AR094896A1 - Moléculas biespecíficas de unión a antígeno activadoras de células t - Google Patents
Moléculas biespecíficas de unión a antígeno activadoras de células tInfo
- Publication number
- AR094896A1 AR094896A1 ARP140100602A ARP140100602A AR094896A1 AR 094896 A1 AR094896 A1 AR 094896A1 AR P140100602 A ARP140100602 A AR P140100602A AR P140100602 A ARP140100602 A AR P140100602A AR 094896 A1 AR094896 A1 AR 094896A1
- Authority
- AR
- Argentina
- Prior art keywords
- antigen binding
- binding molecules
- bispecific molecules
- bispecific antigen
- cell activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Moléculas biespecíficas de unión a antígeno para la activación de las células T y el redireccionamiento a células diana específicas. Además, se refiere a polinucleótidos codificantes de dichas moléculas biespecíficas de unión a antígeno, y a vectores y células huésped que comprenden dichos polinucleótidos. Se refiere además a métodos para producir las moléculas biespecíficas de unión a antígeno de la presente, y a métodos de utilización de estas moléculas biespecíficas de unión a antígeno en el tratamiento de enfermedades.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13156686 | 2013-02-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR094896A1 true AR094896A1 (es) | 2015-09-09 |
Family
ID=47748528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140100602A AR094896A1 (es) | 2013-02-26 | 2014-02-26 | Moléculas biespecíficas de unión a antígeno activadoras de células t |
Country Status (33)
Country | Link |
---|---|
US (11) | US10155815B2 (es) |
EP (2) | EP3708584A1 (es) |
JP (4) | JP6133444B2 (es) |
KR (5) | KR20180023035A (es) |
CN (2) | CN104936986B (es) |
AR (1) | AR094896A1 (es) |
AU (3) | AU2014222779B2 (es) |
BR (1) | BR112015015824B1 (es) |
CA (1) | CA2891493C (es) |
CL (1) | CL2015001988A1 (es) |
CR (1) | CR20150393A (es) |
DK (1) | DK2961771T3 (es) |
EA (2) | EA031214B1 (es) |
ES (1) | ES2775207T3 (es) |
HK (1) | HK1211300A1 (es) |
HR (1) | HRP20200306T1 (es) |
HU (1) | HUE047925T2 (es) |
IL (2) | IL240045B (es) |
LT (1) | LT2961771T (es) |
MA (1) | MA38308B1 (es) |
MX (2) | MX2015008920A (es) |
MY (1) | MY192312A (es) |
NZ (1) | NZ708182A (es) |
PE (1) | PE20151410A1 (es) |
PH (1) | PH12015501340B1 (es) |
PL (1) | PL2961771T3 (es) |
PT (1) | PT2961771T (es) |
RS (1) | RS59992B1 (es) |
SG (1) | SG11201504497TA (es) |
SI (1) | SI2961771T1 (es) |
TW (2) | TWI534155B (es) |
UA (1) | UA119320C2 (es) |
WO (1) | WO2014131712A1 (es) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2681244T3 (da) * | 2011-03-02 | 2018-01-29 | Roche Glycart Ag | Cea-antistoffer |
EP2747781B1 (en) | 2011-08-23 | 2017-11-15 | Roche Glycart AG | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
EP2814587B1 (en) | 2012-02-15 | 2018-05-02 | F.Hoffmann-La Roche Ag | Fc-receptor based affinity chromatography |
US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
WO2014028560A2 (en) | 2012-08-14 | 2014-02-20 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
US20150231241A1 (en) | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
US10087250B2 (en) | 2012-10-08 | 2018-10-02 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
RS59992B1 (sr) * | 2013-02-26 | 2020-04-30 | Roche Glycart Ag | Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije specifični za cd3 i cea |
RU2015140915A (ru) | 2013-02-26 | 2017-04-03 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
WO2015080981A1 (en) | 2013-11-27 | 2015-06-04 | Baylor College Of Medicine | Csgp4-specific chimeric antigen receptor for cancer |
US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
MY179611A (en) | 2014-08-04 | 2020-11-11 | Hoffmann La Roche | Bispecific t cell activating antigen binding molecules |
