BR112022014568A2 - Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos - Google Patents

Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos

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Publication number
BR112022014568A2
BR112022014568A2 BR112022014568A BR112022014568A BR112022014568A2 BR 112022014568 A2 BR112022014568 A2 BR 112022014568A2 BR 112022014568 A BR112022014568 A BR 112022014568A BR 112022014568 A BR112022014568 A BR 112022014568A BR 112022014568 A2 BR112022014568 A2 BR 112022014568A2
Authority
BR
Brazil
Prior art keywords
methods
cars
chimeric antigen
antigen receptors
present disclosure
Prior art date
Application number
BR112022014568A
Other languages
English (en)
Inventor
Ian Frost Gregory
Joseph Onuffer James Jr
Kundu Anirban
M Short Jay
Frey Gerhard
Wen Chang Hwai
Original Assignee
Exuma Biotech Corp
Bioatla Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exuma Biotech Corp, Bioatla Llc filed Critical Exuma Biotech Corp
Publication of BR112022014568A2 publication Critical patent/BR112022014568A2/pt

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464403—Receptors for growth factors
    • A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464452—Transcription factors, e.g. SOX or c-MYC
    • A61K39/464453—Wilms tumor 1 [WT1]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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  • Health & Medical Sciences (AREA)
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Abstract

RECEPTORES DE ANTÍGENO QUIMÉRICOS CONTRA HER2 E MÉTODOS DE USO DOS MESMOS. A presente divulgação fornece receptores de antígenos quiméricos (CARs) e ácidos nucleicos que compreendem sequências nucleotídicas que codificam os CARs, que se ligam ao HER2 e CARs biológicos condicionalmente ativos (CAB) que se ligam ao HER2. A presente divulgação fornece células geneticamente modificadas para produzir os CARs, suspensão de administração compreendendo essas células geneticamente modificadas e métodos para a produção dessas células. Os CARs da presente divulgação podem ser usados em vários métodos, que são também fornecidos, incluindo os métodos para ativação de células imunes sob certas condições e métodos para realizar terapia de células adotivas, tal como terapia de CAR, por exemplo, terapia de CAR contra o câncer.
BR112022014568A 2020-01-23 2021-01-23 Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos BR112022014568A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062964947P 2020-01-23 2020-01-23
PCT/US2021/070073 WO2021151119A1 (en) 2020-01-23 2021-01-23 Chimeric antigen receptors to her2 and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112022014568A2 true BR112022014568A2 (pt) 2022-09-27

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ID=76992754

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BR112022014568A BR112022014568A2 (pt) 2020-01-23 2021-01-23 Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos

Country Status (11)

Country Link
US (1) US20230072955A1 (pt)
EP (1) EP4087867A4 (pt)
JP (1) JP2023513458A (pt)
KR (1) KR20220153578A (pt)
CN (1) CN115485293A (pt)
AU (1) AU2021210446A1 (pt)
BR (1) BR112022014568A2 (pt)
CA (1) CA3168813A1 (pt)
IL (1) IL294877A (pt)
MX (1) MX2022009049A (pt)
WO (1) WO2021151119A1 (pt)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289942B1 (en) * 2002-04-10 2013-07-31 Genentech, Inc. Anti-HER2 antibody variants
US20100183615A1 (en) * 2007-04-03 2010-07-22 Micromet Ag Cross-species-specific bispecific binders
CA2818635C (en) * 2010-12-06 2021-06-15 National Reseach Council Of Canada Antibodies selective for cells presenting erbb2 at high density
EP3333190A1 (en) * 2012-01-13 2018-06-13 Julius-Maximilians-Universität Würzburg Dual antigen-induced bipartite functional complementation
US11197919B2 (en) * 2015-11-04 2021-12-14 City Of Hope Chimeric antigen receptors targeting HER2
US20190367876A1 (en) * 2017-01-18 2019-12-05 F1 Oncology, Inc. Methods of transducing and expanding immune cells and uses thereof
EP3652537A4 (en) * 2017-05-05 2021-10-20 Memorial Sloan Kettering Cancer Center MODULAR SELF-ASSEMBLY / DISASSEMBLY TECHNOLOGIES (SADA)
EP3690038A4 (en) * 2017-09-29 2021-05-19 Daiichi Sankyo Company, Limited ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE
WO2019136167A1 (en) * 2018-01-03 2019-07-11 Palleon Pharmaceuticals Inc. Recombinant human sialidases, sialidase fusion proteins, and methods of using the same
JP2021517907A (ja) * 2018-04-18 2021-07-29 アブクロン・インコーポレイテッドＡｂｃｌｏｎ Ｉｎｃ． スイッチ分子及びスイッチャブルキメラ抗原受容体

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CA3168813A1 (en) 2021-07-29
AU2021210446A1 (en) 2022-07-28
EP4087867A1 (en) 2022-11-16
JP2023513458A (ja) 2023-03-31
WO2021151119A1 (en) 2021-07-29
CN115485293A (zh) 2022-12-16
US20230072955A1 (en) 2023-03-09
EP4087867A4 (en) 2024-02-14
MX2022009049A (es) 2022-11-08
KR20220153578A (ko) 2022-11-18
IL294877A (en) 2022-09-01

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