ATE340590T1 - Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper - Google Patents

Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper

Info

Publication number
ATE340590T1
ATE340590T1 AT95925116T AT95925116T ATE340590T1 AT E340590 T1 ATE340590 T1 AT E340590T1 AT 95925116 T AT95925116 T AT 95925116T AT 95925116 T AT95925116 T AT 95925116T AT E340590 T1 ATE340590 T1 AT E340590T1
Authority
AT
Austria
Prior art keywords
human
chain
reconstituted
directed against
antibody directed
Prior art date
Application number
AT95925116T
Other languages
English (en)
Inventor
Kouji Matsushima
Yoshihiro Matsumoto
Yoshiki Yamada
Koh Sato
Masayuki Tsuchiya
Tatsumi Yamazaki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE340590T1 publication Critical patent/ATE340590T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95925116T 1994-07-13 1995-07-12 Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper ATE340590T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16148194 1994-07-13
JP28995194 1994-11-24
JP31078594 1994-12-14

Publications (1)

Publication Number Publication Date
ATE340590T1 true ATE340590T1 (de) 2006-10-15

Family

ID=27321865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95925116T ATE340590T1 (de) 1994-07-13 1995-07-12 Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper

Country Status (10)

Country Link
US (3) US5994524A (de)
EP (1) EP0770628B9 (de)
KR (1) KR100261941B1 (de)
AT (1) ATE340590T1 (de)
AU (1) AU701342B2 (de)
CA (1) CA2194907A1 (de)
DE (1) DE69535243T2 (de)
HU (1) HU221385B1 (de)
WO (1) WO1996002576A1 (de)
ZA (1) ZA955832B (de)

Families Citing this family (360)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) * 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5707622A (en) * 1994-03-03 1998-01-13 Genentech, Inc. Methods for treating ulcerative colitis
WO1997039772A1 (fr) * 1996-04-19 1997-10-30 Chugai Seiyaku Kabushiki Kaisha Remede contre l'arthrite rhumatoide contenant un anticorps anti-il-8 comme principe actif
AU2405297A (en) 1996-04-23 1997-11-12 Chugai Seiyaku Kabushiki Kaisha Cerebral stroke/cerebral edema preventive or remedy containing il-8 binding inhibitor as active ingredient
WO1997040215A1 (fr) * 1996-04-23 1997-10-30 Chugai Seiyaku Kabushiki Kaisha Medicament contre l'infarctus du myocarde contenant comme principe actif un anticorps anti-il-8
US20020141988A1 (en) * 1996-06-26 2002-10-03 Kouji Matsushima Therapeutic agent for acute lung injury resulting from indirect causes comprising anti-il-8 antibody as active ingredient
AU3048797A (en) * 1996-10-22 1998-05-15 Chugai Seiyaku Kabushiki Kaisha Sepsis remedy comprising anti-il-8 antibody as active ingredient
US6133426A (en) * 1997-02-21 2000-10-17 Genentech, Inc. Humanized anti-IL-8 monoclonal antibodies
US6025158A (en) * 1997-02-21 2000-02-15 Genentech, Inc. Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
US7122636B1 (en) 1997-02-21 2006-10-17 Genentech, Inc. Antibody fragment-polymer conjugates and uses of same
WO1998037200A2 (en) 1997-02-21 1998-08-27 Genentech, Inc. Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies
DK2011514T3 (da) 1997-03-21 2012-03-26 Chugai Pharmaceutical Co Ltd Forebyggende eller terapeutisk middel til sensibiliserede-T-celle-medierede sygdomme omfattende IL-6-antagonist som en aktiv bestanddel
CN1326565C (zh) 1997-10-14 2007-07-18 中外制药株式会社 淋巴细胞肿瘤抗体的增强剂
WO1999037779A1 (en) * 1998-01-22 1999-07-29 Genentech, Inc. Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies and uses of same
US7005504B2 (en) 1998-01-22 2006-02-28 Genentech, Inc. Antibody fragment-peg conjugates
US6458355B1 (en) 1998-01-22 2002-10-01 Genentech, Inc. Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
US6468532B1 (en) 1998-01-22 2002-10-22 Genentech, Inc. Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
WO2000009560A2 (en) * 1998-08-17 2000-02-24 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
KR100608276B1 (ko) * 1998-08-24 2006-08-02 무라마쯔 다카시 동맥경화 및 ptca술후의 혈관 재협착에 대한예방·치료제
TWI248365B (en) 1999-08-23 2006-02-01 Chugai Pharmaceutical Co Ltd HM1.24 antigen expression potentiators
CA2388408A1 (en) 1999-10-01 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Prevention and treatment of diseases associated with blood coagulation
AU2001252618A1 (en) 2000-04-28 2001-11-12 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitors
EP1849479A1 (de) 2000-08-16 2007-10-31 Chugai Seiyaku Kabushiki Kaisha Linderungsmittel für Symptome infolge von Gelenkerkrankungen
JP3523245B1 (ja) 2000-11-30 2004-04-26 メダレックス,インコーポレーテッド ヒト抗体作製用トランスジェニック染色体導入齧歯動物
WO2002052005A1 (fr) 2000-12-22 2002-07-04 Kazusa Dna Research Institute Foundation Genes et proteines codees par ceux-ci
JP3986439B2 (ja) 2001-02-07 2007-10-03 中外製薬株式会社 造血器腫瘍の治療剤
CA2446968C (en) 2001-05-11 2012-07-03 Kirin Beer Kabushiki Kaisha Human artificial chromosome containing human antibody .lambda. light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
AU2003211990A1 (en) 2002-02-14 2003-09-04 Chugai Seiyaku Kabushiki Kaisha Antibody-containing solution pharmaceuticals
US20070037769A1 (en) * 2003-03-14 2007-02-15 Multicell Immunotherapeutics, Inc. Compositions and methods to treat and control tumors by loading antigen presenting cells
CA2479187A1 (en) * 2002-03-15 2003-09-25 Astral, Inc. Immunostimulatory double stranded rna and methods of inducing, enhancing or modulating the immune response
EP2258712A3 (de) * 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Zusammensetzungen und Verfahren zur Einleitung bzw. Verstärkung von Antikörper- und Haupthistokompatibilität-Klasse-I- oder-Klasse-II-beschränkten T-Zell-Reaktionen unter Anwendung von Immunmodulierenden, nicht-codierenden RNA-Motiven
CA2488441C (en) * 2002-06-03 2015-01-27 Genentech, Inc. Synthetic antibody phage libraries
AU2003257536A1 (en) 2002-08-27 2004-03-19 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein solution preparation
WO2004022595A1 (ja) 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha MRL/lprマウスを用いた抗体の作製
WO2004024752A1 (ja) 2002-09-11 2004-03-25 Chugai Seiyaku Kabushiki Kaisha タンパク質精製方法
AU2003299641C1 (en) 2002-12-16 2016-06-02 Cormorant Pharmaceuticals Ab Human monoclonal antibodies against interleukin 8 (IL-8)
EP1613775B1 (de) * 2003-03-26 2012-08-29 Multicell Immunotherapeutics, Inc. Ausgewählte rna-motive zur anti-leukämie behandlung
ES2348008T3 (es) 2003-06-18 2010-11-26 Chugai Seiyaku Kabushiki Kaisha Transportador de fucosa.
