PT2802607T - Complementação funcional bipartida induzida por duplo antigénio - Google Patents

Complementação funcional bipartida induzida por duplo antigénio

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Publication number
PT2802607T
PT2802607T PT137043691T PT13704369T PT2802607T PT 2802607 T PT2802607 T PT 2802607T PT 137043691 T PT137043691 T PT 137043691T PT 13704369 T PT13704369 T PT 13704369T PT 2802607 T PT2802607 T PT 2802607T
Authority
PT
Portugal
Prior art keywords
functional complementation
dual antigen
induced bipartite
bipartite functional
induced
Prior art date
Application number
PT137043691T
Other languages
English (en)
Inventor
Stuhler Gernot
Original Assignee
Univ Wuerzburg J Maximilians
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47715984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2802607(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Wuerzburg J Maximilians filed Critical Univ Wuerzburg J Maximilians
Publication of PT2802607T publication Critical patent/PT2802607T/pt

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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/02Immunomodulators
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    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
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    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/24Immunology or allergic disorders
    • G01N2800/245Transplantation related diseases, e.g. graft versus host disease

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Cell Biology (AREA)
  • Hematology (AREA)
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
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  • Transplantation (AREA)
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PT137043691T 2012-01-13 2013-01-14 Complementação funcional bipartida induzida por duplo antigénio PT2802607T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12151125 2012-01-13

Publications (1)

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PT2802607T true PT2802607T (pt) 2018-01-03

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PT137043691T PT2802607T (pt) 2012-01-13 2013-01-14 Complementação funcional bipartida induzida por duplo antigénio

