BRPI0816094A2 - Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo. - Google Patents
Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo.Info
- Publication number
- BRPI0816094A2 BRPI0816094A2 BRPI0816094A BRPI0816094A2 BR PI0816094 A2 BRPI0816094 A2 BR PI0816094A2 BR PI0816094 A BRPI0816094 A BR PI0816094A BR PI0816094 A2 BRPI0816094 A2 BR PI0816094A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- hybridoma
- polynucleotide
- mammalian
- polypeptide
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007224007 | 2007-08-30 | ||
PCT/JP2008/065486 WO2009028639A1 (ja) | 2007-08-30 | 2008-08-29 | 抗epha2抗体 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0816094A2 true BRPI0816094A2 (pt) | 2015-03-03 |
Family
ID=40387351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0816094 BRPI0816094A2 (pt) | 2007-08-30 | 2008-08-29 | Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo. |
Country Status (26)
Country | Link |
---|---|
US (3) | US8449882B2 (pt) |
EP (1) | EP2199390B1 (pt) |
JP (2) | JP5312333B2 (pt) |
KR (4) | KR101561416B1 (pt) |
CN (1) | CN101848998B (pt) |
AU (1) | AU2008292352B2 (pt) |
BR (1) | BRPI0816094A2 (pt) |
CA (1) | CA2698146C (pt) |
CO (1) | CO6180469A2 (pt) |
CY (1) | CY1118763T1 (pt) |
DK (1) | DK2199390T3 (pt) |
ES (1) | ES2618316T3 (pt) |
HR (1) | HRP20170407T1 (pt) |
HU (1) | HUE032301T2 (pt) |
IL (1) | IL204211A (pt) |
LT (1) | LT2199390T (pt) |
MX (1) | MX2010002248A (pt) |
MY (1) | MY150621A (pt) |
NZ (1) | NZ583966A (pt) |
PL (1) | PL2199390T3 (pt) |
PT (1) | PT2199390T (pt) |
RU (1) | RU2525133C2 (pt) |
SI (1) | SI2199390T1 (pt) |
TW (1) | TWI443109B (pt) |
WO (1) | WO2009028639A1 (pt) |
ZA (1) | ZA201001340B (pt) |
Families Citing this family (19)
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US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
TW201208701A (en) * | 2010-07-12 | 2012-03-01 | Daiichi Sankyo Co Ltd | Anti-EPHA2 antibodies and uses thereof |
KR20130048242A (ko) * | 2010-07-22 | 2013-05-09 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 항-종양 항원 항체 및 이용 방법 |
EP2446895A1 (en) | 2010-10-01 | 2012-05-02 | Stemgen S.P.A. | EPH receptor expression in tumor stem cells |
US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
JP6130307B2 (ja) | 2011-03-17 | 2017-05-17 | ザ ユニバーシティ オブ バーミンガム | 再指向性免疫療法 |
JP5875054B2 (ja) | 2013-02-13 | 2016-03-02 | 国立大学法人 東京大学 | がんの検査方法及び検査用キット |
US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
JP6938536B2 (ja) * | 2016-04-14 | 2021-09-22 | アカデミア シニカAcademia Sinica | 新規のvegfr2コレセプターであるscube2の阻害による、腫瘍血管新生の抑制 |
JP7019609B2 (ja) | 2016-06-09 | 2022-02-15 | ユニバーシティー オブ レスター | 卵巣がんおよび膵臓がんのためのバイオマーカーとしてムチン様タンパク質(mlp)を検出するためのモノクローナル抗体、組成物および方法 |
US20190359722A1 (en) * | 2017-01-23 | 2019-11-28 | Toyo University | Anti-epha2 antibody and immunological detection of epha2 using same |
US11421032B2 (en) * | 2017-05-22 | 2022-08-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for inhibition of MICA/B shedding |
CN109879965B (zh) * | 2017-12-06 | 2022-11-11 | 北京科立思维生物科技有限公司 | 抗epha2单链抗体、抗cd3e单链抗体及融合蛋白及其应用 |
BR112021003472A2 (pt) | 2018-09-06 | 2021-05-18 | Daiichi Sankyo Company, Limited | derivado de dinucleotídeo cíclico e conjugado de anticorpo-fármaco do mesmo |