KR20060069825A (ko) * 2003-08-01 2006-06-22 제넨테크, 인크. 제한된 다양성을 갖는 항체 cdr 폴리펩티드 서열
WO2005014818A1 (ja) 2003-08-08 2005-02-17 Perseus Proteomics Inc. 癌高発現遺伝子
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
WO2005035753A1 (ja) 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha 機能蛋白質を代替する二重特異性抗体
EP2311945A1 (de) 2003-10-14 2011-04-20 Chugai Seiyaku Kabushiki Kaisha Bispezifische Antikörper, die funktionale Proteine ersetzen
FI122368B (fi) * 2003-11-06 2011-12-30 Valtion Teknillinen Menetelmä huokoisen muovikalvon valmistamiseksi ja muovikalvo
CN101133083A (zh) 2003-11-11 2008-02-27 中外制药株式会社 人源化的抗cd47抗体
UA94019C2 (ru) 2004-07-09 2011-04-11 Чугаи Сейяку Кабусики Кайся Антитело, которое специфически связывается с глипиканом 3 (gpc3)
US20090061485A1 (en) 2004-12-22 2009-03-05 Chugai Seiyaku Kabushiki Kaisha Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
PT1831258E (pt) 2004-12-28 2016-01-07 Univ Genova Anticorpos monoclonais contra nkg2a
TWI544076B (zh) 2005-03-31 2016-08-01 Chugai Pharmaceutical Co Ltd A method of manufacturing a polypeptide that controls assembly
CA2603264C (en) 2005-04-08 2017-03-21 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
WO2006132341A1 (ja) 2005-06-10 2006-12-14 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2部位特異的変異体
US8945543B2 (en) 2005-06-10 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
US8952215B2 (en) 2005-10-18 2015-02-10 Nitto Boseki Co., Ltd. Antibody-producing transgenic silkworms and methods for producing the same
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US8679490B2 (en) 2005-11-07 2014-03-25 Genentech, Inc. Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
EP1973951A2 (de) * 2005-12-02 2008-10-01 Genentech, Inc. Bindende polypeptide mit eingeschränkten diversitätssequenzen
EP1977763A4 (de) 2005-12-28 2010-06-02 Chugai Pharmaceutical Co Ltd Antikörper-enthaltende stabilisierende zubereitung
EP2009101B1 (de) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antikörpermodifikationsverfahren für die aufreinigung eines bispezifischen antikörpers
WO2007117410A2 (en) 2006-03-31 2007-10-18 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
WO2007129457A1 (ja) 2006-04-25 2007-11-15 The University Of Tokyo アルツハイマー病および癌の治療薬
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
MY157796A (en) 2006-06-08 2016-07-29 Chugai Pharmaceutical Co Ltd Preventive or remedy for inflammatory disease
JPWO2007145227A1 (ja) 2006-06-14 2009-11-05 中外製薬株式会社 造血幹細胞増加促進剤
BRPI0621800B8 (pt) 2006-06-21 2022-01-04 Oncotherapy Science Inc anticorpos que se ligam à proteína fzd10, clones de hibridoma, composições farmacêuticas, kit compreendendo os referidos anticorpos, e método para diagnose ou prognose de uma doença que é associada a homólogo fzd10 ou de uma predisposição para desenvolver a doença em um indivíduo
ES2531933T3 (es) * 2006-06-30 2015-03-20 Novo Nordisk A/S Anticuerpos anti-NKG2A y usos de los mismos
AR061986A1 (es) 2006-07-13 2008-08-10 Chugai Pharmaceutical Co Ltd Agentes inductores de muerte celular
EP2574625B1 (de) 2006-07-21 2015-02-25 HuBit genomix, Inc. Mittel zur Behandlung von Nierenerkrankungen
DE602006013809D1 (de) 2006-07-24 2010-06-02 Facultad De Medicina Universid Antikörper, Antikörperfragmente und scFv die an posttranslational modifizierte Neurotrophine binden
WO2008020586A1 (en) 2006-08-14 2008-02-21 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-desmoglein-3 antibody
NZ576855A (en) 2006-10-12 2012-08-31 Forerunner Pharma Res Co Ltd Diagnosis and treatment of cancer using anti-ereg antibody
EP2078731A4 (de) 2006-10-20 2012-08-01 Forerunner Pharma Res Co Ltd Anti-hb-egf-antikörper als wirkstoff enthaltende pharmazeutische zusammensetzung
CN101589059A (zh) 2006-10-20 2009-11-25 株式会社未来创药研究所 包含抗hb-egf抗体作为活性成分的药物组合物
EP2103628A4 (de) 2006-12-14 2012-02-22 Forerunner Pharma Res Co Ltd Monoklonaler anti-claudin-3-antikörper und die behandlung und diagnose von krebs unter dessen verwendung
JP5618172B2 (ja) 2007-01-05 2014-11-05 国立大学法人東京大学 抗prg−3抗体を用いる癌の診断および治療
DE602008006041D1 (de) 2007-01-30 2011-05-19 Forerunner Pharma Res Co Ltd CHIMÄRER Fc GAMMA REZEPTOR UND VERFAHREN ZUR BESTIMMUNG VON ADCC-AKTIVITÄT UNTER VERWENDUNG DES REZEPTORS
WO2008105560A1 (ja) 2007-02-27 2008-09-04 Forerunner Pharma Research Co., Ltd. 抗grp78抗体を有効成分として含む医薬組成物
CL2008000719A1 (es) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
JP5117765B2 (ja) 2007-05-28 2013-01-16 国立大学法人 東京大学 抗robo1抗体を含むpet用腫瘍診断剤
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US8722858B2 (en) 2007-06-25 2014-05-13 Chugai Seiyaku Kabushiki Kaisha Anti-Prominin-1 antibody having ADCC activity or CDC activity
US8536313B2 (en) 2007-07-10 2013-09-17 Shionogi & Co., Ltd. Monoclonal antibody having neutralizing activity against MMP13