JP2017536341A (ja) * | 2014-10-09 | 2017-12-07 | エンクマフ アーゲー | 卵巣がんの処置における使用のためのCD3εおよびROR1に対する二特異性抗体 |
EP3204415B1 (en) * | 2014-10-09 | 2020-06-17 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and ror1 |
KR20170078677A (ko) | 2014-11-06 | 2017-07-07 | 에프. 호프만-라 로슈 아게 | Fcrn-결합이 개질된 fc-영역 변이체 및 이의 사용 방법 |
WO2016077638A1 (en) * | 2014-11-12 | 2016-05-19 | Memorial Sloan Kettering Cancer Center | Anti-chondroitin sulfate proteoglycan 4 antibodies and uses thereof |
MX2017006250A (es) * | 2014-11-14 | 2017-11-17 | Hoffmann La Roche | Moleculas de union a antigeno que comprenden un trimero de ligando de la familia de tnf. |
WO2016079081A1 (en) * | 2014-11-20 | 2016-05-26 | F. Hoffmann-La Roche Ag | Common light chains and methods of use |
EP4141032A1 (en) * | 2014-11-20 | 2023-03-01 | F. Hoffmann-La Roche AG | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
JP6802158B2 (ja) | 2014-12-05 | 2020-12-16 | ジェネンテック, インコーポレイテッド | 抗CD79b抗体及び使用方法 |
WO2016103205A1 (en) * | 2014-12-23 | 2016-06-30 | Universita' Degli Studi Di Parma | Pro-apoptotic anti-ng2/cspg4 antibodies and their uses for disease therapy |
EA201792581A1 (ru) | 2015-05-29 | 2018-07-31 | Амфивена Терапьютикс, Инк. | Способы применения биспецифических cd33- и cd3- связывающих белков |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
WO2017055391A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific t cell activating antigen binding molecules binding mesothelin and cd3 |
CA2990755A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffman-La Roche Ag | Bispecific anti-ceaxcd3 t cell activating antigen binding molecules |
JP6654694B2 (ja) | 2015-10-02 | 2020-02-26 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗pd1抗体と使用方法 |
CN107949574A (zh) * | 2015-10-02 | 2018-04-20 | 豪夫迈·罗氏有限公司 | 双特异性t细胞活化性抗原结合分子 |
CN116675776A (zh) | 2015-10-25 | 2023-09-01 | 赛诺菲 | 用于预防或治疗hiv感染的三特异性和/或三价结合蛋白 |
WO2017097723A2 (en) | 2015-12-09 | 2017-06-15 | F. Hoffmann-La Roche Ag | Treatment method |
EP3178848A1 (en) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
US10596257B2 (en) * | 2016-01-08 | 2020-03-24 | Hoffmann-La Roche Inc. | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
DK3433280T3 (da) | 2016-03-22 | 2023-06-19 | Hoffmann La Roche | Protease-aktiverede T-celle-bispecifikke molekyler |
CR20180539A (es) * | 2016-04-13 | 2019-02-15 | Sanofi Sa | Proteínas de unión triespecíficas y/o trivalentes |
MY192090A (en) | 2016-04-13 | 2022-07-26 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
EP3478722A1 (en) | 2016-06-30 | 2019-05-08 | F. Hoffmann-La Roche AG | Improved adoptive t-cell therapy |
TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗gprc5d抗體、結合gprc5d與cd3之雙特異性抗原結合分子及其用途 |
JP7022123B2 (ja) | 2016-09-30 | 2022-02-17 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Cd3に対する二重特異性抗体 |
EP3554542A1 (en) | 2016-12-19 | 2019-10-23 | H. Hoffnabb-La Roche Ag | Combination therapy with targeted 4-1bb (cd137) agonists |
AU2018219887A1 (en) | 2017-02-08 | 2019-08-22 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
CA3235295A1 (en) | 2017-02-20 | 2018-08-23 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
KR20200130514A (ko) * | 2017-02-27 | 2020-11-18 | 드래곤플라이 쎄라퓨틱스, 인크. | Caix, ano1, 메소텔린, trop2, cea, 또는 클라우딘-18.2를 표적화하는 다중특이적 결합 단백질 |
CN110402253B (zh) | 2017-03-10 | 2024-01-05 | 豪夫迈·罗氏有限公司 | 用于生产多特异性抗体的方法 |
TWI690538B (zh) | 2017-04-05 | 2020-04-11 | 瑞士商赫孚孟拉羅股份公司 | 特異性結合至pd1至lag3的雙特異性抗體 |
US11555056B2 (en) | 2017-04-26 | 2023-01-17 | Mayo Foundation for Medical Education and Research and Board of Regents | Methods and materials for treating cancer |
EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
BR112019025792A2 (pt) * | 2017-06-07 | 2020-07-07 | Spark Therapeutics, Inc. | agentes de aperfeiçoamento para transfecção de células melhoradas e/ou produção de vetor raav |