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US (3) US20150079093A1 (pt)
EP (3) EP3907241A1 (pt)
JP (1) JP6408915B2 (pt)
KR (2) KR102100817B1 (pt)
CN (2) CN104159923B (pt)
AU (1) AU2013208895B2 (pt)
CA (1) CA2861003C (pt)
CY (1) CY1119928T1 (pt)
DK (1) DK2802607T3 (pt)
EA (1) EA033947B1 (pt)
ES (1) ES2653287T3 (pt)
HK (1) HK1200175A1 (pt)
HR (1) HRP20171912T1 (pt)
HU (1) HUE035207T2 (pt)
IL (1) IL233566B (pt)
LT (1) LT2802607T (pt)
MX (1) MX359411B (pt)
NO (1) NO2802607T3 (pt)
PL (1) PL2802607T3 (pt)
PT (1) PT2802607T (pt)
RS (1) RS56773B1 (pt)
SG (1) SG11201403997SA (pt)
SI (1) SI2802607T1 (pt)
WO (1) WO2013104804A2 (pt)
ZA (1) ZA201405658B (pt)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013027224A8 (pt) 2011-04-22 2018-08-14 Emergent Product Dev Seattle Proteínas de ligação de antígeno de membrana específico de próstata e composições e métodos relacionados
PL2914286T3 (pl) 2012-10-30 2022-01-31 Aravax Pty Ltd Nowe cząsteczki immunoterapeutyczne oraz ich zastosowania
US11266737B2 (en) 2013-09-25 2022-03-08 Aravax Pty Ltd Immunotherapeutic composition and uses thereof
EP3129908B1 (en) * 2014-03-25 2021-07-21 Five3 Genomics, LLC Systems and methods for rna analysis in functional confirmation of cancer mutations
EP2985294A1 (en) 2014-08-14 2016-02-17 Deutsches Krebsforschungszentrum Recombinant antibody molecule and its use for target cell restricted T cell activation
AU2015339032B2 (en) * 2014-10-31 2020-02-20 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tetravalent TLR9 bispecific antibody
CN104592391B (zh) * 2015-01-21 2020-08-21 武汉友芝友生物制药有限公司 一种双特异性抗体EpCAM×CD3的构建及应用
JP6688551B2 (ja) 2015-05-21 2020-04-28 ハープーン セラピューティクス,インク. 三重特異性結合タンパク質と使用方法
TWI825431B (zh) 2015-06-16 2023-12-11 美商建南德克公司 FcRH5之人源化及親和力成熟抗體及使用方法
EP3112375A1 (en) * 2015-07-03 2017-01-04 Ludwig-Maximilians-Universität München Antigenic peptides for the diagnosis, therapy monitoring and/or treatment of psoriasis vulgaris
SG10202002577XA (en) 2015-09-21 2020-04-29 Aptevo Res & Development Llc Cd3 binding polypeptides
CN108604257B (zh) * 2015-10-12 2022-12-13 南托米克斯有限责任公司 产生特异性免疫治疗组合物及其相关核酸构建体的方法
WO2017087789A1 (en) * 2015-11-19 2017-05-26 Revitope Limited Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells
CN106810610A (zh) * 2015-11-30 2017-06-09 中国科学院深圳先进技术研究院 抗EpCAM和CD3特异性双靶向抗体及其制备方法和应用、含该双靶向抗体表达盒的微环DNA及应用
CU24613B1 (es) 2016-02-06 2022-07-08 Epimab Biotherapeutics Inc Proteínas de unión a inmunoglobulinas fabs en tandem (fit-ig) biespecíficas que se unen a cmet y egfr
US10634680B2 (en) 2016-04-26 2020-04-28 University Of Utah Research Foundation Target-binding activated split reporter systems for analyte detection and related components and methods
IL263102B2 (en) 2016-05-20 2023-11-01 Harpoon Therapeutics Inc A serum albumin-binding protein with a single site
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
CN116987189A (zh) 2016-05-20 2023-11-03 哈普恩治疗公司 单链可变片段cd3结合蛋白质
CN105920618A (zh) * 2016-06-13 2016-09-07 上海交通大学医学院附属新华医院 一种生物靶向纳米基因材料及其制造方法
EP3714944A1 (en) * 2019-03-29 2020-09-30 Medizinische Hochschule Hannover Car for use in the treatment of hvg disease
CN108085333B (zh) * 2016-11-14 2021-06-29 中国科学院分子植物科学卓越创新中心 一种延缓薯类植物生理性变质的方法
KR20190087539A (ko) 2016-11-23 2019-07-24 하푼 테라퓨틱스, 인크. Psma 표적화 삼중특이성 단백질 및 사용 방법
BR112019010604A2 (pt) 2016-11-23 2019-12-17 Harpoon Therapeutics Inc proteína de ligação ao antígeno da membrana próstata-específico
WO2018136725A1 (en) * 2017-01-19 2018-07-26 Harpoon Therapeutics, Inc. Innate immune cell inducible binding proteins and methods of use
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
AU2018246143A1 (en) * 2017-03-28 2019-10-31 The Trustees Of The University Of Pennsylvania Methods to protect transplanted tissue from rejection
KR20200026810A (ko) 2017-05-12 2020-03-11 하푼 테라퓨틱스, 인크. Msln 표적화 삼중 특이적 단백질 및 사용 방법
IL300964A (en) 2017-05-12 2023-04-01 Harpoon Therapeutics Inc mesothelin binding proteins
