BR112012004221A2 - "anticorpos, composição farmacêutica, uso do anticorpo, ácido nucleico, vetores de expressão, célula hospedeira procariótica e método para a produção de um anticorpo humanizado recombinante" - Google Patents

"anticorpos, composição farmacêutica, uso do anticorpo, ácido nucleico, vetores de expressão, célula hospedeira procariótica e método para a produção de um anticorpo humanizado recombinante"

Info

Publication number
BR112012004221A2
BR112012004221A2 BR112012004221A BR112012004221A BR112012004221A2 BR 112012004221 A2 BR112012004221 A2 BR 112012004221A2 BR 112012004221 A BR112012004221 A BR 112012004221A BR 112012004221 A BR112012004221 A BR 112012004221A BR 112012004221 A2 BR112012004221 A2 BR 112012004221A2
Authority
BR
Brazil
Prior art keywords
antibody
antibodies
producing
nucleic acid
pharmaceutical composition
Prior art date
Application number
BR112012004221A
Other languages
English (en)
Inventor
Alexander Lifke
Birgit Bossenmaier
Ekkehard Moessener
Gerhard Niederfellner
Guy Georges
Johannes Auer
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of BR112012004221A2 publication Critical patent/BR112012004221A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR112012004221A 2009-08-28 2010-08-26 "anticorpos, composição farmacêutica, uso do anticorpo, ácido nucleico, vetores de expressão, célula hospedeira procariótica e método para a produção de um anticorpo humanizado recombinante" BR112012004221A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09011046 2009-08-28
EP10000972 2010-02-01
PCT/EP2010/005244 WO2011023389A1 (en) 2009-08-28 2010-08-26 Humanized anti-cdcp1 antibodies

Publications (1)

Publication Number Publication Date
BR112012004221A2 true BR112012004221A2 (pt) 2016-11-29

Family

ID=43086176

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012004221A BR112012004221A2 (pt) 2009-08-28 2010-08-26 "anticorpos, composição farmacêutica, uso do anticorpo, ácido nucleico, vetores de expressão, célula hospedeira procariótica e método para a produção de um anticorpo humanizado recombinante"

Country Status (24)

Country Link
US (2) US8394928B2 (pt)
EP (1) EP2470567A1 (pt)
JP (1) JP5647687B2 (pt)
KR (1) KR101495407B1 (pt)
CN (1) CN102482357B (pt)
AR (1) AR077973A1 (pt)
AU (1) AU2010288879A1 (pt)
BR (1) BR112012004221A2 (pt)
CA (1) CA2770161A1 (pt)
CL (1) CL2012000524A1 (pt)
CO (1) CO6511201A2 (pt)
CR (1) CR20120038A (pt)
EC (1) ECSP12011701A (pt)
HK (1) HK1167412A1 (pt)
IL (1) IL217919A0 (pt)
MA (1) MA33537B1 (pt)
MX (1) MX2012002458A (pt)
NZ (1) NZ597664A (pt)
PE (1) PE20121063A1 (pt)
RU (1) RU2571207C2 (pt)
SG (1) SG178886A1 (pt)
TW (1) TWI412375B (pt)
UA (1) UA106890C2 (pt)
WO (1) WO2011023389A1 (pt)

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JP6290209B2 (ja) 2012-08-07 2018-03-07 ロシュ グリクアート アーゲー 低下した及び増加したエフェクター機能を有するように操作された２つの抗体を含む組成物。
RS60084B1 (sr) 2012-12-10 2020-05-29 Biogen Ma Inc Antitela anti-antigen 2 dendritske ćelije krvi i njihove upotrebe
WO2014172448A2 (en) * 2013-04-17 2014-10-23 Anaptysbio, Inc. Antibodies directed against activin receptor type ii (actrii)
WO2015082446A1 (en) 2013-12-02 2015-06-11 F. Hoffmann-La Roche Ag Treatment of cancer using an anti-cdcp1 antibody and a taxane
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WO2015200522A2 (en) * 2014-06-25 2015-12-30 Integrated Biotherapeutics, Inc. Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species
CA3047115A1 (en) * 2016-12-16 2018-06-21 Bluefin Biomedicine, Inc. Anti-cub domain-containing protein 1 (cdcp1) antibodies, antibody drug conjugates, and methods of use thereof
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EP3700930A1 (en) 2017-10-25 2020-09-02 The Regents of the University of California Antibodies against cdcp1 for the treatment and detection of cancer
US20220119545A1 (en) * 2018-11-09 2022-04-21 Beth Israel Deaconess Medical Center Cdcp1-targeted therapies
US20230174662A1 (en) 2019-02-01 2023-06-08 Fondazione Per L'istituto Oncologico Di Ricerca (Ior) Methods of treating castrate-resistant prostate cancer
WO2021132427A1 (ja) 2019-12-27 2021-07-01 株式会社カイオム・バイオサイエンス 抗ｃｄｃｐ１抗体
CN117264055A (zh) * 2022-06-14 2023-12-22 上海恒润达生生物科技股份有限公司 一种特异性结合人cd318的vhh抗体或其抗原结合片段及其制备方法和应用
WO2023246701A1 (zh) * 2022-06-20 2023-12-28 四川汇宇制药股份有限公司 一种抗体及其用途
WO2024013723A1 (en) 2022-07-15 2024-01-18 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof
KR20240057529A (ko) * 2022-10-24 2024-05-03 주식회사 노벨티노빌리티 신규 항-cdcp1 항체 및 이의 용도

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Also Published As

Publication number Publication date
JP2013502904A (ja) 2013-01-31
CO6511201A2 (es) 2012-08-31
US20130209455A1 (en) 2013-08-15
CR20120038A (es) 2012-04-18
TW201110983A (en) 2011-04-01
PE20121063A1 (es) 2012-08-09
US20110052582A1 (en) 2011-03-03
CA2770161A1 (en) 2011-03-03
AU2010288879A1 (en) 2012-02-02
HK1167412A1 (en) 2012-11-30
US8394928B2 (en) 2013-03-12
SG178886A1 (en) 2012-04-27
MX2012002458A (es) 2012-03-14
IL217919A0 (en) 2012-03-29
MA33537B1 (fr) 2012-08-01
US9346886B2 (en) 2016-05-24
AR077973A1 (es) 2011-10-05
RU2571207C2 (ru) 2015-12-20
JP5647687B2 (ja) 2015-01-07
CN102482357A (zh) 2012-05-30
KR101495407B1 (ko) 2015-02-24
UA106890C2 (uk) 2014-10-27
CL2012000524A1 (es) 2012-08-17
CN102482357B (zh) 2014-06-11
ECSP12011701A (es) 2012-03-30
WO2011023389A1 (en) 2011-03-03
NZ597664A (en) 2013-03-28
RU2012111708A (ru) 2013-10-10
TWI412375B (zh) 2013-10-21
KR20120089658A (ko) 2012-08-13
EP2470567A1 (en) 2012-07-04

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