HRP20211744T1 (hr) * | 2017-07-14 | 2022-02-04 | Immatics Biotechnologies Gmbh | Poboljšana molekula polipeptida dvostruke specifičnosti |
AU2018308930A1 (en) * | 2017-07-28 | 2020-02-06 | F. Hoffmann-La Roche Ag | Bispecific antibody formulation |
EP3692060A1 (en) * | 2017-10-03 | 2020-08-12 | Merck Patent GmbH | Cysteine engineered antigen-binding molecules |
EP3704155A2 (en) * | 2017-11-01 | 2020-09-09 | F. Hoffmann-La Roche AG | Combination therapy with targeted ox40 agonists |
KR20200099135A (ko) * | 2017-12-14 | 2020-08-21 | 에프. 호프만-라 로슈 아게 | Cea cd3 이중특이성 항체 및 pd-1 축 결합 길항제의 암 치료를 위한 투약 요법에서의 용도 |
EP3502140A1 (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
AU2019218959A1 (en) | 2018-02-08 | 2020-09-03 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
PE20220278A1 (es) | 2018-02-08 | 2022-02-25 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d |
TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
WO2019166453A1 (en) * | 2018-03-01 | 2019-09-06 | F. Hoffmann-La Roche Ag | Specificity assay for novel target antigen binding moieties |
AR114284A1 (es) * | 2018-04-13 | 2020-08-12 | Hoffmann La Roche | Moléculas de unión a antígeno dirigidas a her2 que comprenden 4-1bbl |
MX2020011027A (es) * | 2018-04-17 | 2021-01-15 | Invenra Inc | Constructos de anticuerpos biespecíficos trivalentes. |
CN112566938A (zh) | 2018-06-03 | 2021-03-26 | 拉姆卡普生物测试有限公司 | 针对ceacam5和cd47的双特异性抗体 |
BR112021012101A2 (pt) | 2018-12-21 | 2021-09-08 | F. Hoffmann-La Roche Ag | Moléculas de ligação ao antígeno agonístico cd28 biespecífico, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método de produção de uma molécula, composição farmacêutica, uso da molécula e método de inibição do crescimento de células tumorais |
CN113621062A (zh) * | 2018-12-21 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 与cd3结合的抗体 |
WO2020169698A1 (en) | 2019-02-21 | 2020-08-27 | F. Hoffmann-La Roche Ag | Sensitization of cancer cells to tnf by bet inhibition |
US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
WO2020208124A1 (en) | 2019-04-12 | 2020-10-15 | F. Hoffmann-La Roche Ag | Treatment of cancer using a cea cd3 bispecific antibody and a wnt signaling inhibitor |
BR112021025401A2 (pt) * | 2019-06-19 | 2022-02-01 | Hoffmann La Roche | Métodos para produzir um anticorpo trivalente, ácido desoxirribonucleico, uso de um ácido desoxirribonucleico, célula de mamífero recombinante, composição e método para produzir uma célula de mamífero recombinante |
CN114531878A (zh) | 2019-06-27 | 2022-05-24 | 豪夫迈·罗氏有限公司 | 新颖icos抗体及包含它们的肿瘤靶向抗原结合分子 |
AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
EP4004045A1 (en) | 2019-07-31 | 2022-06-01 | F. Hoffmann-La Roche AG | Antibodies binding to gprc5d |
AU2020323686B2 (en) | 2019-07-31 | 2024-03-21 | F. Hoffmann-La Roche Ag | Antibodies binding to GPRC5D |
WO2021053587A1 (en) | 2019-09-18 | 2021-03-25 | Klaus Strein | Bispecific antibodies against ceacam5 and cd3 |
EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
AR122656A1 (es) | 2020-06-19 | 2022-09-28 | Hoffmann La Roche | Anticuerpos que se unen a cd3 / folr1 |
AU2021291405A1 (en) | 2020-06-19 | 2022-09-29 | F. Hoffmann-La Roche Ag | Immune activating Fc domain binding molecules |
CA3177239A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Protease-activated t cell bispecific antibodies |
MX2022016069A (es) | 2020-06-19 | 2023-02-02 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y cd19. |
PE20230835A1 (es) | 2020-06-19 | 2023-05-19 | Hoffmann La Roche | Anticuerpos que se unen a cd3 |
WO2021255146A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cea |
PE20230434A1 (es) | 2020-07-10 | 2023-03-08 | Hoffmann La Roche | Anticuerpos que se unen a celulas cancerosas y dirigen radionucleotidos a dichas celulas |