SG11202002089RA (en) 2017-09-08 2020-04-29 Maverick Therapeutics Inc Constrained conditionally activated binding proteins
KR102429747B1 (ko) 2017-10-13 2022-08-05 하푼 테라퓨틱스, 인크. B 세포 성숙화 항원 결합 단백질
EP3694529A4 (en) 2017-10-13 2021-11-10 Harpoon Therapeutics, Inc. TRISPECIFIC PROTEINS AND METHOD OF USE
GB201719646D0 (en) * 2017-11-27 2018-01-10 Bivictrix Therapeutics Ltd Therapy
EP3759135A1 (en) * 2017-12-21 2021-01-06 Gernot Stuhler Specific dosage regimen for hemibody therapy
AU2019269628A1 (en) * 2018-05-17 2020-12-03 The Board Of Trustees Of The Leland Stanford Junior University Receptor inhibition by phosphatase recruitment
CA3104185A1 (en) * 2018-07-02 2020-01-09 The General Hospital Corporation Antibody tumor-targeting assembly complexes
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
US11702482B2 (en) 2018-12-17 2023-07-18 Revitope Limited Twin immune cell engager
CN114390938A (zh) 2019-03-05 2022-04-22 武田药品工业有限公司 受约束的条件性活化的结合蛋白
CA3138854A1 (en) 2019-05-02 2020-11-05 The General Hospital Corporation Teac and attac immunooncology compositions and methods
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
AR119382A1 (es) * 2019-07-12 2021-12-15 Hoffmann La Roche Anticuerpos de pre-direccionamiento y métodos de uso
WO2021041300A2 (en) * 2019-08-23 2021-03-04 Ab Therapeutics, Inc. Bispecific antibodies and uses thereof
KR20220153578A (ko) * 2020-01-23 2022-11-18 엑수마 바이오테크, 코포레이션 Her2에 대한 키메라 항원 수용체 및 이의 사용 방법
US20230210988A1 (en) * 2020-01-29 2023-07-06 Merus N.V. Means and method for modulating immune cell engaging effects
CN115768463A (zh) 2020-02-21 2023-03-07 哈普恩治疗公司 Flt3结合蛋白及使用方法
IL298921A (en) * 2020-07-10 2023-02-01 Hoffmann La Roche Antibodies that bind to cancer cells and direct radionuclides to said cells
IL301276A (en) 2020-09-24 2023-05-01 Morphosys Ag Novel human antibodies that bind to human CD3-epsilon
CN112724236B (zh) * 2021-01-15 2022-03-04 武汉大学 一种两性蛋白1的抗原肽及其抗体与应用
CN117715939A (zh) 2021-07-27 2024-03-15 莫佛塞斯公司 抗原结合分子的组合
CN113846115B (zh) * 2021-09-24 2023-10-17 广州医科大学 一种屋尘螨I类变应原pro-Der p 1重组蛋白及其制备方法与应用
WO2023183927A2 (en) * 2022-03-24 2023-09-28 Actinium Pharmaceuticals, Inc. Humanized anti-cd45 antibodies
CN114773452A (zh) * 2022-04-21 2022-07-22 谭宏凯 牛乳乳清主要过敏原α-乳白蛋白的IgE结合表位
WO2024026317A2 (en) * 2022-07-25 2024-02-01 Vironexis Biotherapeutics Inc. Adeno-associated virus vectors and methods of their use for reducing the risk of, treating, and preventing metastasis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054561A (en) 1984-02-08 2000-04-25 Chiron Corporation Antigen-binding sites of antibody molecules specific for cancer antigens
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
ATE151113T1 (de) * 1992-01-23 1997-04-15 Merck Patent Gmbh Fusionsproteine von monomeren und dimeren von antikörperfragmenten
GB9221657D0 (en) * 1992-10-15 1992-11-25 Scotgen Ltd Recombinant bispecific antibodies
AU2003266502A1 (en) 2002-08-16 2004-03-03 The University Of Tokyo Method of assaying interaction between proteins
EP1561759B9 (en) * 2002-10-11 2009-08-26 Chugai Seiyaku Kabushiki Kaisha Cell death-inducing agent
CN1735808A (zh) * 2002-11-07 2006-02-15 鹿特丹伊拉兹马斯大学 用于检测相互作用的分子的fret探针和方法
ES2358427T3 (es) 2003-10-16 2011-05-10 Micromet Ag Elementos de unión a cd-3 desinmunizados multiespecíficos.
GB0421836D0 (en) * 2004-10-01 2004-11-03 Avidex Ltd T cell receptors containing a non-native disulfide interchain bond linked to immunomodulatory agents
US8623356B2 (en) * 2005-11-29 2014-01-07 The University Of Sydney Demibodies: dimerization-activated therapeutic agents
CL2008000719A1 (es) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
JP5870404B2 (ja) * 2008-08-20 2016-03-01 アイビーシー ファーマスーティカルズ,インコーポレイテッド 癌治療のためのドック・ロック(dnl)ワクチン
KR102152109B1 (ko) * 2010-04-20 2020-09-07 젠맵 에이/에스 이종이량체 항체 fc-함유 단백질 및 그의 생산 방법

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