CL2012000524A1 - Anticuerpo humanizado que se une a cdcp1 humana útil en el tratamiento del cáncer; composición farmacéutica; ácido nucleico, vector de expresión y célula huésped que lo comprende; y método para producir el anticuerpo. - Google Patents

Anticuerpo humanizado que se une a cdcp1 humana útil en el tratamiento del cáncer; composición farmacéutica; ácido nucleico, vector de expresión y célula huésped que lo comprende; y método para producir el anticuerpo.

Info

Publication number
CL2012000524A1
CL2012000524A1 CL2012000524A CL2012000524A CL2012000524A1 CL 2012000524 A1 CL2012000524 A1 CL 2012000524A1 CL 2012000524 A CL2012000524 A CL 2012000524A CL 2012000524 A CL2012000524 A CL 2012000524A CL 2012000524 A1 CL2012000524 A1 CL 2012000524A1
Authority
CL
Chile
Prior art keywords
antibody
binds
producing
nucleic acid
host cell
Prior art date
Application number
CL2012000524A
Other languages
English (en)
Inventor
Birgit Bossenmaier
Guy Georges
Johannes Auer
Ekkehard Moessner
Alexander Lifke
Gerhard Niederfellner
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of CL2012000524A1 publication Critical patent/CL2012000524A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Anticuerpo que se une a CDCP1 humana; ácido nucleico, vector de expresión y célula huésped que lo comprende; método para producir un anticuerpo.
CL2012000524A 2009-08-28 2012-02-28 Anticuerpo humanizado que se une a cdcp1 humana útil en el tratamiento del cáncer; composición farmacéutica; ácido nucleico, vector de expresión y célula huésped que lo comprende; y método para producir el anticuerpo. CL2012000524A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09011046 2009-08-28
EP10000972 2010-02-01

Publications (1)

Publication Number Publication Date
CL2012000524A1 true CL2012000524A1 (es) 2012-08-17

Family

ID=43086176

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000524A CL2012000524A1 (es) 2009-08-28 2012-02-28 Anticuerpo humanizado que se une a cdcp1 humana útil en el tratamiento del cáncer; composición farmacéutica; ácido nucleico, vector de expresión y célula huésped que lo comprende; y método para producir el anticuerpo.

Country Status (24)

Country Link
US (2) US8394928B2 (es)
EP (1) EP2470567A1 (es)
JP (1) JP5647687B2 (es)
KR (1) KR101495407B1 (es)
CN (1) CN102482357B (es)
AR (1) AR077973A1 (es)
AU (1) AU2010288879A1 (es)
BR (1) BR112012004221A2 (es)
CA (1) CA2770161A1 (es)
CL (1) CL2012000524A1 (es)
CO (1) CO6511201A2 (es)
CR (1) CR20120038A (es)
EC (1) ECSP12011701A (es)
HK (1) HK1167412A1 (es)
IL (1) IL217919A0 (es)
MA (1) MA33537B1 (es)
MX (1) MX2012002458A (es)
NZ (1) NZ597664A (es)
PE (1) PE20121063A1 (es)
RU (1) RU2571207C2 (es)
SG (1) SG178886A1 (es)
TW (1) TWI412375B (es)
UA (1) UA106890C2 (es)
WO (1) WO2011023389A1 (es)