AU2008304778B9 (en) 2007-09-26 2014-05-08 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
RU2010116756A (ru) 2007-09-28 2011-11-10 Чугаи Сейяку Кабусики Кайся (Jp) Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме
CN106244651A (zh) 2007-10-15 2016-12-21 中外制药株式会社 抗体的制备方法
EP2216344B1 (de) 2007-11-14 2017-06-28 Chugai Seiyaku Kabushiki Kaisha Diagnose und behandlung von krebs mit einem anti-gpr49-antikörper
RU2559530C2 (ru) 2007-11-15 2015-08-10 Чугаи Сейяку Кабусики Кайся Моноклональные антитела, способные связываться с белком axl, и их применение
JP5475460B2 (ja) 2007-12-05 2014-04-16 中外製薬株式会社 掻痒症治療剤
RU2531521C2 (ru) 2007-12-05 2014-10-20 Чугаи Сейяку Кабусики Кайся Антитело против nr10 и его применение
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
WO2009087978A1 (ja) 2008-01-11 2009-07-16 The University Of Tokyo 抗cldn6抗体
KR20100110864A (ko) * 2008-01-24 2010-10-13 노보 노르디스크 에이/에스 인간화된 항-인간 nkg2a 모노클로날 항체
EP3153526B1 (de) 2008-01-31 2020-09-23 INSERM - Institut National de la Santé et de la Recherche Médicale Antikörper gegen humanes cd39 und verwendung davon zur hemmung der regulatorischen t-zell-aktivität
CL2009000647A1 (es) 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
EP2275443B1 (de) 2008-04-11 2015-12-02 Chugai Seiyaku Kabushiki Kaisha Antigen bindendes molekül, das dazu in der lage ist, wiederholt zwei oder mehr antigenmoleküle zu binden
EP2116261A1 (de) 2008-05-07 2009-11-11 Institut Pasteur Unterbereich eines Plasmodium-Proteins mit verbessertem Impfstoff-Potenzial und medizinische Verwendungen davon
US9226934B2 (en) 2008-06-02 2016-01-05 The University Of Tokyo Anti-cancer drug
ES2575430T3 (es) 2008-07-10 2016-06-28 Toray Industries, Inc. Composición farmacéutica para el tratamiento y la prevención del cáncer
ES2502940T3 (es) 2008-08-05 2014-10-06 Toray Industries, Inc. Composición farmacéutica para el tratamiento y la prevención del cáncer
WO2010038610A1 (ja) 2008-09-30 2010-04-08 オリエンタル酵母工業株式会社 新しい軟骨細胞増殖及び分化誘導剤
EP2355847A1 (de) 2008-10-07 2011-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Neutralisierende antikörper und fragmente davon gegen thrombozytenfaktor-4-variante 1 (pf4v1)
EP2359852A4 (de) 2008-11-17 2015-05-20 Nat Cancer Ct Neue auf krebs gerichtete therapie mit einem spezifisch an einen tumorstromafaktor bindenden substanzkomplex und antitumirverbindung
JP5756292B2 (ja) 2008-12-22 2015-07-29 中外製薬株式会社 抗hs6st2抗体及びその用途
US9139647B2 (en) 2008-12-25 2015-09-22 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-TM4SF20 antibody
CA2748990A1 (en) 2008-12-26 2010-07-01 The University Of Tokyo Diagnosis and treatment of cancer using anti-lgr7 antibody
EP2391714B2 (de) 2009-01-30 2019-07-24 Whitehead Institute for Biomedical Research Ligaturverfahren und ihre verwendung
JP2010210772A (ja) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd 液晶表示装置の製造方法
US20120064096A1 (en) 2009-03-17 2012-03-15 Universite De La Mediterranee BTLA Antibodies and Uses Thereof
EP2899212B1 (de) 2009-03-30 2017-07-19 Edimer Biotech S.a. Herstellung von isolierten monoklonalen Agonist-Anti-EDAR-Antikörpern
WO2010119691A1 (ja) 2009-04-16 2010-10-21 国立大学法人東京大学 抗tmprss11e抗体を用いた癌の診断と治療
CA2760642A1 (en) 2009-05-01 2010-11-04 The University Of Tokyo Anti-cadherin antibody
WO2010131733A1 (ja) 2009-05-15 2010-11-18 中外製薬株式会社 抗axl抗体
WO2010137654A1 (ja) 2009-05-29 2010-12-02 株式会社未来創薬研究所 Egfファミリーリガンドのアンタゴニストを成分とする医薬組成物
US20120282173A1 (en) 2009-08-17 2012-11-08 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
EP2496604B1 (de) 2009-11-06 2017-08-23 IDEXX Laboratories, Inc. Antikörper gegen hunde-cd20
US9017669B2 (en) 2009-12-28 2015-04-28 Oncotherapy Science, Inc. Anti-CDH3 antibodies and uses thereof
TWI609698B (zh) 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd 穩定化的含抗體溶液製劑
HRP20211444T1 (hr) 2010-01-29 2021-12-24 Chugai Seiyaku Kabushiki Kaisha Anti-dll3 antitijelo
AU2010344596B2 (en) 2010-01-29 2013-08-01 Toray Industries, Inc. Polylactic acid-based resin sheet
RU2607366C2 (ru) 2010-02-04 2017-01-10 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или профилактики рака
MX340016B (es) 2010-02-04 2016-06-22 Toray Industries Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
RU2603742C2 (ru) 2010-02-04 2016-11-27 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или профилактики рака
PL2532680T3 (pl) 2010-02-04 2015-10-30 Toray Industries Kompozycja medyczna do leczenia raka i/lub zapobiegania
ES2606173T3 (es) 2010-02-04 2017-03-23 Toray Industries, Inc. Composición farmacéutica para el tratamiento y/o la prevención del cáncer
KR101900110B1 (ko) 2010-02-10 2018-09-18 후지필름 알아이 파르마 가부시키가이샤 방사성 금속 표지 항카드헤린 항체
