BR112013027224A8 - Proteínas de ligação de antígeno de membrana específico de próstata e composições e métodos relacionados - Google Patents
Proteínas de ligação de antígeno de membrana específico de próstata e composições e métodos relacionadosInfo
- Publication number
- BR112013027224A8 BR112013027224A8 BR112013027224A BR112013027224A BR112013027224A8 BR 112013027224 A8 BR112013027224 A8 BR 112013027224A8 BR 112013027224 A BR112013027224 A BR 112013027224A BR 112013027224 A BR112013027224 A BR 112013027224A BR 112013027224 A8 BR112013027224 A8 BR 112013027224A8
- Authority
- BR
- Brazil
- Prior art keywords
- prostate
- specific membrane
- membrane antigen
- methods
- binding proteins
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/17—Metallocarboxypeptidases (3.4.17)
- C12Y304/17021—Glutamate carboxypeptidase II (3.4.17.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Abstract
PROTEÍNAS DE LIGAÇÃO DE ANTÍGENO DE MEMBRANA ESPECÍFICO DE PRÓSTATA E COMPOSIÇÕES E MÉTODOS RELACIONADOS A presente invenção refere-se aos terapêuticos de polipeptídeo monoespecíficos e multiespecificos que especificamente alvejam as células que expressam o antígeno de membrana específico de próstata (PSMA) e são úteis para o tratamento de câncer de próstata (por exemplo, câncer de próstata resistente à esterilização), angiogênese relacionada ao tumor ou hiperplasia prostática benigna (BPH). Em uma modalidade, os terapêuticos de polipeptídeo multiespecificos ligam igualmente as células de expressão de PSMA e o complexo de receptor de célula T em células T para induzir a citotoxicidade, ativação e proliferação de célula T dependente de alvo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161478449P | 2011-04-22 | 2011-04-22 | |
PCT/US2012/034575 WO2012145714A2 (en) | 2011-04-22 | 2012-04-20 | Prostate-specific membrane antigen binding proteins and related compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013027224A2 BR112013027224A2 (pt) | 2016-12-27 |
BR112013027224A8 true BR112013027224A8 (pt) | 2018-08-14 |
Family
ID=47042195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027224A BR112013027224A8 (pt) | 2011-04-22 | 2012-04-20 | Proteínas de ligação de antígeno de membrana específico de próstata e composições e métodos relacionados |
Country Status (15)
Country | Link |
---|---|
US (4) | US20140161800A1 (pt) |
EP (1) | EP2699596A4 (pt) |
JP (3) | JP2014518615A (pt) |
CN (1) | CN103687872A (pt) |
AU (1) | AU2012245260B2 (pt) |
BR (1) | BR112013027224A8 (pt) |
CA (1) | CA2833019A1 (pt) |
IL (1) | IL228991A0 (pt) |
MX (1) | MX355908B (pt) |
MY (1) | MY171343A (pt) |
RU (1) | RU2632647C2 (pt) |
SG (1) | SG194510A1 (pt) |
UA (1) | UA118950C2 (pt) |
WO (1) | WO2012145714A2 (pt) |
ZA (1) | ZA201307559B (pt) |
Families Citing this family (26)
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SG194510A1 (en) | 2011-04-22 | 2013-12-30 | Emergent Product Dev Seattle | Prostate-specific membrane antigen binding proteins and related compositionsand methods |
WO2013158856A2 (en) | 2012-04-20 | 2013-10-24 | Emergent Product Development Seattle, Llc | Cd3 binding polypeptides |
HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
JP2017520575A (ja) | 2014-07-01 | 2017-07-27 | ファイザー・インク | 二重特異的ヘテロ二量体ダイアボディおよびその使用 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3243837A4 (en) * | 2015-01-08 | 2018-12-05 | Kyowa Hakko Kirin Co., Ltd. | Bispecific antibody binding to trailr2 and psma |
EP3256495A4 (en) * | 2015-02-11 | 2018-09-19 | Aptevo Research and Development LLC | Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins |
JP6898303B2 (ja) | 2015-08-07 | 2021-07-07 | エーエルエックス オンコロジー インコーポレイテッド | Sirp−アルファドメインまたはそのバリアントを有する構築物 |
JP7002446B2 (ja) | 2015-09-21 | 2022-03-04 | アプティーボ リサーチ アンド デベロップメント エルエルシー | Cd3結合ポリペプチド |