CA3193478A1 (en) | 2020-09-24 | 2022-03-31 | F. Hoffmann-La Roche Ag | Prevention or mitigation of t-cell bispecific antibody-related adverse effects |
EP4237450A1 (en) | 2020-10-30 | 2023-09-06 | F. Hoffmann-La Roche AG | Treatment of cancer using a cea cd3 bispecific antibody and a tgfbeta signaling inhibitor |
MX2023005306A (es) | 2020-11-10 | 2023-05-25 | Hoffmann La Roche | Prevencion o mitigacion de efectos adversos relacionados con agentes acopladores de linfocitos t. |
CA3204702A1 (en) | 2020-12-17 | 2022-06-23 | F. Hoffmann-La Roche Ag | Anti-hla-g antibodies and use thereof |
EP4055055B1 (en) | 2020-12-18 | 2023-11-22 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
US20240082437A1 (en) | 2021-01-12 | 2024-03-14 | Hoffmann-La Roche Inc. | Split antibodies which bind to cancer cells and target radionuclides to said cells |
EP4277668A1 (en) | 2021-01-13 | 2023-11-22 | F. Hoffmann-La Roche AG | Combination therapy |
WO2022189377A1 (en) | 2021-03-09 | 2022-09-15 | F. Hoffmann-La Roche Ag | Combination therapy of pd-1-targeted il-2 variant immunoconjugates and fap/4-1bb binding molecules |
AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
AR127887A1 (es) | 2021-12-10 | 2024-03-06 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y plap |
WO2023170474A1 (en) | 2022-03-07 | 2023-09-14 | Novimmune Sa | Cd28 bispecific antibodies for targeted t cell activation |
US20230302044A1 (en) * | 2022-03-28 | 2023-09-28 | Steve Reilly | Composition to increase cellularlongevity |
WO2023242351A1 (en) | 2022-06-16 | 2023-12-21 | Lamkap Bio Beta Ag | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1096187A (en) | 1977-04-18 | 1981-02-24 | Souhei Monden | Ornament adapted to be fixed by permanent magnets |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
WO1991003493A1 (en) | 1989-08-29 | 1991-03-21 | The University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
DE69334255D1 (de) | 1992-02-06 | 2009-02-12 | Novartis Vaccines & Diagnostic | Marker für Krebs und biosynthetisches Bindeprotein dafür |
US5798100A (en) * | 1994-07-06 | 1998-08-25 | Immunomedics, Inc. | Multi-stage cascade boosting vaccine |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
WO1996040210A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
US7727761B2 (en) | 1995-08-01 | 2010-06-01 | Vegenics Limited | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
FR2757863B1 (fr) * | 1996-12-27 | 1999-03-26 | Inovat Sarl | Nouvelles substances a activite biologique, leur procede d'obtention et les compositions en renfermant |
EP0979281B1 (en) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
BR9813365A (pt) | 1997-12-05 | 2004-06-15 | Scripps Research Inst | Método para produção e humanização de um anticorpo monoclonal de rato |
AU2719099A (en) | 1998-01-23 | 1999-08-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Multipurpose antibody derivatives |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
WO2001025454A2 (en) | 1999-10-04 | 2001-04-12 | Medicago Inc. | Method for regulating transcription of foreign genes in the presence of nitrogen |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
HUP0300369A2 (hu) * | 2000-04-11 | 2003-06-28 | Genentech, Inc. | Többértékű antitestek és alkalmazásuk |
US6773883B2 (en) | 2000-07-31 | 2004-08-10 | The Brigham & Women's Hospital, Inc. | Prognostic classification of endometrial cancer |
US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
SI2380911T1 (en) | 2003-11-05 | 2018-07-31 | Roche Glycart Ag | ANTIGEN-RELATED PATIENTS WITH INCREASED ATTENTION ON THE RECEPTOR FC AND EFFECTORAL FUNCTION |
US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
WO2005086875A2 (en) | 2004-03-11 | 2005-09-22 | City Of Hope | A humanized anti-cea t84.66 antibody and uses thereof |