US11702482B2 (en) | 2018-12-17 | 2023-07-18 | Revitope Limited | Twin immune cell engager |
TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體-免疫賦活化劑共軛物之新穎製造方法 |
WO2022187710A1 (en) * | 2021-03-05 | 2022-09-09 | Atreca, Inc. | Epha2 antibodies |
CA3212691A1 (en) | 2021-03-12 | 2022-09-15 | Daiichi Sankyo Company, Limited | Glycan, and method for producing medicine containing glycan |
KR20220159289A (ko) | 2021-05-25 | 2022-12-02 | 주식회사 박셀바이오 | 모노바디 기반 키메라 항원 수용체 및 이를 포함하는 면역 세포 |
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2008
- 2008-08-29 MX MX2010002248A patent/MX2010002248A/es active IP Right Grant
- 2008-08-29 WO PCT/JP2008/065486 patent/WO2009028639A1/ja active Application Filing
- 2008-08-29 LT LTEP08828482.3T patent/LT2199390T/lt unknown
- 2008-08-29 NZ NZ583966A patent/NZ583966A/en not_active IP Right Cessation
- 2008-08-29 CN CN200880114621.5A patent/CN101848998B/zh not_active Expired - Fee Related
- 2008-08-29 PT PT88284823T patent/PT2199390T/pt unknown
- 2008-08-29 AU AU2008292352A patent/AU2008292352B2/en not_active Ceased
- 2008-08-29 SI SI200831748A patent/SI2199390T1/sl unknown
- 2008-08-29 KR KR1020157008277A patent/KR101561416B1/ko not_active IP Right Cessation
- 2008-08-29 KR KR1020107004260A patent/KR101521668B1/ko not_active IP Right Cessation
- 2008-08-29 BR BRPI0816094 patent/BRPI0816094A2/pt not_active Application Discontinuation
- 2008-08-29 KR KR1020147036821A patent/KR101561403B1/ko not_active IP Right Cessation
- 2008-08-29 KR KR1020157008278A patent/KR101561417B1/ko not_active IP Right Cessation
- 2008-08-29 TW TW97133095A patent/TWI443109B/zh not_active IP Right Cessation
- 2008-08-29 PL PL08828482T patent/PL2199390T3/pl unknown
- 2008-08-29 MY MYPI20100815 patent/MY150621A/en unknown
- 2008-08-29 EP EP08828482.3A patent/EP2199390B1/en not_active Not-in-force
- 2008-08-29 RU RU2010111896/10A patent/RU2525133C2/ru not_active IP Right Cessation
- 2008-08-29 DK DK08828482.3T patent/DK2199390T3/en active
- 2008-08-29 JP JP2009530190A patent/JP5312333B2/ja not_active Expired - Fee Related
- 2008-08-29 HU HUE08828482A patent/HUE032301T2/en unknown
- 2008-08-29 ES ES08828482.3T patent/ES2618316T3/es active Active
- 2008-08-29 CA CA2698146A patent/CA2698146C/en not_active Expired - Fee Related
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2010
- 2010-02-24 ZA ZA2010/01340A patent/ZA201001340B/en unknown
- 2010-02-25 US US12/713,041 patent/US8449882B2/en active Active
- 2010-02-28 IL IL204211A patent/IL204211A/en not_active IP Right Cessation
- 2010-03-11 CO CO10028981A patent/CO6180469A2/es active IP Right Grant
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2013
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- 2013-06-05 JP JP2013118547A patent/JP5688433B2/ja not_active Expired - Fee Related
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2015
- 2015-10-05 US US14/875,360 patent/US20160031987A1/en not_active Abandoned
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2017
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- 2017-03-16 CY CY20171100336T patent/CY1118763T1/el unknown
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