ES2102007T3 - Proteinas de fusion de fragmentos de anticuerpo monomeras y dimeras. - Google Patents

Proteinas de fusion de fragmentos de anticuerpo monomeras y dimeras.

Info

Publication number
ES2102007T3
ES2102007T3 ES93902206T ES93902206T ES2102007T3 ES 2102007 T3 ES2102007 T3 ES 2102007T3 ES 93902206 T ES93902206 T ES 93902206T ES 93902206 T ES93902206 T ES 93902206T ES 2102007 T3 ES2102007 T3 ES 2102007T3
Authority
ES
Spain
Prior art keywords
fusion proteins
pct
antibody
antibody fragment
monomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902206T
Other languages
English (en)
Inventor
Andreas Pluckthun
Peter Pack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2102007T3 publication Critical patent/ES2102007T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCION DESCRIBE UNA NUEVA CLASE DE MOLECULAS DE UNION A LOS ANTIGENOS QUE CONTIENEN FRAGMENTOS FV DE UN ANTICUERPO PERO QUE NO UTILIZA DOMINIOS CONSTANTES DE ANTICUERPO. TAMBIEN PUEDEN DIMERIZARSE CON OTRAS MOLECULAS DE FRAGMENTOS DE ANTICUERPO O CON MOLECULAS DE FRAGMENTO DE NO ANTICUERPOS PARA FORMAR PROTEINAS DE FUSION DE ANTICUERPO-FRAGMENTO BI IONALES Y LOS LLAMADOS MINIANTICUERPOS, RESPECTIVAMENTE. LAS NUEVAS PROTEINAS DE FUSION PUEDEN UTILIZARSE EN UN AMPLIO CAMPO DE LA MEDICINA TERAPEUTICA O DE DIAGNOSTICO.
ES93902206T 1992-01-23 1993-01-15 Proteinas de fusion de fragmentos de anticuerpo monomeras y dimeras. Expired - Lifetime ES2102007T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92101069 1992-01-23

Publications (1)

Publication Number Publication Date
ES2102007T3 true ES2102007T3 (es) 1997-07-16

Family

ID=8209260

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902206T Expired - Lifetime ES2102007T3 (es) 1992-01-23 1993-01-15 Proteinas de fusion de fragmentos de anticuerpo monomeras y dimeras.

Country Status (16)

Country Link
US (1) US5910573A (es)
EP (1) EP0654085B1 (es)
JP (2) JP3490437B2 (es)
KR (1) KR100254759B1 (es)
AT (1) ATE151113T1 (es)
AU (1) AU676150B2 (es)
CA (1) CA2128511C (es)
CZ (1) CZ287296B6 (es)
DE (1) DE69309472T2 (es)
DK (1) DK0654085T3 (es)
ES (1) ES2102007T3 (es)
GR (1) GR3023860T3 (es)
HU (1) HU215180B (es)
NO (1) NO942750L (es)
RU (1) RU2128709C1 (es)
WO (1) WO1993015210A1 (es)

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