JPWO2011105573A1 (ja) 2010-02-26 2013-06-20 株式会社 未来創薬研究所 抗icam3抗体およびその用途
US10435458B2 (en) 2010-03-04 2019-10-08 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variants with reduced Fcgammar binding
TWI667257B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的FcRn親和力之抗體
WO2011140182A2 (en) 2010-05-04 2011-11-10 Medimmune, Llc Optimized degenerative muscle disease diagnostics and treatments
WO2011145085A2 (en) 2010-05-21 2011-11-24 Procognia (Israel) Ltd Novel antibodies and methods of use for the treatment and diagnosis of cancer
US9485812B2 (en) 2010-07-08 2016-11-01 Honda Motor Co., Ltd. High frequency heating coil
WO2012010696A1 (en) 2010-07-23 2012-01-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for cancer management targeting co-029
JP5843170B2 (ja) 2010-09-30 2016-01-13 国立研究開発法人理化学研究所 グリオーマの治療方法、グリオーマの検査方法、所望の物質をグリオーマに送達させる方法、及びそれらの方法に用いられる薬剤
AU2011323784A1 (en) 2010-10-25 2013-05-30 Regents Of The University Of Minnesota Therapeutic composition for treatment of glioblastoma
PT2634194T (pt) 2010-10-29 2018-10-19 Perseus Proteomics Inc Anticorpos anti-cdh3 possuidores de elevada capacidade de internalização
KR101962483B1 (ko) 2010-11-17 2019-03-29 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
ES2693232T3 (es) 2010-11-30 2018-12-10 Chugai Seiyaku Kabushiki Kaisha Agente terapéutico que induce citotoxicidad
WO2012073992A1 (ja) 2010-11-30 2012-06-07 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
WO2012080769A1 (en) 2010-12-15 2012-06-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-cd277 antibodies and uses thereof
ES2684602T3 (es) 2010-12-22 2018-10-03 Orega Biotech Anticuerpos contra CD39 humano y uso de los mismos
EP2659910B1 (de) 2010-12-27 2016-11-09 National University Corporation Nagoya University Screeningverfahren zur Identifizierung von Verbindungen die die durch Rezeptortyrosinkinase vermittelte Prosurvival-Signalisierung in Krebszellen hemmen
WO2012093704A1 (ja) 2011-01-07 2012-07-12 中外製薬株式会社 抗体の物性を改善させる方法
WO2012101125A1 (en) 2011-01-24 2012-08-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Specific antibodies against human cxcl4 and uses thereof
EP2487242A1 (de) 2011-02-09 2012-08-15 Ruprecht-Karls-Universität Heidelberg B-Plexin-Antagonisten und Verwendungen davon
KR102147548B1 (ko) 2011-02-25 2020-08-24 추가이 세이야쿠 가부시키가이샤 FcγRIIb 특이적 Fc 항체
AU2012233313C1 (en) 2011-03-30 2017-08-03 Chugai Seiyaku Kabushiki Kaisha Method for altering plasma retention and immunogenicity of antigen-binding molecule
EP3461846A1 (de) 2011-03-31 2019-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Gegen icos gerichtete antikörper und verwendungen davon
US20140030276A1 (en) 2011-03-31 2014-01-30 Oriental Yeast Co., Ltd. Cancer immunopotentiating agent containing rankl antagonist
US10059746B2 (en) 2011-04-04 2018-08-28 University Of Iowa Research Foundation Methods of improving vaccine immunogenicity
US10006879B2 (en) 2011-04-12 2018-06-26 Electronic Biosciences, Inc. Site specific chemically modified nanopore devices
EP2700652B1 (de) 2011-04-18 2018-12-19 The University of Tokyo Diagnose und behandlung von krebs mittels anti-itm2a-antikörpern
JP2014516960A (ja) 2011-05-19 2014-07-17 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) 抗ヒトher3抗体及びその使用
EP2721068B1 (de) 2011-06-17 2018-12-05 Novo Nordisk A/S Selektive eliminierung erosiver zellen
EP2723376B1 (de) 2011-06-22 2018-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl-antikörper und verwendungen damit
CA2839480A1 (en) 2011-06-22 2012-12-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-axl antibodies and uses thereof
US9890218B2 (en) 2011-06-30 2018-02-13 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
EP2543677A1 (de) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur Behandlung und Vorbeugung von Thrombose
EP2543679A1 (de) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur Behandlung und Vorbeugung von Thrombose
EP2543678A1 (de) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur Behandlung und Vorbeugung von Thrombose
US9574005B2 (en) 2011-07-19 2017-02-21 Chugai Seiyaku Kabushiki Kaisha Stable Protein-containing preparation containing argininamide or analogous compound thereof
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
MX348578B (es) 2011-08-04 2017-06-20 Toray Industries Composicion farmaceutica para el tratamiento y/o prevencion de cancer.
PL2740795T3 (pl) 2011-08-04 2017-04-28 Toray Industries, Inc. Kompozycja lekowa do leczenia nowotworu i/lub zapobiegania nowotworowi
WO2013017691A1 (en) 2011-08-04 2013-02-07 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
MX348581B (es) 2011-08-04 2017-06-20 Toray Industries Composicion farmaceutica para el tratamiento y/o prevencion de cancer.