CN108699136B (zh) * | 2015-12-07 | 2022-03-18 | Xencor股份有限公司 | 结合cd3和psma的异二聚抗体 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
JP7284707B2 (ja) * | 2017-04-07 | 2023-05-31 | ジュノー セラピューティクス インコーポレイテッド | 前立腺特異的膜抗原(psma)またはその改変型を発現する操作された細胞および関連方法 |
TW201946656A (zh) * | 2018-03-28 | 2019-12-16 | 日商田邊三菱製藥股份有限公司 | cMET單株抗體結合劑的藥物接合物及其用途 |
MA53493A (fr) * | 2018-08-31 | 2021-07-07 | Alx Oncology Inc | Polypeptides leurres |
MA56045A (fr) | 2019-05-31 | 2022-04-06 | Alx Oncology Inc | Méthodes de traitement du cancer avec une protéine de fusion sirpalpha-fc en association avec un inhibiteur de point de contrôle immunitaire |
CN114206927A (zh) | 2019-06-14 | 2022-03-18 | 特尼奥生物股份有限公司 | 与cd22和cd3结合的多特异性重链抗体 |
CN111303288B (zh) * | 2020-03-04 | 2020-12-25 | 和铂医药(苏州)有限公司 | 一种分离的结合抗原psma的蛋白及其用途 |
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US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
TW202317625A (zh) | 2021-06-17 | 2023-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 新穎三特異性結合分子 |
CN113402590B (zh) * | 2021-07-14 | 2022-05-10 | 呈诺再生医学科技(珠海横琴新区)有限公司 | Khl多肽及其在制备tabp-eic细胞中的应用 |
IL311070A (en) * | 2021-08-27 | 2024-04-01 | Janssen Biotech Inc | Anti-PSMA antibodies and uses thereof |
WO2023141611A2 (en) * | 2022-01-21 | 2023-07-27 | Lyvgen Biopharma Holdings Limited | Multi-specific antibodies in uses thereof in avidity receptor crosslinking and immune modulation |
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-
2012
- 2012-04-20 SG SG2013077086A patent/SG194510A1/en unknown
- 2012-04-20 EP EP12773598.3A patent/EP2699596A4/en not_active Ceased
- 2012-04-20 CA CA2833019A patent/CA2833019A1/en not_active Abandoned
- 2012-04-20 AU AU2012245260A patent/AU2012245260B2/en active Active
- 2012-04-20 RU RU2013142600A patent/RU2632647C2/ru active
- 2012-04-20 BR BR112013027224A patent/BR112013027224A8/pt not_active Application Discontinuation
- 2012-04-20 WO PCT/US2012/034575 patent/WO2012145714A2/en active Application Filing
- 2012-04-20 MX MX2013012127A patent/MX355908B/es active IP Right Grant
- 2012-04-20 JP JP2014506600A patent/JP2014518615A/ja active Pending
- 2012-04-20 MY MYPI2013003838A patent/MY171343A/en unknown
- 2012-04-20 UA UAA201313177A patent/UA118950C2/uk unknown
- 2012-04-20 CN CN201280030553.0A patent/CN103687872A/zh active Pending
- 2012-04-20 US US14/113,353 patent/US20140161800A1/en not_active Abandoned
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2013
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- 2013-10-21 IL IL228991A patent/IL228991A0/en unknown
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2017
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- 2017-09-08 US US15/699,474 patent/US20180100021A1/en not_active Abandoned
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2019
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US20180100021A1 (en) | 2018-04-12 |
NZ616481A (en) | 2015-08-28 |
EP2699596A4 (en) | 2015-01-14 |
US20210095046A1 (en) | 2021-04-01 |
MX355908B (es) | 2018-05-04 |
BR112013027224A2 (pt) | 2016-12-27 |
US9782478B1 (en) | 2017-10-10 |
US20170306045A1 (en) | 2017-10-26 |
SG194510A1 (en) | 2013-12-30 |
EP2699596A2 (en) | 2014-02-26 |
CA2833019A1 (en) | 2012-10-26 |
UA118950C2 (uk) | 2019-04-10 |
JP2014518615A (ja) | 2014-08-07 |
MY171343A (en) | 2019-10-09 |
RU2632647C2 (ru) | 2017-10-06 |
JP2017127305A (ja) | 2017-07-27 |
US20140161800A1 (en) | 2014-06-12 |
JP2019165734A (ja) | 2019-10-03 |
MX2013012127A (es) | 2013-11-21 |
AU2012245260B2 (en) | 2016-09-08 |
WO2012145714A3 (en) | 2012-12-27 |
WO2012145714A2 (en) | 2012-10-26 |
RU2013142600A (ru) | 2015-05-27 |
ZA201307559B (en) | 2017-06-28 |
IL228991A0 (en) | 2013-12-31 |
JP6585105B2 (ja) | 2019-10-02 |
AU2012245260A1 (en) | 2013-10-31 |
CN103687872A (zh) | 2014-03-26 |
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