cell expression patterns
US20020110832A1 (en) 2000-08-03 2002-08-15 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
CA2423424A1 (en) * 2000-09-29 2002-04-04 Incyte Genomics, Inc. Secreted proteins
AU2001294943A1 (en) 2000-10-02 2002-04-15 Bayer Corporation Nucleic acid sequences differentially expressed in cancer tissue
CN102311986B (zh) 2000-10-06 2015-08-19 协和发酵麒麟株式会社 产生抗体组合物的细胞
US20020150922A1 (en) 2000-11-20 2002-10-17 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
AU2002227279A1 (en) * 2000-12-08 2002-06-18 Incyte Genomics, Inc. Polynucleotide and polypeptide sequences of putative transporters and ion channells
WO2002068579A2 (en) * 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US20030073144A1 (en) 2001-01-30 2003-04-17 Corixa Corporation Compositions and methods for the therapy and diagnosis of pancreatic cancer
US6743619B1 (en) * 2001-01-30 2004-06-01 Nuvelo Nucleic acids and polypeptides
WO2002064797A2 (en) 2001-02-16 2002-08-22 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Mitochondrial topoisomerase i
EP1293569A3 (de) * 2001-09-14 2004-03-31 Research Association for Biotechnology Vollständige cDNA-Sequenzen
US20040038223A1 (en) * 2001-10-02 2004-02-26 Glennda Smithson Novel proteins and nucleic acids encoding same
WO2003061681A2 (en) * 2002-01-25 2003-07-31 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Proteins involved in the regulation of energy homeostasis and organelle metabolism
AU2003300776A1 (en) * 2002-09-09 2004-05-25 Omeros Corporation G protein coupled receptors and uses thereof
AU2003303305A1 (en) * 2002-10-02 2004-09-30 Nuvelo,Inc. Novel nucleic acids and polypeptides
US20070020637A1 (en) * 2003-01-21 2007-01-25 Research Association For Biotechnology Full-length cDNA
WO2004087874A2 (en) * 2003-03-28 2004-10-14 Nuvelo, Inc. Novel nucleic acids and polypeptides

Also Published As

Publication number Publication date
JPWO2005014818A1 (ja) 2006-10-05
EP2311468B1 (de) 2014-01-15
EP1652923A4 (de) 2006-07-26
JP2011015681A (ja) 2011-01-27
EP1652923A1 (de) 2006-05-03
JP4643450B2 (ja) 2011-03-02
EP1652923B1 (de) 2011-10-12
US20080153104A1 (en) 2008-06-26
EP2311468A1 (de) 2011-04-20
WO2005014818A1 (ja) 2005-02-17

Similar Documents

Publication Publication Date Title
ATE528397T1 (de) Bei krebs überexprimiertes gen
AU7633001A (en) Diagnosis of diseases associated with apoptosis
ATE446380T1 (de) Methode zur dns-sequenzierung
FR2822164B1 (fr) Polypeptides derives des arn polymerases, et leurs utilisations
PL1601770T3 (pl) Antygeny Streptococcus pyogenes
WO2003093316A3 (en) Immunoglobulin-domain containing cell surface recognition molecules
WO2008087224A3 (en) Mutated netrin 4, fragments thereof and uses thereof as drugs
DK1536006T3 (da) Cancerantigener og anvendelse deraf
WO2004076614A3 (de) Humane nukleinsäuresequenzen aus prostatakarzinomen
EA200300246A1 (ru) Ген и белок, ассоциированные с шизофренией
WO2003020887A3 (en) Gene identification
DE50111824D1 (de) Diagnose von mit humos assoziierten krankheiten
WO2002101002A3 (en) Identification of snps the hgv-v gene
WO2006016172A3 (en) Cell surface glycoprotein
DE60229966D1 (de) Diabetesmodell
ATE311459T1 (de) Die ltr-region von msrv-1 und die durch sie kodierten proteine, und sonden und methoden für detektion des msrv-1 retrovirus
ATE449180T1 (de) Transglutaminase genprodukte
DE602006004966D1 (de) Intrinsic-faktor vom schwein
WO2001051518A3 (en) Nucleic acids encoding human semaphorin proteins and use thereof
NO20011961D0 (no) PRV-1-genet og anvendelsen av dette
ATE412741T1 (de) Neuer vektor und nutzung davon
DE60336015D1 (de) Menschliche Gene in Verbindung mit Krebs, davon kodierte Produkte und Anwendungen davon
WO2004048548A3 (en) Methods for identifying risk of breast cancer and treatments thereof
DE60212861D1 (de) Verfahren zur Diagnose von Fettsucht
EP1312677A4 (de) Nukleinsaeuren, die für lbvv (lettuce big-vein virus) proteine kodieren und deren verwendung(05.12.01)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties