CO6721048A2 - Anticuerpos que se unen a notum pectinacetilesterasa - Google Patents

Anticuerpos que se unen a notum pectinacetilesterasa

Info

Publication number
CO6721048A2
CO6721048A2 CO13149527A CO13149527A CO6721048A2 CO 6721048 A2 CO6721048 A2 CO 6721048A2 CO 13149527 A CO13149527 A CO 13149527A CO 13149527 A CO13149527 A CO 13149527A CO 6721048 A2 CO6721048 A2 CO 6721048A2
Authority
CO
Colombia
Prior art keywords
antibodies
pectinacetilesterase
notum
bind
bind notum
Prior art date
Application number
CO13149527A
Other languages
English (en)
Inventor
Robert Joseph Brommage
Xiao Feng
Seokjoo Hong
Gregory M Landes
Jeff Liu
David Potter
David Reed Powell
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of CO6721048A2 publication Critical patent/CO6721048A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Se describen anticuerpos que neutralizan Notum pectinacetilesterasa, así como composiciones que los comprenden, y métodos de uso para tratar enfermedades y trastornos que afectan los huesos.
CO13149527A 2010-11-24 2013-06-24 Anticuerpos que se unen a notum pectinacetilesterasa CO6721048A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41692710P 2010-11-24 2010-11-24

Publications (1)

Publication Number Publication Date
CO6721048A2 true CO6721048A2 (es) 2013-07-31

Family

ID=46146184

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13149527A CO6721048A2 (es) 2010-11-24 2013-06-24 Anticuerpos que se unen a notum pectinacetilesterasa

Country Status (20)

Country Link
US (3) US20130302346A1 (es)
EP (1) EP2643019B1 (es)
JP (1) JP6033229B2 (es)
KR (2) KR20140026334A (es)
CN (1) CN103298490B (es)
AU (1) AU2011332007C1 (es)
CA (1) CA2817415C (es)
CO (1) CO6721048A2 (es)
DK (1) DK2643019T3 (es)
ES (1) ES2718849T3 (es)
HU (1) HUE043576T2 (es)
IL (1) IL225876A0 (es)
MX (1) MX357166B (es)
NZ (1) NZ609501A (es)
PL (1) PL2643019T3 (es)
PT (1) PT2643019T (es)
RU (1) RU2013123793A (es)
SG (1) SG189982A1 (es)
WO (1) WO2012071381A1 (es)
ZA (1) ZA201302983B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG187965A1 (en) * 2010-08-27 2013-04-30 Stem Centrx Inc Notum protein modulators and methods of use
ES2718849T3 (es) 2010-11-24 2019-07-04 Lexicon Pharmaceuticals Inc Anticuerpos contra notum pectinacetilesterasa
CA2858350A1 (en) 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
US8802365B2 (en) * 2011-03-22 2014-08-12 Whitehead Institute For Biomedical Research Methods for identifying candidate modulators of NOTUM activity
CA2878712A1 (en) * 2012-08-31 2014-03-06 arGEN-X BV Method for producing antibody molecules having inter-species, intra-target cross-reactivity
WO2020150282A1 (en) * 2019-01-18 2020-07-23 Askgene Pharma Inc. Pd-l1 specific monoclonal antibodies for disease treatment and diagnosis
CN110317271B (zh) * 2019-07-02 2021-04-30 武汉云克隆科技股份有限公司 一种pinp重组抗体的重/轻链可变区及编码基因和重组抗体
EP4263613A1 (en) * 2020-12-16 2023-10-25 Memorial Sloan-Kettering Cancer Center Cd40 binding molecules and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US4615885A (en) 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
ATE135370T1 (de) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
JP3068180B2 (ja) 1990-01-12 2000-07-24 アブジェニックス インコーポレイテッド 異種抗体の生成
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
CA2288429C (en) 1991-03-15 2006-04-25 Synergen, Inc. Pegylation of polypeptides
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
TW313568B (es) 1994-12-20 1997-08-21 Hoffmann La Roche
US6127977A (en) 1996-11-08 2000-10-03 Cohen; Nathan Microstrip patch antenna with fractal structure
KR20080059467A (ko) 1996-12-03 2008-06-27 아브게닉스, 인크. 복수의 ｖｈ 및 ｖｋ 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
GB0201808D0 (en) * 2002-01-25 2002-03-13 European Molecular Biology Lab Embl Protein
US20040063924A1 (en) * 2002-01-28 2004-04-01 Y Tom Tang Secreted proteins
EP1652923B1 (en) * 2003-08-08 2011-10-12 Perseus Proteomics Inc. Gene overexpressed in cancer
SG187965A1 (en) * 2010-08-27 2013-04-30 Stem Centrx Inc Notum protein modulators and methods of use
ES2718849T3 (es) 2010-11-24 2019-07-04 Lexicon Pharmaceuticals Inc Anticuerpos contra notum pectinacetilesterasa

Also Published As

Publication number Publication date
KR20140026334A (ko) 2014-03-05
MX357166B (es) 2018-06-28
KR20180069083A (ko) 2018-06-22
US20190241677A1 (en) 2019-08-08
NZ609501A (en) 2014-12-24
US20130302346A1 (en) 2013-11-14
EP2643019B1 (en) 2019-01-02
ZA201302983B (en) 2017-06-28
IL225876A0 (en) 2013-06-27
CN103298490B (zh) 2017-04-26
EP2643019A1 (en) 2013-10-02
ES2718849T3 (es) 2019-07-04
HUE043576T2 (hu) 2019-08-28
AU2011332007C1 (en) 2017-03-02
JP2014501513A (ja) 2014-01-23
US11059907B2 (en) 2021-07-13
PT2643019T (pt) 2019-04-23
SG189982A1 (en) 2013-06-28
JP6033229B2 (ja) 2016-11-30
CA2817415A1 (en) 2012-05-31
AU2011332007A1 (en) 2013-05-09
EP2643019A4 (en) 2014-12-31
DK2643019T3 (en) 2019-04-15
US20160152731A1 (en) 2016-06-02
WO2012071381A1 (en) 2012-05-31
BR112013012858A2 (pt) 2018-09-04
CN103298490A (zh) 2013-09-11
AU2011332007B2 (en) 2016-11-10
MX2013005906A (es) 2013-06-28
CA2817415C (en) 2020-05-12
RU2013123793A (ru) 2014-12-27
PL2643019T3 (pl) 2019-07-31

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