CL2015002754A1 - Método para descelularización de injertos de tejido - Google Patents

Método para descelularización de injertos de tejido

Info

Publication number
CL2015002754A1
CL2015002754A1 CL2015002754A CL2015002754A CL2015002754A1 CL 2015002754 A1 CL2015002754 A1 CL 2015002754A1 CL 2015002754 A CL2015002754 A CL 2015002754A CL 2015002754 A CL2015002754 A CL 2015002754A CL 2015002754 A1 CL2015002754 A1 CL 2015002754A1
Authority
CL
Chile
Prior art keywords
decellularization
tissue grafts
grafts
tissue
Prior art date
Application number
CL2015002754A
Other languages
English (en)
Inventor
David F Muir
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Publication of CL2015002754A1 publication Critical patent/CL2015002754A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CL2015002754A 2013-03-15 2015-09-15 Método para descelularización de injertos de tejido CL2015002754A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361794012P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
CL2015002754A1 true CL2015002754A1 (es) 2016-02-05

Family

ID=51538115

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002754A CL2015002754A1 (es) 2013-03-15 2015-09-15 Método para descelularización de injertos de tejido

Country Status (10)

Country Link
US (2) US9572911B2 (es)
EP (2) EP3928806A1 (es)
JP (1) JP6480911B2 (es)
KR (2) KR102324450B1 (es)
CN (1) CN105188787A (es)
CL (1) CL2015002754A1 (es)
DK (1) DK2968673T3 (es)
ES (1) ES2881079T3 (es)
HK (1) HK1219241A1 (es)
WO (1) WO2014145854A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016001247A (es) 2013-07-30 2016-08-17 Musculoskeletal Transplant Foundation Matrices derivadas de tejido suave acelular y metodos para preparar las mismas.
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US11156595B2 (en) 2015-05-28 2021-10-26 Axogen Corporation Organotypic DRG-peripheral nerve culture system
US11513039B2 (en) 2015-05-28 2022-11-29 Axogen Corporation Nerve culture system
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US9955126B2 (en) * 2015-08-19 2018-04-24 Rapsodo Pte. Ltd. Systems and methods of analyzing moving objects
US10945831B2 (en) 2016-06-03 2021-03-16 Musculoskeletal Transplant Foundation Asymmetric tissue graft
USD856517S1 (en) 2016-06-03 2019-08-13 Musculoskeletal Transplant Foundation Asymmetric tissue graft
CN105920671B (zh) * 2016-06-22 2020-02-11 浙江元太生物科技有限公司 神经移植物的制备方法及其产品
KR101866249B1 (ko) * 2016-11-29 2018-06-12 박순현 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법
WO2019180568A1 (en) * 2018-03-17 2019-09-26 Indian Institute Of Technology Hyderabad Decellularized corneal matrix based hydrogel, bioink formulation and methods thereof
USD895812S1 (en) 2018-09-07 2020-09-08 Musculoskeletal Transplant Foundation Soft tissue repair graft
US10813743B2 (en) 2018-09-07 2020-10-27 Musculoskeletal Transplant Foundation Soft tissue repair grafts and processes for preparing and using same
WO2020101689A1 (en) * 2018-11-15 2020-05-22 Axogen Corporation Materials and methods for nerve repair with animal-sourced nerve grafts
CA3143164A1 (en) 2019-06-11 2020-12-17 Axogen Corporation Wet preservation of tissue
JP2021027803A (ja) * 2019-08-09 2021-02-25 国立研究開発法人国立長寿医療研究センター 象牙質再生用細胞培養物
WO2022138992A1 (ko) * 2020-12-21 2022-06-30 주식회사 엘앤씨바이오 무세포 신경 이식재 및 그 제조방법
AU2022421043A1 (en) 2021-12-22 2024-07-11 Axogen Corporation Nerve grafts containing regenerative compounds, methods of making the same, and methods of treatment using the same
US20230189791A1 (en) 2021-12-22 2023-06-22 Axogen Corporation Tissue preservation solution, tissue preservation system, and methods of preserving tissue

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437090A1 (de) 1974-08-01 1976-02-19 Hoechst Ag Reinigungsmittel
AU2001284968B2 (en) * 2000-08-16 2006-12-21 Duke University Decellularized tissue engineered constructs and tissues
US7402319B2 (en) * 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
CN100372511C (zh) * 2005-11-30 2008-03-05 烟台正海生物技术有限公司 一种脱细胞真皮基质
CN101095963A (zh) * 2006-06-30 2008-01-02 中国人民解放军总医院 一种异体神经移植物、其制备方法及其应用
WO2009017646A2 (en) * 2007-07-27 2009-02-05 Humacyte, Inc. Compositions comprising human collagen and human elastin and methods for soft tissue augmentation
AU2009277252B2 (en) * 2008-07-30 2014-01-16 Mesynthes Limited Tissue scaffolds derived from forestomach extracellular matrix
KR101056069B1 (ko) * 2008-10-13 2011-08-10 아주대학교산학협력단 동물조직 분말을 이용한 다공성 3차원 지지체의 제조방법
EP2393914B1 (en) * 2009-02-04 2017-01-04 Yale University Tissue engineering of lung
WO2012002986A2 (en) * 2009-12-21 2012-01-05 The Regents Of The University Of California Decellularized and delipidized extracellular matrix and methods of use
US8288472B2 (en) * 2009-12-29 2012-10-16 Chung-Yuan Christian University Antibiofouling nonionic-zwitterionic copolymer

Also Published As

Publication number Publication date
EP2968673A1 (en) 2016-01-20
ES2881079T3 (es) 2021-11-26
KR20150127247A (ko) 2015-11-16
US20170128624A1 (en) 2017-05-11
HK1219241A1 (zh) 2017-03-31
KR102324450B1 (ko) 2021-11-10
KR102167247B1 (ko) 2020-10-19
EP2968673A4 (en) 2016-11-02
WO2014145854A1 (en) 2014-09-18
DK2968673T3 (da) 2021-07-12
US9572911B2 (en) 2017-02-21
CN105188787A (zh) 2015-12-23
EP2968673B1 (en) 2021-06-02
JP6480911B2 (ja) 2019-03-13
EP3928806A1 (en) 2021-12-29
US20160030636A1 (en) 2016-02-04
JP2016522000A (ja) 2016-07-28
KR20200119907A (ko) 2020-10-20

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