EA201400811A1 - Двойная индуцированная антигеном двухкомпонентная функциональная комплементация - Google Patents

Двойная индуцированная антигеном двухкомпонентная функциональная комплементация

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EA201400811A1
EA201400811A1 EA201400811A EA201400811A EA201400811A1 EA 201400811 A1 EA201400811 A1 EA 201400811A1 EA 201400811 A EA201400811 A EA 201400811A EA 201400811 A EA201400811 A EA 201400811A EA 201400811 A1 EA201400811 A1 EA 201400811A1
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polypeptides
application describes
addition
specified set
induced
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EA201400811A
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EA033947B1 (ru
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Гернот Штулер
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Юлиус-Максимилианс-Универзитет Вюрцбург
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract

В заявке описан набор полипептидов и его применения. В частности, в заявке описан набор полипептидов, где указанный набор содержит два полипептида, каждый из которых содержит нацеливающий участок "Т", который связывается с антигеном "А", и фрагмент "F" функционального домена, при этом указанные два полипептида не ассоциированы друг с другом в отсутствии субстрата, который несет "А" в(на) своей поверхности, и при этом после димеризации "F" образовавшийся димер становится функциональным. Кроме того, в заявке описаны медицинские и диагностические применения указанного набора. Кроме того, в заявке описана(ы) молекула(ы) нуклеиновой(ых) кислоты(т), кодирующая(ие) указанный набор полипептидов. В заявке описан также вектор, содержащий нуклеотидную последовательность молекулы(л) нуклеиновой(ых) кислоты(т), кодирующей(их) полипептиды. Кроме того, в заявке описаны фармацевтические композиции, содержащие указанный набор полипептидов. Кроме того, в заявке описан комплект, содержащий указанный набор полипептидов.
EA201400811A 2012-01-13 2013-01-14 Набор полипептидов для идентификации и/или элиминации клеток, его применение, молекула нуклеиновой кислоты, которая кодирует один из полипептидов набора, набор нуклеиновых кислот, который кодирует набор полипептидов, фармацевтическая композиция, содержащая эти наборы EA033947B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12151125 2012-01-13
PCT/EP2013/050603 WO2013104804A2 (en) 2012-01-13 2013-01-14 Dual antigen-induced bipartite functional complementation

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EA201400811A1 true EA201400811A1 (ru) 2014-12-30
EA033947B1 EA033947B1 (ru) 2019-12-12

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EA201400811A EA033947B1 (ru) 2012-01-13 2013-01-14 Набор полипептидов для идентификации и/или элиминации клеток, его применение, молекула нуклеиновой кислоты, которая кодирует один из полипептидов набора, набор нуклеиновых кислот, который кодирует набор полипептидов, фармацевтическая композиция, содержащая эти наборы

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US (3) US20150079093A1 (ru)
EP (3) EP3907241A1 (ru)
JP (1) JP6408915B2 (ru)
KR (2) KR20200040893A (ru)
CN (2) CN104159923B (ru)
AU (1) AU2013208895B2 (ru)
CA (1) CA2861003C (ru)
CY (1) CY1119928T1 (ru)
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EA (1) EA033947B1 (ru)
ES (1) ES2653287T3 (ru)
HK (1) HK1200175A1 (ru)
HR (1) HRP20171912T1 (ru)
HU (1) HUE035207T2 (ru)
IL (1) IL233566B (ru)
LT (1) LT2802607T (ru)
MX (1) MX359411B (ru)
NO (1) NO2802607T3 (ru)
PL (1) PL2802607T3 (ru)
PT (1) PT2802607T (ru)
RS (1) RS56773B1 (ru)
SG (1) SG11201403997SA (ru)
SI (1) SI2802607T1 (ru)
WO (1) WO2013104804A2 (ru)
ZA (1) ZA201405658B (ru)

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KR20160075532A (ko) 2013-09-25 2016-06-29 아라백스 피티와이 엘티디 신규한 면역치료제 조성물 및 이의 용도
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