ES2527292T3 (es) | 2004-03-31 | 2015-01-22 | Genentech, Inc. | Anticuerpos anti-TGF-beta humanizados |
CA2885854C (en) | 2004-04-13 | 2017-02-21 | F. Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
AR051836A1 (es) * | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
AU2006211037B2 (en) | 2005-02-07 | 2012-05-24 | Roche Glycart Ag | Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof |
EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
WO2006114115A1 (de) | 2005-04-26 | 2006-11-02 | Trion Pharma Gmbh | Kombination von antikörpern mit glukokortikoiden zur behandlung von krebs |
MX2007013924A (es) | 2005-05-09 | 2008-01-28 | Glycart Biotechnology Ag | Moleculas que unen antigeno que tienen regiones fc modificadas y union alterada a receptores fc. |
MY169746A (en) | 2005-08-19 | 2019-05-14 | Abbvie Inc | Dual variable domain immunoglobulin and uses thereof |
US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
JP5686953B2 (ja) | 2005-10-11 | 2015-03-18 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 交差種特異的(cross−species−specific)抗体を含む組成物および該組成物の使用 |
CA2633486C (en) | 2005-12-16 | 2015-02-03 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
JP5399712B2 (ja) * | 2005-12-21 | 2014-01-29 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 可溶性ceaに対する抵抗性を有する医薬組成物 |
PT1999154E (pt) | 2006-03-24 | 2013-01-24 | Merck Patent Gmbh | Domínios proteicos heterodiméricos modificados |
MX2008015524A (es) | 2006-06-12 | 2009-01-13 | Trubion Pharmaceuticals Inc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー/エス | 二重特異性抗体の生産 |
HUE027165T2 (en) * | 2006-10-02 | 2016-08-29 | Squibb & Sons Llc | Human antibodies that bind to CXCR4 and their uses |
PL2502938T3 (pl) | 2006-10-27 | 2015-07-31 | Genentech Inc | Przeciwciała i immunokoniugaty oraz ich zastosowanie |
TR201816277T4 (tr) | 2007-04-03 | 2018-11-21 | Amgen Res Munich Gmbh | Çapraz-tür-spesifik bağlama alanı. |
US20100183615A1 (en) | 2007-04-03 | 2010-07-22 | Micromet Ag | Cross-species-specific bispecific binders |
ES2695047T3 (es) | 2007-04-03 | 2018-12-28 | Amgen Research (Munich) Gmbh | Dominio de unión específico entre especies |
EP2225275A4 (en) | 2007-11-28 | 2013-04-03 | Medimmune Llc | PROTEIN FORMULATION |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
MX350962B (es) | 2008-01-07 | 2017-09-27 | Amgen Inc | Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion. |
JP2012503612A (ja) | 2008-09-26 | 2012-02-09 | ロシュ グリクアート アクチェンゲゼルシャフト | 二重特異性抗egfr/抗igf−1r抗体 |
KR101431318B1 (ko) | 2009-04-02 | 2014-08-20 | 로슈 글리카트 아게 | 전장 항체 및 단일쇄 fab 단편을 포함하는 다중특이성 항체 |
CA2757931C (en) | 2009-04-07 | 2019-03-26 | Roche Glycart Ag | Trivalent, bispecific antibodies |
CA2759233C (en) | 2009-04-27 | 2019-07-16 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
JP5719354B2 (ja) * | 2009-05-27 | 2015-05-20 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 三重又は四重特異性抗体 |
EP2261258A1 (de) | 2009-06-08 | 2010-12-15 | Schuler, Gerold | MCSP-gerichtete scFv-Antikörperfragmente und deren Verwendung |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
RU2570554C2 (ru) | 2009-08-31 | 2015-12-10 | Роше Гликарт Аг | Гуманизированные моноклональные антитела к сеа с созревшей аффинностью |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
WO2011090762A1 (en) | 2009-12-29 | 2011-07-28 | Emergent Product Development Seattle, Llc | Heterodimer binding proteins and uses thereof |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
CA2797981C (en) | 2010-05-14 | 2019-04-23 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
MX352929B (es) | 2010-11-05 | 2017-12-13 | Zymeworks Inc | DISEÑO DE ANTICUERPOS HETERODIMÉRICOS ESTABLES CON MUTACIONES EN EL DOMINIO Fc. |
KR102244173B1 (ko) | 2010-11-30 | 2021-04-26 | 추가이 세이야쿠 가부시키가이샤 | 세포상해 유도 치료제 |