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TWI412375B (zh) * 2009-08-28 2013-10-21 Roche Glycart Ag 人類化抗ｃｄｃｐ１抗體
TW201113037A (en) * 2009-08-28 2011-04-16 Hoffmann La Roche Antibodies against CDCP1 for the treatment of cancer
WO2012107416A2 (en) 2011-02-10 2012-08-16 Roche Glycart Ag Improved immunotherapy
TR201816437T4 (tr) 2012-08-07 2018-11-21 Roche Glycart Ag Azalmış ve artmış efektör fonksiyonuna sahip olacak şekilde tasarlanmış iki antikor içeren bileşim.
PT2928923T (pt) 2012-12-10 2020-03-27 Biogen Ma Inc Anticorpos antígenos 2 de células dendríticas anti-sangue e os seus usos
WO2014172448A2 (en) * 2013-04-17 2014-10-23 Anaptysbio, Inc. Antibodies directed against activin receptor type ii (actrii)
WO2015082446A1 (en) 2013-12-02 2015-06-11 F. Hoffmann-La Roche Ag Treatment of cancer using an anti-cdcp1 antibody and a taxane
JP2017505124A (ja) 2014-01-24 2017-02-16 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド ヘンドラ及びニパウイルスのｆ糖タンパク質に対する抗体
WO2015200522A2 (en) * 2014-06-25 2015-12-30 Integrated Biotherapeutics, Inc. Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species
CA3047115A1 (en) * 2016-12-16 2018-06-21 Bluefin Biomedicine, Inc. Anti-cub domain-containing protein 1 (cdcp1) antibodies, antibody drug conjugates, and methods of use thereof
US10928391B2 (en) * 2017-06-06 2021-02-23 The Cleveland Clinic Foundation CD318 as a marker for, and CD318 inhibition as a treatment for, autoimmune disease
WO2019084319A1 (en) 2017-10-25 2019-05-02 The Regents Of The University Of California ANTIBODIES AGAINST CDCP1 FOR THE TREATMENT AND DETECTION OF CANCER
CN113382750A (zh) * 2018-11-09 2021-09-10 贝斯以色列女执事医疗中心 Cdcp1靶向疗法
JP2022523746A (ja) * 2019-02-01 2022-04-26 フォンダツィオーネ・ペア・リスチチュート・オンコロジコ・ディ・リチェルカ・（イオエッレ） 去勢抵抗性前立腺がんを処置する方法
US20230050380A1 (en) 2019-12-27 2023-02-16 Chiome Bioscience Inc. Anti-cdcp1 antibody
CN117264055A (zh) * 2022-06-14 2023-12-22 上海恒润达生生物科技股份有限公司 一种特异性结合人cd318的vhh抗体或其抗原结合片段及其制备方法和应用
WO2023246701A1 (zh) * 2022-06-20 2023-12-28 四川汇宇制药股份有限公司 一种抗体及其用途
WO2024013723A1 (en) 2022-07-15 2024-01-18 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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Also Published As

Publication number Publication date
CR20120038A (es) 2012-04-18
EP2470567A1 (en) 2012-07-04
RU2571207C2 (ru) 2015-12-20
AU2010288879A1 (en) 2012-02-02
RU2012111708A (ru) 2013-10-10
MX2012002458A (es) 2012-03-14
JP5647687B2 (ja) 2015-01-07
UA106890C2 (uk) 2014-10-27
US9346886B2 (en) 2016-05-24
MA33537B1 (fr) 2012-08-01
SG178886A1 (en) 2012-04-27
ECSP12011701A (es) 2012-03-30
BR112012004221A2 (pt) 2016-11-29
CN102482357B (zh) 2014-06-11
US8394928B2 (en) 2013-03-12
AR077973A1 (es) 2011-10-05
CA2770161A1 (en) 2011-03-03
KR20120089658A (ko) 2012-08-13
US20110052582A1 (en) 2011-03-03
TWI412375B (zh) 2013-10-21
WO2011023389A1 (en) 2011-03-03
IL217919A0 (en) 2012-03-29
HK1167412A1 (en) 2012-11-30
JP2013502904A (ja) 2013-01-31
NZ597664A (en) 2013-03-28
CN102482357A (zh) 2012-05-30
KR101495407B1 (ko) 2015-02-24
CO6511201A2 (es) 2012-08-31
PE20121063A1 (es) 2012-08-09
TW201110983A (en) 2011-04-01
US20130209455A1 (en) 2013-08-15

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