US20140242085A1 (en) 2011-08-12 2014-08-28 Medical & Biological Laboratories Co., Ltd. Methods and composition for testing, preventing, and treating aspergillus fumigatus infection
EP2749572A4 (de) 2011-08-23 2015-04-01 Chugai Pharmaceutical Co Ltd Neuer anti-ddr1-antikörper mit antitumoraktivität
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
KR102276528B1 (ko) 2011-09-30 2021-07-12 추가이 세이야쿠 가부시키가이샤 이온 농도 의존성 결합 분자 라이브러리
CN104093424A (zh) 2011-09-30 2014-10-08 中外制药株式会社 诱导针对靶抗原的免疫应答的抗原结合分子
TW201326209A (zh) 2011-09-30 2013-07-01 Chugai Pharmaceutical Co Ltd 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
WO2013047748A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
WO2013047752A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 抗原の消失を促進する抗原結合分子
JP6271251B2 (ja) 2011-10-05 2018-01-31 中外製薬株式会社 糖鎖受容体結合ドメインを含む抗原の血漿中からの消失を促進する抗原結合分子
EP3603671A3 (de) 2011-10-28 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Krebstammzellenspezifisches molekül
RU2681885C2 (ru) 2011-10-31 2019-03-13 Чугаи Сейяку Кабусики Кайся Антигенсвязывающая молекула с регулируемой конъюгацией между тяжелой цепью и легкой цепью
WO2013081143A1 (ja) 2011-11-30 2013-06-06 中外製薬株式会社 免疫複合体を形成する細胞内への運搬体(キャリア)を含む医薬
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
EP2802602B1 (de) 2012-01-11 2019-03-27 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Bispezifische antkörperfragmente für neurologische krankheitsproteine und verfahren zur nutzung dieser
WO2013118858A1 (ja) 2012-02-09 2013-08-15 中外製薬株式会社 抗体のFc領域改変体
PL2818481T3 (pl) 2012-02-21 2020-02-28 Toray Industries, Inc. Kompozycja farmaceutyczna do leczenia i/lub zapobiegania nowotworowi złośliwemu
KR102009238B1 (ko) 2012-02-21 2019-08-09 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
HUE034736T2 (en) 2012-02-21 2018-02-28 Toray Industries A pharmaceutical composition for the treatment and / or prevention of cancer
DK2824114T3 (da) 2012-02-21 2019-07-29 Toray Industries Farmaceutisk sammensætning til behandling af cancer
WO2013125667A1 (ja) 2012-02-24 2013-08-29 中外製薬株式会社 FcγRIIBを介して抗原の消失を促進する抗原結合分子
WO2013147153A1 (ja) 2012-03-29 2013-10-03 株式会社未来創薬研究所 抗lamp5抗体およびその利用
CN104203281B (zh) 2012-03-30 2019-07-26 东丽株式会社 胆囊癌的治疗和/或预防用药物组合物
CA2869120C (en) 2012-03-30 2023-05-23 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of liver cancer
CA2869704A1 (en) 2012-04-04 2013-10-10 Perseus Proteomics Inc. Drug conjugate comprising anti-cdh3 (pcadherin) antibody
CA2871417C (en) 2012-04-23 2021-08-31 Genefrontier Corporation Anti-human cd69 antibody, and use thereof for medical purposes
EP2848633B1 (de) 2012-05-11 2019-02-06 Microbial Chemistry Research Foundation Anti-cxadr-antikörper
CN107964042B (zh) 2012-05-30 2022-04-19 中外制药株式会社 靶组织特异性抗原结合分子
DK2857419T3 (da) 2012-05-30 2021-03-29 Chugai Pharmaceutical Co Ltd Antigen-bindende molekyle til eliminering af aggregerede antigener
EP2862875B1 (de) 2012-06-14 2023-09-06 Chugai Seiyaku Kabushiki Kaisha Antigenbindendes molekül mit modifizierter fc-region
EP2861998B1 (de) 2012-06-18 2020-07-22 Electronic Biosciences Inc. Zellfreie testvorrichtung und verfahren zur verwendung
WO2014001368A1 (en) 2012-06-25 2014-01-03 Orega Biotech Il-17 antagonist antibodies
EP2881467B1 (de) 2012-07-30 2018-10-31 National University Corporation Nagoya University Monoklonaler antikörper gegen menschlichen midkine
EP2889376A4 (de) 2012-08-24 2016-11-02 Chugai Pharmaceutical Co Ltd Maus-fc-rii-spezifischer fc-antikörper
TW202237660A (zh) 2012-08-24 2022-10-01 日商中外製藥股份有限公司 FcγRIIb特異性Fc區域變異體
US9695247B2 (en) 2012-09-03 2017-07-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antibodies directed against ICOS for treating graft-versus-host disease
CN104797132B (zh) 2012-09-13 2017-06-30 中外制药株式会社 基因敲入非人动物
RU2673943C2 (ru) 2012-09-27 2018-12-03 Чугаи Сейяку Кабусики Кайся Fgfr3 гибридный ген и лекарственный препарат, нацеленный на него
BR112015006634B1 (pt) 2012-09-28 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Método e kit para avaliação de reação de coagulação sanguínea
JP6361003B2 (ja) 2012-11-09 2018-07-25 ジーンフロンティア株式会社 癌治療のための抗adam28抗体
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
LT3199552T (lt) 2012-11-20 2020-04-10 Sanofi Anti-ceacam5 antikūnai ir jų panaudojimas
EP3400961B1 (de) 2012-12-27 2021-02-24 Sanofi Anti-lamp1 antikörper und antikörper-konjugate und deren verwendung
CN105102618B (zh) 2012-12-27 2018-04-17 中外制药株式会社 异源二聚化多肽
EP2955226B1 (de) 2013-02-08 2019-06-26 Medical & Biological Laboratories Co., Ltd. Antikörper gegen humanes nrg1-protein
WO2014126198A1 (ja) 2013-02-15 2014-08-21 株式会社ペルセウスプロテオミクス 抗cdh3ヒト化抗体、その薬剤コンジュゲート、及びそれらの使用
EP3339327A3 (de) 2013-02-28 2018-09-19 National Cancer Center Antikörper gegen unlösliches fibrin
CN113621057A (zh) 2013-04-02 2021-11-09 中外制药株式会社 Fc区变体
WO2014174596A1 (ja) 2013-04-23 2014-10-30 株式会社医学生物学研究所 ヘパリン結合上皮増殖因子様増殖因子に対する機能性モノクローナル抗体
CN107095872A (zh) 2013-05-16 2017-08-29 国立大学法人京都大学 用于确定癌症预后的方法
US10005839B2 (en) 2013-05-17 2018-06-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antagonist of the BTLA/HVEM interaction for use in therapy
CA2916362A1 (en) 2013-06-24 2014-12-31 Masami Suzuki Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