SI3489255T1 (sl) | 2011-02-10 | 2021-11-30 | Roche Glycart Ag | Mutantni polipeptidi interlevkina-2 |
DK2681244T3 (da) | 2011-03-02 | 2018-01-29 | Roche Glycart Ag | Cea-antistoffer |
WO2012130831A1 (en) | 2011-03-29 | 2012-10-04 | Roche Glycart Ag | Antibody fc variants |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
CN107936121B (zh) | 2011-05-16 | 2022-01-14 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
PL2714733T4 (pl) | 2011-05-21 | 2019-08-30 | Macrogenics, Inc. | Cząsteczki wiążące CD3 zdolne do wiązania z ludzkim i nieludzkim CD3 |
WO2013010955A1 (en) * | 2011-07-15 | 2013-01-24 | Morphosys Ag | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
US20140242081A1 (en) | 2011-07-18 | 2014-08-28 | Micromet Ag | Dosing regimens for treatment of cea-expressing cancers |
KR20140068877A (ko) * | 2011-08-17 | 2014-06-09 | 제넨테크, 인크. | 불응성 종양에서의 혈관신생의 억제 |
US20130078250A1 (en) | 2011-08-23 | 2013-03-28 | Oliver Ast | Bispecific t cell activating antigen binding molecules |
UA116192C2 (uk) | 2011-08-23 | 2018-02-26 | Рош Глікарт Аг | Активуюча т-клітини біоспецифічна антигензв'язуюча молекула |
MY171038A (en) | 2011-08-23 | 2019-09-23 | Roche Glycart Ag | Bispecific antigen binding molecules |
RU2617970C2 (ru) | 2011-08-23 | 2017-04-28 | Рош Гликарт Аг | Антитела, не содержащие fc-фрагмента, включающие два fab-фрагмента, и способы их применения |
JP2014534806A (ja) * | 2011-08-23 | 2014-12-25 | ロシュ グリクアート アーゲー | 抗mcsp抗体 |
TW201326212A (zh) | 2011-08-23 | 2013-07-01 | Roche Glycart Ag | 抗-mcsp抗體 |
EP2747781B1 (en) | 2011-08-23 | 2017-11-15 | Roche Glycart AG | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
EP2578230A1 (en) | 2011-10-04 | 2013-04-10 | Trion Pharma Gmbh | Removal of Tumor Cells from Intraoperative Autologous Blood Salvage |
US10851178B2 (en) * | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
DK2794905T3 (da) | 2011-12-20 | 2020-07-06 | Medimmune Llc | Modificerede polypeptider til bispecifikke antistofgrundstrukturer |
LT2838918T (lt) | 2012-04-20 | 2019-09-10 | Merus N.V. | Būdai ir priemonės heterodimerinių ig-tipo molekulių gamybai |
US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
EP3434695B1 (en) | 2012-08-07 | 2020-12-02 | Roche Glycart AG | Improved immunotherapy |
WO2014028560A2 (en) | 2012-08-14 | 2014-02-20 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
US10087250B2 (en) | 2012-10-08 | 2018-10-02 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
KR102211837B1 (ko) | 2013-01-14 | 2021-02-03 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
EP2953972B1 (en) | 2013-02-05 | 2020-07-08 | EngMab Sàrl | Method for the selection of antibodies against bcma |
JO3529B1 (ar) | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
KR20150122203A (ko) * | 2013-02-26 | 2015-10-30 | 로슈 글리카트 아게 | T 세포 활성화 이중특이적 항원 결합 분자 |
RS59992B1 (sr) * | 2013-02-26 | 2020-04-30 | Roche Glycart Ag | Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije specifični za cd3 i cea |
RU2015140915A (ru) | 2013-02-26 | 2017-04-03 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
EP3721902A1 (en) | 2013-03-14 | 2020-10-14 | The Scripps Research Institute | Targeting agent antibody conjugates and uses thereof |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
EP3686217A1 (en) | 2013-03-15 | 2020-07-29 | GlaxoSmithKline Intellectual Property (No.2) Limited | Low concentration antibody formulations |
EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
JP2016520600A (ja) | 2013-05-28 | 2016-07-14 | ヌマブ アクチェンゲゼルシャフト | 新規抗体 |
AU2014364601A1 (en) | 2013-12-17 | 2016-07-07 | Genentech, Inc. | Methods of treating HER2-positive cancers using PD-1 axis binding antagonists and anti-HER2 antibodies |
PE20210107A1 (es) | 2013-12-17 | 2021-01-19 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
