ES2179824T3 - Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia. - Google Patents
Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia.Info
- Publication number
- ES2179824T3 ES2179824T3 ES92924918T ES92924918T ES2179824T3 ES 2179824 T3 ES2179824 T3 ES 2179824T3 ES 92924918 T ES92924918 T ES 92924918T ES 92924918 T ES92924918 T ES 92924918T ES 2179824 T3 ES2179824 T3 ES 2179824T3
- Authority
- ES
- Spain
- Prior art keywords
- gpiib
- antibodies against
- humanized antibodies
- reactive
- iiia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Abstract
Una inmunoglobulina humanizada que tiene las propiedades: [1] existe un epitopo de la mencionada inmunoglobulina humanizada en una glucoproteína GPIIb/IIIa de las plaquetas humanas, [2] no existe un epitopo de la mencionada inmunoglobulina humanizada en las células endoteliales vasculares humanas, [3] dicha inmunoglobulina humanizada tiene una afinidad de unión de 107 M-1 o mayor, y [4] dicha inmunoglobulina humanizada puede bloquear la agregación de las plaquetas humanas en respuesta a los agonistas, donde la mencionada inmunoglobulina humanizada comprende una secuencia que es la región variable madura de la cadena ligera de la secuencia superior en la Figura 5A y una secuencia que es la región variable madura de la cadena pesada de la secuencia superior en la Figura 5B.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81211191A | 1991-12-20 | 1991-12-20 | |
US89595292A | 1992-06-09 | 1992-06-09 | |
US94415992A | 1992-09-11 | 1992-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179824T3 true ES2179824T3 (es) | 2003-02-01 |
Family
ID=27420074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92924918T Expired - Lifetime ES2179824T3 (es) | 1991-12-20 | 1992-12-15 | Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0619324B1 (es) |
JP (1) | JP2723671B2 (es) |
KR (1) | KR100240159B1 (es) |
AT (1) | ATE220100T1 (es) |
AU (1) | AU3095892A (es) |
CA (1) | CA2126182C (es) |
DE (1) | DE69232669T2 (es) |
ES (1) | ES2179824T3 (es) |
MX (1) | MX9207459A (es) |
WO (1) | WO1993013133A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT676965E (pt) | 1992-11-16 | 2007-10-29 | Centocor Inc | Método para reduzir a imunogenicidade da região variável de anticorpos |
EP0725655B2 (en) * | 1993-11-05 | 2009-04-15 | Centocor Inc. | Use of compounds capable of binding to glycoprotein gpIIb/IIIa for the prevention of restenosis |
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
IL129164A (en) | 1996-09-26 | 2007-05-15 | Chugai Pharmaceutical Co Ltd | An antibody against peptides associated with human parathyroid hormone |
SK155799A3 (en) | 1997-05-15 | 2000-06-12 | Chugai Pharmaceutical Co Ltd | Cachexia remedy |
EP0990034A1 (de) | 1997-06-06 | 2000-04-05 | Asat AG Applied Science & Technology | Anti-gpiib/iiia rekombinante antikörper |
WO2000066160A1 (fr) * | 1999-04-28 | 2000-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Composition medicamenteuse parenterale a fragment d'anticorps monoclonal humanise et procede de stabilisation |
TWI255718B (en) | 1999-07-02 | 2006-06-01 | Chugai Pharmaceutical Co Ltd | Ameliorative agent for low vasopressin concentration |
AU2001252618A1 (en) | 2000-04-28 | 2001-11-12 | Chugai Seiyaku Kabushiki Kaisha | Cell proliferation inhibitors |
GB0302699D0 (en) * | 2003-02-06 | 2003-03-12 | Univ Bradford | Immunoglobulin |
ES2776657T3 (es) | 2005-06-14 | 2020-07-31 | Amgen Inc | Formulaciones de proteínas autotamponantes |
MX2019004580A (es) | 2016-10-21 | 2019-08-12 | Amgen Inc | Formulaciones farmaceuticas y metodos para prepararlas. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
NO873164L (no) * | 1986-07-30 | 1988-02-01 | Teijin Ltd | Muse-humane kimaere antistoffer. |
-
1992
- 1992-12-15 KR KR1019940702179A patent/KR100240159B1/ko not_active IP Right Cessation
- 1992-12-15 ES ES92924918T patent/ES2179824T3/es not_active Expired - Lifetime
- 1992-12-15 AU AU30958/92A patent/AU3095892A/en not_active Abandoned
- 1992-12-15 CA CA002126182A patent/CA2126182C/en not_active Expired - Fee Related
- 1992-12-15 JP JP5509612A patent/JP2723671B2/ja not_active Expired - Lifetime
- 1992-12-15 AT AT92924918T patent/ATE220100T1/de not_active IP Right Cessation
- 1992-12-15 DE DE69232669T patent/DE69232669T2/de not_active Expired - Fee Related
- 1992-12-15 EP EP92924918A patent/EP0619324B1/en not_active Expired - Lifetime
- 1992-12-15 WO PCT/JP1992/001630 patent/WO1993013133A1/ja active IP Right Grant
- 1992-12-18 MX MX9207459A patent/MX9207459A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0619324A1 (en) | 1994-10-12 |
DE69232669T2 (de) | 2003-02-27 |
CA2126182C (en) | 2001-07-17 |
MX9207459A (es) | 1994-03-31 |
EP0619324B1 (en) | 2002-07-03 |
CA2126182A1 (en) | 1993-07-08 |
KR940703859A (ko) | 1994-12-12 |
EP0619324A4 (en) | 1995-11-29 |
AU3095892A (en) | 1993-07-28 |
ATE220100T1 (de) | 2002-07-15 |
DE69232669D1 (de) | 2002-08-08 |
JP2723671B2 (ja) | 1998-03-09 |
WO1993013133A1 (en) | 1993-07-08 |
KR100240159B1 (ko) | 2000-01-15 |
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