WO2015020212A1 (ja) 2013-08-09 2015-02-12 東レ株式会社 癌の治療及び/又は予防用医薬組成物
EP3047857A4 (de) 2013-09-20 2017-08-09 Chugai Seiyaku Kabushiki Kaisha Behandlung von hämorrhagischen erkrankungen durch anti-protein-c-antikörper
RU2758952C1 (ru) 2013-09-27 2021-11-03 Чугаи Сейяку Кабусики Кайся Способ получения полипептидного гетеромультимера
LT3057992T (lt) 2013-10-15 2024-07-25 Genefrontier Corporation Žmogaus antikūnas prieš agrekanazės tipo adamts rūšis, skirtas terapiniams preparatams nuo ligų, susijusių su agrekanaze
EP3070167A4 (de) 2013-11-06 2017-06-07 Osaka University Antikörper mit breiter neutralisierender aktivität bei einem gruppe-1-influenza-a-virus
RU2704228C2 (ru) 2013-11-07 2019-10-24 Инсерм (Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль) Неконкурентные в отношении нейрегулина аллостерические антитела против человеческого her3 и их применения
US20160280787A1 (en) 2013-11-11 2016-09-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified antibody variable region
CA2931296C (en) 2013-12-04 2024-04-23 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
CN105849562B (zh) 2013-12-24 2019-08-16 中外制药株式会社 可溶性gpc3蛋白质的测定方法
NZ722057A (en) 2013-12-27 2022-10-28 Chugai Pharmaceutical Co Ltd Method for purifying antibody having low isoelectric point
EP3087986B1 (de) 2013-12-27 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Mutantes fgfr-gatekeeper-gen und dagegen gerichteter wirkstoff
EP3572093A1 (de) 2014-03-31 2019-11-27 Debiopharm International SA Fgfr-fusionen
US10544231B2 (en) 2014-04-16 2020-01-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the prevention or the treatment of bleeding episodes
TWI831106B (zh) 2014-06-20 2024-02-01 日商中外製藥股份有限公司 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
US10166304B2 (en) 2014-07-11 2019-01-01 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
US20170362304A1 (en) 2014-08-20 2017-12-21 Chugai Seiyaku Kabushiki Kaisha Method for measuring viscosity of protein solution
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
UA127961C2 (uk) 2014-12-19 2024-02-28 Чугей Сейяку Кабусікі Кайся Антитіло до латентного міостатину
TN2018000324A1 (en) 2015-01-23 2020-01-16 Sanofi Sa ANTl-CD3 ANTIBODIES, ANTl-CD123 ANTIBODIES AND BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO CD3 AND/OR CD123
JP2018510842A (ja) 2015-02-05 2018-04-19 中外製薬株式会社 イオン濃度依存的抗原結合ドメインを含む抗体、Fc領域改変体、IL−8に結合する抗体、およびその使用
WO2016128349A1 (en) 2015-02-09 2016-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies specific to glycoprotein (gp) of ebolavirus and uses for the treatment and diagnosis of ebola virus infection
EP3280455A1 (de) 2015-04-07 2018-02-14 INSERM - Institut National de la Santé et de la Recherche Médicale Nichtinvasive abbildung von tumor pd-l1 expression
AU2016248817A1 (en) 2015-04-17 2017-08-17 F. Hoffmann-La Roche Ag Combination therapy with coagulation factors and multispecific antibodies
WO2017005847A1 (en) 2015-07-07 2017-01-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to myosin 18a and uses thereof
EP3331569A1 (de) 2015-08-07 2018-06-13 Gamamabs Pharma Antikörper, antikörper-wirkstoff-konjugate und verfahren zur verwendung
RU2728430C2 (ru) * 2015-09-18 2020-07-29 Чугаи Сейяку Кабусики Кайся Il-8-связывающие антитела и их применения
ES2941968T3 (es) 2015-10-01 2023-05-29 The Whitehead Institute For Biomedical Res Marcaje de anticuerpos
KR20180069839A (ko) 2015-10-08 2018-06-25 자임워크스 인코포레이티드 카파 및 람다 경사슬을 포함하는 항원-결합 폴리펩티드 구조체 및 이의 용도
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
EP3370763B1 (de) 2015-11-03 2024-04-10 Regents of the University of Minnesota Cd200-hemmer und verfahren zur verwendung
EP3378488A4 (de) 2015-11-18 2019-10-30 Chugai Seiyaku Kabushiki Kaisha Verfahren zur verbesserung der humoralen immunreaktion
JP6931329B2 (ja) 2015-11-18 2021-09-01 中外製薬株式会社 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法
WO2017110980A1 (ja) 2015-12-25 2017-06-29 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
WO2017144668A1 (en) 2016-02-26 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity for btla and uses thereof
US11072666B2 (en) 2016-03-14 2021-07-27 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
CA3007135A1 (en) 2016-03-23 2017-09-28 Mabspace Biosciences (Suzhou) Co., Ltd Novel anti-pd-l1 antibodies
MX2018011109A (es) 2016-03-28 2018-11-09 Toray Industries Composicion farmaceutica para el tratamiento y/o prevencion de cancer.
BR112019001693A2 (pt) 2016-07-29 2019-07-02 Ct Hospitalier Universitaire Toulouse anticorpos direcionados a macrófagos associados a tumores e seus usos
TWI831965B (zh) 2016-08-05 2024-02-11 日商中外製藥股份有限公司 Il-8相關疾病之治療用或預防用組成物
CN109661241A (zh) 2016-09-06 2019-04-19 中外制药株式会社 使用识别凝血因子ix和/或活化凝血因子ix以及凝血因子x和/或活化凝血因子x的双特异性抗体的方法
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
BR112019008335A2 (pt) 2016-10-28 2020-01-28 Toray Industries conjugado de um anticorpo, composição farmacêutica e método para o tratamento e/ou a prevenção de um câncer
WO2018091720A1 (en) 2016-11-21 2018-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of metastases
MX2019005947A (es) 2016-11-28 2019-08-26 Chugai Pharmaceutical Co Ltd Molecula de union a ligando que tiene actividad de union a ligando ajustable.