MY179611A (en) * | 2014-08-04 | 2020-11-11 | Hoffmann La Roche | Bispecific t cell activating antigen binding molecules |
EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
WO2016019969A1 (en) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
ES2774380T3 (es) | 2014-08-29 | 2020-07-20 | Hoffmann La Roche | Politerapia de inmunocitocinas de variante de IL-2 dirigida a tumor y anticuerpos frente a PD-L1 humano |
WO2016036678A1 (en) | 2014-09-02 | 2016-03-10 | Medimmune, Llc | Formulations of bispecific antibodies |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
JP2017536341A (ja) | 2014-10-09 | 2017-12-07 | エンクマフ アーゲー | 卵巣がんの処置における使用のためのCD3εおよびROR1に対する二特異性抗体 |
EP3204415B1 (en) | 2014-10-09 | 2020-06-17 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and ror1 |
MX2017006250A (es) | 2014-11-14 | 2017-11-17 | Hoffmann La Roche | Moleculas de union a antigeno que comprenden un trimero de ligando de la familia de tnf. |
MY184889A (en) | 2014-11-20 | 2021-04-29 | Hoffmann La Roche | T cell activating bispecific antigen binding molecules |
WO2016079081A1 (en) | 2014-11-20 | 2016-05-26 | F. Hoffmann-La Roche Ag | Common light chains and methods of use |
EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
EP3778640A1 (en) | 2015-05-01 | 2021-02-17 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use |
MY189840A (en) | 2015-06-16 | 2022-03-11 | Genentech Inc | Humanized and affinity matured antibodies to fcrh5 and methods of use |
CA2992797A1 (en) | 2015-08-03 | 2017-02-09 | Engmab Sarl | Monoclonal antibodies against bcma |
CA2990755A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffman-La Roche Ag | Bispecific anti-ceaxcd3 t cell activating antigen binding molecules |
WO2017055391A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific t cell activating antigen binding molecules binding mesothelin and cd3 |
WO2017055318A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Cd33xcd3 bispecific t cell activating antigen binding molecules |
EP3913000A1 (en) | 2015-10-02 | 2021-11-24 | F. Hoffmann-La Roche AG | Bispecific anti-cd19xcd3 t cell activating antigen binding molecules |
CN107949574A (zh) | 2015-10-02 | 2018-04-20 | 豪夫迈·罗氏有限公司 | 双特异性t细胞活化性抗原结合分子 |
WO2017097723A2 (en) | 2015-12-09 | 2017-06-15 | F. Hoffmann-La Roche Ag | Treatment method |
-
2014
- 2014-02-24 RS RS20200230A patent/RS59992B1/sr unknown
- 2014-02-24 KR KR1020187005120A patent/KR20180023035A/ko active Application Filing
- 2014-02-24 KR KR1020157022986A patent/KR101833602B1/ko active IP Right Grant
- 2014-02-24 LT LTEP14708507.0T patent/LT2961771T/lt unknown
- 2014-02-24 WO PCT/EP2014/053490 patent/WO2014131712A1/en active Application Filing
- 2014-02-24 CN CN201480005567.6A patent/CN104936986B/zh active Active
- 2014-02-24 AU AU2014222779A patent/AU2014222779B2/en active Active
- 2014-02-24 EA EA201500876A patent/EA031214B1/ru not_active IP Right Cessation
- 2014-02-24 SG SG11201504497TA patent/SG11201504497TA/en unknown
- 2014-02-24 MX MX2015008920A patent/MX2015008920A/es active IP Right Grant
- 2014-02-24 DK DK14708507.0T patent/DK2961771T3/da active
- 2014-02-24 US US14/188,486 patent/US10155815B2/en active Active
- 2014-02-24 SI SI201431517T patent/SI2961771T1/sl unknown
- 2014-02-24 PL PL14708507T patent/PL2961771T3/pl unknown
- 2014-02-24 EA EA201891502A patent/EA201891502A1/ru unknown
- 2014-02-24 CA CA2891493A patent/CA2891493C/en active Active
- 2014-02-24 EP EP19217855.6A patent/EP3708584A1/en active Pending
- 2014-02-24 MA MA38308A patent/MA38308B1/fr unknown
- 2014-02-24 BR BR112015015824-2A patent/BR112015015824B1/pt active IP Right Grant
- 2014-02-24 KR KR1020217023163A patent/KR20210094673A/ko active Application Filing
- 2014-02-24 UA UAA201509085A patent/UA119320C2/uk unknown