WO2018106931A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US10980739B2 (en) 2016-12-14 2021-04-20 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
WO2018158398A1 (en) 2017-03-02 2018-09-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
EP3596126A4 (de) 2017-03-15 2021-03-03 Tsinghua University Neuartige anti-trkb-antikörper
CN110382544B (zh) 2017-03-16 2023-12-22 先天制药公司 用于治疗癌症的组合物和方法
AU2018240938A1 (en) 2017-03-24 2019-10-10 Zenyaku Kogyo Co., Ltd. Anti-IgM/B cell surface antigen bispecific antibody
EP3603670A4 (de) 2017-03-31 2021-03-10 Public University Corporation Nara Medical University Medizinische zusammensetzung zur prävention und/oder behandlung von blutgerinnungsfaktor-ix-anomalie mit einer multispezifischen antigenbindenden molekülersatzfunktion des blutgerinnungsfaktors viii
CN118453852A (zh) 2017-04-14 2024-08-09 埃克塞里艾克西斯公司 用于预防或治疗癌症的amhrii结合化合物
CN110944665B (zh) 2017-04-14 2024-04-19 埃克塞里艾克西斯公司 用于预防或治疗肺癌的amhrii结合化合物
JP7261739B2 (ja) 2017-04-27 2023-04-20 中外製薬株式会社 薬物動態が改善された血液凝固第ix因子
WO2019020480A1 (en) 2017-07-24 2019-01-31 INSERM (Institut National de la Santé et de la Recherche Médicale) ANTIBODIES AND PEPTIDES FOR TREATING HCMV RELATED DISEASES
US11085929B2 (en) 2017-08-31 2021-08-10 Arizona Board Of Regents On Behalf Of Arizona State University Nanoshell-structured material as co-matrix for peptide characterization in mass spectrometry
KR20200133323A (ko) 2017-09-21 2020-11-27 임체크 테라퓨틱스 에스에이에스 Btn2에 대해 특이성을 갖는 항체 및 이의 용도
AU2018359218B2 (en) 2017-11-01 2021-11-11 Nantbio, Inc. IL8 blocking EMT pathway and overcoming cancer stem cells
CA3083346A1 (en) 2017-11-28 2019-06-06 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
TWI817974B (zh) 2017-12-28 2023-10-11 日商中外製藥股份有限公司 細胞毒性誘導治療劑
JP2021510697A (ja) 2018-01-12 2021-04-30 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company がん処置のための坑il−8抗体及び坑pd−1抗体を用いる組合せ治療
WO2019177543A1 (en) 2018-03-15 2019-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
AU2019243764A1 (en) 2018-03-28 2020-11-05 Mitsubishi Tanabe Pharma Corporation Drug conjugates of cMET monoclonal binding agents, and uses thereof
CA3095719A1 (en) 2018-03-30 2019-10-03 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of cancer
US20210196568A1 (en) 2018-05-21 2021-07-01 Chugai Seiyaku Kabushiki Kaisha Lyophilized formulation sealed in glass container
CA3102060A1 (en) 2018-05-31 2019-12-05 Shionogi & Co., Ltd. Nav1.7 monoclonal antibody
DK3807316T3 (da) 2018-06-18 2024-07-29 Innate Pharma Sammensætninger og fremgangsmåder til behandling af cancer
US20210308170A1 (en) 2018-07-27 2021-10-07 Osaka University Composition for suppression of aging, prevention, amelioration, or treatment of an age-related disease or symptom, or extension of lifespan
WO2020059847A1 (ja) 2018-09-21 2020-03-26 国立大学法人 東京医科歯科大学 ヒトhmgb1に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物
EP3877413A1 (de) 2018-11-06 2021-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und pharmazeutische zusammensetzungen zur behandlung von akuter myeloischer leukämie durch vernichtung von leukämischen stammzellen
CN116726361A (zh) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
JP2022516408A (ja) 2018-12-14 2022-02-28 インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) 単離されたMHC由来ヒトペプチドおよびCD8+CD45RClowTregの抑制機能を刺激し、かつ活性化するためのその使用
CN113260381A (zh) 2018-12-27 2021-08-13 盐野义制药株式会社 新型抗ccr8抗体
US11680105B2 (en) 2019-01-17 2023-06-20 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
US20220089770A1 (en) 2019-01-24 2022-03-24 Chugai Seiyaku Kabushiki Kaisha Novel cancer antigens and antibodies of said antigens
WO2020169472A2 (en) 2019-02-18 2020-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of inducing phenotypic changes in macrophages
CA3130909A1 (en) 2019-02-28 2020-09-03 Juntendo Educational Foundation Antibodies that bind to cleaved form of mutant calreticulin, and diagnostic, preventive, or therapeutic agent for myeloproliferative neoplasm
US20220153875A1 (en) 2019-03-19 2022-05-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing antigen-binding domain of which binding activity to antigen is changed depending on mta, and library for obtaining said antigen-binding domain
JP2022525937A (ja) 2019-03-20 2022-05-20 イムチェック セラピューティクス エスエーエス Btn2に対する特異性を有する抗体及びその使用
EP3947446A1 (de) 2019-03-25 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Behandlung von tauopathie-erkrankungen durch abzielen auf neue tau-spezies
AU2020273072A1 (en) 2019-04-10 2021-12-09 Chugai Seiyaku Kabushiki Kaisha Method for purifying Fc region-modified antibody
AU2020258025A1 (en) 2019-04-18 2021-11-25 Ac Immune Sa Novel molecules for therapy and diagnosis
US20220324975A1 (en) 2019-06-05 2022-10-13 Chugai Seiyaku Kabushiki Kaisha Antibody cleavage site binding molecule
EP4007775A1 (de) 2019-08-02 2022-06-08 Orega Biotech Neue il-17b-antikörper
WO2021058763A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance antibodies and uses thereof
WO2021058729A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance type i receptor antibodies and uses thereof
EP3812008A1 (de) 2019-10-23 2021-04-28 Gamamabs Pharma Amh-kompetitiver antagonistischer antikörper
JP2023503429A (ja) 2019-11-22 2023-01-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 白血病幹細胞を根絶することによる、急性骨髄性白血病の処置のための、アドレノメデュリン阻害剤
WO2021110995A1 (en) 2019-12-04 2021-06-10 Ac Immune Sa Novel molecules for therapy and diagnosis
US20230040928A1 (en) 2019-12-09 2023-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to her4 and uses thereof
EP3870261B1 (de) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Einnehmbare vorrichtung zur abgabe eines therapeutischen mittels an den magen-darm-trakt
CA3169521A1 (en) 2020-02-28 2021-09-02 Marie-Priscille Brun Modified binding polypeptides for optimized drug conjugation