- 2014-02-24 HU HUE14708507A patent/HUE047925T2/hu unknown
- 2014-02-24 KR KR1020227043458A patent/KR20230004901A/ko not_active Application Discontinuation
- 2014-02-24 CN CN201910633487.XA patent/CN110437337A/zh active Pending
- 2014-02-24 PT PT147085070T patent/PT2961771T/pt unknown
- 2014-02-24 MY MYPI2015702806A patent/MY192312A/en unknown
- 2014-02-24 ES ES14708507T patent/ES2775207T3/es active Active
- 2014-02-24 PE PE2015001762A patent/PE20151410A1/es active IP Right Grant
- 2014-02-24 NZ NZ708182A patent/NZ708182A/en unknown
- 2014-02-24 KR KR1020207007753A patent/KR102282761B1/ko active Application Filing
- 2014-02-24 EP EP14708507.0A patent/EP2961771B1/en active Active
- 2014-02-24 JP JP2015558476A patent/JP6133444B2/ja active Active
- 2014-02-25 TW TW103106320A patent/TWI534155B/zh active
- 2014-02-25 TW TW105104385A patent/TWI638832B/zh active
- 2014-02-26 AR ARP140100602A patent/AR094896A1/es unknown
-
2015
- 2015-06-15 PH PH12015501340A patent/PH12015501340B1/en unknown
- 2015-07-09 MX MX2020009692A patent/MX2020009692A/es unknown
- 2015-07-14 CL CL2015001988A patent/CL2015001988A1/es unknown
- 2015-07-20 IL IL240045A patent/IL240045B/en active IP Right Grant
- 2015-07-28 CR CR20150393A patent/CR20150393A/es unknown
- 2015-12-08 HK HK15112068.5A patent/HK1211300A1/xx unknown
-
2017
- 2017-04-13 JP JP2017080029A patent/JP2017158565A/ja not_active Withdrawn
-
2018
- 2018-07-12 US US16/034,012 patent/US20180312589A1/en not_active Abandoned
- 2018-09-18 US US16/134,494 patent/US10781258B2/en active Active
- 2018-09-18 US US16/134,391 patent/US10781257B2/en active Active
- 2018-11-29 AU AU2018271329A patent/AU2018271329A1/en not_active Abandoned
-
2019
- 2019-02-22 US US16/282,708 patent/US20190177413A1/en not_active Abandoned
- 2019-11-05 JP JP2019200472A patent/JP6913145B2/ja active Active
- 2019-12-02 IL IL271102A patent/IL271102A/en unknown
-
2020
- 2020-02-24 HR HRP20200306TT patent/HRP20200306T1/hr unknown
- 2020-08-18 US US16/996,600 patent/US20200385470A1/en not_active Abandoned
- 2020-10-22 AU AU2020257119A patent/AU2020257119B2/en active Active
- 2020-12-18 US US17/127,291 patent/US20210101979A1/en not_active Abandoned
-
2021
- 2021-05-03 US US17/306,079 patent/US20210253704A1/en not_active Abandoned
- 2021-05-03 US US17/306,068 patent/US20210253703A1/en not_active Abandoned
- 2021-05-07 JP JP2021079198A patent/JP2021129573A/ja active Pending
- 2021-11-12 US US17/525,101 patent/US20220064296A1/en not_active Abandoned
-
2022
- 2022-05-25 US US17/824,628 patent/US20230076791A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR094896A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
AR106201A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
AR109771A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
CR20170032A (es) | Moleculas biespecíficas de unión a antígeno activadoras de células t | |
AR087608A1 (es) | Moleculas biespecificas de union a antigeno activadoras de celulas t | |
CR20170203A (es) | Moleculas de unión a antígeno biespecíficas activadoras de células t | |
MX2017006626A (es) | Cadenas ligeras comunes y metodos de uso. | |
MX2015010350A (es) | Moleculas de union a antigeno biespecificas que activan la celula t. | |
MX2015010843A (es) | Moleculas biespecificas de union al antigeno que activan celulas t. | |
AR117392A1 (es) | Anticuerpos de unión a gprc5d | |
EA201300819A1 (ru) | Молекулы антител, которые связываются с il-17a и il-17f | |
AR090903A1 (es) | Anticuerpos e inmunoconjugados anti-pmel17 | |
AR114001A1 (es) | Anticuerpos que se unen a hla- a2 / wt1 | |
AR104413A1 (es) | Anticuerpo de igf-1r y su utilización para diagnosticar cáncer | |
AR119972A2 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
CR20150259A (es) | Anticuerpos egfr/c-met biespecíficos |