WO2021175954A1 (en) 2020-03-04 2021-09-10 Imcheck Therapeutics Sas Antibodies having specificity for btnl8 and uses thereof
EP4119158A4 (de) 2020-03-12 2024-05-08 Toray Industries, Inc. Medikament zur behandlung und/oder prävention von krebs
US20230139178A1 (en) 2020-03-12 2023-05-04 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
JPWO2021182572A1 (de) 2020-03-12 2021-09-16
JPWO2021182573A1 (de) 2020-03-12 2021-09-16
KR20220151684A (ko) 2020-03-12 2022-11-15 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CN115335082A (zh) 2020-03-27 2022-11-11 光爱科技公司 用于杀死肿瘤细胞的医药品
WO2021200131A1 (ja) 2020-03-30 2021-10-07 国立研究開発法人国立がん研究センター 抗体薬物複合体
JPWO2021206078A1 (de) 2020-04-06 2021-10-14
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
WO2021214222A1 (en) 2020-04-24 2021-10-28 Sanofi Antitumor combinations containing anti-ceacam5 antibody conjugates, trifluridine and tipiracil
JP2023522393A (ja) 2020-04-24 2023-05-30 サノフイ 抗ceacam5抗体コンジュゲートおよびセツキシマブを含有する抗腫瘍組み合わせ
JP2023522392A (ja) 2020-04-24 2023-05-30 サノフイ 抗ceacam5抗体コンジュゲートおよびフォルフィリを含有する抗腫瘍組み合わせ
IL297311A (en) 2020-04-24 2022-12-01 Sanofi Sa Antitumor combinations containing conjugates of antibodies to ceacam5 and folfox
JP2023525053A (ja) 2020-05-12 2023-06-14 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) 皮膚t細胞リンパ腫及びtfh由来リンパ腫を処置する新しい方法
WO2021235537A1 (ja) 2020-05-22 2021-11-25 中外製薬株式会社 凝固第viii因子(f.viii)機能代替活性を有する物質を中和する抗体
JPWO2021261546A1 (de) 2020-06-24 2021-12-30
US20230256092A1 (en) 2020-06-30 2023-08-17 Shionogi & Co., Ltd. Combined use of anti-ccr8 antibody and chemotherapeutic agent
CN116194473A (zh) 2020-07-28 2023-05-30 中外制药株式会社 包含新改造型抗体的具备针护罩的带针预充注射器制剂
CN116194124A (zh) 2020-07-31 2023-05-30 中外制药株式会社 包含表达嵌合受体的细胞的药物组合物
JP2023540732A (ja) 2020-09-04 2023-09-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗ceacam5抗体及びコンジュゲート並びにそれらの使用
EP3981789A1 (de) 2020-10-12 2022-04-13 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives Anti-lilrb-antikörper und verwendungen davon
EP4229082A1 (de) 2020-10-16 2023-08-23 AC Immune SA Alpha-synuclein bindende antikörper zur therapie und diagnose
JPWO2022124247A1 (de) 2020-12-09 2022-06-16
TW202242118A (zh) 2020-12-18 2022-11-01 瑞士商Ac 免疫有限公司 抗體遞送
EP4281187A1 (de) 2021-01-20 2023-11-29 Bioentre LLC Ctla4-bindende proteine und verfahren zur behandlung von krebs
CN117545508A (zh) 2021-06-23 2024-02-09 东丽株式会社 用于癌的治疗和/或预防的药品
EP4360649A1 (de) 2021-06-23 2024-05-01 Toray Industries, Inc. Medikament zur behandlung und/oder prävention von krebs
MX2024001104A (es) 2021-07-27 2024-02-23 Toray Industries Medicamento para el tratamiento y/o prevencion de cancer.
KR20240041917A (ko) 2021-07-27 2024-04-01 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
EP4378477A1 (de) 2021-07-27 2024-06-05 Toray Industries, Inc. Medikament zur behandlung und/oder prävention von krebs
KR20240095160A (ko) 2021-07-29 2024-06-25 인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸) 인간화된 항-인간 βig-h3 단백질 및 이의 용도
JP2024530943A (ja) 2021-08-06 2024-08-27 アンスティテュ・レジオナル・デュ・カンセール・ドゥ・モンペリエ がんの処置のための方法
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び/又は予防用医薬組成物
CN117999098A (zh) 2021-09-24 2024-05-07 光爱科技公司 用于杀死肿瘤细胞的医药品
CN118043031A (zh) 2021-10-04 2024-05-14 诺华股份有限公司 表面活性剂稳定剂
TW202333781A (zh) 2021-10-08 2023-09-01 日商中外製藥股份有限公司 抗hla-dq2﹒5抗體製劑
MX2024004393A (es) 2021-11-01 2024-04-30 Shionogi & Co Nuevo anticuerpo monoclonal nav1.7.
KR20240099412A (ko) 2021-11-05 2024-06-28 사노피 항-ceacam5 항체-약물 접합체 및 항-vegfr-2 항체를 함유하는 항종양 조합
CN115466331B (zh) 2021-11-18 2023-05-30 合源生物科技(天津)有限公司 靶向bcma的嵌合抗原受体及其应用
WO2023100975A1 (ja) 2021-12-01 2023-06-08 中外製薬株式会社 抗体含有製剤の調製方法
AU2023230951A1 (en) 2022-03-09 2024-09-05 Merck Patent Gmbh Anti-gd2 antibodies, immunoconjugates and therapeutic uses thereof
AR128745A1 (es) 2022-03-09 2024-06-12 Merck Patent Gmbh Anticuerpos y conjugados anti-ceacam5 y usos de los mismos
WO2023192478A1 (en) 2022-04-01 2023-10-05 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
WO2023240287A1 (en) 2022-06-10 2023-12-14 Bioentre Llc Combinations of ctla4 binding proteins and methods of treating cancer
WO2024056668A1 (en) 2022-09-12 2024-03-21 Institut National de la Santé et de la Recherche Médicale New anti-itgb8 antibodies and its uses thereof
WO2024180192A1 (en) 2023-03-01 2024-09-06 Sanofi Use of anti-ceacam5 immunoconjugates for treating neuroendocrine cancers expressing ceacam5
EP4427763A1 (de) 2023-03-06 2024-09-11 Sanofi Antitumorkombinationen mit anti-ceacam5-antikörper-wirkstoff-konjugaten, anti-vegfr-2-antikörpern und anti-pd1/pd-l1-antikörpern

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62201598A (ja) * 1986-02-28 1987-09-05 Teijin Ltd マウス−ヒトキメラ抗体h鎖、それをコ−ドするキメラdna配列、プラスミドおよび細胞
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
IE913192A1 (en) * 1990-09-12 1992-02-25 Scripps Research Inst Active site of interleukin-8: polypeptide analogs and¹antibodies
JPH04141095A (ja) * 1990-10-02 1992-05-14 Chemo Sero Therapeut Res Inst 組換え抗hiv改変抗体および改変抗体の調製方法
WO1995001997A1 (en) * 1993-07-09 1995-01-19 Smithkline Beecham Corporation RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
US5874080A (en) * 1994-03-03 1999-02-23 Genentech, Inc. Anti-IL-8 monoclonal antibodies for treatment of asthma
US5707622A (en) * 1994-03-03 1998-01-13 Genentech, Inc. Methods for treating ulcerative colitis

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US20020082396A1 (en) 2002-06-27
US6245894B1 (en) 2001-06-12
EP0770628B1 (de) 2006-09-27
DE69535243T2 (de) 2007-05-10
EP0770628B9 (de) 2007-02-28
DE69535243D1 (de) 2006-11-09
HU221385B1 (en) 2002-09-28
CA2194907A1 (en) 1996-02-01
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EP0770628A4 (de) 2004-10-27
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